2025
Sex-specific gonadal status determines prefrontal cortex proteome response to tibolone
McGovern A, Arevalo M, Ciordia S, Garcia-Segura L, Barreto G. Sex-specific gonadal status determines prefrontal cortex proteome response to tibolone. Biomedicine & Pharmacotherapy 2025, 190: 118419. PMID: 40779885, DOI: 10.1016/j.biopha.2025.118419.Peer-Reviewed Original ResearchPrefrontal cortexHormone therapyCellular stress response pathwaysStress response pathwaysFemale miceFunctional enrichment analysisSex-SpecificEmotion regulationClinical trialsCytoskeletal functionBrain functionMitochondrial metabolismSex differencesMenopausal hormone therapyResponse pathwaysGonadal hormonesProteomic analysisSynaptic plasticityEnrichment analysisNeurotransmitter signalingMolecular mechanismsFunctional convergenceGonadectomized animalsHormone therapy efficacyNeurodegenerative diseases
2024
Sex chromosome complement interacts with gonadal hormones in determining regional-specific neuroactive steroid levels in plasma, hippocampus, and hypothalamus. A study using the four core genotype mouse model
Cioffi L, Grassi D, Diviccaro S, Caruso D, Pinto-Benito D, Arevalo M, Garcia-Segura L, Melcangi R, Giatti S. Sex chromosome complement interacts with gonadal hormones in determining regional-specific neuroactive steroid levels in plasma, hippocampus, and hypothalamus. A study using the four core genotype mouse model. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 241: 106514. PMID: 38554982, DOI: 10.1016/j.jsbmb.2024.106514.Peer-Reviewed Original ResearchSex chromosome complementChromosome complementGenotype mouse modelNeuroactive steroid levelsNeuroactive steroidsMouse modelSteroid levelsSex chromosomesSRY geneSexual dimorphism levelsSex determinationContribution of sex chromosome complementTissue-specific actionsGonadsLiquid chromatography-tandem mass spectrometryGonadal hormonesChromatography-tandem mass spectrometryNeuroprotective actionSteroidsSexual featuresLevel regulationNervous systemSex-SpecificGenotypesComplement
2023
Trajectory of Gonadal Hormones in Adolescent Males up to 2 Years After Sleeve Gastrectomy
Kaur S, Bredella M, Misra M, Singhal V. Trajectory of Gonadal Hormones in Adolescent Males up to 2 Years After Sleeve Gastrectomy. Obesity Surgery 2023, 33: 3323-3326. PMID: 37561269, DOI: 10.1007/s11695-023-06759-0.Peer-Reviewed Original ResearchConceptsSertoli cell functionAssociated with degree of weight lossDegree of weight lossLeydig cell functionSleeve gastrectomyCell functionEffects of SGAssociated with degreeLong-term follow-up studiesWeight lossMale fertilitySertoliFollow-up studyNonsurgical controlsSG groupYoung adult malesTestosterone levelsGonadal hormonesMetabolic benefitsLeydigGastrectomyAdult malesAdolescentsTestisPreliminary study
2022
Correlations between salivary- and blood-derived gonadal hormone assessments and implications for inclusion of female participants in research studies
Huang T, Howse F, Stachenfeld N, Usselman C. Correlations between salivary- and blood-derived gonadal hormone assessments and implications for inclusion of female participants in research studies. AJP Heart And Circulatory Physiology 2022, 324: h33-h46. PMID: 36426884, DOI: 10.1152/ajpheart.00399.2022.Peer-Reviewed Original ResearchConceptsMenstrual cycleGonadal hormonesFemale participantsVenous blood samplesGonadal hormone fluctuationsPrimary gonadalVascular functionBlood concentrationsCardiovascular diseaseHormone assessmentSerial measurementsHormone fluctuationsHormone monitoringBlood samplesStudy designGold standard measurementHuman physiology researchHormoneInclusion of femalesSalivaryResearch studiesCardiovascular researchersParticipantsFemales
2014
Effects of endogenous and exogenous progesterone on emotional intelligence in cocaine‐dependent men and women who also abuse alcohol
Milivojevic V, Sinha R, Morgan PT, Sofuoglu M, Fox HC. Effects of endogenous and exogenous progesterone on emotional intelligence in cocaine‐dependent men and women who also abuse alcohol. Human Psychopharmacology Clinical And Experimental 2014, 29: 589-598. PMID: 25363303, PMCID: PMC4498951, DOI: 10.1002/hup.2446.Peer-Reviewed Original ResearchConceptsEmotional intelligenceStudy 1Caruso Emotional Intelligence TestAbstinent cocaine-dependent individualsEmotional Intelligence TestRegulation of emotionCocaine-dependent individualsCocaine-dependent menFunction of genderManaging emotionsIntelligence testsEmotionsSelective aspectsSubstance dependenceGender effectsSex differencesMenstrual cycle phaseIntelligenceGender discrepancyMSCEITSaloveyImproved abilityIndividualsGonadal hormonesHealthy individualsChallenges and methodology for testing young healthy women in physiological studies
Stachenfeld NS, Taylor HS. Challenges and methodology for testing young healthy women in physiological studies. AJP Endocrinology And Metabolism 2014, 306: e849-e853. PMID: 24569589, PMCID: PMC3989744, DOI: 10.1152/ajpendo.00038.2014.Peer-Reviewed Original ResearchConceptsHormone exposureGonadotropin-releasing hormone agonistFemale gonadal hormonesReproductive hormone exposureHealth careYoung healthy womenWomen's health careNIH Revitalization ActEffects of hormonesHealthy womenHormone agonistFemale reproductive physiologyGonadal hormonesHormone effectsPhysiological studiesHormoneWomenPhysiological responsesStronger research designsEndogenous hormonesRevitalization ActMenReproductive physiologyExposureMethods investigators
2010
Menstrual cycle phase at quit date and smoking abstinence at 6 weeks in an open label trial of bupropion
Mazure CM, Toll B, McKee SA, Wu R, O’Malley S. Menstrual cycle phase at quit date and smoking abstinence at 6 weeks in an open label trial of bupropion. Drug And Alcohol Dependence 2010, 114: 68-72. PMID: 20832955, PMCID: PMC3016455, DOI: 10.1016/j.drugalcdep.2010.07.024.Peer-Reviewed Original ResearchConceptsMenstrual cycle phaseQuit datePoint prevalence abstinencePremenopausal womenBupropion SRFollicular phaseLuteal phaseAbsence of pharmacotherapySustained release bupropionOpen-label trialCycle phaseMechanism of actionRelease bupropionLabel trialNicotine replacementCessation interventionsOpen trialTreatment completionCessation outcomesContinuous abstinenceQuit dayGonadal hormonesTreatment periodAbstinence outcomesQuit attempts
2009
Women sleep objectively better than men and the sleep of young women is more resilient to external stressors: effects of age and menopause
BIXLER E, PAPALIAGA M, VGONTZAS A, LIN H, PEJOVIC S, KARATARAKI M, VELA‐BUENO A, CHROUSOS G. Women sleep objectively better than men and the sleep of young women is more resilient to external stressors: effects of age and menopause. Journal Of Sleep Research 2009, 18: 221-228. PMID: 19302341, PMCID: PMC3594776, DOI: 10.1111/j.1365-2869.2008.00713.x.Peer-Reviewed Original ResearchConceptsPercentage of sleep timePercentage of slow wave sleepPercentage of stage 1Percentage of stage 1 sleepGeneral population sampleHormone treatmentDecreased deep sleepSleep timeYoung womenProlonged sleep latencyAbsence of HTEffects of menopauseStage 1 sleepLow cardiovascular riskObjective sleep patternsSlow wave sleepAssociated with prolonged sleep latencyExternal stressorsHealthy womenHealthy volunteersSleep laboratoryCardiovascular riskGonadal hormonesSleep regulationBlood draw
2007
Effects of Androgens and Estradiol on Spine Synapse Formation in the Prefrontal Cortex of Normal and Testicular Feminization Mutant Male Rats
Hajszan T, MacLusky NJ, Johansen JA, Jordan CL, Leranth C. Effects of Androgens and Estradiol on Spine Synapse Formation in the Prefrontal Cortex of Normal and Testicular Feminization Mutant Male Rats. Endocrinology 2007, 148: 1963-1967. PMID: 17317772, PMCID: PMC2128740, DOI: 10.1210/en.2006-1626.Peer-Reviewed Original ResearchConceptsSpine synapse formationMale ratsWild-type animalsPrefrontal cortexTfm ratsSpine synapsesAndrogen receptorSynapse formationEffects of androgensSynaptogenic actionsTfm malesGonadal steroidsSynaptogenic effectsGonadal hormonesSynaptic remodelingTfm animalsFemale monkeysRatsCortexCortical spinesCognitive effectsAndrogensReceptorsSynapsesAdult malesSex steroids and the dentate gyrus
Hajszan T, Milner TA, Leranth C. Sex steroids and the dentate gyrus. Progress In Brain Research 2007, 163: 399-816. PMID: 17765731, PMCID: PMC1964752, DOI: 10.1016/s0079-6123(07)63023-4.Peer-Reviewed Original ResearchConceptsDentate gyrusSex steroidsGonadal hormonesSynaptic remodelingActivational effectsNormal dentate gyrusExpression of estrogenDentate gyrus neurogenesisCholinergic septohippocampal systemNormal cognitive functionSteroid-mediated actionsMore granule cellsCertain mouse strainsGyrus neurogenesisNeuroprotective potentialDentate neuronsAndrogen receptorGonadal originDentate cellsAdult brainHippocampal formationGranule cellsCellular injuryClinical importanceAlzheimer's disease
2004
Low CA1 Spine Synapse Density is Further Reduced by Castration in Male Non-human Primates
Leranth C, Prange-Kiel J, Frick KM, Horvath TL. Low CA1 Spine Synapse Density is Further Reduced by Castration in Male Non-human Primates. Cerebral Cortex 2004, 14: 503-510. PMID: 15054066, DOI: 10.1093/cercor/bhh012.Peer-Reviewed Original ResearchConceptsSpine synapse densitySynapse densityNon-human primatesSpine synapsesCA1 spine synapse densityPyramidal cell apical dendritesCA1 hippocampal areaCell apical dendritesCA1 stratum radiatumFemale non-human primatesMale non-human primatesMale primatesOrchidectomized animalsApical dendritesCA1 areaDendritic shaftsHippocampal areaStratum radiatumGonadal hormonesControl monkeysMale hippocampusGonadectomized animalsOvariectomized femalesAndrogen hormonesPrimate hippocampus
2000
Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory
Leranth C, Roth R, Elsworth J, Naftolin F, Horvath T, Redmond D. Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory. Journal Of Neuroscience 2000, 20: 8604-8609. PMID: 11102464, PMCID: PMC6773080, DOI: 10.1523/jneurosci.20-23-08604.2000.Peer-Reviewed Original ResearchConceptsNigrostriatal dopamine neuronsDopamine neuronsParkinson's diseaseSubstantia nigraDopamine cellsTyrosine hydroxylase-expressing neuronsTyrosine hydroxylase-immunoreactive cellsNigral dopamine systemsEstrogen replacement therapyNew treatment strategiesUnbiased stereological analysisTypes of neuronsProgression of diseaseEstrogen replacementPostmenopausal womenEstrogen deprivationReplacement therapyTreatment strategiesCompact zoneGonadal hormonesLong-term effectsDopamine systemEstrogenDiseaseNeurons
1999
Estrogen receptor-α in the raphe serotonergic and supramammillary area calretinin-containing neurons of the female rat
Leranth C, Shanabrough M, Horvath T. Estrogen receptor-α in the raphe serotonergic and supramammillary area calretinin-containing neurons of the female rat. Experimental Brain Research 1999, 128: 417-420. PMID: 10501815, DOI: 10.1007/s002210050863.Peer-Reviewed Original ResearchConceptsEstrogen receptorLong-term potentiationMedian rapheSupramammillary areaSubcortical structuresCalretinin-containing neuronsHippocampal long-term potentiationEffects of estrogenHippocampal electric activityCalretinin neuronsFemale ratsGonadal hormonesTheta rhythmRapheVibratome sectionsReceptorsNeuronsSerotoninElectric activityEstrogenRhythm regulationPotentiationLarge populationMemory processesCalretinin
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply