2022
Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone
Novick AM, Duffy KA, Johnson RL, Sammel MD, Cao W, Strasser AA, Sofuoglu M, Kuzma A, Loughead J, Morrow AL, Epperson CN. Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone. Biology Of Sex Differences 2022, 13: 60. PMID: 36274158, PMCID: PMC9590190, DOI: 10.1186/s13293-022-00472-w.Peer-Reviewed Original ResearchConceptsTobacco use disorderProgesterone ratioConversion of progesteroneNicotine withdrawalSmoking cuesTherapeutic effectPlacebo-controlled crossover studySmoking-related outcomesNeural responsesSex-dependent effectsGreater therapeutic benefitDays of abstinenceCrossover studyFemale smokersProgesterone administrationNeurosteroid allopregnanoloneWithdrawal symptomsNicotine effectsWithdrawal severityAllopregnanoloneTherapeutic benefitUse disordersSmoking urgesProgesteroneProgesterone conversionDoes Antenatal Progesterone Administration Modify the Risk of Neonatal Intraventricular Hemorrhage?
Leon-Martinez D, Bank TC, Lundsberg LS, Culhane J, Silasi M, Son M, Partridge C, Reddy UM, Hoffman MK, Merriam A. Does Antenatal Progesterone Administration Modify the Risk of Neonatal Intraventricular Hemorrhage? American Journal Of Perinatology 2022, 41: e46-e52. PMID: 35436803, DOI: 10.1055/a-1827-6712.Peer-Reviewed Original ResearchNeonatal intraventricular hemorrhageIntraventricular hemorrhageBrain injuryOdds ratioDiagnosis of IVHRisk of IVHImproved neurological outcomeNeonatal brain injuryLarge academic medical centerConfidence intervalsRoute of deliveryEffect of progesteroneTraumatic brain injuryAcademic medical centerHospitalization encountersNeurological outcomePreterm neonatesSingleton deliveriesMaternal administrationProgesterone administrationRetrospective studyAntepartum periodLow birthweightPotential confoundersDiagnosis codes
2019
Progesterone Treatment Attenuates Glycolytic Metabolism and Induces Senescence in Glioblastoma
Atif F, Yousuf S, Espinosa-Garcia C, Sergeeva E, Stein D. Progesterone Treatment Attenuates Glycolytic Metabolism and Induces Senescence in Glioblastoma. Scientific Reports 2019, 9: 988. PMID: 30700763, PMCID: PMC6353890, DOI: 10.1038/s41598-018-37399-5.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsApoptosisBehavior, AnimalBiomarkersCell Line, TumorCell ProliferationCell SurvivalCellular SenescenceEnzyme AssaysGlioblastomaGlycolysisLuciferasesMice, NudeModels, BiologicalMotor ActivityNeovascularization, PathologicPhosphatidylinositol 3-KinasesProgesteroneProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesConceptsGrowth of glioblastoma multiformeGlycolytic metabolismEffect of progesterone treatmentHigh-dose progesteroneReduced anxiety-like behaviorFollow-up in vitro studyOrthotopic mouse modelSpontaneous locomotor activityAnxiety-like behaviorAthymic nude miceInduce senescenceExpression of GLUT1Increased survival rateCytoplasmic FOXO1Tumor sizeTumor establishmentProgesterone administrationProgesterone treatmentTumor cellsTumor progressionInduce premature senescenceFollow-upNude micePeripheral organsLocomotor activity
2015
Systematic and Meta-Analytic Review of Research Examining the Impact of Menstrual Cycle Phase and Ovarian Hormones on Smoking and Cessation
Weinberger AH, Smith PH, Allen SS, Cosgrove KP, Saladin ME, Gray KM, Mazure CM, Wetherington CL, McKee SA. Systematic and Meta-Analytic Review of Research Examining the Impact of Menstrual Cycle Phase and Ovarian Hormones on Smoking and Cessation. Nicotine & Tobacco Research 2015, 17: 407-421. PMID: 25762750, PMCID: PMC4429881, DOI: 10.1093/ntr/ntu249.Peer-Reviewed Original ResearchConceptsMenstrual cycle phaseHormone levelsOvarian hormonesLuteal phaseSmoking behaviorSearch termsOvarian hormone levelsMenstrual phase effectsCessation-related behaviorsTiming of interventionNegative subjective effectsMenstrual cycle effectsProgesterone administrationFollicular phaseMedication responseQuit ratesTonic cravingInclusion criteriaMenstrual phaseNonsignificant trendSmoking outcomesCycle phaseSmokingSystematic reviewGreater tonic
2011
Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance
Wenner MM, Taylor HS, Stachenfeld NS. Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance. The Journal Of Physiology 2011, 589: 975-986. PMID: 21173076, PMCID: PMC3060374, DOI: 10.1113/jphysiol.2010.194563.Peer-Reviewed Original ResearchConceptsLow orthostatic toleranceHigh orthostatic toleranceOrthostatic toleranceAdrenergic responseAdrenergic responsivenessNitric oxide synthase inhibitor NG-monomethylEndogenous sex hormone productionSynthase inhibitor NG-monomethylSkin blood flow responseBlood flow responseInhibitor NG-monomethylSex hormone productionFemale sex hormonesLower body negative pressure testSkin blood flowGnRH antagonistProgesterone administrationOrthostatic intoleranceNG-monomethylPeripheral αMicrodialysis infusionSex hormonesCyclooxygenase pathwayHT womenAdrenergic control
2007
Exogenous oestradiol and progesterone administration does not cause oedema in healthy young women
Stachenfeld NS, Taylor HS. Exogenous oestradiol and progesterone administration does not cause oedema in healthy young women. Clinical Endocrinology 2007, 66: 410-418. PMID: 17302877, DOI: 10.1111/j.1365-2265.2007.02748.x.Peer-Reviewed Original ResearchConceptsExtracellular fluid volumeTranscapillary albumin escape rateGonadotropin-releasing hormone antagonistPmol/Plasma renin activitySerum aldosterone concentrationHealthy young womenAlbumin escape rateRenin activityAldosterone concentrationGnRH antagonistHealthy womenProgesterone administrationExogenous oestradiolIntravascular volumeHormone antagonistProgesterone increaseDay 2Day 5Hormone treatmentOestradiolDay 13Extravascular componentOncotic pressureYoung women
2003
Effects of estrogen and progesterone administration on extracellular fluid
Stachenfeld NS, Taylor HS. Effects of estrogen and progesterone administration on extracellular fluid. Journal Of Applied Physiology 2003, 96: 1011-1018. PMID: 14660504, DOI: 10.1152/japplphysiol.01032.2003.Peer-Reviewed Original ResearchConceptsGnRH antagonist administrationExtracellular fluid volumeGnRH antagonistEffects of estrogenAntagonist administrationPlasma volumeTranscapillary escape rateGonadotropin-releasing hormoneExtracellular fluidHealthy womenProgesterone administrationECFV expansionGanirelix acetateEndogenous estrogensStrong negative predictorDay 2Day 5Pg/AntagonistEstrogenDay 12Plasma compartmentCapillary endotheliumAdministrationProgesterone
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