2025
Sex and HIV Modify Immune Activation Biomarkers in Ugandans Post-Tuberculosis.
Abelman R, Fitzpatrick J, Zawedde J, Beck-Engeser G, Rn I, Marzan F, Byanyima P, Ambayec G, Kaswabuli S, Musisi E, Sessolo A, Velasquez E, Lalitha R, Byanova K, Aweeka F, Deitchman A, Lin J, Davis J, Crothers K, Worodria W, Hunt P, Huang L. Sex and HIV Modify Immune Activation Biomarkers in Ugandans Post-Tuberculosis. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2025 PMID: 40530901, DOI: 10.1097/qai.0000000000003713.Peer-Reviewed Original Research
2024
Unlocking the potential of miRNAs in detecting pulmonary tuberculosis: prospects and pitfalls
Arya R, Kumar S, Vinetz J, Kim J, Chaurasia R. Unlocking the potential of miRNAs in detecting pulmonary tuberculosis: prospects and pitfalls. Expert Reviews In Molecular Medicine 2024, 26: e32. PMID: 39639643, PMCID: PMC11629464, DOI: 10.1017/erm.2024.29.Peer-Reviewed Original ResearchConceptsDisease stageHIV Co-InfectionAnti-TB therapyPotential of miRNAsInfectious diseasesPulmonary TBPulmonary tuberculosisActive TBFalse-positive outcomesTB diagnosticsDisease progressionLack of specificityPrognostic signatureCo-InfectionLethal infectious diseaseDeadliest infectious diseasesPoint-of-care testingTuberculosisDiagnostic biomarkersStandard protocolDiseaseBiomarkersGene expressionNon-invasiveRegulatory roleTest and treat approach for tuberculosis infection amongst household contacts of drug-susceptible pulmonary tuberculosis, Mumbai, India
Shah D, Bhide S, Deshmukh R, Smith J, Kaiplyawar S, Puri V, Yeldandi V, Date A, Nyendak M, Ho C, Moonan P. Test and treat approach for tuberculosis infection amongst household contacts of drug-susceptible pulmonary tuberculosis, Mumbai, India. Frontiers In Tuberculosis 2024, 2: 1454277. PMID: 39421397, PMCID: PMC11485165, DOI: 10.3389/ftubr.2024.1454277.Peer-Reviewed Original ResearchInterferon-gamma release assayTB preventive treatmentTB infectionHousehold contactsDrug-susceptible pulmonary tuberculosisTB diseaseTreat approachProgression to active TB diseaseDrug-susceptible pulmonary TBRate of TB infectionPrevalence of TB infectionActive TB diseaseAge 5 yearsSecondary TB casesCross-sectional studyAntituberculosis treatmentIGRA testPulmonary TBPulmonary tuberculosisTuberculosis infectionInterferon-gammaRelease assayClinical evaluationEarly diagnosisTreat strategy
2022
Pulmonary Tuberculosis and Risk of Lung Cancer: A Systematic Review and Meta-Analysis
Hwang S, Kim J, Lee H, Lee S, Kim D, Kim S, Hyun J, Shin J, Lee K, Han S, Song Y. Pulmonary Tuberculosis and Risk of Lung Cancer: A Systematic Review and Meta-Analysis. Journal Of Clinical Medicine 2022, 11: 765. PMID: 35160218, PMCID: PMC8836400, DOI: 10.3390/jcm11030765.Peer-Reviewed Original ResearchHistory of pulmonary TBPulmonary TBLung cancerRisk of lung cancerTB burdenYounger patientsRisk factorsSubgroup analysisMedical diagnostic codesPulmonary tuberculosisUpper-middle income countriesMeta-regression analysisPulmonary TB diagnosisSocioeconomic statusDiagnostic codesTB diagnostic methodsSecondary analysisTreating young patientsIncome countriesPublication biasDiagnosis of lung cancerLung cancer typesSystematic reviewTB diagnosisObservational study
2019
Home-based tuberculosis contact investigation in Uganda: a household randomised trial
Davis JL, Turimumahoro P, Meyer AJ, Ayakaka I, Ochom E, Ggita J, Mark D, Babirye D, Okello DA, Mugabe F, Fair E, Vittinghoff E, Armstrong-Hough M, Dowdy D, Cattamanchi A, Haberer JE, Katamba A. Home-based tuberculosis contact investigation in Uganda: a household randomised trial. ERJ Open Research 2019, 5: 00112-2019. PMID: 31367636, PMCID: PMC6661318, DOI: 10.1183/23120541.00112-2019.Peer-Reviewed Original ResearchCommunity health workersTB contact investigationTuberculosis contact investigationContact investigationTB evaluationIndex patientsWorld Health OrganizationIntervention armHousehold tuberculosis contact investigationCare armHousehold contactsPulmonary TBSputum testingCare contactsHIV diagnosisSecondary outcomesHIV testingPrimary outcomeSymptomatic contactsHealth workersMicrobiologic testingHome evaluationIntervention componentsSputumPatients
2018
807. A Risk-Stratified Approach to Healthcare-Associated Tuberculosis Exposures Following the “Stone in the Pond” Principle
Pepe D, Aniskiewicz M, Paci G, Sullivan L, Dembry L, Martinello R, Advani S. 807. A Risk-Stratified Approach to Healthcare-Associated Tuberculosis Exposures Following the “Stone in the Pond” Principle. Open Forum Infectious Diseases 2018, 5: s289-s289. PMCID: PMC6255516, DOI: 10.1093/ofid/ofy210.814.Peer-Reviewed Original ResearchRisk-stratified approachHealthcare personnelTB exposureType of exposureBed academic medical centerExposure investigationsLatent TB casesLow TB incidenceAcademic medical centerComplete exposure dataTB contactTuberculosis exposureInfectivity riskPulmonary TBTB patientsInfectious tuberculosisTB casesPatient chartsTB incidenceMicrobiology recordsRetrospective studyRisk groupsLower incidenceMedical CenterPrevention database
2017
Accuracy of line probe assays for the diagnosis of pulmonary and multidrug-resistant tuberculosis: a systematic review and meta-analysis
Nathavitharana RR, Cudahy PG, Schumacher SG, Steingart KR, Pai M, Denkinger CM. Accuracy of line probe assays for the diagnosis of pulmonary and multidrug-resistant tuberculosis: a systematic review and meta-analysis. European Respiratory Journal 2017, 49: 1601075. PMID: 28100546, PMCID: PMC5898952, DOI: 10.1183/13993003.01075-2016.Peer-Reviewed Original ResearchConceptsLine probe assayComposite reference standardINH resistanceRIF resistanceSystematic reviewMultidrug-resistant tuberculosis (MDR-TB) casesRapid drug susceptibility testingMultidrug-resistant tuberculosisProbe assayTuberculosis detectionDrug susceptibility testingSmear-positive specimensSmear-negative specimensReference standardM. tuberculosis detectionMycobacterium tuberculosis detectionPulmonary TBTuberculosis casesNew line probe assayStudy qualityIsoniazid resistanceQUADAS-2Indirect testingRifampicinUnique studies
2014
A 33-year-old Haitian immigrant with 7 months of abdominal pain and progressive distension
Farhadian S, Shenoi SV, Villanueva MS. A 33-year-old Haitian immigrant with 7 months of abdominal pain and progressive distension. BMJ Case Reports 2014, 2014: bcr2014205371. PMID: 25008341, PMCID: PMC4091201, DOI: 10.1136/bcr-2014-205371.Peer-Reviewed Case Reports and Technical NotesConceptsTB peritonitisAbdominal painPositive tuberculin skin testNon-necrotising granulomasAnti-TB treatmentLatent tuberculosis infectionSmall bowel mesenteryTuberculin skin testAbdominal CT scanAbnormal soft tissuePeritoneal thickeningAbdominal distensionDilated loopsMild ascitesPulmonary TBHIV testingSputum cultureTuberculosis infectionBowel mesenterySmall bowelOmental massSkin testProgressive distensionBiopsy culturesGreater omentum
2013
Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania
KAWAI K, MEYDANI SN, URASSA W, WU D, MUGUSI FM, SAATHOFF E, BOSCH RJ, VILLAMOR E, SPIEGELMAN D, FAWZI WW. Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania. Epidemiology And Infection 2013, 142: 1505-1509. PMID: 24093552, PMCID: PMC5639693, DOI: 10.1017/s0950268813002495.Peer-Reviewed Original ResearchConceptsCell-mediated immune responsesTB patientsMicronutrient supplementationMicronutrient supplementsImmune responseProliferative responseT cell-mediated immune responsesHIV-negative TB patientsHIV-positive TB patientsLymphocyte proliferative responsesLymphocyte proliferation responseHigher proliferative responsesT cell mitogensPlacebo groupPulmonary TBTB treatmentDaily doseEligible participantsNutritional interventionTuberculosis treatmentTime of initiationClinical relevanceMicronutrient groupProliferation responsePatientsThe Diagnostic Performance of a Single GeneXpert MTB/RIF Assay in an Intensified Tuberculosis Case Finding Survey among HIV-Infected Prisoners in Malaysia
Al-Darraji HA, Razak H, Ng KP, Altice FL, Kamarulzaman A. The Diagnostic Performance of a Single GeneXpert MTB/RIF Assay in an Intensified Tuberculosis Case Finding Survey among HIV-Infected Prisoners in Malaysia. PLOS ONE 2013, 8: e73717. PMID: 24040038, PMCID: PMC3767617, DOI: 10.1371/journal.pone.0073717.Peer-Reviewed Original ResearchConceptsTB casesPositive predictive valuePredictive valueCase detectionSmear microscopyGeneXpert MTB/RIF AssayMedian CD4 lymphocyte countCulture-positive TB casesGeneXpert MTB/RIFActive pulmonary TBActive TB diseaseEarly morning sputumFluorescence smear microscopyUndiagnosed TB casesActive TB casesCD4 lymphocyte countDiagnostic performanceTB case detectionMTB/RIFNegative predictive valueAFB smear microscopyActive TBAntiretroviral therapyPulmonary TBTB disease
2009
Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.
Machado A, Finkmoore B, Emodi K, Takenami I, Barbosa T, Tavares M, Reis M, Arruda S, Riley L. Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil. The International Journal Of Tuberculosis And Lung Disease 2009, 13: 719-25. PMID: 19460247.Peer-Reviewed Original ResearchConceptsHousehold contactsLatent tuberculosis infectionLTBI treatmentLatent tuberculosis infection treatmentTB-endemic countriesRisks of treatmentHigh-risk populationPulmonary TBMedication intoleranceTuberculosis infectionTuberculosis controlRisk factorsHigh riskSide effectsInfection treatmentHospitalVisitsMonthsTreatmentFollowINHRiskTBRegimenPatients
2008
Association of Strong Immune Responses to PPE Protein Rv1168c with Active Tuberculosis ▿
Khan N, Alam K, Nair S, Valluri VL, Murthy KJ, Mukhopadhyay S. Association of Strong Immune Responses to PPE Protein Rv1168c with Active Tuberculosis ▿. MSphere 2008, 15: 974-980. PMID: 18400969, PMCID: PMC2446626, DOI: 10.1128/cvi.00485-07.Peer-Reviewed Original ResearchConceptsTB patientsESAT-6Sensitized peripheral blood mononuclear cellsStrong gamma interferon responseSmear-negative pulmonary TBPeripheral blood mononuclear cellsExtrapulmonary TB casesSerodiagnosis of TBBlood mononuclear cellsPotent T-cell antigenControl of TBT-cell antigensGamma interferon responseStrong immune responseConventional diagnostic testsConventional enzyme immunoassayActive TBMycobacterium bovis BCGPulmonary TBActive tuberculosisTB casesTuberculosis infectionMononuclear cellsImmune responseStrong immunoreactivity
2006
Administration of efavirenz (600 mg/day) with rifampicin results in highly variable levels but excellent clinical outcomes in patients treated for tuberculosis and HIV
Friedland G, Khoo S, Jack C, Lalloo U. Administration of efavirenz (600 mg/day) with rifampicin results in highly variable levels but excellent clinical outcomes in patients treated for tuberculosis and HIV. Journal Of Antimicrobial Chemotherapy 2006, 58: 1299-1302. PMID: 17032686, DOI: 10.1093/jac/dkl399.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlkynesAnti-HIV AgentsAntibiotics, AntitubercularBenzoxazinesCD4 Lymphocyte CountChromatography, High Pressure LiquidCyclopropanesDidanosineDrug Therapy, CombinationFemaleHIV InfectionsHumansLamivudineLongitudinal StudiesMaleOxazinesRifampinTreatment OutcomeTuberculosis, PulmonaryViral LoadConceptsExcellent clinical outcomesEfavirenz concentrationsClinical outcomesAntiretroviral therapyEfavirenz levelsAfrican patientsNon-detectable viral loadSmear-positive pulmonary TBLong-term clinical outcomesAdministration of efavirenzCD4 cell increaseHIV clinical outcomesPlasma efavirenz concentrationsCells/mm3Half of patientsTB regimenPulmonary TBPharmacokinetic interactionsTB outcomesTherapy completionRifampicin administrationViral loadTherapeutic rangePatientsHIV
2004
A Pilot Study of Once-Daily Antiretroviral Therapy Integrated With Tuberculosis Directly Observed Therapy in a Resource-Limited Setting
Jack C, Lalloo U, Karim QA, Karim SA, El-Sadr W, Cassol S, Friedland G. A Pilot Study of Once-Daily Antiretroviral Therapy Integrated With Tuberculosis Directly Observed Therapy in a Resource-Limited Setting. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2004, 36: 929-934. PMID: 15220699, DOI: 10.1097/00126334-200408010-00006.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdolescentAdultAlkynesAntibiotics, AntitubercularAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBenzoxazinesCosts and Cost AnalysisCyclopropanesDidanosineDrug Therapy, CombinationFemaleHIV InfectionsHumansLamivudineMaleMiddle AgedOutpatient Clinics, HospitalOxazinesPilot ProjectsSouth AfricaTreatment OutcomeTuberculosisUrban PopulationConceptsAntiretroviral therapyTB therapyViral loadPilot studyTwenty HIV-positive patientsSmear-positive pulmonary TBCD4 count increaseDrug-sensitive TBObserved therapy programStandard TB therapyActive antiretroviral therapyHIV-positive patientsMean CD4 countMean viral loadCells/Resource limited settingsResource-limited settingsDaily didanosineHAART regimenCD4 countHIV clinicPulmonary TBTB clinicNeurologic toxicityObserved therapy
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