2025
Advanced tissue-engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes
Luo H, Anderson C, Li X, Lu Y, Hoareau M, Xing Q, Fooladi S, Liu Y, Xu Z, Park J, Fallon M, Thomas J, Gruber P, Elder R, Mak M, Riaz M, Campbell S, Qyang Y. Advanced tissue-engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes. Acta Biomaterialia 2025 PMID: 40582540, DOI: 10.1016/j.actbio.2025.06.055.Peer-Reviewed Original ResearchSingle ventricle congenital heart defectsHuman induced pluripotent stem cell-derived cardiomyocytesPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesCell-derived cardiomyocytesCongenital heart defectsHuman umbilical arteryUmbilical arteryHeart defectsPulmonary circulationDecellularized human umbilical arteriesHeart tissueLife-threatening defectsLife-threatening disorderLong-term complicationsEngineered Heart TissueFontan surgeryFunctioning ventriclePrompt treatmentHeart failureSpontaneous beatingPump functionImprove outcomesPressure generationConventional treatmentInfective Complications of Endobronchial Ultrasound-Transbronchial Needle Aspiration (EBUS-TBNA) and Clinical Biomarkers: A Concise Review
Bosgana P, Ampazis D, Vlachakos V, Tzouvelekis A, Sampsonas F. Infective Complications of Endobronchial Ultrasound-Transbronchial Needle Aspiration (EBUS-TBNA) and Clinical Biomarkers: A Concise Review. Diagnostics 2025, 15: 145. PMID: 39857029, PMCID: PMC11764001, DOI: 10.3390/diagnostics15020145.Peer-Reviewed Original ResearchEndobronchial ultrasound transbronchial needle aspirationInfective complicationsLung cancerInterventional pulmonology proceduresIncidence of lung cancerNeedle aspirationPrompt treatmentInfective pathologyRisk factorsClinical biomarkersRising incidenceComplicationsRising incidence of lung cancerCancerBiomarkersConcise reviewMediastinumIncreasing numberPatientsLungReviewClinicDiagnosis
2023
Prediction of Brain Metastases Development in Patients With Lung Cancer by Explainable Artificial Intelligence From Electronic Health Records
Li Z, Li R, Zhou Y, Rasmy L, Zhi D, Zhu P, Dono A, Jiang X, Xu H, Esquenazi Y, Zheng W. Prediction of Brain Metastases Development in Patients With Lung Cancer by Explainable Artificial Intelligence From Electronic Health Records. JCO Clinical Cancer Informatics 2023, 7: e2200141. PMID: 37018650, PMCID: PMC10281421, DOI: 10.1200/cci.22.00141.Peer-Reviewed Original ResearchConceptsBrain metastasesExplainable artificial intelligenceFeature attribution methodsLung cancerEHR dataArtificial intelligenceCerner Health Facts databaseBM developmentExplainable artificial intelligence approachBrain metastasis developmentHealth Facts databaseElectronic health record dataRecurrent neural network modelArtificial intelligence approachHealth record dataModel decision processStructured EHR dataNeural network modelDecision processAttribution methodsHigh-quality cohortElectronic health recordsPrompt treatmentMetastasis developmentIntelligence approach
2022
O-163 Pathophysiology – what’s new
Taylor H. O-163 Pathophysiology – what’s new. Human Reproduction 2022, 37: deac105.073. DOI: 10.1093/humrep/deac105.073.Peer-Reviewed Original ResearchSystemic diseaseGynecological diseasesOral gonadotropin-releasing hormone antagonistClinical diagnosisLow-dose oral contraceptivesGonadotropin-releasing hormone antagonistEndometrial-like tissueFirst-line medicationAccurate clinical diagnosisFemale reproductive tractOral contraceptivesPrompt treatmentSystemic inflammationGnRH antagonistPain sensitizationProgesterone resistanceSymptomatic womenClinical presentationRetrograde menstruationEndometriosis careHormone antagonistReproductive ageEffective therapyTherapeutic alternativeMood disordersInternational guidelines regarding the role of IVIG in the management of Rh‐ and ABO‐mediated haemolytic disease of the newborn
Lieberman L, Lopriore E, Baker JM, Bercovitz RS, Christensen RD, Crighton G, Delaney M, Goel R, Hendrickson JE, Keir A, Landry D, La Rocca U, Lemyre B, Maier RF, Muniz‐Diaz E, Nahirniak S, New HV, Pavenski K, dos Santos M, Ramsey G, Shehata N, Guidelines F. International guidelines regarding the role of IVIG in the management of Rh‐ and ABO‐mediated haemolytic disease of the newborn. British Journal Of Haematology 2022, 198: 183-195. PMID: 35415922, PMCID: PMC9324942, DOI: 10.1111/bjh.18170.Peer-Reviewed Original ResearchConceptsRole of IVIGIntravenous immunoglobulinExchange transfusionHaemolytic diseaseSafety of IVIGRed blood cell transfusionBlood cell transfusionDuration of hospitalizationSeverity of anemiaEvidence-based recommendationsHigh-quality studiesCell transfusionPrompt treatmentBilirubin levelsSignificant morbidityAlternative therapiesIntensive phototherapyNeurocognitive outcomesManagement of RhInternational guidelinesTransfusionNewbornsDiseasePhototherapyInternational panelCytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study
Kauke-Navarro M, Panayi AC, Formica R, Marty F, Parikh N, Foroutanjazi S, Safi AF, Mardini S, Razonable RR, Morelon E, Gelb B, Rodriguez E, Lassus P, Pomahac B. Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study. Transplantation 2022, 106: 2031-2043. PMID: 35389381, DOI: 10.1097/tp.0000000000004132.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyAntiviral prophylaxisCohort studyComposite allotransplantationInternational multicenter retrospective cohort studyMulticenter retrospective cohort studyCMV-related complicationsFirst year posttransplantHigh-risk transplantsMore rejection episodesHigh-risk groupFacial Vascularized Composite AllotransplantationAllograft-related complicationsVascularized Composite AllotransplantationPaucity of dataAllograft lossCMV diseaseCMV viremiaCytomegalovirus serostatusR serostatusRejection episodesCMV infectionPrompt treatmentActive surveillancePatientsPrognosis of hospitalized patients with cirrhosis and acute kidney disease
Wong F, Garcia‐Tsao G, Reddy KR, O'Leary JG, Kamath PS, Tandon P, Lai JC, Vargas HE, Biggins SW, Fallon MB, Thuluvath PJ, Maliakkal BJ, Subramanian R, Thacker L, Bajaj JS. Prognosis of hospitalized patients with cirrhosis and acute kidney disease. Liver International 2022, 42: 896-904. PMID: 35023264, PMCID: PMC11075740, DOI: 10.1111/liv.15154.Peer-Reviewed Original ResearchConceptsAcute kidney diseaseStage 1 AKIAKD patientsPeak ScrAKI patientsCirrhotic patientsKidney diseaseSecond infectionEnd-stage liver diseaseDecompensated cirrhotic patientsHigher hospital admissionsWorse renal dysfunctionNormal renal functionGlomerular filtration rateNorth American ConsortiumBaseline SCrRenal dysfunctionPrompt treatmentRenal functionSerum creatinineHospital admissionClinical outcomesLiver diseasePredictive factorsFiltration rate
2021
Global, regional, and national burden and quality of care index of endocarditis: the global burden of disease study 1990–2019
Momtazmanesh S, Moghaddam S, Rad E, Azadnajafabad S, Ebrahimi N, Mohammadi E, Rouhifard M, Rezaei N, Masinaei M, Rezaei N, Keykhaei M, Aminorroaya A, Ghamari A, Larijani B, Farzadfar F. Global, regional, and national burden and quality of care index of endocarditis: the global burden of disease study 1990–2019. European Journal Of Preventive Cardiology 2021, 29: 1287-1297. PMID: 34897404, DOI: 10.1093/eurjpc/zwab211.Peer-Reviewed Original ResearchConceptsGlobal Burden of Disease StudyBurden of Disease StudyAssess quality of careGlobal burdenQuality of careDisability-adjusted life yearsDisease StudyHigh-income North AmericaAntibiotic prophylaxis guidelinesSocio-demographic IndexAge groupsYears of lifeHigh-income countriesOptimal patient outcomesIndex of MortalityLow-income countriesNational burdenProphylaxis guidelinesAssess qualitySignificant morbidityPrompt treatmentIncidence rateEndocarditisLife yearsTimely diagnosisProgression of PTH Resistance in Autosomal Dominant Pseudohypoparathyroidism Type Ib Due to Maternal STX16 Deletions
Kiuchi Z, Reyes M, Hanna P, Sharma A, DeClue T, Olney R, Tebben P, Jüppner H. Progression of PTH Resistance in Autosomal Dominant Pseudohypoparathyroidism Type Ib Due to Maternal STX16 Deletions. The Journal Of Clinical Endocrinology & Metabolism 2021, 107: e681-e687. PMID: 34477200, PMCID: PMC8899049, DOI: 10.1210/clinem/dgab660.Peer-Reviewed Original ResearchConceptsAutosomal dominant pseudohypoparathyroidism type IbSTX16 deletionPseudohypoparathyroidism type IbParathyroid hormoneYears of ageAD-PHP1BDisease-causing variantsFemale carriersMeasurement of parathyroid hormoneGNAS exon A/BPretreatment laboratory resultsElevated PTH levelsParathyroid hormone resistanceParathyroid hormone levelsSerum calcium levelsThyrotropin (TSHType IbExon A/BOvert hypocalcemiaPTH resistancePTH levelsTSH levelsCalcium abnormalitiesPrompt treatmentLoss of methylationEndometriosis is a chronic systemic disease: clinical challenges and novel innovations
Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. The Lancet 2021, 397: 839-852. PMID: 33640070, DOI: 10.1016/s0140-6736(21)00389-5.Peer-Reviewed Original ResearchConceptsSystemic diseaseGynaecological diseaseOral gonadotropin-releasing hormone antagonistClinical diagnosisLow-dose oral contraceptivesGonadotropin-releasing hormone antagonistEndometrial-like tissueChronic systemic diseaseFirst-line medicationAccurate clinical diagnosisFemale reproductive tractPain sensitisationOral contraceptivesPrompt treatmentSystemic inflammationGnRH antagonistProgesterone resistanceSymptomatic womenClinical presentationRetrograde menstruationEndometriosis careHormone antagonistReproductive ageEffective therapyTherapeutic alternativeUntwisting the complexity of midgut malrotation and volvulus ultrasound
Nguyen HN, Navarro OM, Guillerman RP, Silva CT, Sammer MBK. Untwisting the complexity of midgut malrotation and volvulus ultrasound. Pediatric Radiology 2021, 51: 658-668. PMID: 33398405, DOI: 10.1007/s00247-020-04876-x.Peer-Reviewed Original ResearchConceptsMidgut volvulusMidgut malrotationCommon conditionAcute abdominal signsUpper gastrointestinal seriesUpper GI seriesHypertrophic pyloric stenosisDiagnostic imaging testsOral contrast agentAbdominal signsAbdominal USGastrointestinal seriesGI seriesPrompt treatmentClinical presentationPyloric stenosisDiagnostic findingsImaging testsPictorial essayUS protocolVolvulusMalrotationContrast agentsEnterocolitisAppendicitis
2020
Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women: A Multicenter Case-Control Study
Bauer M, Housey M, Bauer S, Behrmann S, Chau A, Clancy C, Clark E, Einav S, Langen E, Leffert L, Lin S, Madapu M, Maile M, McQuaid-Hanson E, Priessnitz K, Sela H, Shah A, Sobolewski P, Toledo P, Tsen L, Bateman B. Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women: A Multicenter Case-Control Study. Obstetric Anesthesia Digest 2020, 40: 65-66. DOI: 10.1097/01.aoa.0000661332.57510.93.Peer-Reviewed Original ResearchMulticenter case-control studyCase-control studyMaternal sepsisQuick Sequential Organ Failure Assessment criteriaSequential Organ Failure Assessment criteriaSystemic inflammatory response syndrome criteriaPregnancy-related deathsSigns of sepsisMaternal morbidityMaternal outcomesSyndrome criteriaPrompt treatmentPregnant womenEarly sepsisRisk factorsSepsisEarly identificationDifferent screening methodsPregnancyScreening toolScreening criteriaPhysiological changesPrimary objectiveScreening methodHospitalizationSpontaneous recovery in a patient with acquired thrombotic thrombocytopenic purpura (TTP): observation of a ‘subclinical’ TTP state
Browning S, Bahar B, Lee AI, Gorshein E. Spontaneous recovery in a patient with acquired thrombotic thrombocytopenic purpura (TTP): observation of a ‘subclinical’ TTP state. Hematology 2020, 25: 473-477. PMID: 33269995, DOI: 10.1080/16078454.2020.1848973.Peer-Reviewed Original ResearchConceptsThrombotic thrombocytopenic purpuraMicroangiopathic haemolytic anaemiaADAMTS13 activity levelsPlasma exchangeHaemolytic anaemiaThrombocytopenic purpuraHaematologic parametersSpontaneous recoveryAcute thrombotic thrombocytopenic purpuraMild haemolytic anaemiaUrgent plasma exchangeInitiation of therapyHereditary thrombotic thrombocytopenic purpuraActivity levelsDeficiency of ADAMTS13High mortality rateClinical remissionDisease remissionThrombotic microangiopathyPrompt treatmentThrombotic manifestationsADAMTS13 inhibitorUrgent therapyAsymptomatic femalesClinical manifestations
2018
1134 A morbidly obese type I diabetic teenager with sleep apnea, nocturnal eating, and Cushingoid features. Where to start?
Hawkins M, Williams C, Kryger M. 1134 A morbidly obese type I diabetic teenager with sleep apnea, nocturnal eating, and Cushingoid features. Where to start? Sleep 2018, 41: a419-a420. DOI: 10.1093/sleep/zsy063.1133.Peer-Reviewed Original ResearchObstructive sleep apneaMorning glucose levelsNocturnal eatingSleep apneaGlucose levelsDocumentation of hypoglycemiaInsulin resistance riskApnea-hypopnea indexSetting of diabetesBody mass indexDoses of insulinDiagnosis of diabetesAge 5 yearsAdverse health conditionsSalivary cortisol levelsType ICushingoid featuresPAP therapyCushingoid appearanceNight sweatsHypopnea indexHypothalamic dysfunctionPrompt treatmentCushing's diseaseNight-time behaviorDisparities in breast cancer tumor characteristics, treatment, time to treatment, and survival probability among African American and white women
Foy K, Fisher J, Lustberg M, Gray D, DeGraffinreid C, Paskett E. Disparities in breast cancer tumor characteristics, treatment, time to treatment, and survival probability among African American and white women. Npj Breast Cancer 2018, 4: 7. PMID: 29582015, PMCID: PMC5861087, DOI: 10.1038/s41523-018-0059-5.Peer-Reviewed Original ResearchJames Cancer HospitalAA womenBreast cancerTumor characteristicsWhite womenCancer HospitalArthur G. James Cancer HospitalHigher breast cancer death rateBreast cancer tumor characteristicsCox proportional hazards regressionProgression-free survival probabilityBreast cancer death ratesLate-stage breast cancerLikelihood ratio chi-square testProportional hazards regressionStage breast cancerOverall survival probabilityCancer death ratesOnset of treatmentCurrent tobacco useChi-square testAfrican American womenPrompt treatmentCancer RegistryHazards regressionNew‐onset refractory status epilepticus (NORSE) and febrile infection–related epilepsy syndrome (FIRES): State of the art and perspectives
Gaspard N, Hirsch LJ, Sculier C, Loddenkemper T, van Baalen A, Lancrenon J, Emmery M, Specchio N, Farias‐Moeller R, Wong N, Nabbout R. New‐onset refractory status epilepticus (NORSE) and febrile infection–related epilepsy syndrome (FIRES): State of the art and perspectives. Epilepsia 2018, 59: 745-752. PMID: 29476535, DOI: 10.1111/epi.14022.Peer-Reviewed Original ResearchConceptsNew-onset refractory status epilepticusFebrile infection-related epilepsy syndromeRefractory status epilepticusStatus epilepticusCytokine-mediated mechanismOptimal treatment optionsAdult-onset formStrong scientific evidenceStandardized consensus definitionsMulticenter registryPrompt treatmentKetogenic dietUncontrolled trialsEpilepsy syndromesImmune therapyTreatment optionsEarly recognitionClinical careConsensus definitionClinical situationsPatient careEpilepticusStandardized definitionsElectroencephalography featuresScientific evidenceAn Update on the Treatment of Pediatric Autoimmune Encephalitis
Stingl C, Cardinale K, Van Mater H. An Update on the Treatment of Pediatric Autoimmune Encephalitis. Current Treatment Options In Rheumatology 2018, 4: 14-28. PMID: 29780690, PMCID: PMC5957495, DOI: 10.1007/s40674-018-0089-z.Peer-Reviewed Original ResearchSecond-line therapyRefractory diseaseNeuropsychiatric deficitsProspective randomized placebo-controlled trialInterleukin-6 inhibitor tocilizumabLow-dose IL-2Randomized placebo-controlled trialPediatric autoimmune encephalitisPlacebo-controlled trialEarly treatment initiationFirst-line therapyFirst-line treatmentSecond-line agentsIL-6 blockadeMajority of patientsProteasome inhibitorsRecent FindingsTo dateAutoimmune encephalitisTreatment escalationIntravenous immunoglobulinMycophenolate mofetilClinical improvementPharmacologic treatmentPrompt treatmentTreatment initiation
2017
Allogeneic hematopoietic stem cell transplantation is associated with cure and durable remission of late‐onset primary isolated central nervous system hemophagocytic lymphohistiocytosis
Khazal S, Polishchuk V, Soffer G, Prinzing S, Gill J, Mahadeo KM. Allogeneic hematopoietic stem cell transplantation is associated with cure and durable remission of late‐onset primary isolated central nervous system hemophagocytic lymphohistiocytosis. Pediatric Transplantation 2017, 22 PMID: 29239076, DOI: 10.1111/petr.13101.Peer-Reviewed Original ResearchConceptsCNS-HLHDurable remissionsReduced-intensity conditioning regimenHematopoietic stem cell transplantationActive CNS diseaseLate-onset primaryStem cell transplantationAllogeneic HSCTCNS presentationsComorbidity indexConditioning regimenDisease remissionPrompt treatmentHemophagocytic lymphohistiocytosisSignificant morbidityPoor outcomeCell transplantationCNS diseaseAdolescent patientsPRF1 mutationsEarly diagnosisHigh indexRare diseaseRemissionImproved cure
2016
Cost‐effectiveness of the Cardiac Component of the Focused Assessment of Sonography in Trauma Examination in Blunt Trauma
Hall MK, Omer T, Moore CL, Taylor RA. Cost‐effectiveness of the Cardiac Component of the Focused Assessment of Sonography in Trauma Examination in Blunt Trauma. Academic Emergency Medicine 2016, 23: 415-423. PMID: 26857839, DOI: 10.1111/acem.12936.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedBlood PressureCost-Benefit AnalysisDecision Support TechniquesFemaleHeart InjuriesHumansHypotensionLife ExpectancyMedicareMiddle AgedModels, EconometricPoint-of-Care SystemsQuality-Adjusted Life YearsReproducibility of ResultsUltrasonographyUnited StatesWounds, NonpenetratingConceptsNormotensive blunt trauma patientsIncremental cost-effectiveness ratioBlunt trauma patientsTrauma patientsBlunt traumaNormotensive patientsHypotensive patientsFocused assessmentBlunt cardiac injuryIncidental pericardial effusionCardiac componentCost-effectiveness ratioDecision analytic modelProbability of deathPericardial effusionPrompt treatmentClinical probabilityCardiac injurySurgical interventionTrauma (FAST) examFAST examLow prevalencePatientsTrauma (FAST) examinationPay thresholdsMissed Ischemic Stroke Diagnosis in the Emergency Department by Emergency Medicine and Neurology Services
Arch AE, Weisman DC, Coca S, Nystrom KV, Wira CR, Schindler JL. Missed Ischemic Stroke Diagnosis in the Emergency Department by Emergency Medicine and Neurology Services. Stroke 2016, 47: 668-673. PMID: 26846858, DOI: 10.1161/strokeaha.115.010613.Peer-Reviewed Original ResearchConceptsEmergency departmentLarge community hospitalCommunity hospitalIschemic strokeStroke diagnosisAcademic hospitalNausea/vomitingSecondary prevention therapiesAcute ischemic strokeRetrospective chart reviewIschemic stroke diagnosisAcademic teaching hospitalEndovascular considerationsChart reviewPrompt treatmentSymptom onsetPosterior circulationPrevention therapyNeurology serviceAcute interventionAnterior strokeAtypical symptomsStroke historyPosterior strokeTeaching hospital
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