2025
L-type calcium channel blockade attenuates cue-induced cocaine-seeking in female rats
Kimble V, Nunes E, Rajadhyaksha A, Addy N. L-type calcium channel blockade attenuates cue-induced cocaine-seeking in female rats. Behavioural Brain Research 2025, 490: 115613. PMID: 40324598, PMCID: PMC12145892, DOI: 10.1016/j.bbr.2025.115613.Peer-Reviewed Original ResearchConceptsCue-induced cocaine-seekingCocaine-seekingL-type calcium channelsExposure to drug-associated cuesPeriods of cocaine abstinenceCocaine-associated cuesCue-induced relapseCocaine Self-AdministrationCocaine-dependent individualsCocaine-seeking behaviorDrug-associated cuesDrug-seeking behaviorCocaine-takingCocaine abstinenceSex-specific mechanismsSelf-AdministrationRelapse preventionAbstinence periodAddiction treatmentAdministration of isradipineRisk of relapseAbstinenceL-type calcium channel blockadeRelapse riskFemale ratsEmerging Therapeutics in the Treatment of Substance Use Disorders: A Focus on GLP-1 Receptor Agonists, D3R Antagonists, and CRF Antagonists
Draghmeh K, Fuehrlein B. Emerging Therapeutics in the Treatment of Substance Use Disorders: A Focus on GLP-1 Receptor Agonists, D3R Antagonists, and CRF Antagonists. Journal Of Integrative Neuroscience 2025, 24: 26361. PMID: 40302255, DOI: 10.31083/jin26361.Peer-Reviewed Original ResearchConceptsSubstance use disordersCorticotropin-releasing factorTreatment of substance use disordersCorticotropin-releasing factor antagonistTreating substance use disordersDrug-seeking behaviorDopamine D3 receptorGlucagon-like peptide-1Reduce substance useUse of alcoholAddiction processD3R antagonistsReward modulationRelapse preventionD3 receptorsUse disorderStimulant useSubstance useGlucagon-like peptide-1 receptor agonistsPrevent relapseReceptor agonistsTarget different aspectsSignificant public health challengeAntagonistDisorders
2024
Machine Learning Analysis of the Orbitofrontal Cortex Transcriptome of Human Opioid Users Identifies Shisa7 as a Translational Target Relevant for Heroin Seeking Leveraging a Male Rat Model
Ellis R, Ferland J, Rahman T, Landry J, Callens J, Pandey G, Lam T, Kanyo J, Nairn A, Dracheva S, Hurd Y. Machine Learning Analysis of the Orbitofrontal Cortex Transcriptome of Human Opioid Users Identifies Shisa7 as a Translational Target Relevant for Heroin Seeking Leveraging a Male Rat Model. Biological Psychiatry 2024, 98: 23-33. PMID: 39725299, DOI: 10.1016/j.biopsych.2024.12.007.Peer-Reviewed Original ResearchRat orbitofrontal cortexOrbitofrontal cortexOpioid use disorderHeroin seekingBehavioral updatingHeroin usersHeroin-seeking behaviorDrug-seeking behaviorGoal-directed behaviorNeurobiological targetsOperant contingenciesUse disorderControl participantsTranslational rat modelGABAergic receptor subunitsHeroin useNeuroimmune processesShisa7AMPA receptorsMale rat modelReceptor subunitsSeekingGene expression signaturesOpioid usersHeroinAstrocyte Ca2+ in the dorsal striatum suppresses neuronal activity to oppose cue-induced reinstatement of cocaine seeking
Tavakoli N, Malone S, Anderson T, Neeley R, Asadipooya A, Bardo M, Ortinski P. Astrocyte Ca2+ in the dorsal striatum suppresses neuronal activity to oppose cue-induced reinstatement of cocaine seeking. Frontiers In Cellular Neuroscience 2024, 18: 1347491. PMID: 39280793, PMCID: PMC11393831, DOI: 10.3389/fncel.2024.1347491.Peer-Reviewed Original ResearchCue-induced reinstatementCue-induced reinstatement of cocaine seekingCocaine self-administration experienceReinstatement of cocaine seekingCocaine Self-AdministrationSelf-administer cocaineSelf-administration experimentsCocaine seekingDorsal striatumSelf-AdministrationExtinction of cocaine-seeking behaviorCocaine self-administration groupResponse to acute cocaineCocaine-seeking behaviorDorsal striatum neuronsDrug-seeking behaviorNeuronal activitySelf-administration groupLong-term neuronal plasticityBrain slicesAcute cocaineReward processingCocaine groupNeuronal signalingAcute administrationLower Dorsal Putamen D2/3 Receptor Availability and Amphetamine-Induced Dopamine Release are Related to Poorer Cognitive Function in Recently Abstinent People Who Smoke and Healthy Controls
Cheung F, Calakos K, Gueorguieva R, Hillmer A, Cosgrove K, Zakiniaeiz Y. Lower Dorsal Putamen D2/3 Receptor Availability and Amphetamine-Induced Dopamine Release are Related to Poorer Cognitive Function in Recently Abstinent People Who Smoke and Healthy Controls. Nicotine & Tobacco Research 2024, 26: 1038-1044. PMID: 38367211, PMCID: PMC11260895, DOI: 10.1093/ntr/ntae031.Peer-Reviewed Original ResearchAmphetamine-induced dopamine releaseBrain-behavior relationshipsAbstinent peopleDorsal striatumCognitive functionDopamine releasePoorer cognitive functionD2/3R availabilityDelayed RecallHealthy controlsTests of verbal learningDysregulated dopamine signalingD2/3 receptor availabilityDrug-seeking behaviorDorsolateral prefrontal cortexCogState computerized batteryPositron emission tomography scanAmphetamine administrationMesocortical pathwayMesolimbic pathwayDopamine systemPrefrontal cortexVerbal learningBaseline BPNDDopamine signaling
2023
MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration
Zanda M, Saikali L, Morris P, Daws S. MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration. Advances In Drug And Alcohol Research 2023, 3: 11668. PMID: 38389822, PMCID: PMC10880771, DOI: 10.3389/adar.2023.11668.Peer-Reviewed Original ResearchHeroin self-administrationOrbitofrontal cortexSelf-AdministrationDays of forced abstinenceRegulating drug-seeking behaviorSucrose self-administrationDrug-seeking behaviorChronic drug exposureAdult male ratsPeripheral blood samplesHeroin infusionsHeroin seekingMolecular neuroadaptationsForced abstinenceAcute abstinenceNeurobiological consequencesOpioid heroinOpioid misuseHeroinMale ratsSelf-AdministeredSeeking behaviorAbstinenceBlood samplesOpioid exposure
2022
Mechanistic Effects and Use of N-acetylcysteine in Substance Use Disorders
Greenberg N, Farhadi F, Kazer B, Potenza M, Angarita G. Mechanistic Effects and Use of N-acetylcysteine in Substance Use Disorders. Current Behavioral Neuroscience Reports 2022, 9: 124-143. DOI: 10.1007/s40473-022-00250-3.Peer-Reviewed Original ResearchSubstance use disordersN-acetylcysteineUse disordersEfficacy of NACTreatment of SUDsGlial glutamate transporter-1Glutamate transporter 1Drug-seeking behaviorCue-induced reinstatementNAC useAdjunctive useClinical studiesGlutamate homeostasisGlutamate signalingNeurobiological effectsClinical approachRelapse behaviorSubcortical regionsSynaptic plasticityFunctional connectivity networksPrefrontal cortexBehavioral interventionsTransporter 1Oxidative stressImpulsive behaviorIntroduction to Section I
Field M, Moss A, Satel S, Heather N. Introduction to Section I. 2022, 13-19. DOI: 10.4324/9781003032762-3.Peer-Reviewed Original ResearchCompulsive drug-seeking behaviorIncentive salience attributionDrug-seeking behaviorNeurobiological adaptationsSalience attributionAddictive behaviorsSection IPhilosophy of Alcoholics AnonymousAlcoholics AnonymousAddictionBrain diseasesSocial contextPeer-reviewed journalsPublic health interventionsMedical communityDisease
2021
Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task
Zhornitsky S, Dhingra I, Le TM, Wang W, Li CR, Zhang S. Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task. The International Journal Of Neuropsychopharmacology 2021, 24: 634-644. PMID: 33822080, PMCID: PMC8378081, DOI: 10.1093/ijnp/pyab016.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsCocaine Craving QuestionnaireCCQ scoresRecent cocaine useHealthy controlsMonetary incentive delay taskReward-related responsesCocaine useVentral striatumIncentive delay taskMotor cortexReward responsesPrecentral gyrusCocaine addictionPrimary motor cortexSupplementary motor areaDelay taskIntense drug cravingFunctional magnetic resonance imagingMagnetic resonance imagingDrug-seeking behaviorHigher activationReward-related activityMotor areaWhole brain
2018
Sex and Feeding Status Differently Affect Natural Reward Seeking Behavior in Olfactory Bulbectomized Rats
Ruda-Kucerova J, Zanda M, Amchova P, Fratta W, Fattore L. Sex and Feeding Status Differently Affect Natural Reward Seeking Behavior in Olfactory Bulbectomized Rats. Frontiers In Behavioral Neuroscience 2018, 12: 255. PMID: 30425627, PMCID: PMC6218565, DOI: 10.3389/fnbeh.2018.00255.Peer-Reviewed Original ResearchSchedule of reinforcementPalatable food pelletsOBX ratsOBX lesionOperant respondingSelf-AdministrationFood pelletsNatural reward-seeking behaviorsIntravenous drug self-administrationSex differencesFood self-administrationDepressive-like phenotypeDrug Self-AdministrationOperant self-administrationReward-seeking behaviorDrug-seeking behaviorRates of comorbidityPotential sex differencesFood restrictionOBX modelFood intakeOlfactory bulbectomyDrug-takingPalatable foodPsychiatric disordersDorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors
Harris NA, Isaac AT, Günther A, Merkel K, Melchior J, Xu M, Eguakun E, Perez R, Nabit BP, Flavin S, Gilsbach R, Shonesy B, Hein L, Abel T, Baumann A, Matthews R, Centanni SW, Winder DG. Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. Journal Of Neuroscience 2018, 38: 8922-8942. PMID: 30150361, PMCID: PMC6191524, DOI: 10.1523/jneurosci.0963-18.2018.Peer-Reviewed Original ResearchConceptsExcitatory actionAnxiety-like behaviorBed nucleusNeuronal activityAdrenergic receptorsCation channelsEffective treatment modalityDorsal bed nucleusHyperpolarization-activated cyclicCell-specific actionsSubstance use disordersReward-related behaviorsDrug-seeking behaviorDrugs of abuseTreatment of addictionAntidepressant actionBNST neuronsAnxiolytic actionDorsal BNSTTreatment modalitiesReceptor agonistAgonist guanfacineAnxiogenic behaviorStria terminalisClinical utility
2017
Chapter 69 Patient Responses to Guanfacine in Cocaine Addiction
Milivojevic V, Sinha R, Fox H. Chapter 69 Patient Responses to Guanfacine in Cocaine Addiction. 2017, 679-688. DOI: 10.1016/b978-0-12-803750-8.00069-5.ChaptersAnxiety pathophysiologyDrugs of abuseNeural stress systemsDrug-seeking behaviorEmotional controlDrug seekingRecent research findingsChronic stress stateNegative consequencesCocaine addictionCocaine dependenceStress systemResearch findingsLong-term agentsCocaine useDrug useAbuseGuanfacineCravingSeekingStress sensitivityAddictionAbilityRobust adaptationOwn laboratory
2016
Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice1,2,3
Storey GP, Gonzalez-Fernandez G, Bamford IJ, Hur M, McKinley JW, Heimbigner L, Minasyan A, Walwyn WM, Bamford NS. Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice1,2,3. ENeuro 2016, 3: eneuro.0095-15.2015. PMID: 26866057, PMCID: PMC4745180, DOI: 10.1523/eneuro.0095-15.2015.Peer-Reviewed Original ResearchMeSH KeywordsAction Potentialsalpha7 Nicotinic Acetylcholine ReceptorAmphetamineAnimalsCentral Nervous System StimulantsCholinergic NeuronsConditioning, OperantCorpus StriatumDrug-Seeking BehaviorFemaleMaleMiceMice, Inbred C57BLMotor ActivityMotor CortexNeural PathwaysNeuronal PlasticityNicotineNicotinic AgonistsReceptors, NicotinicRewardSelf AdministrationConceptsCorticostriatal activityAmphetamine challengeGlutamate releaseLocomotor sensitizationDirect pathway medium spiny neuronsAmphetamine-induced locomotor sensitizationActive cholinergic interneuronsAmphetamine-seeking behaviorSubsequent drug challengeMedium spiny neuronsActivity ex vivoNicotinic acetylcholine receptorsDrug-seeking behaviorPeriod of abstinenceSelf-administer amphetamineDrugs of abuseSelf-administering miceDrug-taking behaviorDwelling catheterAmphetamine withdrawalCholinergic interneuronsGlutamatergic activityPresynaptic depressionPotentiating responseSpiny neurons
2014
Chapter Six The Role of Guanfacine as a Therapeutic Agent to Address Stress-Related Pathophysiology in Cocaine-Dependent Individuals
Fox H, Sinha R. Chapter Six The Role of Guanfacine as a Therapeutic Agent to Address Stress-Related Pathophysiology in Cocaine-Dependent Individuals. Advances In Pharmacology 2014, 69: 217-265. PMID: 24484979, PMCID: PMC4017947, DOI: 10.1016/b978-0-12-420118-7.00006-8.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsAdaptive goal-directed behaviorNegative emotional statesGoal-directed behaviorCompulsive drug useDrug-seeking behaviorCocaine dependenceStress-related pathophysiologyCognitive regulationNegative affectEmotional controlEmotional statesAnxiety pathophysiologyPrefrontal cortexDrugs of abuseNeural systemsBehavioral processesRecent research findingsBrain regionsCocaine addictionGuanfacinePolydrug abusersResearch findingsCocaine withdrawal symptomsDrug use
2013
Cocaine Cue-Induced Dopamine Release in Amygdala and Hippocampus: A High-Resolution PET [18F]Fallypride Study in Cocaine Dependent Participants
Fotros A, Casey K, Larcher K, Verhaeghe J, Cox S, Gravel P, Reader A, Dagher A, Benkelfat C, Leyton M. Cocaine Cue-Induced Dopamine Release in Amygdala and Hippocampus: A High-Resolution PET [18F]Fallypride Study in Cocaine Dependent Participants. Neuropsychopharmacology 2013, 38: 1780-1788. PMID: 23546387, PMCID: PMC3717549, DOI: 10.1038/npp.2013.77.Peer-Reviewed Original ResearchConceptsDA releaseDopamine releaseVisual analog scaleDrug cue exposureCocaine-dependent volunteersDrug-seeking behaviorCocaine-dependent participantsAnalog scaleDrug-related cuesLimbic networkAnimal studiesCocaine dependenceHippocampusCue exposureAmygdalaPreferential inductionBPND valuesPotent triggerStriatumDependent participantsCocaine cuesReward networkSubjective responsesNeutral cuesFirst evidence
2007
Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females
Fox HC, Hong KA, Paliwal P, Morgan PT, Sinha R. Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females. Psychopharmacology 2007, 195: 527-536. PMID: 17891383, PMCID: PMC2746368, DOI: 10.1007/s00213-007-0936-3.Peer-Reviewed Original ResearchConceptsMenstrual cycleSex hormonesHealthy femalesEstradiol/progesterone ratioSteroid hormonesFirst monthChronic cocaine abuseSex steroid hormonesLevels of cortisolMood rating scalesStress steroid hormonesDrug-seeking behaviorProgesterone ratioHealthy controlsInpatient treatmentObjectivesThe current studyEvidence of alterationsBrain stressCocaine cravingCocaine abuseSalivary samplesCocaine abstinenceCocaine dependenceCocaine reinforcementCocaine patients
2005
Chapter 3.7 Stress and drug abuse
Sinha R. Chapter 3.7 Stress and drug abuse. Techniques In The Behavioral And Neural Sciences 2005, 15: 333-356. DOI: 10.1016/s0921-0709(05)80063-x.Peer-Reviewed Original ResearchRole of stressAddictive processDrug abuseMost major theoriesDrug-seeking behaviorStress-related copingFuture researchModels of addictionHuman laboratory studiesField of addictionSubstantial preclinical dataChronic drug abuseDrug useTreatment developmentMajor theoriesCurrent knowledge baseStress exposureAbuseLittle direct evidenceAddictionEmpirical evidencePreclinical dataCopingEpidemiological studiesClinical observations
2001
A neurobiological basis for substance abuse comorbidity in schizophrenia
Chambers R, Krystal J, Self D. A neurobiological basis for substance abuse comorbidity in schizophrenia. Biological Psychiatry 2001, 50: 71-83. PMID: 11526998, PMCID: PMC2913410, DOI: 10.1016/s0006-3223(01)01134-9.Peer-Reviewed Original ResearchConceptsDrug rewardLong-term substance abuseMedication side effectsPrior drug exposureSubstance abuse comorbidityNeuropathology of schizophreniaPrimary disease symptomsAddictive behaviorsDrug-seeking behaviorHippocampal dysfunctionDrug exposureFrontal cortexNucleus accumbensHippocampal formationSchizophrenic patientsSide effectsCognitive impairmentNegative symptomsSubstance abuseAltered integrationNeural circuitrySymptomsSchizophreniaMotivational changesComorbidities
1999
Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli
Jentsch J, Taylor J. Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharmacology 1999, 146: 373-390. PMID: 10550488, DOI: 10.1007/pl00005483.Peer-Reviewed Original ResearchConceptsControl of behaviorInhibitory controlIncentive learning processesDrug abuseInhibitory response controlReward-related stimuliDrug-seeking behaviorChronic drug useCognitive impulsivityMotivational processesRelated stimuliMotivational qualitiesFrontostriatal systemFrontostriatal dysfunctionDrug seekingDrugs of abuseNeuro-anatomicalVentral striatumDrive stateAllocation of behaviorAppropriate behavioral patternsCognitive dysfunctionResponse controlFrontal cortexPrimate brain
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