2024
Distraction Enterogenesis in Rats: A Novel Approach for the Treatment of Short Bowel Syndrome
O’Quin C, Clayton S, Trosclair L, Meyer H, Dao N, Minagar A, White L, Welch V, Solitro G, Alexander J, Sorrells D. Distraction Enterogenesis in Rats: A Novel Approach for the Treatment of Short Bowel Syndrome. Pathophysiology 2024, 31: 388-397. PMID: 39189165, PMCID: PMC11348226, DOI: 10.3390/pathophysiology31030029.Peer-Reviewed Original ResearchTreatment of short bowel syndromeIn vivo rat studyRat intestinal modelShort bowel syndromeSprague Dawley ratsSmall intestineParenteral nutritionBowel histologyBowel lengthDawley ratsLength-tension relationshipMucosal erosionsRat small intestineRat studiesBowel syndromeEx vivoRatsBowel tissueFailure loadPost-deploymentPatientsBowelHistologyLoad test dataIntestinal modelHistologic Analysis of ‘Distraction Vaginogenesis’ in a Rat Model
Meyer H, Trosclair L, Clayton S, O’Quin C, Crochet C, Colvin J, Welch V, Alhaque A, Solitro G, Shah-Bruce M, Alexander J, Sorrells D. Histologic Analysis of ‘Distraction Vaginogenesis’ in a Rat Model. Pathophysiology 2024, 31: 298-308. PMID: 38921727, PMCID: PMC11206798, DOI: 10.3390/pathophysiology31020022.Peer-Reviewed Original ResearchVaginal agenesisStained with hematoxylin and eosin (H&ERat vaginal tissueSprague Dawley ratsLocal immune reactionHematoxylin and eosin (H&EParaffin-embedded tissuesMasson's trichrome stainingAnti-desmin antibodiesMullerian agenesisResin capEosin (H&EVaginal tissueSurgical vaginoplastyVaginal canalDesmin immunostainingCanal lengthSubmucosal eosinophiliaMechanical dilatationNeutrophilic inflammationPost-surgicalDawley ratsChronic inflammationRat modelTrichrome stainingImpact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors
Bagdas D, Zepei A, Harris L, Minanov K, Jimenez J, Addy N. Impact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors. Psychopharmacology 2024, 241: 2241-2253. PMID: 38839631, PMCID: PMC11836642, DOI: 10.1007/s00213-024-06630-9.Peer-Reviewed Original ResearchTaste reactivity testNicotine choiceNicotine takingTwo-bottle free choice testSeeking behaviorOral nicotine intakeNicotine preferenceFree-choice testNicotine intakeIngestive responsesOral nicotineDecreased dislikeAversive responsesOral cuesYoung adult Sprague Dawley ratsOrosensory propertiesAdult Sprague Dawley ratsIncreased likingNicotineFemale ratsMale ratsSprague Dawley ratsTobacco productsLong-term effectsDawley rats
2023
Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats
Hassan Z, Singh D, Suhaimi F, Chear N, Harun N, See C, Kaur G, Mat N, Bakar S, Yusof N, Kasinather V, Chawarski M, Murugaiyah V, Ramanathan S. Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats. Regulatory Toxicology And Pharmacology 2023, 143: 105466. PMID: 37536550, DOI: 10.1016/j.yrtph.2023.105466.Peer-Reviewed Original ResearchConceptsDays of treatmentToxicity profileFemale Sprague-Dawley ratsOpioid replacement therapyLow platelet countEnd of treatmentSprague-Dawley ratsEvidence of toxicityOccurrence of mortalityPlatelet countDawley ratsHematology profileBody weightMitragyna speciosa KorthBrain tissueHistopathology analysisHistological investigationHerbal drug preparationsDecoctionUric acidDrug preparationTherapeutic propertiesKidneyMortalityRatsYQBS Improves Cognitive Dysfunction in Diabetic Rats: Possible Association with Tyrosine and Tryptophan Metabolism
Liu Y, Cai J, Wang Y, Zhao X, Qiao Y, Liu C. YQBS Improves Cognitive Dysfunction in Diabetic Rats: Possible Association with Tyrosine and Tryptophan Metabolism. Diabetes Metabolic Syndrome And Obesity 2023, 16: 901-912. PMID: 37021127, PMCID: PMC10069430, DOI: 10.2147/dmso.s401863.Peer-Reviewed Original ResearchDiabetic ratsSD ratsCognitive dysfunctionTryptophan metabolismMale Sprague-Dawley ratsDiabetic cognitive dysfunctionDiabetic animal modelsHealthy SD ratsShortening of latencySprague-Dawley ratsSD rat modelDiabetic SD ratsBu-ShenDawley ratsHippocampal tissueRat modelPathological changesProtective effectHippocampal regionPathological alterationsYi-QiAnimal modelsCognitive impairmentHigh dosesPossible association
2022
Analgesic effects of main indole alkaloid of kratom, mitragynine in acute pain animal model
Mat N, Bakar S, Murugaiyah V, Chawarski M, Hassan Z. Analgesic effects of main indole alkaloid of kratom, mitragynine in acute pain animal model. Behavioural Brain Research 2022, 439: 114251. PMID: 36503042, DOI: 10.1016/j.bbr.2022.114251.Peer-Reviewed Original ResearchConceptsAnti-inflammatory propertiesAnalgesic effectTRPV1 expressionAcute pain animal modelsEffective doseFemale Sprague-Dawley ratsPain animal modelsPain-like behaviorsNon-opioid receptorsOpioid receptor activationNumber of writhesSprague-Dawley ratsInflammatory painPain pathwaysTRPV1 receptorsDawley ratsWrithing behaviorED95 valuesRat brainAnimal modelsReceptor activationReceptor pathwayRatsBehavior scoresMain indole alkaloids
2021
Exosomes of MSCs target M2-type Macrophages to promote TGF-β-Dependent Microvascular Stabilization and Functional Recovery in Spinal Cord Injury
Askenase P. Exosomes of MSCs target M2-type Macrophages to promote TGF-β-Dependent Microvascular Stabilization and Functional Recovery in Spinal Cord Injury. The Journal Of Immunology 2021, 206: 95.06-95.06. DOI: 10.4049/jimmunol.206.supp.95.06.Peer-Reviewed Original ResearchMesenchymal stromal cellsSpinal cord injuryM2-type macrophagesFractionated dosesTGF-bExpression of TGF-BMesenchymal stromal cell infusionInfusion of mesenchymal stromal cellsSevere contusion spinal cord injuryMSC-ExosTherapeutic effectInfused mesenchymal stromal cellsInjury siteBlood-spinal cord barrierTGF-B pathwayContusive spinal cord injuryCord injuryIntravenous (IVFunctional neurological recoverySprague Dawley ratsTight junction proteinsYoung Sprague Dawley ratsSingle doseDawley ratsNeurological recovery
2020
Granulocyte-Colony Stimulating Factor Reduces Cocaine-Seeking and Downregulates Glutamatergic Synaptic Proteins in Medial Prefrontal Cortex
Hofford RS, Euston TJ, Wilson RS, Meckel KR, Peck EG, Godino A, Landry JA, Calipari ES, Lam TT, Kiraly DD. Granulocyte-Colony Stimulating Factor Reduces Cocaine-Seeking and Downregulates Glutamatergic Synaptic Proteins in Medial Prefrontal Cortex. Journal Of Neuroscience 2020, 41: 1553-1565. PMID: 33361463, PMCID: PMC7896012, DOI: 10.1523/jneurosci.1452-20.2020.Peer-Reviewed Original ResearchConceptsGranulocyte-colony stimulating factorMedial prefrontal cortexPsychostimulant use disordersPrefrontal cortexNucleus accumbensUse disordersDrug AdministrationMale Sprague-Dawley ratsMajor public health issueG-CSF treatmentSprague-Dawley ratsSynaptic dopamine releasePublic health issueTranslational research strategiesG-CSF effectsCue-induced drugDrug seeking behaviorRapid clinical translationAlters behavioral responsesRecombinant G-CSFReinstatement of cocaineGlutamatergic mechanismsPharmacological treatmentDawley ratsDopamine releaseEffect of High Fructose Corn Sirup on Pancreatic Ductal Adenocarcinoma Induced by Dimethyl Benzantracene (DMBA) in Rats
Ozcan-Sınır G, Inan S, Suna S, Tamer CE, Akgül MB, Bagdas D, Sonmez G, Evrensel T, Kaya E, Sarandol E, Dündar HZ, Tarım OF, Ercan I, Sıgırlı D, Incedayı B, Copur OU. Effect of High Fructose Corn Sirup on Pancreatic Ductal Adenocarcinoma Induced by Dimethyl Benzantracene (DMBA) in Rats. Nutrition And Cancer 2020, 73: 339-349. PMID: 32475178, DOI: 10.1080/01635581.2020.1770811.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaMale Sprague-Dawley ratsDevelopment of PDACSprague-Dawley ratsConsumption of sugarHistopathologic findingsPancreatic cancerDawley ratsDuctal adenocarcinomaRat modelGlucose levelsChow consumptionBody weightHistologic specimensDifferentiated typeDimethyl benzanthraceneDaily intakeRatsEntire groupTissue processing protocolChowTumor formationSignificant differencesFeeding periodGroup
2019
Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats
Hao C, Wu X, Zhou R, Zhang H, Zhou Y, Wang X, Feng Y, Mei L, He C, Cai X, Wu L. Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats. Drug Design Development And Therapy 2019, 13: 3199-3206. PMID: 31686782, PMCID: PMC6751335, DOI: 10.2147/dddt.s214918.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesMarginal cellsStria vascularisOxidative stressAnnexin V/7-AAD stainingInner ear agingResistance to oxidative stressAnnexin-V/7-AADAdenovirus expressing siRNAKnockdown of p66shcEnhanced resistance to oxidative stressSprague Dawley ratsOxidative stress modelMarginal cells of stria vascularisIn vitro oxidative stress modelP66Shc inhibitionReactive oxygen species levelsNeonatal ratsDCFH-DA probeGlucose oxidaseOxidative stress signalingReducing oxidative stressStress signalsDawley ratsP66Shc levelsActivation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine
Barahona MJ, Maina RM, Lysyy T, Finotti M, Caturegli G, Baratta V, D’Amico F, Mulligan D, Geibel JP. Activation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine. Frontiers In Physiology 2019, 10: 439. PMID: 31130866, PMCID: PMC6509940, DOI: 10.3389/fphys.2019.00439.Peer-Reviewed Original ResearchPresence of forskolinFluid secretionSmall intestineAC-265347Fluid absorptionIntestinal fluid secretionCalcium-sensing receptorSprague-Dawley ratsNew therapeutic targetsNet fluid absorptionDose-dependent mannerRat small intestineMM CaAbsence of forskolinMammalian gastrointestinal tractFluid hypersecretionDiarrheal illnessIntraluminal perfusionPotent secretagogueDawley ratsGastrointestinal tractCaSR activatorsElectrolyte balanceTherapeutic targetLuminal perfusate
2017
Reduced Cerebrovascular Reactivity and Increased Resting Cerebral Perfusion in Rats Exposed to a Cafeteria Diet
Gomez-Smith M, Janik R, Adams C, Lake EM, Thomason LAM, Jeffers MS, Stefanovic B, Corbett D. Reduced Cerebrovascular Reactivity and Increased Resting Cerebral Perfusion in Rats Exposed to a Cafeteria Diet. Neuroscience 2017, 371: 166-177. PMID: 29229555, DOI: 10.1016/j.neuroscience.2017.11.054.Peer-Reviewed Original ResearchConceptsRat endothelial cell antigen-1Cerebrovascular reactivityCafeteria dietMagnetic resonance imagingCerebral perfusionStandard chowAnimals fed standard chowEndothelial cell antigen-1Arterial spin labeling magnetic resonance imagingContinuous arterial spin labeling (CASL) magnetic resonance imagingEndothelin-1 injectionReduced Cerebrovascular ReactivityUltra-processed dietFed standard chowSprague-Dawley ratsShort-term consumptionCell antigen-1CAF ratsCerebrovascular functionIschemic lesionsCerebral microvasculatureDiet ratsSensorimotor cortexBrain perfusionDawley ratsEffects of long-term consumption of high fructose corn syrup containing peach nectar on body weight gain in sprague dawley rats
SINIR G, Senem S, Sevda I, BAGDAS D, TAMER C, COPUR O, SIGIRLI D, SARANDOL E, SONMEZ G, ERCAN I, EVRENSEL T, TARIM O, Erdal E, UYLASER V, INCEDAYI B. Effects of long-term consumption of high fructose corn syrup containing peach nectar on body weight gain in sprague dawley rats. Food Science And Technology 2017, 37: 337-343. DOI: 10.1590/1678-457x.25416.Peer-Reviewed Original ResearchAd libitum chowBody mass indexHigh fructose corn syrupSerum triglyceridesLee indexLeptin concentrationsSprague-DawleyConsumption of HFCSWeight gainSprague-Dawley ratsBody weight gainLong-term consumptionFructose corn syrupMass indexMore energy intakeDawley ratsBody weightEnergy intakeChowBiochemical parametersHealth concernMetabolic changesPercentage changeCorn syrupDawley
2013
Differential effects of hepcidin on heme and nonheme iron absorption in a rat model of iron overload
Cao C, Thomas C, Insogna K, O'Brien K. Differential effects of hepcidin on heme and nonheme iron absorption in a rat model of iron overload. The FASEB Journal 2013, 27: 634.18-634.18. DOI: 10.1096/fasebj.27.1_supplement.634.18.Peer-Reviewed Original ResearchFe overloadMale Sprague-Dawley ratsWeeks of treatmentFe absorptionBi-weekly injectionsNonheme iron absorptionRed cell incorporationSprague-Dawley ratsLiver hepcidinDawley ratsRat modelRats inhibitsIron overloadRodent modelsIron absorptionAlternate daysRegulatory hormonesHepcidin transcriptsHepcidinFpn degradationRatsCell incorporationGreater associationDifferential effectsPorcine RBCs
2011
Changes in intracortical microporosities induced by pharmaceutical treatment of osteoporosis as detected by high resolution micro-CT
Tommasini SM, Trinward A, Acerbo AS, De Carlo F, Miller LM, Judex S. Changes in intracortical microporosities induced by pharmaceutical treatment of osteoporosis as detected by high resolution micro-CT. Bone 2011, 50: 596-604. PMID: 22226688, PMCID: PMC3278519, DOI: 10.1016/j.bone.2011.12.012.Peer-Reviewed Original ResearchConceptsAge-matched controlsUntreated OVXEstrogen withdrawalSix-month-old female SpragueDifferent osteoporosis treatmentsUntreated OVX ratsStart of treatmentEndosteal regionOsteocyte lacunar sizeEffect of treatmentOVX ratsOsteoporosis treatmentFemale SpraguePTH treatmentDawley ratsCurrent treatmentNumber of lacunaeMedial cortexOsteocyte lacunaePharmaceutical treatmentOVXMedial quadrantAlendronateBone strengthFemoral diaphysis
2010
The Effect of Dietary Protein on Intestinal Calcium Absorption in Rats
Gaffney-Stomberg E, Sun BH, Cucchi CE, Simpson CA, Gundberg C, Kerstetter JE, Insogna KL. The Effect of Dietary Protein on Intestinal Calcium Absorption in Rats. Endocrinology 2010, 151: 1071-1078. PMID: 20147526, PMCID: PMC2840679, DOI: 10.1210/en.2009-0744.Peer-Reviewed Original ResearchConceptsIntestinal Ca absorptionCa absorptionHigh-protein dietUrinary calciumBrush border membrane vesiclesProtein intakeFemale Sprague-Dawley ratsProtein dietProtein intake resultsIntestinal calcium absorptionDietary protein intakeHigh protein intakeSprague-Dawley ratsLow-protein groupHigh protein groupDietary protein effectsCalcium absorptionAcute increaseDawley ratsDuodenal mucosaIntake resultsRatsCa balanceTranscellular CaDietary protein
2009
Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model
Cadet ER, Vorys GC, Rahman R, Park S, Gardner TR, Lee FY, Levine WN, Bigliani LU, Ahmad CS. Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model. Journal Of Orthopaedic Research® 2009, 28: 308-314. PMID: 19743506, DOI: 10.1002/jor.20972.Peer-Reviewed Original ResearchConceptsBone densityRotator cuff footprintOVX groupRat modelSupraspinatus tendonCuff footprintQuantitative micro-computed tomographyMonths of ageBisphosphonate treatmentOVX ratsBilateral ovariectomyProximal humerusDawley ratsAdditional ratsOVXRatsTendonOvariectomyMicro-computed tomographyTreatmentGroupBisphosphonatesSpragueHumerusMonths
2008
Introducing the first polymer-free leflunomide eluting stent
Deuse T, Erben R, Ikeno F, Behnisch B, Boeger R, Connolly A, Reichenspurner H, Bergow C, Pelletier M, Robbins R, Schrepfer S. Introducing the first polymer-free leflunomide eluting stent. Atherosclerosis 2008, 200: 126-134. PMID: 18295768, DOI: 10.1016/j.atherosclerosis.2007.12.055.Peer-Reviewed Original ResearchConceptsOptical coherence tomographySprague Dawley ratsDawley ratsIdentical bare metal stentIn vitro proliferation assaySmooth-muscle-cellEffect of leflunomideInhibition of EC proliferationEC proliferationComputer-assisted morphometryIn vitro SMC proliferationIn vivo efficacyAssessed 6 weeksBare metal stentsLuminal obliterationSafety profileIn vitro mechanismsInflammation scoreCoherence tomographyDose-dependentlyPharmacological characteristicsHuman EC proliferationSMC proliferationNeointimal areaMetal stents
2007
Role of Calcineurin in Nicotine-Mediated Locomotor Sensitization
Addy NA, Fornasiero EF, Stevens TR, Taylor JR, Picciotto MR. Role of Calcineurin in Nicotine-Mediated Locomotor Sensitization. Journal Of Neuroscience 2007, 27: 8571-8580. PMID: 17687035, PMCID: PMC6672935, DOI: 10.1523/jneurosci.2601-07.2007.Peer-Reviewed Original ResearchConceptsVentral tegmental areaEffects of nicotineLocomotor sensitizationCalcineurin inhibitorsRole of calcineurinInfusion of rapamycinCultured cortical neuronsSprague-Dawley ratsNicotine-mediated behaviorsCyclosporine administrationTegmental areaCortical neuronsDawley ratsFK-binding proteinActivation of calcineurinNicotineSensitizationCalcineurin activityInfusionIntracellular signalingAdministrationCalcineurinFK506InhibitorsDirect infusion
2006
DNA damage and mismatch repair pathway in lung ischemia and reperfusion injury
Bonde P, Gao D, Chen L, Moreno-Vinasco L, Jacobson J, Garcia J, Wei C. DNA damage and mismatch repair pathway in lung ischemia and reperfusion injury. Journal Of Cardiothoracic-Renal Research 2006, 1: 147-152. DOI: 10.1016/j.jccr.2006.05.007.Peer-Reviewed Original ResearchLung ischemiaLung transplantationReperfusion groupReperfusion injuryWestern blotDNA mismatch repair pathwayAdult Sprague-Dawley ratsMismatch repair pathwaySprague-Dawley ratsModel of ischemiaAttractive therapeutic interventionCaspase-3 immunohistochemistryDNA damageCaspase-3 levelsDawley ratsLung tissueOxidative DNA damageReperfusionDNA repair enzymeIschemiaTherapeutic interventionsImmunohistochemistryRepair pathwaysProtein levelsTransplantation
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