2024
Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke
Dylla L, Higgins H, Poisson S, Vu T, Reisz J, Herson P, Monte A. Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke. Clinical Therapeutics 2024, 46: 960-966. PMID: 39603869, PMCID: PMC11637908, DOI: 10.1016/j.clinthera.2024.10.015.Peer-Reviewed Original ResearchAcute ischemic strokeQuinolinic acid levelsLevels of tryptophanNIHSS scoreTryptophan metabolismMetabolite levelsKynurenine pathwayLinear regression modelsIncreased lifetime risk of strokeLifetime risk of strokeMass spectrometry-based metabolomicsPotential sex differencesDownstream kynurenine metabolitesAssociated with poor outcomesIschemic strokeKynurenine pathway metabolitesDecreased tryptophan concentrationsIncreased lifetime riskRegression modelsMultivariate linear regression modelSex differencesExperience worse outcomesRisk of strokeAcid levelsKynurenine metabolitesSex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory
Li G, Cao Y, Yang C, Li X, Yang Y, Yang L, Hao D, Li C. Sex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory. Quantitative Imaging In Medicine And Surgery 2024, 14: 4972986-4974986. PMID: 39022273, PMCID: PMC11250293, DOI: 10.21037/qims-24-156.Peer-Reviewed Original ResearchAlcohol use severityWorking memoryPittsburgh Sleep Quality IndexAlcohol misuseSex differencesHuman Connectome ProjectPath modelAssociated with working memory deficitsNeural correlates of working memoryPittsburgh Sleep Quality Index scoreCorrelates of working memoryPrefrontal cortex responsesImpact working memoryWhole-brain regressionComorbid alcohol misusePotential sex differencesManipulation of informationImpact of drinkingDLPFC activationDrinking severityPublished routinesNeural correlatesMemory deficitsNeural measuresSleep deficiency
2023
Sleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young adults
Li G, Chen Y, Chaudhary S, Li C, Hao D, Yang L, Li C. Sleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young adults. NeuroImage 2023, 279: 120340. PMID: 37611815, DOI: 10.1016/j.neuroimage.2023.120340.Peer-Reviewed Original ResearchConceptsPittsburgh Sleep Quality IndexRight insulaSymptom severityMediation analysisSleep dysfunctionWhole-brain regressionHuman Connectome Project datasetSubjective mood stateYoung adultsState functional connectivityDepression symptom severityNegative emotionsCognitive performanceEmotional deficitsEmotional statesPotential sex differencesAffective functionsDrinking severityMood statesMotivated behaviorFunctional connectivityPoor sleep qualityRSFCSleep Quality IndexSleep qualityAssociation of marital/partner status and patient-reported outcomes following myocardial infarction: a systematic review and meta-analysis
Zhu C, Tran P, Leifheit E, Spatz E, Dreyer R, Nyhan K, Wang S, Lichtman J. Association of marital/partner status and patient-reported outcomes following myocardial infarction: a systematic review and meta-analysis. European Heart Journal Open 2023, 3: oead018. PMID: 36942107, PMCID: PMC10023828, DOI: 10.1093/ehjopen/oead018.Peer-Reviewed Original ResearchPatient-reported outcome measuresMarital/partner statusPersonal recovery outcomesMyocardial infarctionHigher HRQoLMI patientsPartner statusSystematic reviewOutcome domainsRecovery outcomesSex differencesPatient-reported outcomesNewcastle-Ottawa ScaleStandardized mean differenceSymptoms of anxietyPotential sex differencesUnpartnered patientsFunctional statusSubgroup analysisEligible studiesStudy qualityOutcome measuresPeer-reviewed studiesMean differencePatientsVentral Tegmental Area M5 Muscarinic Receptors Mediate Effort-Choice Responding and Nucleus Accumbens Dopamine in a Sex-Specific Manner
Nunes E, Kebede N, Haight J, Foster D, Lindsley C, Conn P, Addy N. Ventral Tegmental Area M5 Muscarinic Receptors Mediate Effort-Choice Responding and Nucleus Accumbens Dopamine in a Sex-Specific Manner . Journal Of Pharmacology And Experimental Therapeutics 2023, 385: 146-156. PMID: 36828630, PMCID: PMC10108441, DOI: 10.1124/jpet.122.001438.Peer-Reviewed Original ResearchConceptsNucleus accumbens coreVentral tegmental areaM5 receptorsDA releaseMale ratsVTA infusionsDepressive disorderNucleus accumbensMuscarinic M5 receptorsSelective negative allosteric modulatorM5 muscarinic receptorsNegative allosteric modulatorsEffort-related choicePhasic DA releasePotential sex differencesSex-specific mannerACh toneVTA administrationCholinergic effectsMuscarinic receptorsFemale ratsTegmental areaPreclinical modelsDopamine releaseTherapeutic targetChapter 11 Cholinergic modulation of circuits
Addy N, Fowler C, Wickham R. Chapter 11 Cholinergic modulation of circuits. 2023, 409-444. DOI: 10.1016/b978-0-12-823453-2.00004-7.Chapters
2022
Trait anger representation in microstructural white matter tracts: A diffusion MRI study
Sinaeifar Z, Mayeli M, Shafie M, Pooyan A, Cattarinussi G, Aarabi M, Sambataro F. Trait anger representation in microstructural white matter tracts: A diffusion MRI study. Journal Of Affective Disorders 2022, 322: 249-257. PMID: 36368424, DOI: 10.1016/j.jad.2022.11.020.Peer-Reviewed Original ResearchConceptsTrait anger temperamentState-Trait Anger Expression InventoryTrait angerSplenium of corpus callosumSelf-report measures of angerDiffusion magnetic resonance imagingLeft inferior cerebellar peduncleQuantitative anisotropyAnger Expression InventoryMeasures of angerSelf-report measuresMovement-related regionsPotential sex differencesInvestigate white matterWhite matter tractsWM circuitsAnger temperamentLeft fornixState angerAnger expressionBilateral corticospinal tractsWhite matterConnectometry approachBrain pathwaysState-TraitAlcohol and cannabis co‐use and longitudinal gray matter volumetric changes in early and late adolescence
Luo X, Yang JJ, Buu A, Trucco EM, Li C. Alcohol and cannabis co‐use and longitudinal gray matter volumetric changes in early and late adolescence. Addiction Biology 2022, 27: e13208. PMID: 36001427, PMCID: PMC9413216, DOI: 10.1111/adb.13208.Peer-Reviewed Original ResearchConceptsGray matter volumeLate adolescenceCaudal middle frontal cortexEarly adolescent onsetGray matter volumetric changesMiddle frontal cortexSevere alcohol useBrain developmentCross-sectional findingsSocial cognitionExecutive controlNCANDA studyVolumetric declinesSupramarginal gyrusPotential sex differencesSuperior temporalImpact of alcoholAdolescent onsetSubstance useCortical regionsAlcohol useMatter volumeFrontal cortexResult of alcoholMixed-effects modelingSex Differences in PrEsentation, Risk Factors, Drug and Interventional Therapies, and OUtcomes of Elderly PatientS with Pulmonary Embolism: Rationale and design of the SERIOUS-PE study
Bikdeli B, Piazza G, Jimenez D, Muriel A, Wang Y, Khairani CD, Rosovsky RP, Mehdipoor G, O'Donoghue ML, Spagnolo P, Dreyer RP, Bertoletti L, López-Jiménez L, Núñez MJ, Blanco-Molina Á, Bates SM, Gerhard-Herman M, Goldhaber SZ, Monreal M, Krumholz HM. Sex Differences in PrEsentation, Risk Factors, Drug and Interventional Therapies, and OUtcomes of Elderly PatientS with Pulmonary Embolism: Rationale and design of the SERIOUS-PE study. Thrombosis Research 2022, 214: 122-131. PMID: 35537232, DOI: 10.1016/j.thromres.2022.04.019.Peer-Reviewed Original ResearchConceptsRisk factorsElderly patientsUS Medicare feeInterventional therapyMedicare feeInternational registryService beneficiariesSex differencesNational US databasePrognostic prediction rulePulmonary embolism studyLarge international registryPrincipal discharge diagnosisSex-based disparitiesAssessment of outcomesPotential sex differencesSex-specific findingsPE presentationPulmonary embolismVenous thromboembolismTreatment patternsDischarge diagnosisAvailable therapiesDisease presentationTreatment-based differences
2021
Perceived friendship and binge drinking in young adults: A study of the Human Connectome Project data
Li G, Chen Y, Le TM, Zhornitsky S, Wang W, Dhingra I, Zhang S, Tang X, Li CR. Perceived friendship and binge drinking in young adults: A study of the Human Connectome Project data. Drug And Alcohol Dependence 2021, 224: 108731. PMID: 33915512, PMCID: PMC8641247, DOI: 10.1016/j.drugalcdep.2021.108731.Peer-Reviewed Original ResearchConceptsNon-binge drinkersRight posterior insulaPeer influenceYoung adult binge drinkingSocial cognition tasksSocial cognitive processingAlcohol useBinge drinkingWhole-brain regressionAdult binge drinkingYoung adultsMedial orbitofrontal cortexHuman Connectome ProjectRPI activityAlcohol use severityHuman Connectome Project dataSocial cognitionCognition tasksCognitive processingNeural correlatesNeural processesPotential sex differencesOrbitofrontal cortexPosterior insulaConnectome ProjectMPEP Lowers Binge Drinking in Male and Female C57BL/6 Mice: Relationship with mGlu5/Homer2/Erk2 Signaling
Huang G, Thompson SL, Taylor JR. MPEP Lowers Binge Drinking in Male and Female C57BL/6 Mice: Relationship with mGlu5/Homer2/Erk2 Signaling. Alcohol Clinical And Experimental Research 2021, 45: 732-742. PMID: 33587295, PMCID: PMC8076072, DOI: 10.1111/acer.14576.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinge DrinkingDose-Response Relationship, DrugDrug Evaluation, PreclinicalExcitatory Amino Acid AntagonistsFemaleHomer Scaffolding ProteinsMaleMAP Kinase Signaling SystemMice, Inbred C57BLMitogen-Activated Protein Kinase 1Nucleus AccumbensPyridinesReceptor, Metabotropic Glutamate 5Septal NucleiSex CharacteristicsConceptsEffects of MPEPFemale C57BL/6 miceAlcohol intakeAlcohol consumptionNegative allosteric modulatorsLocomotor activityC57BL/6 miceFemale miceMale miceHomer2 expressionBinge drinkingMetabotropic glutamate receptor 5MGlu5 negative allosteric modulatorsSex differencesBinge alcohol consumptionGlutamate receptor 5Dose-response effectExcessive alcohol useERK2 expressionDose-response relationshipPotential sex differencesERK2 signalingBed nucleusNucleus accumbensStria terminalis
2020
Neural responsivity to social rewards in autistic female youth
Lawrence KE, Hernandez LM, Eilbott J, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, Geschwind DH, McPartland JC, Nelson CA, Webb SJ, Pelphrey KA, Bookheimer SY, Dapretto M. Neural responsivity to social rewards in autistic female youth. Translational Psychiatry 2020, 10: 178. PMID: 32488083, PMCID: PMC7266816, DOI: 10.1038/s41398-020-0824-8.Peer-Reviewed Original ResearchConceptsImplicit learning taskSocial rewardsAutistic girlsAutistic boysLearning taskSocial reward processingSocial reward systemFemale youthPrevious neuroimaging studiesFunctional magnetic resonanceLateral frontal cortexSocial stimuliNeural responsivityReward processingSocial motivationRewarding stimuliAnterior insulaGreater activityNeural activationNeuroimaging studiesPotential sex differencesRewarding natureSalience detectionAutistic femalesBehavioral evidence
2019
0341 Men and Women Veterans’ Military Experiences and Associated Risk of Insomnia
Gaffey A, Redeker N, Haskell S, Brandt C, Burg M. 0341 Men and Women Veterans’ Military Experiences and Associated Risk of Insomnia. Sleep 2019, 42: a139-a140. DOI: 10.1093/sleep/zsz067.340.Peer-Reviewed Original ResearchTraumatic brain injuryMilitary sexual traumaWomen veteransCombat traumaService-related experiencesSymptoms of insomniaSelf-reported demographicsPosttraumatic stress disorderNumber of deploymentsPotential sex differencesChronic painBrain injuryInsomnia symptomsWomen's healthInsomniaVA OfficeStress disorderTraumaWomenVeteransSexual traumaPhysical tollRecent cohortsSex differencesSymptoms
2018
Sex and Feeding Status Differently Affect Natural Reward Seeking Behavior in Olfactory Bulbectomized Rats
Ruda-Kucerova J, Zanda M, Amchova P, Fratta W, Fattore L. Sex and Feeding Status Differently Affect Natural Reward Seeking Behavior in Olfactory Bulbectomized Rats. Frontiers In Behavioral Neuroscience 2018, 12: 255. PMID: 30425627, PMCID: PMC6218565, DOI: 10.3389/fnbeh.2018.00255.Peer-Reviewed Original ResearchSchedule of reinforcementPalatable food pelletsOBX ratsOBX lesionOperant respondingSelf-AdministrationFood pelletsNatural reward-seeking behaviorsIntravenous drug self-administrationSex differencesFood self-administrationDepressive-like phenotypeDrug Self-AdministrationOperant self-administrationReward-seeking behaviorDrug-seeking behaviorRates of comorbidityPotential sex differencesFood restrictionOBX modelFood intakeOlfactory bulbectomyDrug-takingPalatable foodPsychiatric disordersSex-Differences in Children Referred for Assessment: An Exploratory Analysis of the Autism Mental Status Exam (AMSE)
Øien RA, Vambheim SM, Hart L, Nordahl-Hansen A, Erickson C, Wink L, Eisemann MR, Shic F, Volkmar FR, Grodberg D. Sex-Differences in Children Referred for Assessment: An Exploratory Analysis of the Autism Mental Status Exam (AMSE). Journal Of Autism And Developmental Disorders 2018, 48: 2286-2292. PMID: 29423603, DOI: 10.1007/s10803-018-3488-y.Peer-Reviewed Original ResearchConceptsAutism Mental Status ExamMental status examSymptoms of ASDLanguage deficitsPotential sex differencesAutism assessmentDisruptive behaviorAreas of developmentTest performanceASDObservational assessmentGold standard assessmentSex differencesExploratory analysisChildrenDeficitsSensory symptomsSymptomsPerformanceResting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers
Hu S, Ide JS, Chao HH, Zhornitsky S, Fischer KA, Wang W, Zhang S, Li CR. Resting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers. Drug And Alcohol Dependence 2018, 185: 173-180. PMID: 29454928, PMCID: PMC5889735, DOI: 10.1016/j.drugalcdep.2017.11.026.Peer-Reviewed Original ResearchConceptsState functional connectivityDorsal anterior cingulate cortexAlcohol misuseAlcohol drinkersFunctional connectivityInvolvement scoreProblem drinkingSubstance useWhole-brain rsFCComorbid substance useAmygdala-prefrontal cortical circuitAnterior cingulate cortexStatistical parametric mappingPotential sex differencesPrefrontal cortical structuresAmygdala connectivityCortical functionCortical circuitsCingulate cortexAmygdalaCortical structuresParametric mappingSex differencesDrinkingDrinkers
2014
Age‐Dependent Sex Effects on Outcomes After Pediatric Cardiac Surgery
Kochilas LK, Vinocur JM, Menk JS. Age‐Dependent Sex Effects on Outcomes After Pediatric Cardiac Surgery. Journal Of The American Heart Association 2014, 3: e000608. PMID: 24496232, PMCID: PMC3959673, DOI: 10.1161/jaha.113.000608.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsCardiac Surgical ProceduresChi-Square DistributionChildChild, PreschoolFemaleHealth Status DisparitiesHeart Defects, CongenitalHospital MortalityHumansInfantInfant, NewbornLogistic ModelsMaleMultivariate AnalysisNorth AmericaOdds RatioRegistriesRetrospective StudiesRisk FactorsSex FactorsTime FactorsTreatment OutcomeConceptsPediatric cardiac operationsPediatric cardiac surgeryCardiac surgeryCardiac operationsPostsurgical mortalityHigh-risk cardiac operationsPediatric Cardiac Care ConsortiumRisk of deathMonths of lifePotential sex differencesAge-dependent relationshipSurgical yearHospital mortalityUnadjusted mortalityPatient sexWhole cohortHigh-risk operationsCardiovascular diseaseSex effectsCardiovascular stressCare ConsortiumEarly infancyZ-scoreLogistic regressionMortality
2011
Childhood Adversity Increases Risk for Nicotine Dependence and Interacts with α5 Nicotinic Acetylcholine Receptor Genotype Specifically in Males
Xie P, Kranzler HR, Zhang H, Oslin D, Anton RF, Farrer LA, Gelernter J. Childhood Adversity Increases Risk for Nicotine Dependence and Interacts with α5 Nicotinic Acetylcholine Receptor Genotype Specifically in Males. Neuropsychopharmacology 2011, 37: 669-676. PMID: 22012472, PMCID: PMC3260970, DOI: 10.1038/npp.2011.240.Peer-Reviewed Original ResearchConceptsChildhood adversityRs16969968 genotypeND riskSex differencesNicotinic acetylcholine receptor genesAcetylcholine receptor genesPotential sex differencesNicotine dependence riskFagerstrom TestNicotine intakeSmoking riskIncrease riskNicotine dependenceRodent modelsReceptor genotypeND scoresEarly life experiencesEuropean AmericansReceptor geneWomenRiskGene × environment effectsMen
2001
An Eight-Year Longitudinal Comparison of Clinical Course and Characteristics of Social Phobia Among Men and Women
Yonkers KA, Dyck IR, Keller MB. An Eight-Year Longitudinal Comparison of Clinical Course and Characteristics of Social Phobia Among Men and Women. Psychiatric Services 2001, 52: 637-643. PMID: 11331798, DOI: 10.1176/appi.ps.52.5.637.Peer-Reviewed Original ResearchConceptsHealth-related qualityHarvard/Brown Anxiety Research ProgramSuicide attemptsSocial phobiaComorbid substance use disorderPoorer baseline functioningLower Global AssessmentPercent of menPercent of womenSubstance use disordersPotential sex differencesComplete remissionRemission rateClinical courseChronic courseEight-year study periodChronic disordersHigh prevalenceObservational studyFunctioning scoresUse disordersBaseline functioningConcurrent agoraphobiaGreater chronicityGlobal assessment
1999
Potential Sex Differences Remain Understudied: A Case Study of the Inclusion of Women in HIV/AIDS-Related Neuropsychological Research
Fox-Tierney R, Ickovics J, Cerreta C, Ethier K. Potential Sex Differences Remain Understudied: A Case Study of the Inclusion of Women in HIV/AIDS-Related Neuropsychological Research. Review Of General Psychology 1999, 3: 44-54. DOI: 10.1037/1089-2680.3.1.44.Peer-Reviewed Original ResearchSex differencesQuality of studiesHIV/AIDSPopulation of personsPotential sex differencesNeuropsychological manifestationsClinical researchMore womenWomenHIVNeuropsychological researchComprehensive literature reviewLiterature reviewInclusion of womenComplicationsReliable sex differencesStudyAIDSDifferences
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