2024
β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction
Joyce M, Yang S, Morin K, Duque A, Arellano J, Datta D, Wang M, Arnsten A. β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction. Neurobiology Of Stress 2024, 30: 100628. PMID: 38550854, PMCID: PMC10973161, DOI: 10.1016/j.ynstr.2024.100628.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexStress-induced cognitive dysfunctionTreat stress-related disordersPrimate dorsolateral prefrontal cortexImpaired working memoryWorking Memory DeficitsWorking Memory TaskCalcium-binding proteins calbindinStress-related disordersClasses of inhibitory neuronsLevels of norepinephrineFast-spikingMemory taskDopamine releaseWorking memoryMemory deficitsInhibitory neuronsCognitive dysfunctionPV interneuronsGABAergic interneuronsDLPFCBehavior analysisCortexPyramidal cells
2023
Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics
Batista-Brito R, Majumdar A, Nuño A, Ward C, Barnes C, Nikouei K, Vinck M, Cardin J. Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics. Molecular Psychiatry 2023, 28: 3133-3143. PMID: 37069344, PMCID: PMC10618960, DOI: 10.1038/s41380-023-02066-3.Peer-Reviewed Original ResearchConceptsPV interneuronsCortical neuronsCortical circuitsCortical circuit dynamicsCortical GABAergic cellsNRG1/ErbB4Excitatory cortical neuronsParvalbumin-Expressing InterneuronsInhibitory cortical neuronsApical dendritic tuftsActivity of excitatorySecond postnatal weekProper synaptic connectivityLate postnatal developmentState-dependent modulationLoss of ERBB4Excitatory componentGABAergic cellsGABAergic inhibitionSpine densityDendritic tuftsPostnatal weekNormal tuningSynaptic connectivityReceptor ErbB4
2020
Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits
Datta D, Enwright JF, Arion D, Paspalas CD, Morozov YM, Lewis DA, Arnsten AFT. Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits. Frontiers In Neuroanatomy 2020, 14: 578483. PMID: 33328902, PMCID: PMC7714912, DOI: 10.3389/fnana.2020.578483.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexSmooth endoplasmic reticulumPrefrontal cortexHuman dlPFCPrimate dorsolateral prefrontal cortexHuman post-mortem tissueInternal calcium releasePrimate association corticesPost-mortem tissueMacaque dorsolateral prefrontal cortexPrimate dlPFCAxospinous synapsesPV interneuronsGlutamatergic connectionsGlutamatergic synapsesPyramidal cellsAxon terminalsTransmitter releaseTau phosphorylationDendritic spinesPDE4 isozymesAssociation cortexLayer IIICAMP actionPostsynaptic labeling
2011
A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior
Carlén M, Meletis K, Siegle J, Cardin J, Futai K, Vierling-Claassen D, Rühlmann C, Jones S, Deisseroth K, Sheng M, Moore C, Tsai L. A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. Molecular Psychiatry 2011, 17: 537-548. PMID: 21468034, PMCID: PMC3335079, DOI: 10.1038/mp.2011.31.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAssociation LearningBrain WavesConditioning, PsychologicalExcitatory Postsynaptic PotentialsGABA AntagonistsGABAergic NeuronsInterneuronsMaleMaze LearningMemory, Short-TermMiceMice, TransgenicParvalbuminsPhotic StimulationPicrotoxinReceptors, N-Methyl-D-AspartateSensory GatingStereotyped BehaviorConceptsGamma oscillationsSpecific cognitive behaviorSelective cognitive impairmentsGamma rhythmsPsychosis-like symptomsCognitive tasksAssociative learningNeural network dysfunctionCognitive behaviorCortical gamma rhythmsCognitive impairmentNetwork dysfunctionNMDAR neurotransmissionOptogenetic drivePV interneuronsParvalbumin interneuronsNMDAR antagonistsMemoryReduced sensitivityBehaviorTaskHabituationDeficitsNormal behaviorLearning
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply