2023
Prevalence and Correlates of Cannabis Use among U.S. Veterans during the Second Wave of the COVID-19 Pandemic
Manzo L, Sarkar S, Nicholson N, Sanft T, Poghosyan H. Prevalence and Correlates of Cannabis Use among U.S. Veterans during the Second Wave of the COVID-19 Pandemic. Military Medicine 2023, 189: e1230-e1239. PMID: 37715685, DOI: 10.1093/milmed/usad360.Peer-Reviewed Original ResearchCurrent tobacco smokersE-cigarette useComorbid conditionsTobacco smokersU.S. veteransNon-Hispanic Black veteransMultivariable logistic regression analysisSurvey's complex designMore comorbid conditionsNon-Hispanic white veteransFrequent mental distressHigh-risk subgroupsCoronavirus disease 2019 (COVID-19) pandemicMilitary veteransCurrent e-cigarette useCurrent e-cigarette usersLogistic regression analysisNon-Hispanic blacksTimes higher oddsSubstance use disordersDisease 2019 pandemicCOVID-19 pandemicNon-Hispanic whitesE-cigarette usersFormer smokersCannabis use among cancer survivors before and during the COVID-19 pandemic, 2019-2021
Sarkar S, Braun I, Nayak M, Bryan A, Poghosyan H. Cannabis use among cancer survivors before and during the COVID-19 pandemic, 2019-2021. JNCI Cancer Spectrum 2023, 7: pkad031. PMID: 37079754, PMCID: PMC10166585, DOI: 10.1093/jncics/pkad031.Peer-Reviewed Original ResearchConceptsCancer survivorsSubpopulation of cancer survivorsBehavioral Risk Factor Surveillance SystemRisk Factor Surveillance SystemCannabis usePoor mental healthEvidence-informed discussionsFactors associated with cannabis useCOVID-19 pandemicMental healthAlcohol consumersTobacco smokersSurveillance systemSurvivorsMedical reasonsCOVID-19PrevalenceCannabisCancerUseHealthPandemicSmokersTobacco
2022
Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers
Zakiniaeiz Y, Hoye J, Ryan Petrulli J, LeVasseur B, Stanley G, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Chen MK, Matuskey D, Barron DS, Kelmendi B, Fulbright RK, Hampson M, Cosgrove KP, Morris ED. Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers. Brain Behavior And Immunity 2022, 106: 262-269. PMID: 36058419, PMCID: PMC10097458, DOI: 10.1016/j.bbi.2022.08.016.Peer-Reviewed Original ResearchConceptsEffects of LPSDopamine elevationTobacco smokersHealthy controlsSystemic inflammationDopamine systemImmune-brain interactionReward-related brain regionsAdministration of placeboAdministration of LPSSmoking statusRepeated-measures ANOVAPathophysiology of addictionDrug dosingPlaceboIndependent cohortSmokersDrug reinforcementEffect size determinationImmune systemRandomized orderBrain regionsLPSMethylphenidatePBO conditionThe Effect of Tobacco Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch Repair Mechanism and miRNA Markers, in Hypopharyngeal Squamous Cell Carcinoma: An In Vivo Model and Clinical Evidence
Doukas SG, Vageli DP, Doukas PG, Nikitovic D, Tsatsakis A, Judson BL. The Effect of Tobacco Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch Repair Mechanism and miRNA Markers, in Hypopharyngeal Squamous Cell Carcinoma: An In Vivo Model and Clinical Evidence. Current Oncology 2022, 29: 5531-5549. PMID: 36005175, PMCID: PMC9406897, DOI: 10.3390/curroncol29080437.Peer-Reviewed Original ResearchConceptsHypopharyngeal squamous cell carcinomaSquamous cell carcinomaClinical evidenceCell carcinomaTobacco smokeChronic exposureUpper aerodigestive tract cancerHuman hypopharyngeal squamous cell carcinomaAerodigestive tract cancerUpper aerodigestive tract carcinogenesisAerodigestive tract carcinogenesisDose-dependent effectDNA mismatch repair mechanismHypopharyngeal cellsTract cancerTobacco smokersPoor prognosisHypopharyngeal mucosaMouse modelClinical testingVivo modelMiR-155MiR-451aVivo dose-dependent effectMismatch repair mechanismNicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response
Zakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Matuskey D, Chen MK, Cosgrove KP, Morris ED. Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response. Nicotine & Tobacco Research 2022, 24: 1597-1606. PMID: 35100429, PMCID: PMC9575980, DOI: 10.1093/ntr/ntac026.Peer-Reviewed Original ResearchConceptsNicotine replacement therapyDopamine releasePlacebo patchDorsal striatumTobacco smokingReplacement therapyFirst-line pharmacological treatmentVentral striatumMajor public health burdenPositron emission tomography scanEmission tomography scanPublic health burdenNicotine dependence levelNicotine metabolism rateNicotinic acetylcholine receptorsCounter-balanced orderTobacco smokersCigarette smokingSmoking cessationDopamine terminalsPharmacological treatmentDependent smokersFast metabolizersSlow metabolizersNicotine acts
2021
Recently Abstinent Smokers Exhibit Mood-Associated Dopamine Dysfunction in the Ventral Striatum Compared to Nonsmokers: A [11C]-(+)-PHNO PET Study
Calakos KC, Hillmer AT, Angarita GA, Baldassarri SR, Najafzadeh S, Emery PR, Matuskey D, Huang Y, Cosgrove KP. Recently Abstinent Smokers Exhibit Mood-Associated Dopamine Dysfunction in the Ventral Striatum Compared to Nonsmokers: A [11C]-(+)-PHNO PET Study. Nicotine & Tobacco Research 2021, 24: 745-752. PMID: 34628508, PMCID: PMC8962719, DOI: 10.1093/ntr/ntab208.Peer-Reviewed Original ResearchConceptsSmoking cessationAbstinent smokersDopamine releaseVentral striatumPercent changeTobacco smokersDopamine dysfunctionDopamine functionPHNO scansPositron emission tomography brainHigher CES-D scoresAbstinent tobacco smokersEarly quit attemptsHuman tobacco smokersPHNO PET StudyStriatal dopamine dysfunctionEpidemiologic Studies Depression ScaleStriatal dopamine releaseChronic nicotine exposureCES-D scoresSmoking cessation attemptNegative mood symptomsReceptor agonist radioligandStriatal dopamine functionLong-term abstinenceEffects of Smoking Status and State on Intrinsic Connectivity
Yip SW, Lichenstein SD, Garrison K, Averill CL, Viswanath H, Salas R, Abdallah CG. Effects of Smoking Status and State on Intrinsic Connectivity. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 7: 895-904. PMID: 33618016, PMCID: PMC8373998, DOI: 10.1016/j.bpsc.2021.02.004.Peer-Reviewed Original ResearchConceptsSmoking statusIntrinsic connectivityResting-state functional magnetic resonance imagingDefault mode connectivityIntrinsic connectivity distributionLong-term abstinenceFunctional magnetic resonance imagingMagnetic resonance imagingResting-state scanWhole-brain patternsControl nonsmokersSmoking reinstatementInterest-based analysisTobacco smokersFunctional connectivity dataTobacco abstinenceQuit attemptsOvernight abstinenceTobacco deprivationNovel treatmentsSmoking behaviorEarly abstinenceResonance imagingSalience networkFunctional connectivityElevated plasma level of Pentraxin 3 is associated with emphysema and mortality in smokers
Zhang Y, Tedrow J, Nouraie M, Li X, Chandra D, Bon J, Kass DJ, Fuhrman CR, Leader JK, Duncan SR, Kaminski N, Sciurba FC. Elevated plasma level of Pentraxin 3 is associated with emphysema and mortality in smokers. Thorax 2021, 76: 335-342. PMID: 33479043, PMCID: PMC8249179, DOI: 10.1136/thoraxjnl-2020-215356.Peer-Reviewed Original ResearchConceptsAirflow obstructionPlasma levelsLung tissueEmphysema severitySmoking-related lung diseaseAssociation of lungExpiratory airflow obstructionFormer tobacco smokersLevels of PTX3PTX3 gene expressionElevated plasma levelsHyaluronic acid levelsBlood of subjectsPlasma PTX3PTX3 levelsLung functionTobacco exposureClinical outcomesTobacco smokersLung diseasePentraxin 3Predictive biomarkersPTX3 expressionLower riskDisease patterns
2020
A Cross-Sectional Analysis of Tobacco Use and Concurrent Alcohol and Substance Use Among Patients Living with HIV/HCV Co-infection: Findings from a Large Urban Tertiary Center
Sims OT, Jackson A, Guo Y, Truong DN, Odame EA, Mamudu HM. A Cross-Sectional Analysis of Tobacco Use and Concurrent Alcohol and Substance Use Among Patients Living with HIV/HCV Co-infection: Findings from a Large Urban Tertiary Center. Journal Of Clinical Psychology In Medical Settings 2020, 28: 553-561. PMID: 33001329, PMCID: PMC7528154, DOI: 10.1007/s10880-020-09744-2.Peer-Reviewed Original ResearchConceptsHIV/HCVTobacco useConcurrent alcoholSubstance useHIV/HCV co-infectionLarge urban tertiary centerHCV Co-InfectionUrban tertiary centerTreatment of HCVSubstance use disordersCross-sectional analysisTertiary centerTobacco smokersCo-InfectionClinical evaluationHCVUse disordersPatientsMultivariate analysisClinical interventionsBehavioral interventionsCOVID-19 pandemicPrevalenceHigher proportionInterventionMarijuana use among cancer survivors: Quantifying prevalence and identifying predictors
Poghosyan H, Poghosyan A. Marijuana use among cancer survivors: Quantifying prevalence and identifying predictors. Addictive Behaviors 2020, 112: 106634. PMID: 32920457, DOI: 10.1016/j.addbeh.2020.106634.Peer-Reviewed Original ResearchConceptsBehavioral Risk Factor Surveillance System surveyPrevalence of current marijuana useCancer survivorsCurrent marijuana useAdult cancer survivorsNon-Hispanic blacksComplex survey designWeighted prevalence estimatesMarijuana useMultivariate logistic regressionFair/poor healthCross-sectional dataIndividual-level predictorsNon-HispanicPrevalence of marijuana useSystem surveyRacial/ethnic groupsQuantify prevalencePrevalence estimatesIndividual-levelLogistic regressionTobacco smokersSurvey designU.S. statesHighest prevalenceTobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study
Hillmer AT, Matuskey D, Huang Y, Nabulsi N, Ropchan J, Carson RE, O'Malley SS, Cosgrove KP. Tobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study. Journal Of Nuclear Medicine 2020, 61: 1200-1204. PMID: 32005773, PMCID: PMC7413239, DOI: 10.2967/jnumed.119.237735.Peer-Reviewed Original ResearchConceptsTobacco smokingTobacco smokersTSPO levelsImmune systemPET studiesBrain immune systemBrain TSPO levelsPrimary immunocompetent cellsPrevious PET studiesTranslocator proteinTranslocator protein (TSPO) levelsInflammatory effectsImmunocompetent cellsArterial bloodTobacco smokePET scansNonsmokersSmokersRadiotracer concentrationMedium effect sizeSmokingPET imagingBrainProtein levelsSignificant differencesDifferential effects of nicotine delivery rate on subjective drug effects, urges to smoke, heart rate and blood pressure in tobacco smokers
Jensen KP, Valentine G, Gueorguieva R, Sofuoglu M. Differential effects of nicotine delivery rate on subjective drug effects, urges to smoke, heart rate and blood pressure in tobacco smokers. Psychopharmacology 2020, 237: 1359-1369. PMID: 31996940, PMCID: PMC7386792, DOI: 10.1007/s00213-020-05463-6.Peer-Reviewed Original ResearchConceptsSubjective drug effectsBlood pressureHeart rateDrug effectsSmoking urgesDifferential effectsBlood pressure increaseBody weight doseEffects of nicotineDelivery rateGreater heart rateAmount of nicotineWeight doseFemale smokersTobacco smokersAbstinence symptomsNicotine doseSaline infusionInfusion protocolNon-treatment seekingTobacco cigarettesHuman studiesInfusionTobacco productsNicotine
2019
Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers
Zakiniaeiz Y, Hillmer AT, Matuskey D, Nabulsi N, Ropchan J, Mazure CM, Picciotto MR, Huang Y, McKee SA, Morris ED, Cosgrove KP. Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers. Neuropsychopharmacology 2019, 44: 2205-2211. PMID: 31269510, PMCID: PMC6897943, DOI: 10.1038/s41386-019-0456-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDA releasePositron emission tomographyD2R availabilityDorsolateral prefrontal cortexMale smokersFemale smokersTobacco smokingPrefrontal cortexAmphetamine-induced DA releaseAmphetamine-induced dopamine releaseCortical DA releaseMesocortical DA systemEffects of nicotineSmoking-related behaviorsMesolimbic dopamine systemLong-term abstinenceSex differencesGender-specific treatmentFemale nonsmokersTobacco smokersAmphetamine administrationDopamine releaseNeurochemical mechanismsNonsmokersSmokers
2018
Tobacco and Substance Use among Psychiatric Inpatients in a Community Hospital: Cessation Counseling, Correlates, and Patterns of Use
Jegede O, Ojo O, Ahmed S, Kodjo K, Virk I, Rimawi D, Mellon C, Jolayemi A, Olupona T. Tobacco and Substance Use among Psychiatric Inpatients in a Community Hospital: Cessation Counseling, Correlates, and Patterns of Use. Journal Of Addiction 2018, 2018: 7919704. PMID: 30662786, PMCID: PMC6312619, DOI: 10.1155/2018/7919704.Peer-Reviewed Original ResearchCessation counselingTobacco smokingSubstance usePsychiatric diagnosisUnderserved African American populationEffective public health strategiesTobacco cessation counselingTobacco treatment strategiesPrimary psychiatric diagnosisCommunity teaching hospitalCurrent tobacco smokersPublic health strategiesInpatient psychiatric unitUrine toxicology reportsIllicit drug usePublic health concernOnly significant predictorCurrent smokersTobacco screeningRetrospective reviewSmoking groupUrine toxicologyTobacco smokersEntire cohortTobacco dependenceChildhood and adult exposure to secondhand tobacco smoke and cardiac structure and function: results from Echo-SOL
Peña M, Swett K, Kaplan RC, Perreira K, Daviglus M, Kansal MM, Cai J, Giachello AL, Gellman MD, Velazquez EJ, Rodriguez CJ. Childhood and adult exposure to secondhand tobacco smoke and cardiac structure and function: results from Echo-SOL. Open Heart 2018, 5: e000831. PMID: 30402256, PMCID: PMC6203071, DOI: 10.1136/openhrt-2018-000831.Peer-Reviewed Original ResearchLeft ventricular global longitudinal strainLeft ventricular ejection fractionIsovolumic relaxation timeSHS exposureCardiac structureTobacco smokersRight ventricular fractional area changeVentricular global longitudinal strainVentricular fractional area changeHousehold SHS exposureAtrial volume indexClinical heart failureSevere valvular diseaseVentricular ejection fractionCoronary artery diseaseGlobal longitudinal strainSecondhand smoke exposureFractional area changeHousehold secondhand smoke exposureAdolescents/adultsECHO-SOLArtery diseaseCardiac systolicDiastolic functionEchocardiographic measures
2017
Electronic cigarettes for adults with tobacco dependence enrolled in a tobacco treatment program: A pilot study
Baldassarri SR, Bernstein SL, Chupp GL, Slade MD, Fucito LM, Toll BA. Electronic cigarettes for adults with tobacco dependence enrolled in a tobacco treatment program: A pilot study. Addictive Behaviors 2017, 80: 1-5. PMID: 29304395, PMCID: PMC6463885, DOI: 10.1016/j.addbeh.2017.11.033.Peer-Reviewed Original ResearchConceptsTobacco treatment programTreatment-seeking smokersElectronic cigarettesWeek 24Tobacco treatmentTobacco smokersTreatment programTobacco treatment interventionsTobacco smokingPatch therapyTobacco dependenceEffective adjunctBehavioral counselingMean reductionSmokersSmoking outcomesTreatment settingsTreatment interventionsSmokingNicotine solutionPilot studyNicotineCigarettesSignificant differencesSubjectsEvaluation of (‐)‐[18F]Flubatine‐specific binding: Implications for reference region approaches
Bhatt S, Hillmer AT, Nabulsi N, Matuskey D, Lim K, Lin S, Esterlis I, Carson RE, Huang Y, Cosgrove KP. Evaluation of (‐)‐[18F]Flubatine‐specific binding: Implications for reference region approaches. Synapse 2017, 72 PMID: 29105121, PMCID: PMC6547815, DOI: 10.1002/syn.22016.Peer-Reviewed Original ResearchConceptsNicotinic acetylcholine receptorsPositron emission tomographyCorpus callosumAcetylcholine receptorsGreater receptor occupancyReference regionRegion-based quantificationMin bolusTobacco smokersFrontal cortexTobacco cigarettesReceptor occupancyConstant infusionDistribution volumeEmission tomographyCallosumSpecific bindingBrainReceptorsSmokersSmokingPutamenInfusionBolusCortexThe Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET Study
Sandiego CM, Matuskey D, Lavery M, McGovern E, Huang Y, Nabulsi N, Ropchan J, Picciotto MR, Morris ED, McKee SA, Cosgrove KP. The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET Study. Neuropsychopharmacology 2017, 43: 1052-1058. PMID: 28944773, PMCID: PMC5854798, DOI: 10.1038/npp.2017.223.Peer-Reviewed Original ResearchConceptsTobacco smokersGuanfacine treatmentPositron emission tomographyTobacco smokingDA releaseDopaminergic toneDopamine releaseAmphetamine-induced DA releaseTobacco smoking cessationCortical dopamine releaseExtrastriatal brain regionsAlpha2-adrenergic agonistExtrastriatal dopamine releaseEffect of treatmentBaseline BPNDSmoking cessationReceptor radiotracerAdrenergic agonistsPET scansAnimal modelsBrain regionsEmission tomographyPET studiesDopamine signalingSmokers
2016
Depression motivates quit attempts but predicts relapse: differential findings for gender from the International Tobacco Control Study
Cooper J, Borland R, McKee SA, Yong HH, Dugué PA. Depression motivates quit attempts but predicts relapse: differential findings for gender from the International Tobacco Control Study. Addiction 2016, 111: 1438-1447. PMID: 26888199, PMCID: PMC4940212, DOI: 10.1111/add.13290.Peer-Reviewed Original ResearchConceptsQuit attemptsCessation supportTobacco control studiesDepressive symptomsControl studyInternational Tobacco Control studyQuasi-experimental cohort studyMore quit attemptsMixed-effects logistic regressionLow positive affectNon-depressed counterpartsShort-term abstinenceProspective cohortCohort studyTobacco smokersDepression IndexCurrent depressionSmokersLogistic regressionFirst monthAbstinenceDepressionTelephone surveyDifferential findingsSymptoms
2015
Polymorphisms in genes in the androgen pathway and risk of Barrett's esophagus and esophageal adenocarcinoma
Ek WE, Lagergren K, Cook M, Wu AH, Abnet CC, Levine D, Chow W, Bernstein L, Risch HA, Shaheen NJ, Bird NC, Corley DA, Hardie LJ, Fitzgerald RC, Gammon MD, Romero Y, Liu G, Ye W, Vaughan TL, MacGregor S, Whiteman DC, Westberg L, Lagergren J. Polymorphisms in genes in the androgen pathway and risk of Barrett's esophagus and esophageal adenocarcinoma. International Journal Of Cancer 2015, 138: 1146-1152. PMID: 26414697, PMCID: PMC4715576, DOI: 10.1002/ijc.29863.Peer-Reviewed Original ResearchConceptsRisk of BEBarrett's esophagusEsophageal adenocarcinomaSingle nucleotide polymorphismsAndrogen pathwayRisk of EACStrong male predominanceBody mass indexMale predominanceTobacco smokingTobacco smokersBE patientsHip ratioEAC patientsSex hormonesReflux statusLarger sample sizeEsophagusInfluence riskGenetic epidemiological analysisPatientsControl participantsAdenocarcinomaRiskGenetic variants
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