2024
Optimized Enzyme-Linked Immunosorbent Assay for Anti-PEG Antibody Detection in Healthy Donors and Patients Treated with PEGylated Liposomal Doxorubicin
Li Y, Ettah U, Jacques S, Gaikwad H, Monte A, Dylla L, Guntupalli S, Moghimi S, Simberg D. Optimized Enzyme-Linked Immunosorbent Assay for Anti-PEG Antibody Detection in Healthy Donors and Patients Treated with PEGylated Liposomal Doxorubicin. Molecular Pharmaceutics 2024, 21: 3053-3060. PMID: 38743264, PMCID: PMC12109707, DOI: 10.1021/acs.molpharmaceut.4c00278.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayLiposomal doxorubicinHealthy donorsPatients treated with pegylated liposomal doxorubicinEnzyme-linked immunosorbent assay signalCancer patientsAnti-PEG IgGPegylated Liposomal DoxorubicinImmunosorbent assayOptimized ELISAEnzyme-linked immunosorbent assay protocolsAnti-PEG antibodiesChemotherapy cyclesBetween-assay variabilityPEGylated liposomesCutoff valueAccelerated clearanceTreatment cyclesDrug delivery systemsAntibody titersComplement activationInfused drugAnti-PEGOptimized assayPatients
2023
Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2′,5,5′-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats
Wang H, Bullert A, Li X, Stevens H, Klingelhutz A, Ankrum J, Adamcakova-Dodd A, Thorne P, Lehmler H. Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2′,5,5′-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats. Toxicology 2023, 500: 153677. PMID: 37995827, PMCID: PMC10757425, DOI: 10.1016/j.tox.2023.153677.Peer-Reviewed Original ResearchConceptsPersistent organic pollutantsPolychlorinated biphenylsPolymeric implantsDrug delivery systemsPCB 52Tandem mass spectrometryOrganic pollutantsMass spectrometryGas chromatographySustained releaseDelivery systemHuman metabolitesHole-board testAdolescent Sprague DawleyMale adolescent ratsAnxiety-like behaviorOpen field testLoading concentrationStraightforward methodHydroxylated metabolitesSubacute neurotoxicitySubacute exposureImmune inhibitionNeurotoxic outcomesSprague-Dawley
2022
A three-layered hydrogel patch with hierarchy releasing of PLGA nanoparticle drugs decrease neointimal hyperplasia
Wei S, Li J, He H, Shu C, Dardik A, Bai H. A three-layered hydrogel patch with hierarchy releasing of PLGA nanoparticle drugs decrease neointimal hyperplasia. Smart Materials In Medicine 2022, 3: 139-147. DOI: 10.1016/j.smaim.2021.12.005.Peer-Reviewed Original Research
2021
A Deep Dive: SIWV Tetra-Peptide Enhancing the Penetration of Nanotherapeutics into the Glioblastoma
Kang R, Park J, Kim J, Chowdhury T, Oh J, Kim J, Shin J, Kim M, Park C, Lee S, Lee J, Kim D. A Deep Dive: SIWV Tetra-Peptide Enhancing the Penetration of Nanotherapeutics into the Glioblastoma. ACS Biomaterials Science & Engineering 2021, 8: 4163-4174. PMID: 34196517, DOI: 10.1021/acsbiomaterials.1c00653.Peer-Reviewed Original ResearchConceptsDrug delivery systemsNanoparticle-based drug delivery systemsPolyethylene glycolHigher anticancer efficacyPorous silicon nanoparticlesDevelopment of nanotherapeuticsGlioblastoma multiformeSilicon nanoparticlesTetra peptideIRGD peptideTargeting abilityDelivery systemAnticancer efficacyNanoparticlesTherapeutic formulationsGreat promiseAggressive malignant tumorSite targetingNanotherapeuticsCell spheroidsPenetration abilityStructure specificityMalignant tumorsPenetration depthXenograft mice
2020
Antibacterial activity and synergism of the essential oil of Nectandra megapotamica (L.) flowers against OXA-23-producing Acinetobacter baumannii
Vasconcelos N, Mallmann V, Costa É, Simionatto E, Coutinho E, Da Silva R, Ribeiro S, Franco O, Migliolo L, Croda J, Simionatto S. Antibacterial activity and synergism of the essential oil of Nectandra megapotamica (L.) flowers against OXA-23-producing Acinetobacter baumannii. Journal Of Essential Oil Research 2020, 32: 260-268. DOI: 10.1080/10412905.2020.1740802.Peer-Reviewed Original ResearchGas chromatography/mass spectrometry analysisChromatography/mass spectrometry analysisGas chromatography/flame ionization detectorNatural plant essential oilsDrug delivery systemsAntibacterial activityEssential oilMass spectrometry analysisFlame ionization detectorSpectrometry analysisChemical compositionDelivery systemAntimicrobial activityIonization detectorBiological propertiesSynergistic effectOxygenated sesquiterpenesCaryophyllene oxideNew drug developmentOilPlant essential oilsDrug developmentExcipientsOxideiDDS: An Edge-Device in IoMT for Automatic Seizure Control using On-Time Drug Delivery
Abu Sayeed, Mohanty S, Kougianos E, Zaveri H. iDDS: An Edge-Device in IoMT for Automatic Seizure Control using On-Time Drug Delivery. 2020, 00: 1-6. DOI: 10.1109/icce46568.2020.9043143.Peer-Reviewed Original ResearchDeep neural network classifierNeural network classifierStatistical feature extractionUnique piezoelectricSeizure detectionImplantable solutionsEdge devicesMedical ThingsAutomatic seizure detectionDrug delivery systemsNetwork classifierFeature extractionAverage latencyPiezoelectricReal timeDetection unitDrug delivery unitsGood drug controlDrug deliveryDelivery systemSimulinkMicropumpIoMTThinkspeakInternetChapter 9 Cell-nanoparticle interactions
Aieneravaie M, Ho J, Arabi L, Kim A, Liang S, Jones S, Javdani N, Georgala P, Sepand M, Rafat M, Zanganeh S. Chapter 9 Cell-nanoparticle interactions. 2020, 125-142. DOI: 10.1016/b978-0-12-817434-0.00009-x.Peer-Reviewed Original Research
2019
An IoT-based Drug Delivery System for Refractory Epilepsy
Abu Sayeed, Mohanty S, Kougianos E, Zaveri H. An IoT-based Drug Delivery System for Refractory Epilepsy. 2019, 00: 1-4. DOI: 10.1109/icce.2019.8661979.Peer-Reviewed Original Research
2018
Peptides derived from the histidine–proline rich glycoprotein bind copper ions and exhibit anti-angiogenic properties
Magrì A, Grasso G, Corti F, Finetti F, Greco V, Santoro AM, Sciuto S, La Mendola D, Morbidelli L, Rizzarelli E. Peptides derived from the histidine–proline rich glycoprotein bind copper ions and exhibit anti-angiogenic properties. Dalton Transactions 2018, 47: 9492-9503. PMID: 29963662, DOI: 10.1039/c8dt01560k.Peer-Reviewed Original ResearchConceptsElectron paramagnetic resonanceCircular dichroismSpray ionization mass spectrometryPotential drug delivery systemElectron spray ionization mass spectrometryMeans of potentiometryIonization mass spectrometryDrug delivery systemsAmidic bondCopper ionsRole of copperParamagnetic resonanceMass spectrometryComplex speciesTrehalose derivativesProdrug systemEnzymatic degradationDelivery systemCopperPeptidesPotentiometryBondsUVSpectrometryDichroismTowards an arthritis flare-responsive drug delivery system
Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter K, Sherman N, Amirault J, Wang Y, Riegel L, He X, Rui T, Valic M, Vemula P, Miranda O, Levy O, Gravallese E, Aliprantis A, Ermann J, Karp J. Towards an arthritis flare-responsive drug delivery system. Nature Communications 2018, 9: 1275. PMID: 29615615, PMCID: PMC5882944, DOI: 10.1038/s41467-018-03691-1.Peer-Reviewed Original ResearchConceptsTriamcinolone acetonideInflammatory arthritisArthritis activityFree triamcinolone acetonideIA therapyArthritic miceRheumatoid arthritisArthritis flaresLocal drug delivery methodSingle doseDrug delivery methodsSynovial fluidDrug delivery approachEquivalent doseLocal deliveryArthritisDoseDelivery approachDrug delivery systemsTreatmentDelivery methodsDelivery systemPatientsTherapyIA severity
2017
Science to Practice: Molecular-targeted Drug Delivery in Combination with Radiofrequency Ablation of Liver Cancer: A Magic Bullet?
Adam LC, Murali N, Chapiro J, Geschwind JF. Science to Practice: Molecular-targeted Drug Delivery in Combination with Radiofrequency Ablation of Liver Cancer: A Magic Bullet? Radiology 2017, 285: 333-335. PMID: 29045226, PMCID: PMC5673055, DOI: 10.1148/radiol.2017171527.Peer-Reviewed Original ResearchConceptsRadiofrequency ablationRF ablationHepatocellular carcinoma mouse modelTechnical success rateSurvival end pointsChemotherapeutic drug concentrationsCarcinoma mouse modelAnimal tumor modelsTumor-penetrating peptideClinical outcomesTarget lesionsDrug delivery systemsLiver cancerMouse modelTumor modelEnd pointDrug concentrationsDrug deliverySuccess rateTumor treatmentToxic effectsDelivery systemAblationMagic bulletLesions
2014
Intrathecal drug delivery for chronic pain management-scope, limitations and future
Czernicki M, Sinovich G, Mihaylov I, Nejad B, Kunnumpurath S, Kodumudi G, Vadivelu N. Intrathecal drug delivery for chronic pain management-scope, limitations and future. Journal Of Clinical Monitoring And Computing 2014, 29: 241-249. PMID: 25173564, DOI: 10.1007/s10877-014-9607-1.Peer-Reviewed Original ResearchConceptsIntrathecal drug delivery systemsChronic painOptimal medical managementIntrathecal drug deliveryDifferent implantation techniquesLicensing of drugsSevere morbidityMedical managementMuscle spasmMain indicationsIntrathecal useInvasive techniquesOutcome studiesPainAdverse effectsHealthcare practitionersImplantation techniqueTherapyDrug delivery systemsTherapy systemReview articleDelivery systemDate knowledgeMorbiditySpasm
2013
Polymeric microparticles-based formulation for the eradication of cutaneous candidiasis: development and characterization
Kumar L, Verma S, Jamwal S, Vaidya S, Vaidya B. Polymeric microparticles-based formulation for the eradication of cutaneous candidiasis: development and characterization. Pharmaceutical Development And Technology 2013, 19: 318-325. PMID: 23560821, DOI: 10.3109/10837450.2013.778874.Peer-Reviewed Original ResearchConceptsCutaneous candidiasisVivo antifungal activity studiesFungal infectionsInvasive fungal infectionsMicrosphere gelSkin retention studyBetter therapeutic activitySystemic absorptionTopical applicationDrug accumulationGuinea pigsNovel drug delivery systemsTopical fungal infectionsTherapeutic activityCandidiasisAdverse effectsDermal penetrationInfectionSkinDermal deliveryConfocal microscopyDrug delivery systemsCarbopol 934Entrapment of drugDermal region
2012
Synthesis and evaluation of 11β-(4-Substituted phenyl) estradiol analogs: Transition from estrogen receptor agonists to antagonists
Hanson RN, Hua E, Hendricks JA, Labaree D, Hochberg RB. Synthesis and evaluation of 11β-(4-Substituted phenyl) estradiol analogs: Transition from estrogen receptor agonists to antagonists. Bioorganic & Medicinal Chemistry 2012, 20: 3768-3780. PMID: 22608920, PMCID: PMC3581310, DOI: 10.1016/j.bmc.2012.04.041.Peer-Reviewed Original ResearchConceptsSynthetic strategyNew compoundsERα-LBDPotential drug delivery systemPrevious synthetic studiesSeries of compoundsDrug delivery systemsClass of compoundsSynthetic methodTerminal groupsFacile accessSynthetic studiesDrug conjugationSpecific structural featuresCompetitive ligandCompoundsSteroidal agonistsDelivery systemRepresentative scaffoldsStructural featuresERβ-LBDSubtype selectivityActive groupAnaloguesScaffolds
2005
Use of an implantable drug delivery system for refractory chronic sickle cell pain
Smith TJ, Coyne PJ, Smith WR, Roberts JD, Smith V. Use of an implantable drug delivery system for refractory chronic sickle cell pain. American Journal Of Hematology 2005, 78: 153-154. PMID: 15682408, DOI: 10.1002/ajh.20252.Peer-Reviewed Original ResearchConceptsImplantable intrathecal drug delivery systemsSickle cell patientsCell patientsChronic sickle cell painIntrathecal drug delivery systemsRefractory bone painRefractory cancer painSustained-release opioidsSickle cell painRandomized clinical trialsComprehensive medical managementBone painCancer painRefractory painProspective trialSustained reliefMedical managementCancer patientsDrug delivery systemsClinical trialsPainClinical successPatientsDelivery systemImplantable drug delivery systems
1982
Implantable Insulin Infusion Devices
Blackshear P, Nathan D, Cohen A, Hurxthal K, Shulman G. Implantable Insulin Infusion Devices. JAMA 1982, 248: 2111-2111. PMID: 7120635, DOI: 10.1001/jama.1982.03330170019006.Peer-Reviewed Original ResearchConceptsInsulin infusion devicesInfusion devicesSimilar glycemic controlIntensive conventional therapyImplantation of devicesGlycemic controlSubstantial morbidityConventional therapyInsulin delivery systemsAnimal studiesClinical useDelivery systemLong-term studiesImplantable drug delivery systemsResearch protocolDrug delivery systemsExtreme cautionImplantationMorbidityTherapyMortality
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