2022
Aromatase-Inhibitor-Induced Musculoskeletal Inflammation Is Observed Independent of Oophorectomy in a Novel Mouse Model
Young N, Hampton J, Sharma J, Jablonski K, DeVries C, Bratasz A, Wu L, Lustberg M, Reinbolt R, Jarjour W. Aromatase-Inhibitor-Induced Musculoskeletal Inflammation Is Observed Independent of Oophorectomy in a Novel Mouse Model. Pharmaceuticals 2022, 15: 1578. PMID: 36559029, PMCID: PMC9785754, DOI: 10.3390/ph15121578.Peer-Reviewed Original ResearchAI treatmentFemale BALB/cHalf of patientsPositive breast cancerPro-inflammatory cytokines analysisFuture interventional strategiesNovel mouse modelBALB/cPhysiological estrogen levelsNovel animal modelMusculoskeletal inflammationSerum cytokinesEstrogen deficiencyCytokine analysisEstrogen combinationEstrogen levelsEstrogen productionAromatase inhibitorsBreast cancerHuman PBMCsInterventional strategiesMouse modelAnimal modelsNFκB activationBioluminescent imaging
2020
Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology
Wisnewski AV, Liu J, Redlich CA. Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology. American Journal Of Respiratory Cell And Molecular Biology 2020, 0: 25-35. PMID: 32101465, PMCID: PMC7328250, DOI: 10.1165/rcmb.2019-0400oc.Peer-Reviewed Original ResearchConceptsRespiratory tract exposureAirway eosinophiliaMonocytes/macrophagesMouse modelGene expressionGene transcriptsBiological pathwaysAsthma pathologyUpregulated gene transcriptsIgE-independent mechanismsLung gene expressionLung tissue gene expressionCause of asthmaBALB/cTransgenic B cellsTissue gene expressionExpression changesDiisocyanate asthmaSensitized workersAsthma pathogenesisAirway fluidDeficient miceMRNA microarrayEosinophiliaB cells
2018
The Anticancer Effects of Garlic Extracts on Bladder Cancer Compared to Cisplatin: A Common Mechanism of Action via Centromere Protein M
Kim W, Seo S, Byun Y, Kang H, Kim Y, Lee S, Jeong P, Song H, Choe S, Kim D, Kim S, Ha Y, Moon S, Lee G, Kim I, Yun S, Kim W. The Anticancer Effects of Garlic Extracts on Bladder Cancer Compared to Cisplatin: A Common Mechanism of Action via Centromere Protein M. The American Journal Of Chinese Medicine 2018, 46: 689-705. PMID: 29595070, DOI: 10.1142/s0192415x18500362.Peer-Reviewed Original ResearchConceptsCentromere protein MBladder cancerBC patientsGarlic extractBetter progression-free survivalNude mouse xenograft modelProgression-free survivalCisplatin-treated miceBALB/cTissue microarray analysisNegative control miceMouse xenograft modelBC cell linesEffect of garlicMicroarray analysisCisplatin groupControl miceTumor weightControl tumorsTumor volumeNormal controlsXenograft modelSide effectsBody weightTumor tissue
2017
Garlic extract in bladder cancer prevention: Evidence from T24 bladder cancer cell xenograft model, tissue microarray, and gene network analysis
Kim W, Seo S, Byun Y, Kang H, Kim Y, Lee S, Jeong P, Seo Y, Choe S, Kim D, Kim S, Moon S, Choi Y, Lee G, Kim I, Yun S, Kim W. Garlic extract in bladder cancer prevention: Evidence from T24 bladder cancer cell xenograft model, tissue microarray, and gene network analysis. International Journal Of Oncology 2017, 51: 204-212. PMID: 28498422, DOI: 10.3892/ijo.2017.3993.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBiomarkers, TumorCell ProliferationGarlicGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMaleMiceMice, Inbred BALB CMice, NudePlant ExtractsSignal TransductionTissue Array AnalysisTumor Cells, CulturedUrinary Bladder NeoplasmsXenograft Model Antitumor AssaysConceptsCancer preventionBladder cancerGarlic extractXenograft modelNude mouse xenograft modelAcceptable safety profileBladder cancer preventionCancer prevention activitiesCell xenograft modelBALB/cTissue microarray analysisMouse xenograft modelMicroarray analysisTumor weightBC patientsSafety profileTumor volumeTissue microarrayControl groupGene network analysisControl dietPrevention activitiesPreventionExtract intakePotential mechanisms
2015
Correction: Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells
Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA. Correction: Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature 2015, 530: 504-504. PMID: 26605525, DOI: 10.1038/nature16074.Peer-Reviewed Original ResearchModulation of aggressive behavior in mice by nicotinic receptor subtypes
Lewis AS, Mineur YS, Smith PH, Cahuzac EL, Picciotto MR. Modulation of aggressive behavior in mice by nicotinic receptor subtypes. Biochemical Pharmacology 2015, 97: 488-497. PMID: 26212554, PMCID: PMC4600457, DOI: 10.1016/j.bcp.2015.07.019.Peer-Reviewed Original ResearchConceptsAcute nicotine administrationNicotine administrationHypolocomotor effectNicotinic acetylcholine receptor agonist nicotineAgonist GTS-21Nicotinic receptor subtypesAnti-aggressive propertiesDihydro-β-erythroidineBALB/cNeurobiology of aggressionSocial interaction timeCurrent pharmacotherapyAntagonist methyllycaconitineC57BL/6 miceWorse outcomesGTS-21Receptor subtypesPathological aggressionAgonist nicotineΑ7 nAChRsSpecific treatmentSide effectsPharmacological studiesNeuropsychiatric conditionsNicotine
2011
Differential long term effects of early diisopropylfluorophosphate exposure in Balb/C and C57Bl/J6 mice
Lin T, Duek O, Dori A, Kofman O. Differential long term effects of early diisopropylfluorophosphate exposure in Balb/C and C57Bl/J6 mice. International Journal Of Developmental Neuroscience 2011, 30: 113-120. PMID: 22197972, DOI: 10.1016/j.ijdevneu.2011.12.004.Peer-Reviewed Original ResearchConceptsLong-term effectsSwim testIrreversible acetylcholinesterase inhibitor diisopropylfluorophosphateBALB/c miceBALB/c strainPostnatal day 14BALB/cDifferential long-term effectsSub-toxic dosePostnatal administrationC miceMore immobilityDay 14Anxiety behaviorDFP pretreatmentC57BL/6J strainSweet preferenceConsecutive daysMouse strainsC strainMiceAge 3Term effectsFirst sessionSecond session
2010
Murine visceral leishmaniasis: IgM and polyclonal B‐cell activation lead to disease exacerbation
Deak E, Jayakumar A, Cho KW, Goldsmith‐Pestana K, Dondji B, Lambris JD, McMahon‐Pratt D. Murine visceral leishmaniasis: IgM and polyclonal B‐cell activation lead to disease exacerbation. European Journal Of Immunology 2010, 40: 1355-1368. PMID: 20213734, PMCID: PMC2944234, DOI: 10.1002/eji.200939455.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, ProtozoanAntigen PresentationB-LymphocytesComplement C5aDisease ProgressionFemaleHypergammaglobulinemiaImmunity, InnateImmunization, PassiveImmunoglobulin GImmunoglobulin MInterleukin-10Leishmania infantumLeishmaniasis, VisceralLymph NodesLymphocyte ActivationLymphocyte DepletionMaleMiceMice, Inbred BALB CMice, TransgenicParasitemiaConceptsBALB/c miceC miceDisease exacerbationImmune responseVisceral leishmaniasisB cell-derived IL-10WT BALB/c miceB cell antigen presentationPolyclonal B cell activationAnti-Leishmania responseOngoing immune responseL. infantum infectionHuman visceral leishmaniasisBALB/cB cell expansionIntradermal infection modelB cell activationEstablishment of infectionElevated parasitemiaParasite visceralizationCytokine levelsIL-10Infantum infectionPassive transferAntigen presentation
2009
Immunization with host-type CD8α+ dendritic cells reduces experimental acute GVHD in an IL-10–dependent manner
Toubai T, Malter C, Tawara I, Liu C, Nieves E, Lowler K, Sun Y, Reddy P. Immunization with host-type CD8α+ dendritic cells reduces experimental acute GVHD in an IL-10–dependent manner. Blood 2009, 115: 724-735. PMID: 19965670, PMCID: PMC2810989, DOI: 10.1182/blood-2009-06-229708.Peer-Reviewed Original ResearchConceptsT cell responsesDendritic cellsT cellsImmune responseUndesirable immune responsesIL-10Major histocompatibilityDonor T-cell responsesIL-10-dependent mannerExperimental acute GVHDImmunization of donorsDonor T cellsAntigen-specific mannerB6 modelBALB/c T cellsCertain immune responsesBALB/cAcute GVHDHost diseaseInterleukin-10Active immunizationInflammatory cytokinesVaccination strategiesAntigen specificityGVHDComparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/γc−/−, Balb/c-Rag1−/−γc−/−, and C.B-17-scid/bg immunodeficient mice
Lepus CM, Gibson TF, Gerber SA, Kawikova I, Szczepanik M, Hossain J, Ablamunits V, Kirkiles-Smith N, Herold KC, Donis RO, Bothwell AL, Pober JS, Harding MJ. Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/γc−/−, Balb/c-Rag1−/−γc−/−, and C.B-17-scid/bg immunodeficient mice. Human Immunology 2009, 70: 790-802. PMID: 19524633, PMCID: PMC2949440, DOI: 10.1016/j.humimm.2009.06.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFetal BloodGranulocyte Colony-Stimulating FactorHematopoietic Stem Cell MobilizationHematopoietic Stem Cell TransplantationHematopoietic Stem CellsHemocyaninsHumansHypersensitivity, DelayedImmunoglobulinsInfluenza A Virus, H5N1 SubtypeLiverLymph NodesLymphocyte SubsetsMiceMice, Inbred BALB CMice, Inbred NODMice, KnockoutMice, SCIDRadiation DosageSpleenThymus GlandWhole-Body IrradiationConceptsNOD-scid/Umbilical cord bloodBALB/cHuman fetal liverCord bloodUCB-HSCImmunodeficient miceSecond trimester human fetal liverHematopoietic stem cell preparationsFetal liverTotal human immunoglobulinWhite pulp expansionHumanized mouse modelHematopoietic stem cell engraftmentHuman immune responseHuman immune cellsStem cell engraftmentHuman immune systemHuman T cellsStem cell preparationsDendritic cellsAntigenic challengeDependent antigenPeripheral bloodImmune cells
2008
Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease
Tawara I, Maeda Y, Sun Y, Lowler K, Liu C, Toubai T, McKenzie A, Reddy P. Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease. Experimental Hematology 2008, 36: 988-996. PMID: 18410989, PMCID: PMC2603625, DOI: 10.1016/j.exphem.2008.02.010.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsBone Marrow TransplantationCD4-Positive T-LymphocytesCell ProliferationDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryGraft vs Host DiseaseImmunologic TestsInterleukin-2 Receptor alpha SubunitInterleukinsMajor Histocompatibility ComplexMiceMice, Inbred BALB CMice, Inbred C57BLSurvival RateT-LymphocytesTh2 CellsTransplantation, HomologousConceptsDonor T cellsT cellsWT T cellsTh2 cytokinesAcute graftAllogeneic bone marrow transplantationAllogeneic antigen-presenting cellsT cell proliferative responsesAnti-CD3 monoclonal antibodyEnhanced T cell proliferationExperimental acute graftNumber of immunoregulatoryTarget organ damageTh2 cytokine secretionBone marrow transplantationT helper 1Antigen-presenting cellsWild-type T cellsT cell proliferationGreater clinical severityBALB/cB6 recipientsGVHD mortalityHost diseaseIL-17Voluntary oral nicotine intake in mice down-regulates GluR2 but does not modulate depression-like behaviors
Vieyra-Reyes P, Picciotto MR, Mineur YS. Voluntary oral nicotine intake in mice down-regulates GluR2 but does not modulate depression-like behaviors. Neuroscience Letters 2008, 434: 18-22. PMID: 18261852, PMCID: PMC2757003, DOI: 10.1016/j.neulet.2008.01.021.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsAnxiety DisordersBehavior, AnimalBrainCyclic AMP Response Element-Binding ProteinDepressive DisorderDown-RegulationGlutamic AcidMaleMiceMice, Inbred BALB CMice, Inbred C57BLMotor ActivityNeural PathwaysNicotineNicotinic AgonistsNucleus AccumbensReceptors, AMPARewardSynaptic TransmissionTobacco Use DisorderVentral Tegmental AreaVolitionConceptsCAMP response element-binding proteinDepression-like behaviorVentral tegmental areaNucleus accumbensMesolimbic systemNicotine preferenceChronic nicotine exposureDepression-related behaviorsNon-treated animalsBALB/cOral nicotine intakeCentral nervous systemResponse element-binding proteinNicotine exposureNicotine rewardMesolimbic dopamine projectionsTegmental areaNicotine intakeGlutamate receptorsDopamine projectionsElement-binding proteinNervous systemLocomotor activityMice C57BL/6JGluR1 levels
2006
Adenosine metabolism and murine strain–specific IL-4–induced inflammation, emphysema, and fibrosis
Ma B, Blackburn MR, Lee CG, Homer RJ, Liu W, Flavell RA, Boyden L, Lifton RP, Sun CX, Young HW, Elias JA. Adenosine metabolism and murine strain–specific IL-4–induced inflammation, emphysema, and fibrosis. Journal Of Clinical Investigation 2006, 116: 1274-1283. PMID: 16670768, PMCID: PMC1451205, DOI: 10.1172/jci26372.Peer-Reviewed Original ResearchConceptsIL-4C57BL/6 miceBALB/cAirway fibrosisEosinophilic inflammationAdenosine metabolismEmphysematous alveolar destructionTissue adenosine levelsAdenosine receptor expressionIL-4 inducesAdenosine deaminase activityAlveolar destructionTh1 cytokinesC57BL/6 animalsEmphysematous destructionAdenosine levelsReceptor expressionTg animalsMurine lungMetalloproteinase-2Alveolar remodelingTissue inhibitorFibrosisInflammationPremature death
2005
Correlation of tumor phenotype with c-fms proto-oncogene expression in an in vivo intraperitoneal model for experimental human breast cancer metastasis
Toy EP, Bonafé N, Savlu A, Zeiss C, Zheng W, Flick M, Chambers SK. Correlation of tumor phenotype with c-fms proto-oncogene expression in an in vivo intraperitoneal model for experimental human breast cancer metastasis. Clinical & Experimental Metastasis 2005, 22: 1-9. PMID: 16132573, DOI: 10.1007/s10585-005-0718-4.Peer-Reviewed Original ResearchConceptsBALB/cProto-oncogene expressionC-fms proto-oncogene expressionExpression groupAthymic BALB/cHuman breast cancer metastasisIntraperitoneal modelBreast cancer metastasisHuman breast carcinoma cellsBreast carcinoma cellsClinical outcomesClinical evidenceTumor sizeC-fmsIntrasplenic injectionPrimary tumorMetastatic spreadOral administrationRU 486SCID miceBreast carcinomaSCID animalsImmunodeficient miceIHC stainingNovel treatments
2004
Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice.
Compton SR, Ball-Goodrich LJ, Johnson LK, Johnson EA, Paturzo FX, Macy JD. Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice. Journal Of The American Association For Laboratory Animal Science 2004, 54: 681-9. PMID: 15679267.Peer-Reviewed Original ResearchConceptsT cell-deficient miceCell-deficient miceMouse hepatitis virusBALB/cGastrointestinal tractC57BL/6 miceLymphoid tissueViral RNASubclinical infectionHepatitis virusInfected B-cell-deficient miceSmall intestineEnterotropic mouse hepatitis virusB cell-deficient miceImmunocompetent BALB/cMost natural infectionsChronic subclinical infectionMultiple organ systemsTranscriptase-polymerase chain reaction analysisImmunocompetent miceLethal infectionEnterotropic strainsT cellsImmunodeficient miceIntestinal mucosaTarget Antigens Determine Graft-versus-Host Disease Phenotype
Kaplan DH, Anderson BE, McNiff JM, Jain D, Shlomchik MJ, Shlomchik WD. Target Antigens Determine Graft-versus-Host Disease Phenotype. The Journal Of Immunology 2004, 173: 5467-5475. PMID: 15494494, DOI: 10.4049/jimmunol.173.9.5467.Peer-Reviewed Original ResearchConceptsHost diseaseSkin diseasesBALB/c recipientsAllogeneic stem cell transplantationBALB/c miceSubset of patientsStem cell transplantationT cell repertoireKey pathologic featuresBALB/cX BALB/Host disease phenotypesCutaneous cGVHDMurine donorsSystemic GVHDC recipientsFrequent complicationCutaneous fibrosisPathologic featuresSystemic diseaseB miceCell transplantationC miceK miceImmunodominant Ag
1994
Enterotropic Strains of Mouse Coronavirus Differ in Their Use of Murine Carcinoembryonic Antigen-Related Glycoprotein Receptors
Compton S. Enterotropic Strains of Mouse Coronavirus Differ in Their Use of Murine Carcinoembryonic Antigen-Related Glycoprotein Receptors. Virology 1994, 203: 197-201. PMID: 8030279, PMCID: PMC7131022, DOI: 10.1006/viro.1994.1475.Peer-Reviewed Original ResearchConceptsSJL miceLimited tissue tropismMHV-RIEnterotropic mouse hepatitis virusBALB/c miceTissue tropismMonoclonal antibody CC1BALB/cMouse hepatitis virusRole of receptorsMurine carcinoembryonic antigenC miceEnterotropic strainsHepatitis virusCarcinoembryonic antigenBHK cellsInfectionMiceDifferent receptorsReceptorsCell linesGlycoprotein receptorsMurine tissuesMouse coronavirusMHVDevelopment of a Mouse Model for Nonbacterial Prostatitis
Keetch D, Humphrey P, Ratliff T. Development of a Mouse Model for Nonbacterial Prostatitis. Journal Of Urology 1994, 152: 247-250. PMID: 8201676, DOI: 10.1016/s0022-5347(17)32871-9.Peer-Reviewed Original ResearchConceptsNonbacterial prostatitisProstatic inflammationC57BL/6-lpr miceLpr miceBALB/c miceAdoptive transfer studiesCommon clinical entityDegree of inflammationBALB/cPeriglandular regionsAutoimmune processAJ miceLymphocytic infiltrationC57BL/6 miceClinical entityProstate antigenC miceImmune parametersSyngeneic miceProstatitisMouse modelProstatic tissueDisease processAnimal modelsInflammation
1991
Pathogenesis of infection with a virulent allotropic variant of minute virus of mice and regulation by host genotype.
Brownstein D, Smith A, Jacoby R, Johnson E, Hansen G, Tattersall P. Pathogenesis of infection with a virulent allotropic variant of minute virus of mice and regulation by host genotype. Laboratory Investigation 1991, 65: 357-64. PMID: 1653878.Peer-Reviewed Original ResearchConceptsViral capsid antigenH miceInfectious virus titersB6 miceMVMi infectionCapsid antigenLethal infectionVirus titersPathogenesis of infectionBALB/cStrains of miceMinute virusAccelerated involutionSitu hybridizationC57BL/6 miceAsymptomatic infectionIntestinal hemorrhageNeonatal micePapillary hemorrhageDBA/2 miceC3H miceTarget organsVirus titrationVirus replicationGenetic susceptibility
1990
Adoptive transfer of CD8+ T cells from immune animals does not transfer immunity to blood stage Plasmodium yoelii malaria.
Vinetz J, Kumar S, Good M, Fowlkes B, Berzofsky J, Miller L. Adoptive transfer of CD8+ T cells from immune animals does not transfer immunity to blood stage Plasmodium yoelii malaria. The Journal Of Immunology 1990, 144: 1069-74. PMID: 1967271, DOI: 10.4049/jimmunol.144.3.1069.Peer-Reviewed Original ResearchConceptsBlood-stage infectionT cellsSpleen cellsBALB/c miceBALB/c nu/nuMouse strainsClass I MHC AgMechanisms of CD8Vivo CD8 depletionAbsence of CD4Depletion of CD8P. yoelii infectionPopulation of CD4T-cell involvementAdoptive transfer experimentsPlasmodium yoelii 17XPlasmodium yoelii malariaUnfractionated spleen cellsBALB/cImmune CD4Immune CD8Vivo CD4CD8 depletionAdoptive transferImmune animals
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