2023
Epidemiology of anticoagulation for children supported by extracorporeal membrane oxygenation in the United States: A Pediatric Hospital Information System database study
Nellis M, An A, Mahmood H, Prishtina F, Hena Z, Karam O. Epidemiology of anticoagulation for children supported by extracorporeal membrane oxygenation in the United States: A Pediatric Hospital Information System database study. Perfusion 2023, 39: 536-542. PMID: 36606508, DOI: 10.1177/02676591221151027.Peer-Reviewed Original ResearchDirect thrombin inhibitorMembrane oxygenationPediatric Health Information System databaseThrombin inhibitorsHealth Information System databaseDifferent anticoagulant regimensRetrospective cohort studyUse of anticoagulationUse of bivalirudinPercent of encountersOccurrence of thrombosisRisk of thrombosisLarge administrative databaseMajority of childrenEligible encountersCardiac indicationsHeparin anticoagulationAnticoagulation regimensCohort studyMedian ageSystemic anticoagulationAnticoagulant regimensProspective studyPatient populationAdministrative databases
2021
Creation of a standardized pediatric emergency medicine simulation curriculum for emergency medicine residents
Burns R, Madhok M, Bank I, Nguyen M, Falk M, Waseem M, Auerbach M. Creation of a standardized pediatric emergency medicine simulation curriculum for emergency medicine residents. AEM Education And Training 2021, 5: e10685. PMID: 34632245, PMCID: PMC8489268, DOI: 10.1002/aet2.10685.Peer-Reviewed Original ResearchIll pediatric patientsPediatric patientsEM residentsMajority of facilitatorsMajority of childrenEmergency departmentCare knowledgeEmergency medicine residentsResidency program graduatesResuscitation skillsMost facilitatorsMedicine residentsEmergency medicineSimulation-based curriculumEmergent assessmentMost participantsElectronic surveyPatientsEM traineesChildrenDelphi studyParticipantsSimulation curriculumFacilitatorsResidentsSociodemographic and hospital‐based predictors of intense end‐of‐life care among children, adolescents, and young adults with hematologic malignancies
Mun S, Wang R, Ma X, Ananth P. Sociodemographic and hospital‐based predictors of intense end‐of‐life care among children, adolescents, and young adults with hematologic malignancies. Cancer 2021, 127: 3817-3824. PMID: 34185881, PMCID: PMC8478813, DOI: 10.1002/cncr.33764.Peer-Reviewed Original ResearchConceptsHematologic malignanciesYoung adultsLife careMultivariable logistic regression modelCancer-directed treatmentPremier Healthcare DatabaseRetrospective cohort studyEmergency department visitsIntensive care unitHigh-intensity endDays of lifeMajority of childrenLogistic regression modelsIntravenous chemotherapyTracheostomy placementCohort studyDepartment visitsCare unitMechanical ventilationHospital characteristicsMultivariable modelCardiopulmonary resuscitationType of insuranceHealthcare databasesMalignancy
2019
Treatment-seeking behavior and practices among caregivers of children aged ≤5 y with presumed malaria in rural Uganda
Lee YJ, Adusumilli G, Kazungu R, Anywar G, Kyakulaga F, Katuura E, Parikh S, Willcox M. Treatment-seeking behavior and practices among caregivers of children aged ≤5 y with presumed malaria in rural Uganda. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2019, 113: 525-533. PMID: 31140566, DOI: 10.1093/trstmh/trz039.Peer-Reviewed Original ResearchArtemether-lumefantrineFormal health facilitiesDrug shopsHealth facilitiesHerbal medicineTreatment-seeking patternsCaregivers of childrenFormal health centersHerbal medicine usageQuality of careSelf-reported outcomesTreatment-seeking behaviorMajority of childrenModern medical careInappropriate antibioticsHealth centersIllness historyMedicine usageCorrect diagnosisEndemic areasCorrect doseMedical careDiagnostic testsPatientsMalaria
2018
Emergency Care for Children in the United States: Epidemiology and Trends Over Time
Whitfill T, Auerbach M, Scherzer DJ, Shi J, Xiang H, Stanley RM. Emergency Care for Children in the United States: Epidemiology and Trends Over Time. Journal Of Emergency Medicine 2018, 55: 423-434. PMID: 29793812, DOI: 10.1016/j.jemermed.2018.04.019.Peer-Reviewed Original ResearchConceptsLower-volume EDsPediatric ED visitsED visitsPediatric visitsEmergency careInterhospital transferPediatric volumeUtilization Project Nationwide Emergency Department SampleNationwide Emergency Department SampleSelf-pay insuranceEmergency Department SampleHigh-volume EDsEmergency care systemLower mortality rateMajority of childrenEmergency department volumeMedicaid insuranceHospital characteristicsGastrointestinal diseasesPediatric careEpidemiological trendsRespiratory diseaseCommon reasonMortality rateTotal visitsTrends in the use of puberty blockers among transgender children in the United States
Lopez CM, Solomon D, Boulware SD, Christison-Lagay ER. Trends in the use of puberty blockers among transgender children in the United States. Journal Of Pediatric Endocrinology And Metabolism 2018, 31: 665-670. PMID: 29715194, DOI: 10.1515/jpem-2018-0048.Peer-Reviewed Original ResearchConceptsPediatric Health Information SystemCentral precocious pubertyHistrelin acetatePrecocious pubertyMinority patientsWhite non-Hispanic patientsOlder ageNon-Hispanic patientsDistribution of patientsPotential racial disparitiesMajority of childrenBilling diagnosisPatient populationTransgender patientsLarge cohortPatientsAverage ageTreatment dataCommercial insuranceHealth information systemsTransgender careNatal femalesRacial disparitiesDiagnosisNational trendsChapter 17 Managing a Child With OCD Who Is Treatment Refractory
Bloch M. Chapter 17 Managing a Child With OCD Who Is Treatment Refractory. 2018, 329-356. DOI: 10.1016/b978-0-12-811427-8.00017-4.Peer-Reviewed Original ResearchObsessive-compulsive disorderTreatment-refractory obsessive-compulsive disorderCognitive behavioral therapyFirst-line treatmentOCD symptomsPediatric obsessive-compulsive disorderSelective serotonin reuptake inhibitor (SSRI) pharmacotherapyEffective first-line treatmentSelective serotonin reuptake inhibitorsIntensive treatment programSerotonin reuptake inhibitorsGlutamate-modulating agentsMajority of childrenTreatment programAntipsychotic augmentationReuptake inhibitorsTreatment refractoryPharmacological treatmentAvailable treatmentsChildrenSubstantial proportionPharmacotherapyTreatmentTherapySymptoms
2017
Endoscopic Treatment of Vesicoureteral Reflux
Arlen A, Kirsch A. Endoscopic Treatment of Vesicoureteral Reflux. Current Bladder Dysfunction Reports 2017, 12: 217-224. DOI: 10.1007/s11884-017-0431-6.Peer-Reviewed Original ResearchPrimary vesicoureteral refluxVesicoureteral refluxRenal scarringClinical courseRecurrent febrile urinary tract infectionsFebrile urinary tract infectionLaparoscopic/robotic approachChild's clinical courseContinuous antibiotic prophylaxisUltimate success rateUrinary tract infectionMajority of childrenInvasive surgical proceduresAntibiotic prophylaxisEfficacy rateEndoscopic injectionPersistent refluxReflux gradeTract infectionsEndoscopic correctionEndoscopic treatmentSurgical repairRecurrent infectionsSurgical interventionSurgical correction
2014
Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism
Piochon C, Kloth A, Grasselli G, Titley H, Nakayama H, Hashimoto K, Wan V, Simmons D, Eissa T, Nakatani J, Cherskov A, Miyazaki T, Watanabe M, Takumi T, Kano M, Wang S, Hansel C. Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism. Nature Communications 2014, 5: 5586. PMID: 25418414, PMCID: PMC4243533, DOI: 10.1038/ncomms6586.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderMotor learningDelay eyeblink conditioningSocial behavior deficitsSpectrum disorderCerebellum-dependent motor learningEyeblink conditioningSurplus climbing fibresAutismLong-term depressionMotor problemsMajority of childrenMotor behaviorMotor controlBehavior deficitsCerebellar functionCerebellar plasticityMouse modelDeficitsSynaptic plasticitySynaptic pruningLearningParallel fiber-Purkinje cell synapsesFiber-Purkinje cell synapsesCerebellar synaptic plasticity
2012
Management of chronic hepatitis C infection in children
Porto AF, Tormey L, Lim JK. Management of chronic hepatitis C infection in children. Current Opinion In Pediatrics 2012, 24: 113-120. PMID: 22157364, DOI: 10.1097/mop.0b013e32834eb73f.Peer-Reviewed Original ResearchConceptsChronic hepatitis C infectionHepatitis C infectionC infectionPeginterferon αAntiviral therapyLiver fibrosisGenotype 1Global public health burdenDevelopment of cirrhosisSustained virologic responseIndolent clinical courseLarge prospective studiesProgressive liver fibrosisPublic health burdenImportant clinical implicationsMajority of childrenAreas of controversyVirologic responseViral eradicationCombination regimensInfected childrenClinical courseProspective studyTreatment courseEarly treatment
2011
Seroepidemiology of WU polyomavirus among children exposed perinatally to HIV‐1
Miller MA, Weibel C, Kahn JS, Andiman WA. Seroepidemiology of WU polyomavirus among children exposed perinatally to HIV‐1. Journal Of Medical Virology 2011, 84: 188-193. PMID: 22170536, DOI: 10.1002/jmv.23189.Peer-Reviewed Original ResearchConceptsWU polyomavirusIgM antibodiesIgG antibodiesHIV-1Specific clinical syndromesAntibody detection assaysMonths of ageMajority of childrenWUPyV infectionIgG seroprevalenceGroup of childrenClinical syndromeChildren 0Overall seroprevalenceHIVSerum samplesSeroprevalenceAntibodiesYear oldsEarly childhoodChildrenTissues of individualsWUPyVFamily PolyomaviridaeInfectionPediatric Liver Transplantation for Inherited Metabolic Liver Disease: A Single-Center Experience
Rosencrantz R, Cimsit B, Seashore M, Arvelakis A, Kulkarni S, Ghiroli M, Emre S. Pediatric Liver Transplantation for Inherited Metabolic Liver Disease: A Single-Center Experience. Transplantation Proceedings 2011, 43: 896-900. PMID: 21486623, DOI: 10.1016/j.transproceed.2011.02.035.Peer-Reviewed Original ResearchConceptsMetabolic liver diseaseLiver diseaseMS patientsMetabolic diseasesLiver transplantLiver transplantationStatus 1Pediatric liver transplant recipientsPELD/MELD scoreM groupHeterozygote parentsNeurologic motor functionAcute cellular rejectionDonor liver transplantLiver transplant recipientsDetectable EBV DNAPediatric liver transplantationSingle-center experiencePatients' overall survivalPatient survival outcomesMajority of childrenGenetic liver diseasesCellular rejectionCMV viremiaExcellent allograft
2010
Examining How the Mental Health Needs of Children Who Have Experienced Maltreatment are Addressed within Ontario Children’s Aid Societies
Czincz J, Romano E. Examining How the Mental Health Needs of Children Who Have Experienced Maltreatment are Addressed within Ontario Children’s Aid Societies. Canadian Journal Of Family And Youth / Le Journal Canadien De Famille Et De La Jeunesse 2010, 2: 25-51. DOI: 10.29173/cjfy7466.Peer-Reviewed Original ResearchMental health servicesMental health difficultiesHealth servicesHealth difficultiesMental health service provisionMental health needsHealth service provisionMajority of childrenChildren's Aid SocietyHigh prevalenceCommunity referralsReferral processCommunity-based psychologistsHealth needsChildrenReferralStandardized approachHigh ratePsychological difficultiesLittle Canadian researchMaltreatmentGeneral sampleInteragency collaborationService provisionPrevalence
2009
Comparison of Neurocognitive Functioning in Children Previously Randomly Assigned to Intrathecal Methotrexate Compared With Triple Intrathecal Therapy for the Treatment of Childhood Acute Lymphoblastic Leukemia
Kadan-Lottick NS, Brouwers P, Breiger D, Kaleita T, Dziura J, Northrup V, Chen L, Nicoletti M, Bostrom B, Stork L, Neglia JP. Comparison of Neurocognitive Functioning in Children Previously Randomly Assigned to Intrathecal Methotrexate Compared With Triple Intrathecal Therapy for the Treatment of Childhood Acute Lymphoblastic Leukemia. Journal Of Clinical Oncology 2009, 27: 5986-5992. PMID: 19884541, PMCID: PMC2793042, DOI: 10.1200/jco.2009.23.5408.Peer-Reviewed Original ResearchMeSH KeywordsAntimetabolites, AntineoplasticAntineoplastic Combined Chemotherapy ProtocolsAttentionChildChild, PreschoolCognitionCross-Sectional StudiesCytarabineFemaleHumansHydrocortisoneInfantInjections, SpinalIntelligence TestsLinear ModelsMaleMemoryMethotrexateNeuropsychological TestsPrecursor Cell Lymphoblastic Leukemia-LymphomaPsychomotor PerformanceTime FactorsTreatment OutcomeUnited StatesConceptsAcute lymphoblastic leukemiaIT therapyIntrathecal methotrexateMethotrexate groupLymphoblastic leukemiaChildhood acute lymphoblastic leukemiaTriple intrathecal therapyPost-therapy periodLong-term neurotoxicityNeurocognitive functioningAssociation of treatmentMajority of childrenCNS prophylaxisFull-scale intelligence quotientIntrathecal therapyNeurologic eventsPsychotropic medicationsVisual-motor integrationTherapy groupAttention/concentrationNeurocognitive evaluationIndex scoreTherapyPatientsMethotrexateImpact of the Method of G6PD Deficiency Assessment on Genetic Association Studies of Malaria Susceptibility
Johnson MK, Clark TD, Njama-Meya D, Rosenthal PJ, Parikh S. Impact of the Method of G6PD Deficiency Assessment on Genetic Association Studies of Malaria Susceptibility. PLOS ONE 2009, 4: e7246. PMID: 19789650, PMCID: PMC2748715, DOI: 10.1371/journal.pone.0007246.Peer-Reviewed Original Research
2007
An Optimal Treatment for Pediatric Graves’ Disease Is Radioiodine
Rivkees SA, Dinauer C. An Optimal Treatment for Pediatric Graves’ Disease Is Radioiodine. The Journal Of Clinical Endocrinology & Metabolism 2007, 92: 797-800. PMID: 17341574, DOI: 10.1210/jc.2006-1239.Commentaries, Editorials and LettersConceptsGraves' diseaseAntithyroid medicationRadioactive iodineThyroid cancerSide effectsLong-term adverse side effectsPediatric Graves' diseaseAcute side effectsLong-term remissionTreatment of hyperthyroidismAdverse side effectsMajority of childrenCurative therapyThyroid irradiationPediatric populationSpontaneous remissionOptimal treatmentSufficient dosesDefinite riskTreatment approachesMedicationsEffective cureDiseaseRemissionChildren
1997
The Differential Diagnosis of Torticollis in Children
Cooperman D. The Differential Diagnosis of Torticollis in Children. Physical & Occupational Therapy In Pediatrics 1997, 17: 1-11. DOI: 10.1080/j006v17n02_01.Peer-Reviewed Original ResearchCongenital muscular torticollisAcquired torticollisPost-encephalitic syndromeSternocleido-mastoid muscleSymptomatic hiatal herniaSoft tissue involvementBenign paroxysmal torticollisPosterior fossa pathologyKlippel-Feil syndromeMajority of childrenUnilateral fibrosisAggressive treatmentBony involvementHiatal herniaCervical musclesMuscular torticollisOcular lesionsNeurologic problemsNeurologic syndromeResidual deformityInflammatory conditionsTissue involvementCervical spineParoxysmal torticollisCongenital anomalies
1996
Long-Term Outcome in Infants with the Shaking-Impact Syndrome
Duhaime A, Christian C, Moss E, Seidl T. Long-Term Outcome in Infants with the Shaking-Impact Syndrome. Pediatric Neurosurgery 1996, 24: 292-298. PMID: 8988494, DOI: 10.1159/000121058.Peer-Reviewed Original ResearchConceptsLong-term outcomesMajority of childrenDiffuse hypodensityCT scanAcute factorsAggressiveness of careInfants 2 yearsMajor permanent morbidityGray-white differentiationPermanent morbidityHospital admissionSignificant morbiditySurgical managementTerm outcomesAcute injuryInjury characteristicsPoor outcomeHead injurySingle hospitalNonaccidental injuryOverall groupBetter outcomesInjuryBehavioral statusSyndrome
1994
Seizure control following tumor surgery for childhood cortical low-grade gliomas.
Packer R, Sutton L, Patel K, Duhaime A, Schiff S, Weinstein S, Gaillard W, Conry J, Schut L. Seizure control following tumor surgery for childhood cortical low-grade gliomas. Journal Of Neurosurgery 1994, 80: 998-1003. PMID: 8189281, DOI: 10.3171/jns.1994.80.6.0998.Peer-Reviewed Original ResearchConceptsSeizure controlPoor seizure controlLow-grade gliomasElectrocortical mappingSeizure focusTumor resectionTumor surgeryEEG monitoringLong-term seizure controlLow-grade glial tumorsPartial tumor resectionGood seizure controlHistory of seizuresExtensive tumor resectionLow-grade neoplasmsMajority of childrenCortical tumorsSeizure outcomeSurgical resectionPartial resectionTumor locationTumor removalGlial tumorsHigh riskResection
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