2025
Deep learning unlocks the true potential of organ donation after circulatory death with accurate prediction of time-to-death
Sun X, De Brouwer E, Liu C, Krishnaswamy S, Batra R. Deep learning unlocks the true potential of organ donation after circulatory death with accurate prediction of time-to-death. Scientific Reports 2025, 15: 13565. PMID: 40253393, PMCID: PMC12009369, DOI: 10.1038/s41598-025-95079-7.Peer-Reviewed Original Research
2024
Experiences of Simulated Phone Death Notification
Murtha T, Johnson R, Ellman M, Martin A, Morrison L, Talwalkar J. Experiences of Simulated Phone Death Notification. The Clinical Teacher 2024, 22: e13846. PMID: 39710510, DOI: 10.1111/tct.13846.Peer-Reviewed Original ResearchConceptsCommunication skills workshopDeath notificationDebriefing sessionsSkills workshopMedical studentsFaculty-led debriefingFourth-year medical studentsCommunication skills curriculumCommunication challengesPatient encountersPostsession surveysAudio-recordedDidactic lessonsSense of safetyCoded responsesDebriefingMedical schoolsEmotional safetyFamily membersSkills curriculumTelephoneFormative peer feedbackExperiences of silenceThemesStudents expressed appreciationA Dream of Death
Hua C, Kryger M. A Dream of Death. Sleep Health 2024, 10: 371-372. DOI: 10.1016/j.sleh.2024.07.001.Peer-Reviewed Original ResearchDeathHumansIntravascular Imaging–Guided Versus Angiography‐Guided Percutaneous Coronary Intervention: A Systematic Review and Meta‐Analysis of Randomized Trials
Sreenivasan J, Reddy R, Jamil Y, Malik A, Chamie D, Howard J, Nanna M, Mintz G, Maehara A, Ali Z, Moses J, Chen S, Chieffo A, Colombo A, Leon M, Lansky A, Ahmad Y. Intravascular Imaging–Guided Versus Angiography‐Guided Percutaneous Coronary Intervention: A Systematic Review and Meta‐Analysis of Randomized Trials. Journal Of The American Heart Association 2024, 13: e031111. PMID: 38214263, PMCID: PMC10926835, DOI: 10.1161/jaha.123.031111.Peer-Reviewed Original ResearchConceptsAdverse cardiac eventsPercutaneous coronary interventionAngiography-guided percutaneous coronary interventionTarget vessel revascularizationTarget-lesion revascularizationCardiac eventsCardiac deathImaging-guided percutaneous coronary interventionWeighted mean follow-up durationMeta-analysisPrimary outcomeMean follow-up durationStent thrombosisMeta-analysis of randomized trialsStudy-level meta-analysisComplex lesion subsetsIntravascular imagingAll-cause deathRandom-effects meta-analysisStandard of careIntention-to-treat principleUpdates of clinical guidelinesMixed-effects meta-regressionComplex percutaneous coronary interventionIntravascular imaging-guided percutaneous coronary intervention
2023
Research involving the recently deceased: ethics questions that must be answered
Parent B, Kates O, Arap W, Caplan A, Childs B, Dickert N, Homan M, Kinlaw K, Lang A, Latham S, Levan M, Truog R, Webb A, Wolpe P, Pentz R. Research involving the recently deceased: ethics questions that must be answered. Journal Of Medical Ethics 2023, 50: 622-625. PMID: 38071588, DOI: 10.1136/jme-2023-109413.Peer-Reviewed Original ResearchDeactivation of Left Ventricular Assist Devices at the End of Life Narrative Review and Ethical Framework
Zaidi D, Kirkpatrick J, Fedson S, Hull S. Deactivation of Left Ventricular Assist Devices at the End of Life Narrative Review and Ethical Framework. JACC Heart Failure 2023, 11: 1481-1490. PMID: 37768252, DOI: 10.1016/j.jchf.2023.08.004.Peer-Reviewed Original ResearchConceptsEthical frameworkEthical practiceEthical questionsEthical considerationsDevice deactivationLVAD deactivationVentricular assist deviceWider contextSuch decisionsPalliative medicine specialistsAssist deviceSevere symptomatic heart failureLeft ventricular assist deviceHeart failure teamSymptomatic heart failureAdvance care planningUnique natureIntroductory frameworkNaturePracticeDeeper understandingLVAD implantationHeart failurePatient identityPatient preferencesOncology hospitalist impact on hospice utilization
Prsic E, Morris J, Adelson K, Parker N, Gombos E, Kottarathara M, Novosel M, Castillo L, Rothberg BE. Oncology hospitalist impact on hospice utilization. Cancer 2023, 129: 3797-3804. PMID: 37706601, DOI: 10.1002/cncr.35008.Peer-Reviewed Original ResearchConceptsMedical oncology serviceOncology servicesEnd of lifeAdvanced cancerInpatient hospiceHospice utilizationHigher total health care costsTotal health care costsComfort-focused careInpatient oncology serviceSmilow Cancer HospitalAdjusted odds ratioLength of staySolid tumor malignanciesLong-term survivalMultivariable linear regressionHealth care costsElectronic medical recordsHospice transitionUnplanned hospitalizationDischarge dispositionHospice referralInpatient managementLate referralCancer HospitalComparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression
Park D, An S, Jolly N, Attanasio S, Yadav N, Gutierrez J, Nanna M, Rao S, Vij A. Comparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression. Catheterization And Cardiovascular Interventions 2023, 102: 440-450. PMID: 37483068, PMCID: PMC10908343, DOI: 10.1002/ccd.30784.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsPercutaneous coronary interventionOptical coherence tomographyCoronary angiographyIntravascular ultrasoundCoronary interventionCardiac deathClinical outcomesClinical efficacyConventional angiography-guided PCIAngiography-guided percutaneous coronary interventionCoherence tomographyUse of IVUSSuperiority of OCTAdverse cardiovascular eventsRandomized clinical trialsConventional coronary angiographyImaging modalitiesComparative clinical efficacyBest imaging modalityIntracoronary imaging modalityLesion revascularizationPCI guidanceCardiovascular eventsCause mortalityThe Cost of Cancer Care at the End of Life: Implications for Centers for Medicare and Medicaid Services and for Radiation Oncology
Yu J. The Cost of Cancer Care at the End of Life: Implications for Centers for Medicare and Medicaid Services and for Radiation Oncology. International Journal Of Radiation Oncology • Biology • Physics 2023, 116: 736-738. PMID: 37355309, DOI: 10.1016/j.ijrobp.2023.02.012.Peer-Reviewed Original ResearchEnd-of-Life Systemic Oncologic Treatment in the Immunotherapy Era: The Role of Race, Insurance, and Practice Setting
Canavan M, Wang X, Ascha M, Miksad R, Showalter T, Calip G, Gross C, Adelson K. End-of-Life Systemic Oncologic Treatment in the Immunotherapy Era: The Role of Race, Insurance, and Practice Setting. Journal Of Clinical Oncology 2023, 41: 4729-4738. PMID: 37339389, PMCID: PMC10602547, DOI: 10.1200/jco.22.02180.Peer-Reviewed Original ResearchConceptsSystemic treatmentEnd of lifeWhite patientsBlack patientsOdds ratioLarge real-world populationPractice settingsTreatment ratesPatient-level factorsEmergency department useIntensive care unitReal-world populationDay of deathImmunotherapy eraSystemic therapyOncologic treatmentCare unitDeidentified databaseDepartment usePatient raceInsurance typeMetastatic cancerDownstream careMedicaid patientsHigher oddsParent Priorities in End-of-Life Care for Children With Cancer
Ananth P, Lindsay M, Mun S, McCollum S, Shabanova V, de Oliveira S, Pitafi S, Kirch R, Ma X, Gross C, Boyden J, Feudtner C, Wolfe J. Parent Priorities in End-of-Life Care for Children With Cancer. JAMA Network Open 2023, 6: e2313503. PMID: 37184834, PMCID: PMC10878399, DOI: 10.1001/jamanetworkopen.2023.13503.Peer-Reviewed Original ResearchDaniel Callahan's Decade of Doubt.
Shulman K, Fins J. Daniel Callahan's Decade of Doubt. Perspectives In Biology And Medicine 2023, 66: 249-266. PMID: 37755715, DOI: 10.1353/pbm.2023.0022.Peer-Reviewed Original ResearchConceptsDaniel CallahanFabric of American lifeAmerican civic lifeReligious perspectiveCatholic journalistsHastings CenterPublic lifeContemporary worldCallahanRelevant todayAmerican lifeCivic lifeWomen's rightsDanielPolitical discourseFaithHalf-centurySecularismReligionThinkersBioethicsLifeMisgivingsDialogueScholarshipAutomatable end‐of‐life screening for older adults in the emergency department using electronic health records
Haimovich A, Xu W, Wei A, Schonberg M, Hwang U, Taylor R. Automatable end‐of‐life screening for older adults in the emergency department using electronic health records. Journal Of The American Geriatrics Society 2023, 71: 1829-1839. PMID: 36744550, PMCID: PMC10258151, DOI: 10.1111/jgs.18262.Peer-Reviewed Original ResearchConceptsAdvance care planningDecision curve analysisLife screeningComorbidity indexCode statusPrognostic modelHealth systemOlder adultsCurve analysisOlder ED patientsPalliative care interventionsObservational cohort studyEmergency department visitsPalliative care servicesElixhauser Comorbidity IndexReceiver-operating characteristic curveIdentification of patientsMultivariable logistic regressionLarge regional health systemLife-limiting illnessRisk older adultsCode status ordersLife Screening ToolMortality predictive modelsElectronic health recordsAdvance Care Planning and End-of-Life Education in Heart Failure: Insights From the NCDR PINNACLE Registry
Cavanagh C, Rosman L, Chui P, Minges K, Desai N, Goodlin S, Fedson S, Spertus J, Gluckman T, Song Y, Zheng L, Turchin A, Doros G, Lee J, Burg M. Advance Care Planning and End-of-Life Education in Heart Failure: Insights From the NCDR PINNACLE Registry. Circulation Cardiovascular Quality And Outcomes 2023, 16: e008989. PMID: 36649391, PMCID: PMC9848210, DOI: 10.1161/circoutcomes.122.008989.Peer-Reviewed Original Research
2022
Outcomes of Liver Transplantation Using Machine Perfusion in Donation after Cardiac Death vs Brain Death in the US.
Okumura K, Dhand A, Misawa R, Sogawa H, Veillette G, Nishida S. Outcomes of Liver Transplantation Using Machine Perfusion in Donation after Cardiac Death vs Brain Death in the US. Journal Of The American College Of Surgeons 2022, 236: 73-80. PMID: 36519910, DOI: 10.1097/xcs.0000000000000425.Peer-Reviewed Original ResearchConceptsLiver transplantationPropensity score matchingMachine perfusionCardiac deathIndependent risk factor of mortalityEnd-stage liver disease scoreOutcome of liver transplantationRisk factors of mortalityAdult LT recipientsMedian recipient ageScore matchingIndependent risk factorLiver Disease scoreMedian donor ageCox regression analysisDCD groupFactors of mortalityHigher prevalence of diabetesUnited Network for Organ SharingBrain deathPrevalence of diabetesLT recipientsRecipient ageLT outcomesTransplant recipientsClinical Characteristics and Prognosis of MINOCA Caused by Atherosclerotic and Nonatherosclerotic Mechanisms Assessed by OCT
Zeng M, Zhao C, Bao X, Liu M, He L, Xu Y, Meng W, Qin Y, Weng Z, Yi B, Zhang D, Wang S, Luo X, Lv Y, Chen X, Sun Q, Feng X, Gao Z, Sun Y, Demuyakor A, Li J, Hu S, Guagliumi G, Mintz G, Jia H, Yu B. Clinical Characteristics and Prognosis of MINOCA Caused by Atherosclerotic and Nonatherosclerotic Mechanisms Assessed by OCT. JACC Cardiovascular Imaging 2022, 16: 521-532. PMID: 36648054, DOI: 10.1016/j.jcmg.2022.10.023.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsOptical coherence tomographyTarget lesion revascularizationCardiac deathLesion revascularizationPredictors of Major Adverse Cardiac EventsAssociated with worse outcomesSpontaneous coronary artery dissectionClinical diagnosis of MIPrognosis of MINOCAMechanisms of MINOCAAdverse cardiac eventsNonobstructive coronary arteriesPrognosis of patientsCoronary artery dissectionDiagnosis of MIOCT findingsAtherosclerotic causeCardiac eventsClinical characteristicsClinical outcomesArtery dissectionComposite endpointMINOCACoronary spasmAssociations Between Extreme Temperatures and Cardiovascular Cause-Specific Mortality: Results From 27 Countries
Alahmad B, Khraishah H, Royé D, Vicedo-Cabrera A, Guo Y, Papatheodorou S, Achilleos S, Acquaotta F, Armstrong B, Bell M, Pan S, de Sousa Zanotti Stagliorio Coelho M, Colistro V, Dang T, Van Dung D, De' Donato F, Entezari A, Guo Y, Hashizume M, Honda Y, Indermitte E, Íñiguez C, Jaakkola J, Kim H, Lavigne E, Lee W, Li S, Madureira J, Mayvaneh F, Orru H, Overcenco A, Ragettli M, Ryti N, Saldiva P, Scovronick N, Seposo X, Sera F, Silva S, Stafoggia M, Tobias A, Garshick E, Bernstein A, Zanobetti A, Schwartz J, Gasparrini A, Koutrakis P. Associations Between Extreme Temperatures and Cardiovascular Cause-Specific Mortality: Results From 27 Countries. Circulation 2022, 147: 35-46. PMID: 36503273, PMCID: PMC9794133, DOI: 10.1161/circulationaha.122.061832.Peer-Reviewed Original ResearchConceptsMinimum mortality temperatureExcess deathsIschemic heart diseaseCardiovascular causesCardiovascular deathCause-specific mortalityCardiovascular health needsCase-crossover modelsMortality temperatureAssociated with higher riskHeart diseaseRisk of mortalityCold daysHealth needsMortality associationsTemperature percentileData collection protocolsExtreme temperaturesDeath proportionCardiovascular conditionsHeart failureCardiovascular diseaseCold temperaturesReanalysis modelsHigh riskSystemic Anticancer Therapy at the End of Life—Changes in Usage Pattern in the Immunotherapy Era
Canavan ME, Wang X, Ascha MS, Miksad RA, Calip GS, Gross CP, Adelson KB. Systemic Anticancer Therapy at the End of Life—Changes in Usage Pattern in the Immunotherapy Era. JAMA Oncology 2022, 8: 1847-1849. PMID: 36264566, PMCID: PMC9585458, DOI: 10.1001/jamaoncol.2022.4666.Peer-Reviewed Original ResearchNetwork Meta-Analysis Comparing Angiotensin Receptor-Neprilysin Inhibitors, Angiotensin Receptor Blockers, and Angiotensin-Converting Enzyme Inhibitors in Heart Failure With Reduced Ejection Fraction
Park D, An S, Attanasio S, Jolly N, Malhotra S, Doukky R, Samsky M, Sen S, Ahmad T, Nanna M, Vij A. Network Meta-Analysis Comparing Angiotensin Receptor-Neprilysin Inhibitors, Angiotensin Receptor Blockers, and Angiotensin-Converting Enzyme Inhibitors in Heart Failure With Reduced Ejection Fraction. The American Journal Of Cardiology 2022, 187: 84-92. PMID: 36459752, PMCID: PMC10958453, DOI: 10.1016/j.amjcard.2022.10.026.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsBayes TheoremDeathHeart FailureHumansHypotensionNeprilysinNetwork Meta-AnalysisRandomized Controlled Trials as TopicReceptors, AngiotensinStroke VolumeTreatment OutcomeVentricular Dysfunction, LeftConceptsAngiotensin receptor neprilysin inhibitorAngiotensin receptor blockersReduced ejection fractionHeart failureEjection fractionHigh riskCause mortalityReceptor blockersCardiac deathLower riskEnzyme inhibitorsMajor adverse cardiac eventsAngiotensin converting enzyme (ACE) inhibitorsAdverse cardiac eventsEfficacy end pointNetwork meta-analysis approachImproved clinical outcomesRandomized clinical trialsP scoreCardiac eventsAngiotensin receptorsClinical outcomesNeprilysin inhibitorClinical benefitRecent trialsEnd-of-life care trajectories among older adults with lung cancer
Davidoff AJ, Canavan ME, Prsic E, Saphire M, Wang SY, Presley CJ. End-of-life care trajectories among older adults with lung cancer. Journal Of Geriatric Oncology 2022, 14: 101381. PMID: 36202695, PMCID: PMC9974538, DOI: 10.1016/j.jgo.2022.09.010.Peer-Reviewed Original ResearchConceptsCancer-directed therapyLung cancerCare trajectoriesOlder adultsSupportive care servicesSEER-Medicare dataSkilled nursing facilitiesNon-Hispanic whitesRace/ethnicityCancer decedentsSymptom managementIntensive careOlder decedentsConcurrent careHospice careReferral regionsHigh riskMultinomial logistic regressionNursing facilitiesMedicare decedentsCare servicesLogistic regressionCancerHospiceDecedents
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