2025
589. Late Onset Invasive Group B Streptococcal Disease Outbreak in a Neonatal Intensive Care Unit Identified Through Whole Genome Sequencing — Connecticut, 2020–2024
Lambert M, Jones S, Mueller K, Maloney M, Perera N, Incekara K, Petit S, Ramachandran V, Grossman M, Valderrama A, Chochua S, McGee L, Metcalf B, Schrag S, Sosa L. 589. Late Onset Invasive Group B Streptococcal Disease Outbreak in a Neonatal Intensive Care Unit Identified Through Whole Genome Sequencing — Connecticut, 2020–2024. Open Forum Infectious Diseases 2025, 12: ofae631.184. PMCID: PMC11778314, DOI: 10.1093/ofid/ofae631.184.Peer-Reviewed Original ResearchNeonatal intensive care unitGroup B streptococciGroup B Streptococcus isolatesWhole-genome sequencingIntensive care unitLate-onset diseaseOutbreak-related casesSingle nucleotide polymorphismsColonized infantsCare unitColon screeningGroup B streptococcus colonizationActive Bacterial Core surveillance programIntegration of whole genome sequencingDepartment of Public HealthAssessment of infection preventionDays of lifeIPC gapsLOD casesNeonatal sepsisB streptococciReview of dataConnecticut Department of Public HealthOutbreak-relatedIllness onset
2018
Epidemiology and Etiology of Invasive Bacterial Infection in Infants ≤60 Days Old Treated in Emergency Departments
Woll C, Neuman MI, Pruitt CM, Wang ME, Shapiro ED, Shah SS, McCulloh RJ, Nigrovic LE, Desai S, DePorre AG, Leazer RC, Marble RD, Balamuth F, Feldman EA, Sartori LF, Browning WL, Aronson PL, Collaborative F, Alpern E, Hayes K, Lee B, Lumb C, Mitchell C, Peaper D, Rooholamini S, Shin S, Williams D. Epidemiology and Etiology of Invasive Bacterial Infection in Infants ≤60 Days Old Treated in Emergency Departments. The Journal Of Pediatrics 2018, 200: 210-217.e1. PMID: 29784512, PMCID: PMC6109608, DOI: 10.1016/j.jpeds.2018.04.033.Peer-Reviewed Original ResearchConceptsInvasive bacterial infectionsThird-generation cephalosporinsMicrobiology laboratory databaseEmergency departmentBacterial infectionsBacterial meningitisPediatric emergency departmentCombination of ampicillinAntimicrobial treatment regimenCross-sectional studyGroup B streptococciElectronic medical record systemEmpiric treatmentMedical record systemTreatment regimenChildren's HospitalMost infantsMedical recordsB streptococciCerebrospinal fluidCommon pathogensInfantsAntimicrobial susceptibilityDay oldsInfection
2015
Neonatal Sepsis 2004-2013: The Rise and Fall of Coagulase-Negative Staphylococci
Bizzarro MJ, Shabanova V, Baltimore RS, Dembry LM, Ehrenkranz RA, Gallagher PG. Neonatal Sepsis 2004-2013: The Rise and Fall of Coagulase-Negative Staphylococci. The Journal Of Pediatrics 2015, 166: 1193-1199. PMID: 25919728, PMCID: PMC4413005, DOI: 10.1016/j.jpeds.2015.02.009.Peer-Reviewed Original ResearchConceptsEarly-onset sepsisLate-onset sepsisNeonatal intensive care unitCoagulase-negative staphylococciIntensive care unitCare unitLevel IV neonatal intensive care unitEpisodes of sepsisLow birth weightInfection prevention initiativesInfection prevention effortsPercent of casesGroup B streptococciHospital courseSepsis episodesMost infantsBirth weightCommon organismB streptococciSepsisOutcome dataAdditional surveillancePrevention effortsStudy periodInfants
2014
RNA and β-Hemolysin of Group B Streptococcus Induce Interleukin-1β (IL-1β) by Activating NLRP3 Inflammasomes in Mouse Macrophages*
Gupta R, Ghosh S, Monks B, DeOliveira R, Tzeng T, Kalantari P, Nandy A, Bhattacharjee B, Chan J, Ferreira F, Rathinam V, Sharma S, Lien E, Silverman N, Fitzgerald K, Firon A, Trieu-Cuot P, Henneke P, Golenbock D. RNA and β-Hemolysin of Group B Streptococcus Induce Interleukin-1β (IL-1β) by Activating NLRP3 Inflammasomes in Mouse Macrophages*. Journal Of Biological Chemistry 2014, 289: 13701-13705. PMID: 24692555, PMCID: PMC4022842, DOI: 10.1074/jbc.c114.548982.Peer-Reviewed Original Research
2010
Interpretation of 2002 Centers for Disease Control Guidelines for Group B Streptococcus and Evolving Provider Practice Patterns
Barber E, Funai E, Bracken M, Illuzzi J. Interpretation of 2002 Centers for Disease Control Guidelines for Group B Streptococcus and Evolving Provider Practice Patterns. American Journal Of Perinatology 2010, 28: 097-102. PMID: 20640975, PMCID: PMC3224803, DOI: 10.1055/s-0030-1262907.Peer-Reviewed Original ResearchMeSH KeywordsAntibiotic ProphylaxisCarrier StateFemaleGuideline AdherenceHumansInfant, NewbornInfectious Disease Transmission, VerticalLabor, ObstetricMaleMidwiferyPhysiciansPractice Guidelines as TopicPractice Patterns, Physicians'PregnancyPregnancy Complications, InfectiousStreptococcal InfectionsStreptococcus agalactiaeConceptsDisease Control guidelinesGroup B streptococciManagement of labourCDC guidelinesB streptococciControl guidelinesHours of prophylaxisPerinatal GBS diseaseIntrapartum antibiotic prophylaxisProvider practice patternsAntibiotic prophylaxisIntrapartum prophylaxisGBS diseasePositive womenArtificial ruptureOxytocin infusionPractice patternsEligible cliniciansLabor floorClinical settingProphylaxisCliniciansClinical applicationStreptococciGuidelines
2006
Use of Vaginally Administered Chlorhexidine During Labor to Improve Pregnancy Outcomes
Goldenberg RL, McClure EM, Saleem S, Rouse D, Vermund S. Use of Vaginally Administered Chlorhexidine During Labor to Improve Pregnancy Outcomes. Obstetrics And Gynecology 2006, 107: 1139-1146. PMID: 16648420, DOI: 10.1097/01.aog.0000215000.65665.dd.Peer-Reviewed Original ResearchConceptsPregnancy outcomesHuman immunodeficiency virusExcellent safety profileGroup B streptococciUse of chlorhexidineChild transmissionNeonatal sepsisNeonatal infectionChlorhexidine useVaginal treatmentImmunodeficiency virusNeonatal mortalityPregnant womenSafety profileAdverse outcomesNewborn periodSTUDY SELECTIONB streptococciPromising treatmentChlorhexidine treatmentBacterial loadChlorhexidineEffective killersEnglish literatureFurther studies
2005
Seventy-Five Years of Neonatal Sepsis at Yale: 1928–2003
Bizzarro MJ, Raskind C, Baltimore RS, Gallagher PG. Seventy-Five Years of Neonatal Sepsis at Yale: 1928–2003. 2005, 116: 595-602. PMID: 16140698, DOI: 10.1542/peds.2005-0552.Peer-Reviewed Original ResearchConceptsYale-New Haven HospitalEpisodes of sepsisLate-onset sepsisRecords of infantsPositive blood culturesNeonatal sepsisPreterm infantsBlood culturesSepsis-related mortality rateEarly-onset sepsisProlonged mechanical ventilationCentral vascular catheterNeonatal sepsis casesPopulation of infantsGroup B streptococciPercentage of casesDays of ageParenteral nutritionSepsis casesMechanical ventilationVascular cathetersIntensive careS pyogenesB streptococciSepsis
1989
Rapid detection of vaginal colonization with group B streptococci by means of latex agglutination
Stiller R, Blair E, Clark P, Tinghitella T. Rapid detection of vaginal colonization with group B streptococci by means of latex agglutination. American Journal Of Obstetrics And Gynecology 1989, 160: 566-568. PMID: 2648833, DOI: 10.1016/s0002-9378(89)80028-6.Peer-Reviewed Original Research
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