2025
Ethical challenges and justice concerns for infants and children with life-limiting conditions and significant disability, including trisomy 13 and 18
Pyle A, Mercurio M. Ethical challenges and justice concerns for infants and children with life-limiting conditions and significant disability, including trisomy 13 and 18. Seminars In Perinatology 2025, 152101. PMID: 40517086, DOI: 10.1016/j.semperi.2025.152101.Peer-Reviewed Original ResearchShared Decision-Making ProcessPositive quality of lifeLife-limiting conditionsQuality of lifeComfort careImpact counselingSignificant neurodevelopmental impairmentMedical/surgical interventionDisabilityEthical frameworkEthical challengesNeurodevelopmental impairmentTrisomy 13Surgical treatmentLong-established practiceInterventionEarly deathTrisomyDecision-making processJustice concerns
2023
2288. Short and Longer-Term All-Cause Mortality among SARS CoV-2-Infected Persons and the Pull-Forward Phenomenon in Qatar
Chemaitelly H, Faust J, Krumholz H, Ayoub H, Abu-Raddad L. 2288. Short and Longer-Term All-Cause Mortality among SARS CoV-2-Infected Persons and the Pull-Forward Phenomenon in Qatar. Open Forum Infectious Diseases 2023, 10: ofad500.1910. PMCID: PMC10676887, DOI: 10.1093/ofid/ofad500.1910.Peer-Reviewed Original ResearchSevere COVID-19Incidence of deathCause mortalityPrimary infectionCOVID-19Primary SARS-CoV-2 infectionSARS-CoV-2-infected personsCox proportional hazards regression modelSARS-CoV-2 infectionProportional hazards regression modelsPrimary infection cohortRetrospective cohort studyCOVID-19 mortalitySARS-CoV-2Short life expectancyCohort studyHazard ratioUnvaccinated personsMonth 3Uninfected personsVaccinated personsControl cohortNational cohortEarly deathCohort1632-P: Effects of MTOR Signaling in Muscle-Specific Irs1/2 Knockout Mice
STOEHR O, COPPS K, TAO R, WHITE M. 1632-P: Effects of MTOR Signaling in Muscle-Specific Irs1/2 Knockout Mice. Diabetes 2023, 72 DOI: 10.2337/db23-1632-p.Peer-Reviewed Original ResearchMTKO miceGlucose uptakeMTOR pathwayMdKO miceReduced ejection fractionCardiac fatty acid uptakeHigh-fat dietInsulin-resistant heartMuscle glucose uptakeDays of lifeWhite adipose tissueCardiac glucose uptakeFatty acid uptakeEffects of mTORInsulin-stimulated conditionsEjection fractionFat dietFat massMuscle atrophyIRS2 expressionCardiac hypertrophyEarly deathCardiac energyKnockout miceAdipose tissueLived Experience–Led Research Agenda to Address Early Death in People With a Diagnosis of a Serious Mental Illness
Fortuna K, Lebby S, Geiger P, Johnson D, MacDonald S, Chefetz I, Ferron J, St George L, Rossom R, Kalisa J, Mestrovic T, Nicholson J, Pringle W, Rotondi A, Sippel L, Sica A, Solesio M, Wright M, Zisman-Ilani Y, Gambee D, Hill J, Brundrett A, Cather C, Rhee T, Daumit G, Angel J, Manion I, Deegan P, Butler J, Pitts N, Brodey D, Williams A, Parks J, Reimann B, Wahrenberger J, Morgan O, Bradford D, Bright N, Stafford E, Bohm A, Carney T, Haragirimana C, Gold A, Storm M, Walker R. Lived Experience–Led Research Agenda to Address Early Death in People With a Diagnosis of a Serious Mental Illness. JAMA Network Open 2023, 6: e2315479. PMID: 37234010, PMCID: PMC11905947, DOI: 10.1001/jamanetworkopen.2023.15479.Peer-Reviewed Original ResearchConceptsSerious mental illnessEarly mortalityMental illnessMajor depressive disorderCo-occurring disordersCaregivers of peopleExpert group consensusSchizophrenia spectrum disordersPeer support specialistsSMI diagnosisMedication useDepressive disorderRecovery coachesEarly deathGeneral populationHealth literacySupport cliniciansBipolar disorderSubstance misuseMortalityDiagnostic accuracyMental healthDiagnosisDisordersPrecision medicineRisk of early death in adolescents and young adults with cancer: a population-based study
Berkman A, Andersen C, Hildebrandt M, Livingston J, Green A, Puthenpura V, Peterson S, Milam J, Miller K, Freyer D, Roth M. Risk of early death in adolescents and young adults with cancer: a population-based study. Journal Of The National Cancer Institute 2023, 115: 447-455. PMID: 36682385, PMCID: PMC10086632, DOI: 10.1093/jnci/djac206.Peer-Reviewed Original ResearchConceptsCentral nervous system tumorsNervous system tumorsEarly deathHematologic malignanciesSolid tumorsCancer typesInsurance statusSystem tumorsYoung adultsEnd Results registrySocioeconomic statusPopulation-based studyLow socioeconomic statusSupportive careHigh riskSociodemographic factorsAYAsTumorsHealth systemMalignancyCancerDeathRiskDeath percentageDiagnosis
2022
Chapter 9 Addiction management in the outpatient setting
Shi J, Slocum B, Tetrault J, Yanagisawa K. Chapter 9 Addiction management in the outpatient setting. 2022, 169-187. DOI: 10.1016/b978-0-323-79016-1.00008-8.ChaptersOpioid use disorderNonmedical opioid useOpioid useUntreated opioid use disorderPain management strategiesCurrent treatment optionsOpioid overdose crisisPostoperative painOutpatient settingTreatment optionsRisk factorsGeneral practitionersHigh riskEarly deathUse disordersAddiction specialistsCurrent opioid overdose crisisMedical providersBrain physiologyInfectious diseasesAddiction managementOverdose crisisAffected individualsDisordersThoughtful approach
2020
Leukapheresis for the management of hyperleukocytosis in acute myeloid leukemia—A systematic review and meta‐analysis
Bewersdorf JP, Giri S, Tallman MS, Zeidan AM, Stahl M. Leukapheresis for the management of hyperleukocytosis in acute myeloid leukemia—A systematic review and meta‐analysis. Transfusion 2020, 60: 2360-2369. PMID: 32776542, PMCID: PMC8631180, DOI: 10.1111/trf.15994.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaEarly mortality rateWhite blood cellsRisk ratioMyeloid leukemiaMortality rateSystematic reviewShort-term mortality benefitHigh early mortality rateManagement of hyperleukocytosisCochrane Central RegisterIndividual study estimatesWeb of ScienceCentral RegisterMortality benefitControlled TrialsPrimary outcomeEarly mortalityRetrospective studyMultiarm studiesTreatment strategiesTwo-armEarly deathLeukapheresisPatientsParadoxical aortic stiffening and subsequent cardiac dysfunction in Hutchinson–Gilford progeria syndrome
Murtada SI, Kawamura Y, Caulk AW, Ahmadzadeh H, Mikush N, Zimmerman K, Kavanagh D, Weiss D, Latorre M, Zhuang ZW, Shadel GS, Braddock DT, Humphrey JD. Paradoxical aortic stiffening and subsequent cardiac dysfunction in Hutchinson–Gilford progeria syndrome. Journal Of The Royal Society Interface 2020, 17: 20200066. PMID: 32453981, PMCID: PMC7276555, DOI: 10.1098/rsif.2020.0066.Peer-Reviewed Original ResearchConceptsHutchinson-Gilford progeria syndromeSubsequent cardiac dysfunctionSmooth muscle functionPulse wave velocityUltra-rare disordersCardiovascular eventsDevastating sequelaeDiastolic dysfunctionSystolic functionCardiac dysfunctionProgeria syndromeVascular functionAortic functionMuscle functionEarly deathMouse modelTherapeutic windowCardiovascular dataBiomechanical phenotypingDysfunctionSyndromeExcessive accumulationBiomechanical functionArterial developmentPressure-related effects
2019
Acute promyelocytic leukemia (APL): remaining challenges towards a cure for all
Stahl M, Tallman M. Acute promyelocytic leukemia (APL): remaining challenges towards a cure for all. Leukemia & Lymphoma 2019, 60: 3107-3115. PMID: 31842650, PMCID: PMC7479633, DOI: 10.1080/10428194.2019.1613540.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Combined Chemotherapy ProtocolsArsenic TrioxideDisease-Free SurvivalHemorrhageHumansIncidenceLeukemia, Promyelocytic, AcuteMortalityNeoplasm Recurrence, LocalPractice Guidelines as TopicRandomized Controlled Trials as TopicRemission InductionStandard of CareTime FactorsTretinoinConceptsAcute promyelocytic leukemiaApplication of all-trans retinoic acidArsenic trioxideHigher early death rateHigh-risk acute promyelocytic leukemiaOutcome of high-riskRelapsed APLPromyelocytic leukemiaEarly death rateRelapsed APL patientsTreatment of acute promyelocytic leukemiaAll-Trans Retinoic AcidAPL patientsCare of patientsEarly deathHigh riskPatientsLeukemiaRetinoic acidDeath rateEarly postoperative death in extreme-risk patients: A perspective on surgical futility
Chiu A, Jean R, Resio B, Pei K. Early postoperative death in extreme-risk patients: A perspective on surgical futility. Surgery 2019, 166: 380-385. PMID: 31208864, DOI: 10.1016/j.surg.2019.05.002.Peer-Reviewed Original ResearchConceptsExtreme-risk patientsFutile careSurgical futilityFutile surgeryExtreme-riskEmergency general surgery patientsEstimate mortality riskAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseEmergency general surgery operationsEarly deathEmergency general surgeryQuality Improvement Program databaseDependent functional statusEarly postoperative deathLysis of adhesionsSmall bowel resectionGeneral surgery patientsHigher oddsGeneral surgery operationsMortality riskFunctional statusCareAmerican CollegeRethinking our definition of operative success: predicting early mortality after emergency general surgery colon resection
DeWane MP, Davis KA, Schuster KM, Maung AA, Becher RD. Rethinking our definition of operative success: predicting early mortality after emergency general surgery colon resection. Trauma Surgery & Acute Care Open 2019, 4: e000244. PMID: 31245613, PMCID: PMC6560481, DOI: 10.1136/tsaco-2018-000244.Peer-Reviewed Original ResearchPostoperative septic shockEarly deathSeptic shockEarly mortalityColon resectionSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseNew-onset renal failureEmergency general surgery patientsQuality Improvement Program databaseGeneral surgery patientsRetrospective cohort studyImprovement Program databasePostoperative day 5Overall mortality rateMultivariable logistic regressionImmediate perioperative complicationsSurgical Risk CalculatorKaplan-Meier modelEmergent colectomyLate deathsVentilator dependencePerioperative complicationsPostoperative complicationsPreoperative factors
2018
Multi-institutional competing risks analysis of distant brain failure and salvage patterns after upfront radiosurgery without whole brain radiotherapy for brain metastasis
McTyre E, Ayala-Peacock D, Contessa J, Corso C, Chiang V, Chung C, Fiveash J, Ahluwalia M, Kotecha R, Chao S, Attia A, Henson A, Hepel J, Braunstein S, Chan M. Multi-institutional competing risks analysis of distant brain failure and salvage patterns after upfront radiosurgery without whole brain radiotherapy for brain metastasis. Annals Of Oncology 2018, 29: 497-503. PMID: 29161348, DOI: 10.1093/annonc/mdx740.Peer-Reviewed Original ResearchConceptsDistant brain failureWhole brain radiotherapyUpfront stereotactic radiosurgerySalvage whole brain radiotherapySalvage stereotactic radiosurgeryBrain metastasesStereotactic radiosurgerySystemic diseaseMultivariate analysisBrain radiotherapyBrain failureDecreased hazardMelanoma histologyProgressive systemic diseaseWidespread systemic diseaseSystemic disease statusLower KPSSRS doseUpfront radiosurgeryIncreased hazardCompeting Risk AnalysisEarly deathAcademic centersPatientsMetastasis
2017
Obesity in America
Rosenthal RJ, Morton J, Brethauer S, Mattar S, De Maria E, Benz JK, Titus J, Sterrett D. Obesity in America. Surgery For Obesity And Related Diseases 2017, 13: 1643-1650. PMID: 28935198, DOI: 10.1016/j.soard.2017.08.002.Peer-Reviewed Original ResearchConceptsPrevalence of obesityDisease of obesityBest treatment modalityTreatment of obesityUS household populationConsequences of obesityGeneral US populationSerious health problemHIV infectionExcess weightObesity treatmentTreatment modalitiesTreatment optionsUniversity HospitalHeart diseaseObese AmericansEarly deathObesityHealth problemsUS populationMental illnessDiseaseWeight lossProbability-based panelOversamples of blacksIs Pre-Hospital CPR a Risk Factor for Early Death in Patients Transferred to an Adult Burn Center?
Trehan K, Rotta S, Gregg SC, Glasgow K, Crombie RE, Cholewczynski WM, Atweh N, Savetamal A. Is Pre-Hospital CPR a Risk Factor for Early Death in Patients Transferred to an Adult Burn Center? Journal Of The American College Of Surgeons 2017, 225: 210-215. PMID: 28522168, DOI: 10.1016/j.jamcollsurg.2017.05.002.Peer-Reviewed Original ResearchConceptsBurn centerEarly deathInitial arterialMore total body surface areaPatients meeting inclusion criteriaTotal body surface areaPredictors of deathPre-hospital CPRHours of admissionRetrospective chart reviewAdult burn centerBody surface areaMeeting inclusion criteriaCPR patientsLate deathsChart reviewAdult patientsBurn patientsPre-hospitalRisk factorsInitial lactateInclusion criteriaHigh riskPatientsHigh mortalityFactors Associated with Early Mortality Among Patients with De Novo Metastatic Breast Cancer: A Population‐Based Study
Vaz‐Luis I, Lin NU, Keating NL, Barry WT, Winer EP, Freedman RA. Factors Associated with Early Mortality Among Patients with De Novo Metastatic Breast Cancer: A Population‐Based Study. The Oncologist 2017, 22: 386-393. PMID: 28242790, PMCID: PMC5388378, DOI: 10.1634/theoncologist.2016-0369.Peer-Reviewed Original ResearchConceptsMetastatic breast cancerMonths of diagnosisQuarter of patientsEarly deathBreast cancerPoor outcomeUninsured statusHigh riskDe novo metastatic breast cancerEarly palliative care referralNovo metastatic breast cancerHuman epidermal growth factor receptor 2Older ageEpidermal growth factor receptor 2Palliative care referralHalf of patientsProportion of patientsEnd Results (SEER) dataGrowth factor receptor 2Identification of patientsClinical trial participationFactor receptor 2Additional supportive servicesProportion of womenEquitable patient access
2015
Knowledge and perceptions of sexual and reproductive health and HIV among perinatally HIV-infected adolescents in rural China
Mu W, Zhao Y, Khoshnood K, Cheng Y, Sun X, Liu X, Xu W, Wang S, Ma Y, Zhang F. Knowledge and perceptions of sexual and reproductive health and HIV among perinatally HIV-infected adolescents in rural China. AIDS Care 2015, 27: 1137-1142. PMID: 25894204, DOI: 10.1080/09540121.2015.1032206.Peer-Reviewed Original ResearchConceptsHIV knowledgeReproductive healthDescriptive cross-sectional studyRural HIV clinicActive antiretroviral therapyHIV treatment programsMultivariable logistic regressionCross-sectional studyLong-term careAntiretroviral therapyHIV clinicHIV statusMedical visitsSRH servicesAdult careComprehensive carePuberty developmentEarly deathHIVPsychosocial supportTreatment programLogistic regressionVulnerable populationsMore childrenPHIVAFunctional Trajectories Among Older Persons Before and After Critical Illness
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Functional Trajectories Among Older Persons Before and After Critical Illness. JAMA Internal Medicine 2015, 175: 523-529. PMID: 25665067, PMCID: PMC4467795, DOI: 10.1001/jamainternmed.2014.7889.Peer-Reviewed Original ResearchConceptsIntensive care unitLong-term mortalityCritical illnessICU admissionModerate disabilityOlder personsMinimal disabilitySevere disabilityFunctional trajectoriesFunctional declineEarly deathProspective cohort studyDay of admissionPersons 70 yearsGoals of careRisk of deathShort-term mortalityGreater New HavenSignificant functional declineICU lengthCohort studyHospital dischargePremorbid disabilityCare unitMechanical ventilation
2014
Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice
Hafler BP, Klein ZA, Zhou Z, Strittmatter SM. Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice. Brain Research 2014, 1588: 168-174. PMID: 25234724, PMCID: PMC4254024, DOI: 10.1016/j.brainres.2014.09.023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedElectroretinographyGranulinsImmunohistochemistryIntercellular Signaling Peptides and ProteinsMice, Inbred C57BLMice, KnockoutMicroscopy, ConfocalNeuronal Ceroid-LipofuscinosesOptical ImagingPhotoreceptor Cells, VertebrateProgranulinsRetinal DegenerationRetinal Ganglion CellsConceptsProgranulin-deficient miceNeuronal ceroid lipofuscinosisAdult-onset neuronal ceroid lipofuscinosisDeficient miceRetinal degenerationCeroid lipofuscinosisRetinal ganglion cellsCentral nervous systemAutofluorescent storage materialMotor dysfunctionNeuropathological analysisGanglion cellsVision lossOptic atrophyEarly deathAutofluorescent lipopigmentsClinical observationsNervous systemDegenerative pathologyMiceDegenerationHomozygous mutationAutofluorescent materialPatientsNeuronsA trial of in-hospital, electronic alerts for acute kidney injury: Design and rationale
Wilson FP, Reese PP, Shashaty MG, Ellenberg SS, Gitelman Y, Bansal AD, Urbani R, Feldman HI, Fuchs B. A trial of in-hospital, electronic alerts for acute kidney injury: Design and rationale. Clinical Trials 2014, 11: 521-529. PMID: 25023200, PMCID: PMC4156885, DOI: 10.1177/1740774514542619.Peer-Reviewed Original ResearchConceptsAcute kidney injuryKidney injuryElectronic alert systemHospitalized patientsElectronic alertsInformed consentStage 1 acute kidney injuryStage 3 acute kidney injuryAcute kidney injury severityStudy outcomesAcute kidney injury alertsLow-risk interventionBroad inclusion criteriaInpatient mortalitySerum creatinineMedical recordsClinical trialsPatient outcomesInclusion criteriaProvider recognitionEarly deathDichotomous outcomesInjury severityPatientsInjury
2012
Fetal growth and later maternal death, cardiovascular disease and diabetes
LYKKE J, PAIDAS M, TRICHE E, LANGHOFF‐ROOS J. Fetal growth and later maternal death, cardiovascular disease and diabetes. Acta Obstetricia Et Gynecologica Scandinavica 2012, no-no. DOI: 10.1111/j.1600-0412.2012.01355.x.Peer-Reviewed Original ResearchSubsequent maternal deathIschemic heart diseaseFetal growthPonderal indexMaternal deathsStandardized birthweightHeart diseaseCardiovascular diseaseSubsequent mortalityFirst singleton deliverySmaller risk estimatesSubsequent diabetes mellitusProportional hazards modelCardiovascular morbidityPregnancy complicationsSingleton deliveriesDiabetes mellitusGestational ageLow birthweightPrimary exposureSubsequent riskEarly deathHazards modelBirthweightPremature death
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