2024
Maternal Prenatal Social Disadvantage and Neonatal Functional Connectivity: Associations With Psychopathology Symptoms at Age 12 Months
Herzberg M, Nielsen A, Brady R, Kaplan S, Alexopoulos D, Meyer D, Arora J, Miller J, Smyser T, Barch D, Rogers C, Warner B, Smyser C, Luby J. Maternal Prenatal Social Disadvantage and Neonatal Functional Connectivity: Associations With Psychopathology Symptoms at Age 12 Months. Developmental Psychology 2024, 60: 1562-1579. PMID: 38386382, PMCID: PMC11869658, DOI: 10.1037/dev0001708.Peer-Reviewed Original ResearchConceptsFunctional connectivityNeonatal functional connectivityRight amygdalaInfant-Toddler Social and Emotional AssessmentInfant brain functionSocioeconomically diverse sampleMotor-related regionsInfant neurobehavioral outcomesEffect of socioeconomic statusPsychopathological symptomsInfant externalizingInternalizing symptomsExternalizing symptomsNeonatal amygdalaBrain structuresInternalizing behaviorsBrain functionSocial disadvantageDiverse sampleAmygdalaInfant-ToddlerEmotional AssessmentNeurobehavioral developmentNeurobehavioral outcomesMagnetic resonance imaging98 The Crosstalk between Mitochondrial Dysfunction and Neurodevelopmental Outcomes in Preterm Infants with Pain/Stress in the NICU
Zhao T, Chang X, Biswas S, Balsbaugh J, Liddle J, Chen M, Matson A, Cong X. 98 The Crosstalk between Mitochondrial Dysfunction and Neurodevelopmental Outcomes in Preterm Infants with Pain/Stress in the NICU. Journal Of Clinical And Translational Science 2024, 8: 27-27. PMCID: PMC11023861, DOI: 10.1017/cts.2024.96.Peer-Reviewed Original ResearchNICU Network Neurobehavioral ScalePreterm premature rupture of membranesPost-menstrual agePreterm infantsNeurodevelopmental outcomesNeurobehavioral outcomesAssociated with neurobehavioral outcomesNNNS summary scoresPremature rupture of membranesWeeks post-menstrual ageAssociated with neurodevelopmental outcomesPreterm premature ruptureRupture of membranesAssociated with protein levelsProspective cohort studyMitochondrial dysfunctionNICU hospitalizationNeurobehavioral ScaleClinical characteristicsPretermEpithelial barrierCohort studyReceptor binding activityNICUInfantsPain/Stress, Mitochondrial Dysfunction, and Neurodevelopment in Preterm Infants
Zhao T, Chang X, Biswas S, Balsbaugh J, Liddle J, Chen M, Matson A, Alder N, Cong X. Pain/Stress, Mitochondrial Dysfunction, and Neurodevelopment in Preterm Infants. Developmental Neuroscience 2024, 46: 341-352. PMID: 38286121, PMCID: PMC11284246, DOI: 10.1159/000536509.Peer-Reviewed Original ResearchNeonatal intensive care unitPreterm premature rupture of membranesNICU Network Neurobehavioral ScalePost-menstrual ageNeurodevelopmental outcomesPreterm infantsNeurobehavioral outcomesNeonatal Intensive Care Unit Network Neurobehavioral ScaleNeonatal intensive care unit hospitalizationPremature rupture of membranesWeeks post-menstrual agePreterm premature ruptureRupture of membranesAssociated with neurobehavioral outcomesAssociated with protein levelsAdverse neurodevelopmental outcomesBuccal swabsOptimal neurodevelopmental outcomesProspective cohort studyIntensive care unitEvaluate protein expression levelsNeurobehavioral ScaleClinical characteristicsPretermMitochondrial function-related proteins
2023
The Impact of Early Life Experiences and Gut Microbiota on Neurobehavioral Development in Preterm Infants: A Longitudinal Cohort Study
Chen J, Li H, Zhao T, Chen K, Chen M, Sun Z, Xu W, Maas K, Lester B, Cong X. The Impact of Early Life Experiences and Gut Microbiota on Neurobehavioral Development in Preterm Infants: A Longitudinal Cohort Study. Microorganisms 2023, 11: 814. PMID: 36985387, PMCID: PMC10056840, DOI: 10.3390/microorganisms11030814.Peer-Reviewed Original ResearchNeonatal intensive care unitNeonatal neurobehavioral scaleNeonatal intensive care unit hospitalizationOperational taxonomic unitsPreterm infantsPost-menstrual ageNeurobehavioral developmentGut microbiotaNeonatal intensive care unit admissionWeeks of post-menstrual ageFifty-five infantsDaily stool samplesIntensive care unitLongitudinal cohort studyImpact of early life experiencesNeurobehavioral ScalePretermPostnatal dayClinical featuresCohort studyEarly life experiencesStool samplesCare unitNeurobehavioral outcomesInfants
2022
Developmental Milestones of Infancy and Associations with Later Childhood Neurodevelopmental Outcomes in the Adolescent Brain Cognitive Development (ABCD) Study
Zhuo H, Xiao J, Tseng WL, Liew Z. Developmental Milestones of Infancy and Associations with Later Childhood Neurodevelopmental Outcomes in the Adolescent Brain Cognitive Development (ABCD) Study. Children 2022, 9: 1424. PMID: 36291360, PMCID: PMC9600325, DOI: 10.3390/children9101424.Peer-Reviewed Original ResearchAdolescent Brain Cognitive Development (ABCD) studyCognitive Development StudyNeurocognitive functionLanguage milestonesBehavioral problemsDevelopmental milestonesBrief Problem MonitorBiological mothersPoorer neurocognitive functionNeurobehavioral outcomesDevelopment studiesNIH ToolboxFirst wordBehavioral outcomesDiverse sampleLinear mixed effects modelsLater neurodevelopmental outcomeMixed effects modelsChildrenNeurodevelopmental outcomesWorse neurocognitive functionChildhood neurodevelopmental outcomesInfancyResearch assistantsPercentile of ageEarly-life factors associated with neurobehavioral outcomes in preterm infants during NICU hospitalization
Zhao T, Griffith T, Zhang Y, Li H, Hussain N, Lester B, Cong X. Early-life factors associated with neurobehavioral outcomes in preterm infants during NICU hospitalization. Pediatric Research 2022, 92: 1695-1704. PMID: 35338349, PMCID: PMC9509490, DOI: 10.1038/s41390-022-02021-y.Peer-Reviewed Original ResearchConceptsNeonatal Infant Stressor ScalePreterm infantsNeurobehavioral outcomesBreastmilk intakeGestational ageNICU hospitalizationMaternal breastmilkAssociated with increasing GADay of NICU hospitalizationWeeks post-menstrual ageNICU Network Neurobehavioral ScalePoorer quality of movementOlder gestational agePost-menstrual ageMethodsA prospective cohort studyNISS scoresInfant neurobehavioral outcomesProspective cohort studyDays of lifeConclusionsPreterm infantsGA infantsYounger GAPain/stressNeurobehavioral ScalePreterm
2020
Log-contrast regression with functional compositional predictors: Linking preterm infants’ gut microbiome trajectories to neurobehavioral outcome
Sun Z, Xu W, Cong X, Li G, Chen K. Log-contrast regression with functional compositional predictors: Linking preterm infants’ gut microbiome trajectories to neurobehavioral outcome. The Annals Of Applied Statistics 2020, 14: 1535-1556. PMID: 34163544, PMCID: PMC8218926, DOI: 10.1214/20-aoas1357.Peer-Reviewed Original ResearchNeonatal intensive care unitPreterm infantsNeurobehavioral outcomesPreterm infant studyWeeks of post-menstrual ageVery preterm neonatesPost-menstrual ageIntensive care unitInfant studiesMicrobiome markersIdentified microbiome markersStressful early life experiencesBrain-gut axisPreterm neonatesPostnatal ageInfant fecal samplesPretermInfant neurodevelopmentInfant's first monthCare unitPostnatal stagesInfantsGut microbiome compositionEstimated time dynamicsFirst month
2017
The impact of cumulative pain/stress on neurobehavioral development of preterm infants in the NICU
Cong X, Wu J, Vittner D, Xu W, Hussain N, Galvin S, Fitzsimons M, McGrath J, Henderson W. The impact of cumulative pain/stress on neurobehavioral development of preterm infants in the NICU. Early Human Development 2017, 108: 9-16. PMID: 28343092, PMCID: PMC5444300, DOI: 10.1016/j.earlhumdev.2017.03.003.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitPreterm infantsNeurobehavioral outcomesNeurobehavioral development of preterm infantsOutcomes of preterm infantsDevelopment of preterm infantsSkin-to-skin holdingVulnerable preterm infantsIntensive care unitProspective exploratory studyInfant developmental outcomesNeurodevelopmental outcomesAltered neurodevelopmentNeurobehavioral developmentCare unitNeuroprotective strategiesInfantsAssociated with habituationAcute eventPretermEarly lifeOutcomesNeurodevelopmentDevelopmental outcomesCumulative timeFKBP5 genotype and early life stress exposure predict neurobehavioral outcomes for preterm infants
D'Agata A, Walsh S, Vittner D, Cong X, McGrath J, Young E. FKBP5 genotype and early life stress exposure predict neurobehavioral outcomes for preterm infants. Developmental Psychobiology 2017, 59: 410-418. PMID: 28247564, DOI: 10.1002/dev.21507.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitNeurobehavioral outcomesNeonatal intensive care unit stressNeonatal intensive care unit careFKBP5 genotypeIntensive care unitEarly life stress exposureStress response-associated genesGenetic susceptibility to stressInfant neurobehavioral developmentPreterm infantsImpact of genetic variationNeurodevelopmental impairmentResponse-associated genesLife stress exposureNeurobehavioral developmentCare unitEnvironmental risk factorsRisk factorsInfant problemsAssociated with neurobehavioral outcomesStatistical analysisPretermSusceptibility to stressStress exposure
2011
Characteristics of an Explosive Blast-Induced Brain Injury in an Experimental Model
de Lanerolle NC, Bandak F, Kang D, Li AY, Du F, Swauger P, Parks S, Ling G, Kim JH. Characteristics of an Explosive Blast-Induced Brain Injury in an Experimental Model. Journal Of Neuropathology & Experimental Neurology 2011, 70: 1046-1057. PMID: 22002430, DOI: 10.1097/nen.0b013e318235bef2.Peer-Reviewed Original ResearchConceptsBrain injuryAxonal injuryΒ-amyloid precursor protein immunohistochemistryAnesthetized Yorkshire swineBlast-Induced Brain InjuryMild traumatic brain injuryPrecursor protein immunohistochemistryTraumatic brain injuryBlast injury modelAstrocyte activationNeuronal injuryNeuropathologic changesIntracranial hemorrhageNeuropathologic consequencesProtein immunohistochemistryHistologic changesNeurobehavioral outcomesInjury modelPathologic changesSham controlsMood disordersInjuryYorkshire swineExperimental modelHuman brain
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