2023
Clinical and cost implications of deferred testing in low-risk patients with stable chest pain: a simulation using the PROMISE trial
Nanna M, Yow E, Vemulapalli S, Mark D, Kelsey M, Patel M, Al-Khalidi H, Rogers C, Udelson J, Douglas P. Clinical and cost implications of deferred testing in low-risk patients with stable chest pain: a simulation using the PROMISE trial. American Heart Journal 2023, 261: 124-126. PMID: 36828202, PMCID: PMC10903188, DOI: 10.1016/j.ahj.2023.02.010.Peer-Reviewed Original Research
2022
Are risk factors necessary for pretest probability assessment of coronary artery disease? A patient similarity network analysis of the PROMISE trial
Kolossváry M, Mayrhofer T, Ferencik M, Karády J, Pagidipati NJ, Shah SH, Nanna MG, Foldyna B, Douglas PS, Hoffmann U, Lu MT. Are risk factors necessary for pretest probability assessment of coronary artery disease? A patient similarity network analysis of the PROMISE trial. Journal Of Cardiovascular Computed Tomography 2022, 16: 397-403. PMID: 35393245, PMCID: PMC9452442, DOI: 10.1016/j.jcct.2022.03.006.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseCoronary CT angiographyCalcium scoreRisk factorsLuminal narrowingPTP scoreArtery diseasePatient characteristicsPROMISE trialStable chest pain patientsObstructive coronary artery diseasePretest probability assessmentChest pain patientsSimilar risk profilesCT angiographyImaging markerRisk profileDiagnostic accuracyCAD predictionSex groupsProbability calculatorScoresSubanalysesDiseaseGroup individuals
2021
A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST)
Oikonomou EK, Van Dijk D, Parise H, Suchard MA, de Lemos J, Antoniades C, Velazquez EJ, Miller EJ, Khera R. A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST). European Heart Journal 2021, 42: 2536-2548. PMID: 33881513, PMCID: PMC8488385, DOI: 10.1093/eurheartj/ehab223.Peer-Reviewed Original ResearchConceptsStable chest painChest painPrimary endpointMajor adverse cardiovascular eventsNon-fatal myocardial infarctionAdverse cardiovascular eventsStudy's primary endpointCoronary artery diseaseClinical trial populationsCox regression modelParticipant-level dataSCOT-HEARTCardiovascular eventsCause mortalityHazard ratioPatients 5Artery diseaseFunctional testingPROMISE trialTrial populationMyocardial infarctionLower incidenceStudy populationPainCollected variables
2017
Safety of coronary CT angiography and functional testing for stable chest pain in the PROMISE trial: A randomized comparison of test complications, incidental findings, and radiation dose
Lu MT, Douglas PS, Udelson JE, Adami E, Ghoshhajra BB, Picard MH, Roberts R, Lee KL, Einstein AJ, Mark DB, Velazquez EJ, Carter W, Ridner M, Al-Khalidi HR, Hoffmann U. Safety of coronary CT angiography and functional testing for stable chest pain in the PROMISE trial: A randomized comparison of test complications, incidental findings, and radiation dose. Journal Of Cardiovascular Computed Tomography 2017, 11: 373-382. PMID: 28838846, PMCID: PMC6201309, DOI: 10.1016/j.jcct.2017.08.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina PectorisComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary StenosisEchocardiography, StressFemaleHumansIncidental FindingsMaleMiddle AgedMultidetector Computed TomographyNorth AmericaPredictive Value of TestsProspective StudiesRadiation DosageRadiation ExposureRadionuclide ImagingRisk AssessmentRisk FactorsConceptsStable chest painMore incidental findingsIncidental findingLow radiation doseChest painPatient characteristicsRadiation doseNuclear stress testingCoronary CT angiographyRadiation dose variesCumulative radiation doseAdvanced CT scannersMinor complicationsPROMISE trialRandomized comparisonTomography angiographyFunctional testingTest choiceFunctional testing strategyCT angiographyNuclear stressPulmonary nodulesSimilar outcomesComplicationsDose
2014
PROspective Multicenter Imaging Study for Evaluation of chest pain: Rationale and design of the PROMISE trial
Douglas PS, Hoffmann U, Lee KL, Mark DB, Al-Khalidi HR, Anstrom K, Dolor RJ, Kosinski A, Krucoff MW, Mudrick DW, Patel MR, Picard MH, Udelson JE, Velazquez EJ, Cooper L, investigators P. PROspective Multicenter Imaging Study for Evaluation of chest pain: Rationale and design of the PROMISE trial. American Heart Journal 2014, 167: 796-803.e1. PMID: 24890527, PMCID: PMC4044617, DOI: 10.1016/j.ahj.2014.03.003.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePROMISE trialAnatomical testingProspective Multicenter Imaging StudyDiagnostic strategiesInitial diagnostic strategyMajor procedural complicationsSubsequent care decisionsComposite of deathPrimary end pointLarge pragmatic trialClinical care teamQuality of lifeDiagnostic testing strategiesMultidetector coronaryChest painSymptomatic patientsUnstable anginaArtery diseaseProcedural complicationsRandomized trialsSymptomatic subjectsClinical effectivenessMyocardial infarctionPragmatic trial
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