2023
Temperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions
Beekman R, Khosla A, Buckley R, Honiden S, Gilmore E. Temperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions. Journal Of Intensive Care Medicine 2023, 39: 611-622. PMID: 37787185, DOI: 10.1177/08850666231203596.Peer-Reviewed Original ResearchHypoxic-ischemic brain injuryCardiac arrestPopulation-based thresholdsDuration of therapyCardiac arrest survivorsCause of deathRobust preclinical evidencePatient-centered careCritical future stepNeurologic outcomeNeuroprotective therapiesPreclinical evidenceArrest survivorsClinical equipoiseBrain injuryCurrent guidelinesFever preventionIndividualized targetOnly interventionTherapeutic windowInsufficient evidenceResearch prioritiesPersonalized approachMetabolic demandsCore temperatureTowards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs
Roseberry K, Le-Niculescu H, Levey D, Bhagar R, Soe K, Rogers J, Palkowitz S, Pina N, Anastasiadis W, Gill S, Kurian S, Shekhar A, Niculescu A. Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. Molecular Psychiatry 2023, 28: 2894-2912. PMID: 36878964, PMCID: PMC10615756, DOI: 10.1038/s41380-023-01998-0.Peer-Reviewed Original ResearchConceptsIndependent cohortCandidate biomarkersPsychiatric subjectsPersonalized approachConvergent functional genomics approachAnxiety disordersBest overall evidenceAdverse life eventsClinical worseningGene expression signaturesBlood biomarkersAnxiety medicationClinical utilityPsychiatric disordersHigh anxiety stateSevere anxietyUntreated anxietyDecrease qualityIndividual biomarkersAddiction potentialBiomarkersTop biomarkersAnxiety statesRisk predictionExpression signatures
2022
Limited evidence for graft selection in pediatric ACL reconstruction: a narrative review
De Petrillo G, Pauyo T, Franklin C, Chafetz R, Nault M, Veilleux L. Limited evidence for graft selection in pediatric ACL reconstruction: a narrative review. Journal Of Experimental Orthopaedics 2022, 9: 9. PMID: 35028782, PMCID: PMC8758832, DOI: 10.1186/s40634-022-00448-0.Peer-Reviewed Original ResearchAnterior cruciate ligament injuryGraft selectionCruciate ligament injuryEfficient return to sportsLigament injuriesAnterior cruciate ligament reconstructionSkeletally Immature PatientsPediatric ACL reconstructionReturn to sportCruciate ligament reconstructionKnee flexor/extensor strengthImmature patientsBone maturationACL reconstructionLigament reconstructionPatient recoveryPatientsNarrative reviewGraftLigament strengthPersonalized approachAnatomical characteristicsInjury
2021
Post-9/11 Veterans’ Heart Disease Knowledge, Self-Perceived Risk, and Prevention Beliefs and Behaviors
Gaffey AE, Haskell SG, Brandt CA, Bastian LA, Meadows JL, Burg MM. Post-9/11 Veterans’ Heart Disease Knowledge, Self-Perceived Risk, and Prevention Beliefs and Behaviors. Health Psychology 2021, 40: 737-746. PMID: 34780203, PMCID: PMC10691753, DOI: 10.1037/hea0001110.Peer-Reviewed Original ResearchConceptsSelf-perceived riskHeart diseasePrevention beliefsExact testHeart disease risk factorsPrevention behaviorsNontraditional factorsHeart disease awarenessDisease risk factorsHeart disease riskDisease-related knowledgeHeart disease knowledgeFisher's exact testMental health treatmentPost-9/11 veteransRisk factorsDisease awarenessDisease knowledgeWomen veteransPrevention strategiesHealth treatmentDisease riskGreater riskPersonalized approachDiseaseA personalized approach empowering successful aging: Patient perspective on fall prevention education
Collins C, Schultz K, Mathew P, Chandra A, Nguyen B, Chen T, Renshaw S, Rose K, Santry H. A personalized approach empowering successful aging: Patient perspective on fall prevention education. PM&R 2021, 14: 786-792. PMID: 34181824, DOI: 10.1002/pmrj.12663.Peer-Reviewed Original ResearchConceptsFall prevention educationHistory of fallsFall educationPrevention educationPatient's perspectivePersonalized approachOlder adultsOutpatient geriatric servicesTertiary care centerProspective qualitative studyInpatient traumaNonfatal traumaOne-hour faceMajority of participantsCare centerCare teamCommon causeGeriatric servicesMAIN OUTCOMEHealthy agingParticipants' historyFatal injuriesAdultsParticipant familiesTraumaRole of Biliary Organoids in Cholestasis Research and Regenerative Medicine
Soroka CJ, Roberts SJ, Boyer JL, Assis DN. Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine. Seminars In Liver Disease 2021, 41: 206-212. PMID: 33957696, DOI: 10.1055/s-0041-1728663.Peer-Reviewed Original ResearchConceptsHuman cholestatic diseasesCholestatic diseaseBiliary organoidsStudy of pathophysiologyCholestasis ResearchBiliary treeDisease stageIndividual patientsTranslational studiesPrimary cholangiocytesPersonalized approachBiliary tissueApplication of organoidsStandardization of terminologyTranslational medicineDiseaseOrganoidsMedicineOrganoid technologyPatientsPathophysiology
2020
Decision analysis and personalized clinical tool for cerebrospinal fluid drains in thoracoabdominal aortic aneurysms repair
Tam DY, Khan FM, Robinson NB, Hameed I, Rong LQ, Fremes SE, Girardi LN, Gaudino M. Decision analysis and personalized clinical tool for cerebrospinal fluid drains in thoracoabdominal aortic aneurysms repair. Journal Of Cardiac Surgery 2020, 36: 171-175. PMID: 33135254, DOI: 10.1111/jocs.15162.Peer-Reviewed Original ResearchConceptsCSF drainTAAA repairThoracoabdominal aneurysmsOperative repairDrain insertionLife expectancyThoracoabdominal aortic aneurysm repairRoutine useCSF drain placementSpinal cord ischemiaAortic aneurysm repairCerebrospinal fluid drainsCerebrospinal fluid drainageState-transition cohort modelCord ischemiaEpidural hematomaAneurysm repairSubarachnoid hemorrhageDrain placementFluid drainageClinical toolPersonalized approachPatientsFluid drainsCohort model
2019
Phenotypic Subtypes of OSA A Challenge and Opportunity for Precision Medicine
Zinchuk A, Yaggi HK. Phenotypic Subtypes of OSA A Challenge and Opportunity for Precision Medicine. CHEST Journal 2019, 157: 403-420. PMID: 31539538, PMCID: PMC7005379, DOI: 10.1016/j.chest.2019.09.002.BooksConceptsPhenotypic subtypesImpact of CPAPManagement of OSAApnea-hypopnea indexHealth-related qualitySeverity of OSASubtypes of patientsPrecision medicineSymptom-based subtypesPhenotype reproducibilitySleep apneaClinical manifestationsPathophysiological causesDisturbed sleepRisk factorsCardiovascular diseaseTreatment approachesPatient's lifeRelevant outcomesPersonalized approachCPAPSubtypesOSAPotential rolePatients
2018
Latent typologies of DSM-5 PTSD symptoms in U.S. military veterans
Byrne SP, Harpaz-Rotem I, Tsai J, Southwick SM, Pietrzak RH. Latent typologies of DSM-5 PTSD symptoms in U.S. military veterans. Psychiatry Research 2018, 273: 266-273. PMID: 30658212, DOI: 10.1016/j.psychres.2018.12.094.Peer-Reviewed Original ResearchConceptsHigh symptom classPosttraumatic stress disorderSymptom classUse disordersLifetime historyDSM-5 PTSD symptomsPTSD symptomsLatent class analysisDrug use disordersNicotine use disorderDSM-5 posttraumatic stress disorderDSM-5 criteriaU.S. military veteransMajor depressiveCognitive impairmentU.S. veteransSymptomsPersonalized approachHigher symptomsStress disorderGeneralized anxietyMilitary veteransThree-class solutionDisordersVeteransPersonalized ovarian stimulation for assisted reproductive technology: study design considerations to move from hype to added value for patients
Mol BW, Bossuyt PM, Sunkara SK, Velasco J, Venetis C, Sakkas D, Lundin K, Simón C, Taylor HS, Wan R, Longobardi S, Cottell E, D'Hooghe T. Personalized ovarian stimulation for assisted reproductive technology: study design considerations to move from hype to added value for patients. Fertility And Sterility 2018, 109: 968-979. PMID: 29935655, DOI: 10.1016/j.fertnstert.2018.04.037.Peer-Reviewed Original ResearchConceptsPersonalized approachObservational studyTrial designSingle-arm observational studyReproductive technology treatmentSame study protocolLarge observational studiesBenefit-harm balanceOvarian stimulationMonocenter studyOnly patientsRelevant study designsRandomized trialsMulticenter studyStudy protocolRetrospective analysisAverage patientCurrent evidenceMedical treatmentTreatment aspectsPatient careTechnology treatmentPatientsStudy designReproductive medicine
2017
Precision medicine for suicidality: from universality to subtypes and personalization
Niculescu A, Le-Niculescu H, Levey D, Phalen P, Dainton H, Roseberry K, Niculescu E, Niezer J, Williams A, Graham D, Jones T, Venugopal V, Ballew A, Yard M, Gelbart T, Kurian S, Shekhar A, Schork N, Sandusky G, Salomon D. Precision medicine for suicidality: from universality to subtypes and personalization. Molecular Psychiatry 2017, 22: 1250-1273. PMID: 28809398, PMCID: PMC5582166, DOI: 10.1038/mp.2017.128.Peer-Reviewed Original ResearchConceptsSuicidal ideationIndependent cohortPersonalized approachFuture hospitalizationPsychiatric diagnosisCandidate biomarkersUniversal biomarkerBlood gene expression biomarkersBiology of suicideTop biomarkersNovel predictive biomarkerHigh-risk groupNon-psychiatric disordersDrug repurposing analysisPublic health problemMonitoring of responseNovel potential therapeuticsHigher suicidal ideationPredictive biomarkersClinical trialsComprehensive stepwise approachRisk groupsLarge cohortMood disordersPreventive therapeutics
2016
Individual variation in functional brain connectivity: implications for personalized approaches to psychiatric disease
Finn E, Constable R. Individual variation in functional brain connectivity: implications for personalized approaches to psychiatric disease. Dialogues In Clinical Neuroscience 2016, 18: 277-287. PMID: 27757062, PMCID: PMC5067145, DOI: 10.31887/dcns.2016.18.3/efinn.Peer-Reviewed Original ResearchConceptsFunctional brain connectivityFunctional magnetic resonance imagingFunctional brain connectionsBrain connectivityMagnetic resonance imagingFunctional connectivity profilesPsychiatric illnessHealthy subjectsFuture illnessPsychiatric diagnosisPsychiatric diseasesMental illnessResonance imagingSingle-subject levelInterindividual variabilityPersonalized approachFunctional connectivityBrain connectionsIllnessConnectivity profilesRecent evidenceReliable correlateBehavioral phenotypesNeural organizationSubjects
2015
Personalized Approaches to Gastrointestinal Cancers Importance of Integrating Genomic Information to Guide Therapy
He J, Ahuja N. Personalized Approaches to Gastrointestinal Cancers Importance of Integrating Genomic Information to Guide Therapy. 2015, 95: 1081-1094. PMID: 26315525, DOI: 10.1016/j.suc.2015.05.002.Peer-Reviewed Original ResearchConceptsGenetic testingPersonalized approachHigh-risk family membersCancer prevention strategiesComplex tumor heterogeneityTherapeutic decision makingProphylactic surgeryClinical trialsPrevention strategiesCancer behaviorGermline mutationsSuch personalized approachesTumor heterogeneityPatientsTherapyFamily membersBiopsySurgeryCancerCliniciansDifferent groupsTrialsAsthme de l’adulte : quelques actualités sur les évolutions à venir
Justet A, Pradère P, Taillé C. Asthme de l’adulte : quelques actualités sur les évolutions à venir. Revue Des Maladies Respiratoires 2015, 32: 629-638. PMID: 26163989, DOI: 10.1016/j.rmr.2015.01.002.Peer-Reviewed Original ResearchConceptsSevere asthmaMurine models of obesitySubgroup of asthmaticsModels of obesityObese asthmaticsBiologic therapyLong-term managementTh2 activityTh2 cytokinesBronchial thermoplastyMurine modelIL-17IL-1Asthma treatmentInflammatory pathwaysTreatment pathwaysWeight lossAsthmaTherapyClinical researchAsthmaticsPersonalized approachTreatmentLong standing effectsTh2
2013
Identification of Novel Predictor Classifiers for Inflammatory Bowel Disease by Gene Expression Profiling
Montero-Meléndez T, Llor X, García-Planella E, Perretti M, Suárez A. Identification of Novel Predictor Classifiers for Inflammatory Bowel Disease by Gene Expression Profiling. PLOS ONE 2013, 8: e76235. PMID: 24155895, PMCID: PMC3796518, DOI: 10.1371/journal.pone.0076235.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseIBD patientsBowel diseaseGene expression profilingGlucocorticoid receptor degradationDegree of inflammationIntestinal inflammationPatients' qualityPinch biopsiesDifferential diagnosisImmune responseEffective treatmentSide effectsClinical practiceExpression profilingNew biomarkersMicroarray gene expression profilingPersonalized approachPatientsPersonalized therapyCurrent markersTranscriptional signatureInter-individual differencesGene expression profilesInflammationChk1/2 Inhibition Overcomes the Cisplatin Resistance of Head and Neck Cancer Cells Secondary to the Loss of Functional p53
Gadhikar MA, Sciuto MR, Alves MV, Pickering CR, Osman AA, Neskey DM, Zhao M, Fitzgerald AL, Myers JN, Frederick MJ. Chk1/2 Inhibition Overcomes the Cisplatin Resistance of Head and Neck Cancer Cells Secondary to the Loss of Functional p53. Molecular Cancer Therapeutics 2013, 12: 1860-1873. PMID: 23839309, PMCID: PMC3955083, DOI: 10.1158/1535-7163.mct-13-0157.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, Squamous CellCell Line, TumorCellular SenescenceCheckpoint Kinase 1Checkpoint Kinase 2CisplatinDNA DamageDrug Resistance, NeoplasmHead and Neck NeoplasmsHumansMitosisMolecular Targeted TherapyMutationProtein Kinase InhibitorsProtein KinasesSignal TransductionThiophenesTumor Suppressor Protein p53UreaConceptsHNSCC cellsCisplatin resistanceAdvanced stage squamous cell carcinomaStage squamous cell carcinomaSquamous cell carcinomaTreatment of HNSCCP53 mutant tumorsLoss of TP53Neck cancer cellsWild-type TP53Multimodality therapyStandard therapyTreatment failureCell carcinomaPreclinical dataHNSCC tumorsTherapeutic advantageTP53 mutationsP53 mutationsTargeted inhibitionPersonalized approachHNSCCP53-deficient cellsKinase inhibitorsSynthetic lethal manner
2012
Emerging personalized approaches for the management of advanced urothelial carcinoma
Tsao C, Gartrell B, Oh W, Galsky M. Emerging personalized approaches for the management of advanced urothelial carcinoma. Expert Review Of Anticancer Therapy 2012, 12: 1537-1543. PMID: 23253220, PMCID: PMC4744482, DOI: 10.1586/era.12.141.Peer-Reviewed Original ResearchConceptsUrothelial carcinomaManagement of advanced urothelial carcinomaManagement of urothelial carcinomaClinical stateAdvanced urothelial carcinomaTolerability of treatmentResponse to treatmentSpectrum of illnessAdvanced/metastatic diseaseOptimal treatmentCarcinomaUnique pathogenesisPersonalized managementPersonalized medicinePrognosisTreatmentStratified medicinePersonalized approachBladderPatientsPathogenesis
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