2024
Comparison of brain imaging and physical health between research and clinical neuroimaging cohorts of ageing
Mossa-Basha M, Andre J, Yuh E, Hunt D, LaPiana N, Howlett B, Krakauer C, Crane P, Nelson J, DeZelar M, Meyers K, Larson E, Ralston J, Mac Donald C. Comparison of brain imaging and physical health between research and clinical neuroimaging cohorts of ageing. British Journal Of Radiology 2024, 97: 614-621. PMID: 38303547, PMCID: PMC11027291, DOI: 10.1093/bjr/tqae004.Peer-Reviewed Original ResearchConceptsCommon data elementsMRI groupThought (ACTClinical health measuresResearch MRIAging populationWhite matter hyperintensityPrevalence of hypertensionBrain MRI measuresMRI scansNeuroimaging cohortMRI participantsAdult ChangesPhysical healthHealth measuresOverall healthOutcome measuresResearch cohortBrain imagingWMH burdenCongestive heart failureData elementsBrainMRI measurementsMRI metrics
2019
Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume
Spartano NL, Davis-Plourde KL, Himali JJ, Andersson C, Pase MP, Maillard P, DeCarli C, Murabito JM, Beiser AS, Vasan RS, Seshadri S. Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume. JAMA Network Open 2019, 2: e192745. PMID: 31002329, PMCID: PMC6481600, DOI: 10.1001/jamanetworkopen.2019.2745.Peer-Reviewed Original ResearchConceptsLight-intensity physical activityTotal brain volumeHigher total brain volumeMagnetic resonance imagingPA guidelinesPhysical activityBrain volumeBrain agingVigorous PA levelsCommunity-based cohort studyPA levelsBrain magnetic resonance imagingAssociation of accelerometerCurrent PA guidelinesBrain MRI measuresFramingham Heart Study participantsVigorous physical activityAdditional hourMost older adultsFramingham Heart StudyHigher brain volumesCohort studyDementia preventionDementia riskMean ageAssociation of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts
Weinstein G, Davis-Plourde KL, Conner S, Himali JJ, Beiser AS, Lee A, Rawlings AM, Sedaghat S, Ding J, Moshier E, van Duijn CM, Beeri MS, Selvin E, Ikram MA, Launer LJ, Haan MN, Seshadri S. Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts. PLOS ONE 2019, 14: e0212293. PMID: 30768625, PMCID: PMC6377188, DOI: 10.1371/journal.pone.0212293.Peer-Reviewed Original ResearchConceptsInsulin useMRI measuresDementia/AD riskCognitive functionAssociation of metforminGlycemic control propertiesNew-onset dementiaSacramento Area Latino StudyCox regression analysisBrain MRI measuresPopulation-based cohortRisk of dementiaAdverse cognitive outcomesLife style changesGlobal cognitive functionFramingham Heart StudySulfonylurea useDiabetes medicationsReykjavik StudyGlycemic dysregulationRenal functionGlycemic controlRotterdam StudyDementia riskIncident dementia
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