2025
401. Disentangling Neuropsychological Deficits and Circuit Dysfunctions in OCD: Abnormal Resting-State Functional Connectivity is Associated With Specific Deficits in Processes That Mediate Goal-Directed Behavioral Control
de Queiroz Vattimo E, Batistuzzo M, Cappi C, Shavitt R, Miguel E, Sato J, Hoexter M. 401. Disentangling Neuropsychological Deficits and Circuit Dysfunctions in OCD: Abnormal Resting-State Functional Connectivity is Associated With Specific Deficits in Processes That Mediate Goal-Directed Behavioral Control. Biological Psychiatry 2025, 97: s262-s263. DOI: 10.1016/j.biopsych.2025.02.639.Peer-Reviewed Original ResearchDiminished reward circuit response underlies pain avoidance learning deficits in problem drinkers
Le T, Oba T, Li C. Diminished reward circuit response underlies pain avoidance learning deficits in problem drinkers. NeuroImage Clinical 2025, 45: 103762. PMID: 40009903, PMCID: PMC11908557, DOI: 10.1016/j.nicl.2025.103762.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexAvoidance learningReward circuitDrinking severityReward deficiencyLearning deficitsPain avoidanceProblem drinkersAlcohol useAvoidance learning deficitMedial orbitofrontal cortexReward circuit dysfunctionVentral tegmental areaPoor avoidance learningAssociated with problem drinkingOrbitofrontal cortexTegmental areaGo/NoGo taskCingulate cortexNeural correlatesBehavioral findingsCircuit dysfunctionAdult drinkersBrain regionsNeural processes
2024
Association between the oral microbiome and brain resting state connectivity in schizophrenia
Lin D, Fu Z, Liu J, Perrone-Bizzozero N, Hutchison K, Bustillo J, Du Y, Pearlson G, Calhoun V. Association between the oral microbiome and brain resting state connectivity in schizophrenia. Schizophrenia Research 2024, 270: 392-402. PMID: 38986386, DOI: 10.1016/j.schres.2024.06.045.Peer-Reviewed Original ResearchOral microbiomeMicrobial speciesArea under curveResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingMicrobial 16S rRNA sequencingBrain circuit dysfunctionHealthy controlsBrain functional connectivity alterationsFunctional connectivity alterationsFunctional neuroimaging techniquesHypothalamic-pituitary-adrenal axisBrain functional connectivityFunctional network connectivityBrain functional activityBrain functional network connectivityHealthy control subjectsNeurotransmitter signaling pathwaysBeta diversityMicrobiome communitiesOral microbiome dysbiosisRRNA sequencingCircuit dysfunctionConnectivity alterationsSchizophreniaPersonalized brain circuit scores identify clinically distinct biotypes in depression and anxiety
Tozzi L, Zhang X, Pines A, Olmsted A, Zhai E, Anene E, Chesnut M, Holt-Gosselin B, Chang S, Stetz P, Ramirez C, Hack L, Korgaonkar M, Wintermark M, Gotlib I, Ma J, Williams L. Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety. Nature Medicine 2024, 30: 2076-2087. PMID: 38886626, PMCID: PMC11271415, DOI: 10.1038/s41591-024-03057-9.Peer-Reviewed Original ResearchBehavioral therapyFunctional magnetic resonance imaging protocolTask-free functional connectivityHeterogeneity of depressionBrain circuit dysfunctionResponse to pharmacotherapyTheoretical taxonomyAttentional circuitsNeurobiological dysfunctionBehavioral performanceCircuit dysfunctionCognitive tasksSubcortical regionsFunctional connectivityTask-freeAnxietyDepressionTheory-DrivenPharmacotherapyStratification of patientsMagnetic resonance imaging protocolScoresPsychiatryDysfunctionClinical careDeficient sleep, altered hypothalamic functional connectivity, depression and anxiety in cigarette smokers
Chen Y, Chaudhary S, Li G, Fucito L, Bi J, Li C. Deficient sleep, altered hypothalamic functional connectivity, depression and anxiety in cigarette smokers. Neuroimage Reports 2024, 4: 100200. PMID: 38605733, PMCID: PMC11008573, DOI: 10.1016/j.ynirp.2024.100200.Peer-Reviewed Original ResearchResting state functional connectivitySeverity of depressionPittsburgh Sleep Quality IndexMotivated behaviorNicotine dependenceFunctional connectivityPittsburgh Sleep Quality Index scoreAchenbach Adult Self-ReportSeverity of alcohol useAssociated with greater severityComorbid nicotine dependenceDeficient sleepAdult Self-ReportHypothalamic functional connectivityHuman Connectome ProjectAnxiety disordersAnxiety severityPublished routinesAnxiety symptomsCircuit dysfunctionGreater severityPsychiatric problemsSleep-wake cyclePoor sleep qualityNeural markers
2022
Emotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Emotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology. American Journal Of Alzheimer's Disease & Other Dementias® 2022, 37: 15333175221082834. PMID: 35357236, PMCID: PMC9212074, DOI: 10.1177/15333175221082834.Peer-Reviewed Original ResearchConceptsEmotional processing deficitsProcessing dysfunctionProcessing deficitsMultiple behavioral paradigmsEmotional memoryEmotional stimuliPositive emotionsAltered emotionsNegative emotionsNeural correlatesEmotional processing dysfunctionAmygdala reactivityBehavioral findingsEmotional disordersCognitive deficitsBehavioral paradigmsProminent deficitsEmotionsAlzheimer's diseaseBehavioral studiesLongitudinal studyNoradrenergic signalingDeficitsCircuit dysfunctionMemory
2021
Ucp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior
Yasumoto Y, Stoiljkovic M, Kim JD, Sestan-Pesa M, Gao XB, Diano S, Horvath TL. Ucp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior. Molecular Psychiatry 2021, 26: 2740-2752. PMID: 33879866, PMCID: PMC8056795, DOI: 10.1038/s41380-021-01105-1.Peer-Reviewed Original ResearchConceptsAnxiety-like behaviorReactive oxygen speciesMicroglia-synapse contactsSpine synapse numberHippocampal circuit functionNeuronal circuit dysfunctionMicroglial productionVentral hippocampusCircuit dysfunctionSpine synapsesSynapse numberAdult brainTransient riseMitochondrial ROS generationMicrogliaBrain functionConditional ablationPhagocytic inclusionsSynaptic elementsProtein 2ROS generationSignificant reductionCircuit functionConsequent accumulationOxygen speciesDevelopmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration
Nagy D, Ennis K, Wei R, Su S, Hinckley C, Gu R, Gao B, Massol R, Ehrenfels C, Jandreski L, Thomas A, Nelson A, Gyoneva S, Hajós M, Burkly L. Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2001679118. PMID: 33526652, PMCID: PMC8017933, DOI: 10.1073/pnas.2001679118.Peer-Reviewed Original ResearchConceptsTWEAK/Fn14Basal synaptic transmissionSynaptic functionNeuronal axisHippocampal slicesSynaptic transmissionAdult mouse hippocampal slicesTWEAK/Fn14 pathwayMature central nervous systemModels of strokeCentral nervous systemMouse hippocampal slicesNeural circuit developmentSynaptic deficitsSynaptic refinementCircuit dysfunctionMature brainTherapeutic targetMolecular mediatorsNervous systemSynaptic regulatorsNeurophysiological outcomesSynaptic physiologyNeurological disordersVisual development
2020
Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction
Zhang S, Zhornitsky S, Wang W, Le TM, Dhingra I, Chen Y, Li C. Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction. Addiction Biology 2020, 26: e12989. PMID: 33300238, PMCID: PMC8614224, DOI: 10.1111/adb.12989.Peer-Reviewed Original ResearchConceptsPeriaqueductal grayPain circuitsDrug useCocaine addictionFunctional connectivityPrefrontal cortical connectivityState functional connectivityReward circuit dysfunctionRecent cocaine useHealthy control participantsInferior parietal cortexCompulsive drug useHabitual drug useCircuit dysfunctionCocaine withdrawalCocaine-dependent individualsCocaine cravingCortical connectivitySignificant anxietyDorsomedial prefrontalParietal cortexCocaine useIntrinsic connectivitySubcortical hubsDrug seekingCue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving
Zhang S, Zhornitsky S, Wang W, Dhingra I, Le TM, Li CR. Cue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving. Drug And Alcohol Dependence 2020, 216: 108240. PMID: 32853997, PMCID: PMC7606798, DOI: 10.1016/j.drugalcdep.2020.108240.Peer-Reviewed Original ResearchConceptsPeriaqueductal grayPain circuitsHabitual drug useCocaine withdrawalCocaine cravingDrug useCue exposureNeutral cue exposureReward circuit dysfunctionCocaine Craving QuestionnaireCocaine cue exposureChronic cocaine useSex differencesCocaine-dependent participantsCircuit dysfunctionFemale CDVentromedial prefrontal cortexCocaine useCocaine addictionFunctional connectivityPrefrontal cortexDependent participantsWithdrawalHigher activationCocaine
2019
Integrating sleep, neuroimaging, and computational approaches for precision psychiatry
Goldstein-Piekarski AN, Holt-Gosselin B, O’Hora K, Williams LM. Integrating sleep, neuroimaging, and computational approaches for precision psychiatry. Neuropsychopharmacology 2019, 45: 192-204. PMID: 31426055, PMCID: PMC6879628, DOI: 10.1038/s41386-019-0483-8.Peer-Reviewed Original ResearchConceptsSleep impairmentAnxiety disordersBrain circuit dysfunctionPrecision psychiatryLarge-scale neural circuitsDefault mode networkMode networkAffective networkPoor sleep qualityExplanatory roleDistal featuresMood symptomsMoodNetwork dysfunctionSleep qualityNeural circuitsSleep disturbancesTestable frameworkCircuit dysfunctionImpairmentPersonalized tailoringDigital phenotypingFuture directionsMachine learning approachesCurrent diagnostic criteria
2017
Magnetoencephalography as a Tool in Psychiatric Research: Current Status and Perspective
Uhlhaas P, Liddle P, Linden D, Nobre A, Singh K, Gross J. Magnetoencephalography as a Tool in Psychiatric Research: Current Status and Perspective. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2017, 2: 235-244. PMID: 28424797, PMCID: PMC5387180, DOI: 10.1016/j.bpsc.2017.01.005.Peer-Reviewed Original ResearchPsychiatric researchAberrant rhythmic activityAbnormal brain dynamicsAutism spectrum disorderNeurobiological mechanismsPsychiatric conditionsCircuit dysfunctionNeuropsychiatric disordersNeuropsychiatric conditionsSpectrum disorderApplication of magnetoencephalographyNeural oscillationsBrain dynamicsMagnetoencephalographyNeuronal eventsPreclinical researchDisordersMEG signalsMillisecond resolutionDevelopment of biomarkersSchizophreniaPathophysiological mechanismsPsychiatricAutismTranslational research
2006
Hypersexuality following bilateral thalamic infarction: case report
Mutarelli EG, Omuro AM, Adoni T. Hypersexuality following bilateral thalamic infarction: case report. Arquivos De Neuro-Psiquiatria 2006, 64: 146-148. PMID: 16622574, DOI: 10.1590/s0004-282x2006000100032.Peer-Reviewed Original ResearchConceptsThalamic infarctionFrontal-subcortical circuit dysfunctionBilateral paramedian thalamic infarctionParamedian thalamic infarctionBilateral thalamic infarctionYear old manModerate memory lossThalamic modulationFrontal hypoperfusionCase reportCircuit dysfunctionBrain injuryNeuropsychological disturbancesOrbitofrontal circuitFrontal lobeInfarctionMemory lossFrontal functionSexual behaviorDysfunctionHypersexualityHypoperfusionHuman sexual behaviorHypersomniaHypothalamus
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