2025
214-OR: Increases in TUG Abundance and Expression Are a Feature of Insulin-Resistant Human Adipose Tissue
STROBER J, TER HORST K, SLUSHER A, PAULO J, GASSAWAY B, SHUKEN S, CAPRIO S, SERLIE M, BOGAN J, VATNER D. 214-OR: Increases in TUG Abundance and Expression Are a Feature of Insulin-Resistant Human Adipose Tissue. Diabetes 2025, 74 DOI: 10.2337/db25-214-or.Peer-Reviewed Original ResearchWhite adipose tissueHuman white adipose tissueInsulin signalingInsulin resistanceInsulin-stimulated Akt phosphorylationInsulin-responsive GLUT4Pathogenesis of metabolic diseasesTUG cleavageFructose-sweetened beveragesBariatric surgery cohortMetabolic diseasesCohort of patientsAdipose tissueProteomic analysisHuman IRGene expressionMolecular regulationPathway proteinsHyperinsulinemic euglycemic clampAkt phosphorylationSurgery cohortBariatric surgeryHuman adipose tissueNational Institutes of HealthTC10
2024
Single-nucleus multi-omics analyses reveal cellular and molecular innovations in the anterior cingulate cortex during primate evolution
Yuan J, Dong K, Wu H, Zeng X, Liu X, Liu Y, Dai J, Yin J, Chen Y, Guo Y, Luo W, Liu N, Sun Y, Zhang S, Su B. Single-nucleus multi-omics analyses reveal cellular and molecular innovations in the anterior cingulate cortex during primate evolution. Cell Genomics 2024, 4: 100703. PMID: 39631404, PMCID: PMC11701334, DOI: 10.1016/j.xgen.2024.100703.Peer-Reviewed Original ResearchConceptsChromatin accessibilitySingle-nucleusGene expressionTranscription factor bindingPatterns of gene expressionSingle-nucleus resolutionCell lineage originACC gene expressionPrimate evolutionMulti-omics analysisAnterior cingulate cortexFactor bindingEvolutionary roleFunctional innovationSequence changesMolecular innovationsVon Economo neuronsMolecular regulationMarker genesPublished mouse dataCell typesChromatinMolecular identityHuman originCingulate cortexLymphotoxin
Ruddle N. Lymphotoxin. 2024 DOI: 10.1016/b978-0-128-24465-4.00033-8.Peer-Reviewed Original Research
2023
Effects of short-term endurance and strength exercise in the molecular regulation of skeletal muscle in hyperinsulinemic and hyperglycemic Slc2a4+/− mice
Muñoz V, Botezelli J, Gaspar R, da Rocha A, Vieira R, Crisol B, Braga R, Severino M, Nakandakari S, Antunes G, Brunetto S, Ramos C, Velloso L, Simabuco F, de Moura L, da Silva A, Ropelle E, Cintra D, Pauli J. Effects of short-term endurance and strength exercise in the molecular regulation of skeletal muscle in hyperinsulinemic and hyperglycemic Slc2a4+/− mice. Cellular And Molecular Life Sciences 2023, 80: 122. PMID: 37052684, PMCID: PMC11072257, DOI: 10.1007/s00018-023-04771-2.Peer-Reviewed Original ResearchConceptsWhole-body glucose homeostasisSkeletal muscle glucose uptakeMuscle glucose uptakeMitochondrial adaptationsMitochondrial activityPost-translational mechanismsSkeletal muscleGlucose uptakeC2C12 cell lineInsulin resistanceStrength exercisesGlucose homeostasisMouse modelPhysical exerciseProtein response markersShort-term physical activityMolecular regulationTranscriptomic modulationRNA sequencingImpact of hyperglycemiaC2C12 cellsStrength exercise trainingType 2 diabetesStrength training protocolsMitochondrial function
2021
A transgenic system for targeted ablation of reproductive and maternal-effect genes
Bertho S, Kaufman O, Lee K, Santos-Ledo A, Dellal D, Marlow F. A transgenic system for targeted ablation of reproductive and maternal-effect genes. Development 2021, 148 PMID: 34143203, PMCID: PMC8254866, DOI: 10.1242/dev.198010.Peer-Reviewed Original ResearchConceptsMaternal-effect genesForward genetic screensReverse genetics systemEmbryonic developmentRegulation of embryonic developmentTransgenic systemZygotic functionGenetic systemGenetic screeningGene productsMolecular regulationGenesEarly embryosDevelopmental processesNormal embryogenesisLate functionMolecular pathwaysBucky ballEmbryosMutagenesisMolecular Evolution of CatSper in Mammals and Function of Sperm Hyperactivation in Gray Short-Tailed Opossum
Hwang JY, Maziarz J, Wagner GP, Chung JJ. Molecular Evolution of CatSper in Mammals and Function of Sperm Hyperactivation in Gray Short-Tailed Opossum. Cells 2021, 10: 1047. PMID: 33946695, PMCID: PMC8147001, DOI: 10.3390/cells10051047.Peer-Reviewed Original ResearchConceptsMolecular evolutionHigh sequence divergenceSperm-specific ion channelIQ-like motifSequence divergenceCatSper activityCatSper subunitsMolecular regulationFertilization environmentSperm hyperactivationCatSper proteinsAmerican marsupialsCatSper functionSequence analysisMarsupialsFemale reproductive tractGray Short-Tailed OpossumsEutheriansSperm flagellaCatSper channelsIon channelsCatSperCurrent understandingOpossumSperm
2020
Stac protein regulates release of neuropeptides
Hsu IU, Linsley JW, Zhang X, Varineau JE, Berkhoudt DA, Reid LE, Lum MC, Orzel AM, Leflein A, Xu H, Collins CA, Hume RI, Levitan ES, Kuwada JY. Stac protein regulates release of neuropeptides. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 29914-29924. PMID: 33168737, PMCID: PMC7703553, DOI: 10.1073/pnas.2009224117.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBehavior Observation TechniquesBehavior, AnimalCalcium ChannelsDrosophila melanogasterDrosophila ProteinsFemaleIntracellular Signaling Peptides and ProteinsIntravital MicroscopyLarvaMaleModels, AnimalMotor NeuronsMuscle, SkeletalNeuromuscular JunctionNeuropeptidesOptical ImagingPatch-Clamp TechniquesPresynaptic TerminalsConceptsSTAC proteinsRelease of neuropeptidesVertebrate skeletal muscleSubset of neuronsMolecular regulationGenetic manipulationKey regulatorMotor neuronsCytosolic CaNumerous neural functionsSmall familyCentral nervous systemExcitation-contraction couplingGenesSkeletal muscleL-type CaProteinNeuropeptide releaseNervous systemNeural functionDrosophilaNeuropeptidesVertebratesNeuronsRegulatorChapter 20 Phosphorus homeostasis and related disorders
Carpenter T, Bergwitz C, Insogna K. Chapter 20 Phosphorus homeostasis and related disorders. 2020, 469-507. DOI: 10.1016/b978-0-12-814841-9.00020-8.ChaptersEndocrine fibroblast growth factorsSupply of phosphateComplex regulatory systemMolecular regulationRegulatory signalsFibroblast growth factorIntricate mechanismsPhosphate transferRegulatory systemNovel targetBone biologyMammalian boneCritical roleDistinct classesGrowth factorSkeletal mineralizationCentral rolePhosphate metabolismPrincipal mediatorEndocrine organClasses of transportersPhosphorus homeostasisBiologyTransportersLocal milieu
2019
Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation
Wang N, Zheng J, Chen Z, Liu Y, Dura B, Kwak M, Xavier-Ferrucio J, Lu YC, Zhang M, Roden C, Cheng J, Krause DS, Ding Y, Fan R, Lu J. Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation. Nature Communications 2019, 10: 95. PMID: 30626865, PMCID: PMC6327095, DOI: 10.1038/s41467-018-07981-6.Peer-Reviewed Original ResearchConceptsSame single cellMicroRNA-mRNASingle cellsGenome-scale analysisNon-genetic cellNon-genetic heterogeneityMultiple omic profilesGenomic approachesMicroRNA regulationMolecular regulationTarget mRNAsExpression variabilityCellular pathwaysRegulatory relationshipsLevels of microRNAsIntercellular heterogeneityOmics profilesIntercellular variabilityCell heterogeneityMRNA profilesMicroRNAsMRNACellsRegulationExpression23 Cardiovascular Physiology Cellular and Molecular Regulation
Assaad S, Heerdt P, Crystal G. 23 Cardiovascular Physiology Cellular and Molecular Regulation. 2019, 456-472. DOI: 10.1016/b978-0-323-48110-6.00023-5.Chapters
2018
Molecular regulations and therapeutic targets of Gaucher disease
Chen Y, Sud N, Hettinghouse A, Liu C. Molecular regulations and therapeutic targets of Gaucher disease. Cytokine & Growth Factor Reviews 2018, 41: 65-74. PMID: 29699937, PMCID: PMC8108120, DOI: 10.1016/j.cytogfr.2018.04.003.Peer-Reviewed Original ResearchConceptsGaucher diseaseHeat shock proteinsProper foldingMolecular regulationActivity of GCaseLysosomal localizationShock proteinsCommon lysosomal storage diseaseLysosomal appearanceIon channelsCalcium ion channelsLysosomal accumulationSaposin CLysosomal storage diseaseSubstrate glucosylceramideInflammatory mediatorsProinflammatory moleculesNew targetsPathogenic mechanismsTherapeutic targetGCaseNovel moleculesSmall moleculesDiseaseStorage disease
2016
Chapter 1 Methods to study maternal regulation of germ cell specification in zebrafish
Kaufman O, Marlow F. Chapter 1 Methods to study maternal regulation of germ cell specification in zebrafish. Methods In Cell Biology 2016, 134: 1-32. PMID: 27312489, PMCID: PMC5039941, DOI: 10.1016/bs.mcb.2016.02.001.Peer-Reviewed Original ResearchConceptsGerm cell specificationGerm cell formationCell-specificGerm lineControl of maternal gene productsProcess of germ cell specificationMaternal gene productsGerm cell regulationGerm cell developmentLoss-of-function studiesZebrafish genomeManipulating genomesGenetic tractabilityGenetic regulationGenetic screeningGene productsCell formationMolecular biology techniquesExpression analysisCell developmentMolecular regulationCell regulationEarly embryosIn situ hybridizationGenetic models
2014
Reversal of Anchorage-Independent Multicellular Spheroid into a Monolayer Mimics a Metastatic Model
Kunjithapatham R, Karthikeyan S, Geschwind JF, Kieserman E, Lin M, Fu DX, Ganapathy-Kanniappan S. Reversal of Anchorage-Independent Multicellular Spheroid into a Monolayer Mimics a Metastatic Model. Scientific Reports 2014, 4: 6816. PMID: 25351825, PMCID: PMC4212233, DOI: 10.1038/srep06816.Peer-Reviewed Original ResearchConceptsMetastatic phenotypeAnchorage-independent growthMolecular regulationMulticellular spheroidsStem cell markersMolecular eventsCancer stem cell markersVitro modelModel of metastasisMetastatic processSpecific therapeutic targetsTherapeutic targetAntimetastatic agentPhenotypeMetastatic modelRegulationVivo dataExpressionChemoresistanceInvasivenessSpheroidsMajor impedimentInductionMimicsGrowthLymphatic vessels and tertiary lymphoid organs
Ruddle NH. Lymphatic vessels and tertiary lymphoid organs. Journal Of Clinical Investigation 2014, 124: 953-959. PMID: 24590281, PMCID: PMC3934190, DOI: 10.1172/jci71611.Peer-Reviewed Original Research
2013
An Extensive Network of TET2-Targeting MicroRNAs Regulates Malignant Hematopoiesis
Cheng J, Guo S, Chen S, Mastriano SJ, Liu C, D’Alessio A, Hysolli E, Guo Y, Yao H, Megyola CM, Li D, Liu J, Pan W, Roden CA, Zhou XL, Heydari K, Chen J, Park IH, Ding Y, Zhang Y, Lu J. An Extensive Network of TET2-Targeting MicroRNAs Regulates Malignant Hematopoiesis. Cell Reports 2013, 5: 471-481. PMID: 24120864, PMCID: PMC3834864, DOI: 10.1016/j.celrep.2013.08.050.Peer-Reviewed Original ResearchConceptsKey tumor suppressorMyeloid differentiation biasTET2 expressionTranslocation 2 (TET2) geneMolecular regulationDifferentiation biasHematopoietic malignanciesTen-ElevenMalignant hematopoiesisTumor suppressorHematopoietic expansionActivity screenMiR-7MiRNAsExpression of TET2Normal hematopoiesisOncogenic potentialTET2Important pathogenic mechanismMiR-101Extensive roleMiR-29cHematopoiesisExpressionRegulation
2011
Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b
Garg S, Sharma M, Ung C, Tuli A, Barral D, Hava D, Veerapen N, Besra G, Hacohen N, Brenner M. Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b. Immunity 2011, 35: 182-193. PMID: 21802320, PMCID: PMC3584282, DOI: 10.1016/j.immuni.2011.06.009.Peer-Reviewed Original ResearchMeSH KeywordsADP-Ribosylation FactorsAntigen PresentationAntigensAntigens, CD1dCytokinesCytotoxicity, ImmunologicHeLa CellsHumansLymphocyte ActivationLysosomesNatural Killer T-CellsProtein BindingProtein TransportProteolipidsrab GTP-Binding Proteinsrab7 GTP-Binding ProteinsRNA, Small InterferingVesicular Transport ProteinsConceptsHomotypic fusion and vacuole protein sortingGTPase Arl8bMicrobial killingVacuole protein sortingPhagosome-lysosome fusionCargo traffickingProtein sortingArl8bShRNA librarySilenced cellsLysosomal traffickingPlasma membraneMolecular regulationImmunological screeningHost defenseLysosomesTraffickingAntigen presentationT cell activationCargo deliveryRegulationKillingCell activationImmunological functionsEffector
2007
Infusion of a biotinylated bis-glucose photolabel: a new method to quantify cell surface GLUT4 in the intact mouse heart
Miller EJ, Li J, Sinusas KM, Holman GD, Young LH. Infusion of a biotinylated bis-glucose photolabel: a new method to quantify cell surface GLUT4 in the intact mouse heart. AJP Endocrinology And Metabolism 2007, 292: e1922-e1928. PMID: 17341550, DOI: 10.1152/ajpendo.00170.2006.Peer-Reviewed Original ResearchConceptsBio-LCCell surface GLUT4Glucose transporterSurface GLUT4Cell surface glucose transportersGlucose transporter contentCell surface GLUT1Glucose transporter GLUT4Intracellular storage vesiclesMouse heartsTransporter contentSpecific glucose transportersCell surface membraneGlucose uptakeCell surface contentMolecular regulationIntact mouse heartsGLUT4Cell surfaceStorage vesiclesGlucose transportMetabolic stressTransgenic mouse heartsSurface membraneTransporters
2004
Molecular Regulation of Müllerian Development by Hox Genes
DU H, TAYLOR HS. Molecular Regulation of Müllerian Development by Hox Genes. Annals Of The New York Academy Of Sciences 2004, 1034: 152-165. PMID: 15731308, DOI: 10.1196/annals.1335.018.Peer-Reviewed Original ResearchConceptsHox genesMolecular regulationCommon genetic systemConserved transcription factorHox gene expressionAspects of morphogenesisNormal embryonic developmentEmbryonic patterningGenetic systemTranscription factorsEmbryonic developmentDevelopmental processesGene expressionRegulatory moleculesCell differentiationGenesReproductive tract developmentAdult functionHOXA10 geneTract developmentEmbryonic periodReproductive tractRegulationMullerian tractMetazoans
2002
Engraftment and differentiation of human metanephroi into functional mature nephrons after transplantation into mice is accompanied by a profile of gene expression similar to normal human kidney development.
Dekel B, Amariglio N, Kaminski N, Schwartz A, Goshen E, Arditti FD, Tsarfaty I, Passwell JH, Reisner Y, Rechavi G. Engraftment and differentiation of human metanephroi into functional mature nephrons after transplantation into mice is accompanied by a profile of gene expression similar to normal human kidney development. Journal Of The American Society Of Nephrology 2002, 13: 977-990. PMID: 11912257, DOI: 10.1681/asn.v134977.Peer-Reviewed Original ResearchConceptsHuman kidney developmentKidney developmentNormal human kidney developmentSpecific genesGene expressionGlobal gene expression patternsGlobal gene expressionMature nephronsGene expression patternsCell cycle regulatorsExtracellular matrix moleculesResult of hybridizationMolecular regulationCDNA arraysEmbryonic precursorsExpression patternsCycle regulatorsExpression profilesGenesMatrix moleculesExpression levelsAdult kidneyGrowth factorMetanephroiDevelopment of strategies
2001
Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors.
Hines R, Luo Z, Cresteil T, Ding X, Prough R, Fitzpatrick J, Ripp S, Falkner K, Ge N, Levine A, Elferink C. Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors. Drug Metabolism And Disposition 2001, 29: 623-33. PMID: 11302926.Peer-Reviewed Original ResearchConceptsDevelopmental-specific expressionSignal transduction pathwaysMolecular regulationTransduction pathwaysCommon signal transduction pathwayReceptor-mediated signal transduction pathwaysRegulation of xenobioticGenome levelTranscription factorsMolecular mechanismsMolecular biologyEndogenous factorsGenesRegulatory systemXenobiotic-metabolizing enzymesEnzymeRegulationExpressionCytochrome P450Fundamental rolePathwayRapid proliferationTissueBiologyExperimental therapeutics
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