2024
Single-nucleus multi-omics analyses reveal cellular and molecular innovations in the anterior cingulate cortex during primate evolution
Yuan J, Dong K, Wu H, Zeng X, Liu X, Liu Y, Dai J, Yin J, Chen Y, Guo Y, Luo W, Liu N, Sun Y, Zhang S, Su B. Single-nucleus multi-omics analyses reveal cellular and molecular innovations in the anterior cingulate cortex during primate evolution. Cell Genomics 2024, 4: 100703. PMID: 39631404, PMCID: PMC11701334, DOI: 10.1016/j.xgen.2024.100703.Peer-Reviewed Original ResearchConceptsChromatin accessibilitySingle-nucleusGene expressionTranscription factor bindingPatterns of gene expressionSingle-nucleus resolutionCell lineage originACC gene expressionPrimate evolutionMulti-omics analysisAnterior cingulate cortexFactor bindingEvolutionary roleFunctional innovationSequence changesMolecular innovationsVon Economo neuronsMolecular regulationMarker genesPublished mouse dataCell typesChromatinMolecular identityHuman originCingulate cortex
2009
Contribution of individual histidines to the global stability of human prolactin
Keeler C, Tettamanzi MC, Meshack S, Hodsdon ME. Contribution of individual histidines to the global stability of human prolactin. Protein Science 2009, 18: 909-920. PMID: 19384991, PMCID: PMC2771294, DOI: 10.1002/pro.100.Peer-Reviewed Original ResearchConceptsIndividual histidineClosest evolutionary cousinsEvolutionary roleDouble mutant cyclesHomologous residuesEvolutionary cousinsNearby histidineExtracellular domainNative proteinTertiary structureStability of hGHNative stateMutant cyclesHuman growth hormoneHistidineStructural interactionsHuman prolactinResiduesPolypeptide hormonesPhysiologic pH rangeFunctional propertiesStructural locationAffinityProteinMutations
1997
Bilirubin, Rem Sleep, and Phototransduction of Environmental Time Cues. A Hypothesis
Oren D. Bilirubin, Rem Sleep, and Phototransduction of Environmental Time Cues. A Hypothesis. Chronobiology International 1997, 14: 319-329. PMID: 9167892, DOI: 10.3109/07420529709001423.Peer-Reviewed Original ResearchConceptsBiological clockEndogenous biological clockPlant phytochromesEvolutionary roleBiological clock systemEnvironmental time cuesDifferent speciesZeitgeber signalsClock systemVisual pigmentsHeme moietyCommon molecular structurePrimary effectPhototransductionBiological rhythmsPlantsPrevailing hypothesisPigmentsSimilar chromophoresTime cuesClockAnimalsPhytochromeSpeciesBile pigments
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply