2025
Chikungunya Fever and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
Amaral J, Schoen R, Weinblatt M, Cândido E. Chikungunya Fever and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Tropical Medicine And Infectious Disease 2025, 10: 54. PMID: 39998058, PMCID: PMC11861052, DOI: 10.3390/tropicalmed10020054.Peer-Reviewed Original ResearchChikungunya virus infectionRheumatoid arthritisChikungunya virusChikungunya feverChronic chikungunya arthritisRheumatology follow-upIncidence of RARisk of biasChikungunya arthritisAutoimmune mechanismsImmunological mechanismsFollow-upRA incidenceRA diagnosisDiagnostic criteriaRA developmentInfectionPRISMA guidelinesRe-emerging infectious diseasesLiterature searchDiagnostic biomarkersLong-term health impactsData extractionInfectious diseasesIncidence
2024
Correlation Between Pain, Disease Activity, and Rheumatoid Factor Positivity in Patients with Chikungunya Arthritis
Amaral J, Schoen R, Bingham C, Firmino P, Cândido E. Correlation Between Pain, Disease Activity, and Rheumatoid Factor Positivity in Patients with Chikungunya Arthritis. The Yale Journal Of Biology And Medicine 2024, 97: 417-422. PMID: 39703605, PMCID: PMC11650909, DOI: 10.59249/hgxw4816.Peer-Reviewed Original ResearchConceptsVisual analog scaleChikungunya arthritisDisease activityDAS28-ESRRheumatoid factorPain visual analog scaleChikungunya feverDisease Activity ScoreRheumatoid factor positivityDisease activity indexChikungunya virusSignificantly with disease activityAcute viral diseasePain intensityAnalog scaleRetrospective cohortPain riskProspective cohortFactor positivityImproved therapiesActivity scoreClinical evaluationJoint symptomsPainAcute phaseDetection of Chikungunya Virus RNA in Oral Fluid and Urine: An Alternative Approach to Diagnosis?
Jacob-Nascimento L, Portilho M, Anjos R, Moreira P, Stauber C, Weaver S, Kitron U, Reis M, Ribeiro G. Detection of Chikungunya Virus RNA in Oral Fluid and Urine: An Alternative Approach to Diagnosis? Viruses 2024, 16: 235. PMID: 38400011, PMCID: PMC10891727, DOI: 10.3390/v16020235.Peer-Reviewed Original ResearchConceptsChikungunya virus infectionAcute-phase seraOral fluidChikungunya virusIgM seroconversionChikungunya virus diagnosisUrine samplesAcute febrile illnessConvalescent-phase seraAcute chikungunyaChikungunya patientsChikungunya virus RNADisease courseFebrile illnessPaired seraRT-qPCRAcute phaseIgM detectionConvalescent-phasePatientsControl group samplesSerumUrineCHIKV transmissionIgMBone erosions and joint damage caused by chikungunya virus: a systematic review
Amaral J, Taylor P, Schoen R. Bone erosions and joint damage caused by chikungunya virus: a systematic review. Revista Da Sociedade Brasileira De Medicina Tropical 2024, 57: e00404-2024. PMID: 38597523, PMCID: PMC11000508, DOI: 10.1590/0037-8682-0433-2023.Peer-Reviewed Original ResearchConceptsChronic chikungunya arthritisChikungunya arthritisJoint damageRheumatoid arthritisJoint painDisease-modifying antirheumatic drug therapyBone erosionProgression of radiographic joint damageDisease-modifying antirheumatic drugsSystematic reviewAntirheumatic drug therapyAcute febrile illnessPersistent joint painSimilar to rheumatoid arthritisRadiographic joint damageChikungunya virusYears post-infectionChronic joint damagePrevent joint damageDisease-modifying therapiesJoint structural damageRheumatoid arthritis treatmentAntirheumatic drugsProspective studyChikungunya infection
2022
Pathogenesis of chronic chikungunya arthritis: Resemblances and links with rheumatoid arthritis
Amaral J, Bingham C, Taylor P, Vilá L, Weinblatt M, Schoen R. Pathogenesis of chronic chikungunya arthritis: Resemblances and links with rheumatoid arthritis. Travel Medicine And Infectious Disease 2022, 52: 102534. PMID: 36549417, DOI: 10.1016/j.tmaid.2022.102534.Peer-Reviewed Original ResearchConceptsChronic chikungunya arthritisMesenchymal stem cellsJoint painChikungunya virusReactivation of dormant virusesMorphologically similar to fibroblastsChikungunya feverEpigenetic changesChronic joint painAcute febrile illnessChikungunya virus infectionSimilar to fibroblastsMaculopapular rashChikungunya arthritisDormant virusesFebrile illnessLatent infectionMultipotent cellsStem cellsHeterogeneous groupRheumatoid arthritisPathogenic hypothesisGroup of multipotent cellsPainPatientsUBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by Maintaining Hematopoietic Homeostasis
Geng T, Yang D, Lin T, Cahoon J, Wang P. UBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by Maintaining Hematopoietic Homeostasis. MBio 2022, 13: e02687-22. PMID: 36377866, PMCID: PMC9765034, DOI: 10.1128/mbio.02687-22.Peer-Reviewed Original ResearchConceptsUbiquitin regulatory X domain-containing proteinDomain-containing proteinsDiverse cellular processesCell-intrinsic mannerCellular processesHematopoietic homeostasisPhysiological functionsRNA virus replicationEssential roleControl of infectionChikungunya virusHuman genomeArthritogenic alphavirusesImmune responseCHIKV replicationDNA virusesRNA virusesInnate immune responseVirus-specific immunoglobulin GO'nyong'nyong virusLong-term neurological disordersSignificant public health problemSerum cytokine levelsSpecific antiviral drugsHigh viral loadInteractions between seasonal temperature variation and temporal synchrony drive increased arbovirus co-infection incidence
Poterek ML, Vogels CBF, Grubaugh ND, Ebel GD, Perkins T, Cavany SM. Interactions between seasonal temperature variation and temporal synchrony drive increased arbovirus co-infection incidence. Royal Society Open Science 2022, 9: 220829. PMID: 36277835, PMCID: PMC9579765, DOI: 10.1098/rsos.220829.Peer-Reviewed Original ResearchInterleukin-17 Contributes to Chikungunya Virus-Induced Disease
Liu X, Poo YS, Alves JC, Almeida RP, Mostafavi H, Tang PCH, Bucala R, Teixeira MM, Taylor A, Zaid A, Mahalingam S. Interleukin-17 Contributes to Chikungunya Virus-Induced Disease. MBio 2022, 13: e00289-22. PMID: 35254128, PMCID: PMC9040832, DOI: 10.1128/mbio.00289-22.Peer-Reviewed Original ResearchConceptsIL-17Chikungunya virusCHIKV infectionRheumatoid arthritisIL-17-deficient miceIL-17A-deficient miceInterleukin-17 ContributesSpecific antiviral drugsWild-type miceIL-17 signalingAlphaviral arthritidesIL-17AIL-23Neutrophil infiltrationPsoriatic arthritisArthritic inflammationIL-21Acute phaseIL-22Interleukin-17Chronic phaseIL-6Tissue infiltratesTissue inflammationDisease patients
2021
Chikungunya: an emerging rheumatological pandemic?
Bilsborrow J, Amaral J, Schoen R. Chikungunya: an emerging rheumatological pandemic? Current Rheumatology Research 2021, 2: 12-17. PMID: 40444259, PMCID: PMC12120434, DOI: 10.46439/rheumatology.2.012.Peer-Reviewed Original ResearchChikungunya feverChikungunya virusAnti-rheumatic drugsChronic rheumatic diseasesMaculopapular rashRheumatic syndromesCausative pathogenIndian Ocean islandsGastrointestinal disturbancesRheumatic diseasesEndemic regionsAcute illnessOceanic islandsSARS-CoV-2Zika virusDecrease transmissionRNA alphavirusSpecies mosquitoesFeverRisk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
Silva M, Kikuti M, Anjos R, Portilho M, Santos V, Gonçalves T, Tauro L, Moreira P, Jacob-Nascimento L, Santana P, Campos G, Siqueira A, Kitron U, Reis M, Ribeiro G. Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil. International Journal Of Infectious Diseases 2021, 105: 608-616. PMID: 33684559, DOI: 10.1016/j.ijid.2021.03.003.Peer-Reviewed Original ResearchConceptsChronic arthralgiaChikungunya virus infectionRisk factorsVirus infectionDaily activitiesAcute febrile illnessIndependent risk factorPersistence of painCohort of patientsImpact of painProgression of diseaseTranscriptase-polymerase chain reactionPersistent arthralgiaFebrile illnessSubstantial disabilityViral loadFemale sexPolymerase chain reactionIgM enzymeArthralgiaSurveillance studyChikungunya virusDengue virusPatientsImmunosorbent assay
2020
CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses
Lin T, Geng T, Harrison AG, Yang D, Vella AT, Fikrig E, Wang P. CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses. Viruses 2020, 12: 1252. PMID: 33147869, PMCID: PMC7692144, DOI: 10.3390/v12111252.Peer-Reviewed Original ResearchConceptsChikungunya virusAlphaviral arthritisArthritogenic alphavirusesLargest immune cell populationMacrophages/T cellsImmune cell populationsInflammatory immune responseLow viral loadWild-type miceO'nyong-nyong virusWild-type animalsRheumatic manifestationsImmune infiltratesViral loadT cellsImmune responseAlphaviral diseaseArthritic diseasesTherapeutic targetCXCL10PathogenesisViral RNACell populationsArthritisFootpadMacrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice
Yang L, Geng T, Yang G, Ma J, Wang L, Ketkar H, Yang D, Lin T, Hwang J, Zhu S, Wang Y, Dai J, You F, Cheng G, Vella AT, Flavell RA, Fikrig E, Wang P. Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice. Communications Biology 2020, 3: 556. PMID: 33033362, PMCID: PMC7545163, DOI: 10.1038/s42003-020-01285-6.Peer-Reviewed Original ResearchConceptsMacrophage scavenger receptor 1Scavenger receptor 1Chikungunya virusReceptor 1Antiviral roleType I IFN responseChikungunya virus infectionLow-density lipoproteinImportant antiviral roleI IFN responseMarkers of autophagyCHIKV infectionViral loadArthritogenic alphavirusesVirus infectionCHIKV replicationATG5-ATG12Antiviral actionKnockout miceMSR1 expressionIFN responseInfectionMiceNsp1 proteinAutophagic functionEpidemiologic and spatiotemporal trends of Zika Virus disease during the 2016 epidemic in Puerto Rico
Sharp T, Quandelacy T, Adams L, Aponte J, Lozier M, Ryff K, Flores M, Rivera A, Santiago G, Muñoz-Jordán J, Alvarado L, Rivera-Amill V, Garcia-Negrón M, Waterman S, Paz-Bailey G, Johansson M, Rivera-Garcia B. Epidemiologic and spatiotemporal trends of Zika Virus disease during the 2016 epidemic in Puerto Rico. PLOS Neglected Tropical Diseases 2020, 14: e0008532. PMID: 32956416, PMCID: PMC7529257, DOI: 10.1371/journal.pntd.0008532.Peer-Reviewed Original ResearchConceptsZIKV diseaseDisease casesZika virusZIKV infectionArboviral diseasesEvidence of infectionZika virus diseaseLaboratory-based surveillancePuerto Rico DepartmentPublic health authoritiesIgM ELISAZIKV epidemicHigh incidenceChikungunya virusLaboratory evidenceHealth authoritiesDiseaseEarly detectionRT-PCRInfectionSocioeconomic factorsVirus diseaseEpidemicEarlier midpointIncidenceTransmission of Chikungunya Virus in a Brazilian Urban Slum - Volume 26, Number 7—July 2020 - Emerging Infectious Diseases journal - CDC
Anjos RO, Mugabe VA, Moreira PSS, Carvalho CX, Portilho MM, Khouri R, Sacramento GA, Nery NRR, Reis MG, Kitron UD, Ko AI, Costa F, Ribeiro GS. Transmission of Chikungunya Virus in a Brazilian Urban Slum - Volume 26, Number 7—July 2020 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2020, 26: 1364-1373. PMID: 32568045, PMCID: PMC7323528, DOI: 10.3201/eid2607.190846.Peer-Reviewed Original ResearchConceptsEpisodes of feverChikungunya outbreakInfectious Diseases journal - CDCSymptomatic infection ratePresumptive clinical diagnosisSufficient herd immunityCommunity-based studyFurther longitudinal studiesCHIKV seroprevalenceSeropositive personsVirus seroprevalenceClinical dataHerd immunityChikungunya virusInfection rateClinical diagnosisSerum samplesDisease pointUnpaved streetsArthralgiaLongitudinal studyFeverSeroprevalenceEpisodesOutbreakImpact of Gut Bacteria on the Infection and Transmission of Pathogenic Arboviruses by Biting Midges and Mosquitoes
Möhlmann TWR, Vogels CBF, Göertz GP, Pijlman GP, ter Braak CJF, te Beest DE, Hendriks M, Nijhuis EH, Warris S, Drolet BS, van Overbeek L, Koenraadt CJM. Impact of Gut Bacteria on the Infection and Transmission of Pathogenic Arboviruses by Biting Midges and Mosquitoes. Microbial Ecology 2020, 80: 703-717. PMID: 32462391, PMCID: PMC7476999, DOI: 10.1007/s00248-020-01517-6.Peer-Reviewed Original ResearchConceptsAntibiotic treatmentGut bacteriaChikungunya virusInfection ratePathogenic arbovirusesInfectious blood mealAegypti mosquitoesGut bacterial communitiesResident gut bacteriaGut bacterial compositionSchmallenberg virusAedes aegypti mosquitoesArbovirus infectionViral pathogensVirusTreatmentBlood mealInfectionMidgut bacteriaArbovirus transmissionHealth of animalsMosquitoesArbovirusesZikaBacterial compositionQuantitative Proteomic Analysis of Chikungunya Virus-Infected Aedes aegypti Reveals Proteome Modulations Indicative of Persistent Infection
Cui Y, Liu P, Mooney BP, Franz AWE. Quantitative Proteomic Analysis of Chikungunya Virus-Infected Aedes aegypti Reveals Proteome Modulations Indicative of Persistent Infection. Journal Of Proteome Research 2020, 19: 2443-2456. PMID: 32375005, PMCID: PMC7419016, DOI: 10.1021/acs.jproteome.0c00173.Peer-Reviewed Original ResearchConceptsSerine-type endopeptidasesMetabolism related pathwaysQuantitative proteomic analysisFunctional enrichment analysisChikungunya virusRibosome biogenesisLabel-free quantificationRNA machineryNonpathogenic relationshipsNovel proteinProteome modulationProteomic analysisVesicular transportEnrichment analysisCHIKV infectionOxidative phosphorylationBiological pathwaysRelated pathwaysMass spectrometry dataPresence of CHIKVProteinMosquito samplesProteomeOral acquisitionMolecular interactions
2019
Return of the founder Chikungunya virus to its place of introduction into Brazil is revealed by genomic characterization of exanthematic disease cases
Maia Z, Pereira F, do Carmo Said R, Fonseca V, Gräf T, de Bruycker Nogueira F, Nardy V, Xavier J, Maia M, Abreu A, de Albuquerque C, Oliveira W, Croda J, de Filippis A, Cunha R, Lourenço J, de Oliveira T, Faria N, Alcantara L, Giovanetti M. Return of the founder Chikungunya virus to its place of introduction into Brazil is revealed by genomic characterization of exanthematic disease cases. Emerging Microbes & Infections 2019, 9: 53-57. PMID: 31880218, PMCID: PMC6968431, DOI: 10.1080/22221751.2019.1701954.Peer-Reviewed Original ResearchConceptsNumber of patientsGenomic surveillance strategiesFebrile illnessArboviral infectionsEpidemic seasonChikungunya virusWhole-genome sequencingDisease casesSurveillance strategiesGenetic diversityEpidemiological analysisMolecular clockCHIKV ECSA genotypeTransmission potentialGenome sequencingArboviral transmissionGenomic characterizationCHIKVLocal persistenceZika Virus Dissemination from the Midgut of Aedes aegypti is Facilitated by Bloodmeal-Mediated Structural Modification of the Midgut Basal Lamina
Cui Y, Grant DG, Lin J, Yu X, Franz AWE. Zika Virus Dissemination from the Midgut of Aedes aegypti is Facilitated by Bloodmeal-Mediated Structural Modification of the Midgut Basal Lamina. Viruses 2019, 11: 1056. PMID: 31739432, PMCID: PMC6893695, DOI: 10.3390/v11111056.Peer-Reviewed Original ResearchConceptsZika virusMidgut basal laminaBasal laminaDengue 4 virusDissemination patternsSame mosquito speciesMeal ingestionZIKV infectionZIKV disseminationInfectious bloodmealHuman pathogenic virusesChikungunya virusInfected mosquitoesViral titersVirus disseminationMosquito midgutSalivary glandsFive daysBloodmeal digestionBloodmeal ingestionIngestionVirusMidgut infectionIncreased numberKey tissuesGenomic Epidemiology as a Public Health Tool to Combat Mosquito-Borne Virus Outbreaks
Pollett S, Fauver JR, Berry I, Melendrez M, Morrison A, Gillis LD, Johansson MA, Jarman RG, Grubaugh ND. Genomic Epidemiology as a Public Health Tool to Combat Mosquito-Borne Virus Outbreaks. The Journal Of Infectious Diseases 2019, 221: s308-s318. PMID: 31711190, PMCID: PMC11095994, DOI: 10.1093/infdis/jiz302.Peer-Reviewed Original ResearchConceptsGenomic epidemiologyVirus outbreakPublic health responsePublic health toolPublic health agenciesPublic health emergencyKey epidemiological questionsStructured surveillanceChikungunya virusHealth responseEpidemiologyVirus controlHealth toolsHealth agenciesWest NileHealth emergencyVirus genomic dataYellow feverEpidemiological questionsControl of mosquitoesOutbreakOngoing advancesVirus threatsMosquitoesFeverChronic Chikungunya Arthritis and Rheumatoid Arthritis: What They Have in Common
Amaral JK, Bilsborrow JB, Schoen RT. Chronic Chikungunya Arthritis and Rheumatoid Arthritis: What They Have in Common. The American Journal Of Medicine 2019, 133: e91-e97. PMID: 31705850, PMCID: PMC7385732, DOI: 10.1016/j.amjmed.2019.10.005.Peer-Reviewed Original ResearchConceptsChronic chikungunya arthritisChikungunya arthritisRheumatoid arthritisChikungunya virusAcute febrile illnessAcute illnessFebrile illnessHigh feverInflammatory arthritisMaculopapular rashAcute infectionInfectious causesClinical manifestationsInflammatory processChikungunya feverArthritisFamily TogaviridaeGenus AlphavirusPatientsFeverBetter diagnosisIllnessSignificant proportionRNA virusesVirus
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