2020
Impact of Gut Bacteria on the Infection and Transmission of Pathogenic Arboviruses by Biting Midges and Mosquitoes
Möhlmann TWR, Vogels CBF, Göertz GP, Pijlman GP, ter Braak CJF, te Beest DE, Hendriks M, Nijhuis EH, Warris S, Drolet BS, van Overbeek L, Koenraadt CJM. Impact of Gut Bacteria on the Infection and Transmission of Pathogenic Arboviruses by Biting Midges and Mosquitoes. Microbial Ecology 2020, 80: 703-717. PMID: 32462391, PMCID: PMC7476999, DOI: 10.1007/s00248-020-01517-6.Peer-Reviewed Original ResearchConceptsAntibiotic treatmentGut bacteriaChikungunya virusInfection ratePathogenic arbovirusesInfectious blood mealAegypti mosquitoesGut bacterial communitiesResident gut bacteriaGut bacterial compositionSchmallenberg virusAedes aegypti mosquitoesArbovirus infectionViral pathogensVirusTreatmentBlood mealInfectionMidgut bacteriaArbovirus transmissionHealth of animalsMosquitoesArbovirusesZikaBacterial composition
2016
Different immunological responses to early-life antibiotic exposure affecting autoimmune diabetes development in NOD mice
Hu Y, Jin P, Peng J, Zhang X, Wong FS, Wen L. Different immunological responses to early-life antibiotic exposure affecting autoimmune diabetes development in NOD mice. Journal Of Autoimmunity 2016, 72: 47-56. PMID: 27178773, PMCID: PMC4958594, DOI: 10.1016/j.jaut.2016.05.001.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsType 1 diabetesAutoimmune diabetes developmentDiabetes developmentPregnant mothersEarly-life antibiotic exposureTolerogenic antigen-presenting cellsUntreated control miceInflammatory T cellsDifferent immunological responsesGut microbiota compositionDifferent immune responsesImportant environmental agentsGut bacterial compositionEarly time pointsNOD miceControl miceAutoimmune diseasesPrenatal exposureLymphoid organsAntibiotic exposureT cellsImmune responseImmunological responseNew therapies
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