2024
Peripheral blood immune parameters, response, and adverse events after neoadjuvant chemotherapy plus durvalumab in early-stage triple-negative breast cancer
Foldi J, Blenman K, Marczyk M, Gunasekharan V, Polanska A, Gee R, Davis M, Kahn A, Silber A, Pusztai L. Peripheral blood immune parameters, response, and adverse events after neoadjuvant chemotherapy plus durvalumab in early-stage triple-negative breast cancer. Breast Cancer Research And Treatment 2024, 208: 369-377. PMID: 39002068, DOI: 10.1007/s10549-024-07426-3.Peer-Reviewed Original ResearchImmune-related adverse eventsTriple-negative breast cancerAssociated with pathological responsePathological complete responseNeoadjuvant chemotherapyCytokine levelsPathological responseAdverse eventsBreast cancerEarly-stage triple-negative breast cancerPatients treated with immune checkpoint inhibitorsB cell clonal expansionMeasured serum cytokine levelsImmune checkpoint inhibitorsGM-CSF levelsPeripheral blood cytokine levelsBlood cytokine levelsSerum cytokine levelsB cell receptorMagnetic bead panelBenjamini-Hochberg correctionSample of patientsImmunoSEQ platformCheckpoint inhibitorsComplete responsePost-COVID-19 condition: systemic inflammation and low functional exercise capacity
de Castro G, Gama L, Ramos A, da Silva G, de Souza Teixeira A, Cunha-Neto E, de Souza H, Marie S, Talib L, Coelho V, Kalil J, de Araujo A, Ritto A, Belon A, Santos A, Barrére A, Sawamura M, Lamas C, Baldi B, Carvalho C, Kulikowski L, Damiano R, Imamura M, Neto J, Lira F, Otoch J, Miguel E, Battistella L, Forlenza O, Busatto G, Seelaender M. Post-COVID-19 condition: systemic inflammation and low functional exercise capacity. Frontiers In Nutrition 2024, 11: 1295026. PMID: 38549752, PMCID: PMC10973152, DOI: 10.3389/fnut.2024.1295026.Peer-Reviewed Original ResearchPost-COVID-19 conditionTimed Up and Go testUp-and-go testPhysical performance testsAcute COVID-19Low handgrip strengthFollow-up assessment 6Cross-sectional studySelf-reported symptomsFollow-up assessmentQuality of lifeDiagnosing pulmonary lesionsHandgrip strengthSerum cytokine profilesSerum cytokine levelsImpact of inflammationControl groupMCP-1 levelsIL-4 concentrationMale participantsHospital dischargeSymptom questionnaireSymptom groupsFemale participantsDebilitating symptoms
2022
UBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by Maintaining Hematopoietic Homeostasis
Geng T, Yang D, Lin T, Cahoon J, Wang P. UBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by Maintaining Hematopoietic Homeostasis. MBio 2022, 13: e02687-22. PMID: 36377866, PMCID: PMC9765034, DOI: 10.1128/mbio.02687-22.Peer-Reviewed Original ResearchConceptsUbiquitin regulatory X domain-containing proteinDomain-containing proteinsDiverse cellular processesCell-intrinsic mannerCellular processesHematopoietic homeostasisPhysiological functionsRNA virus replicationEssential roleControl of infectionChikungunya virusHuman genomeArthritogenic alphavirusesImmune responseCHIKV replicationDNA virusesRNA virusesInnate immune responseVirus-specific immunoglobulin GO'nyong'nyong virusLong-term neurological disordersSignificant public health problemSerum cytokine levelsSpecific antiviral drugsHigh viral load
2021
Clinical spectrum of endemic leptospirosis in relation to cytokine response
Dahanayaka NJ, Agampodi SB, Seneviratna I, Warnasekara J, Rajapakse R, Ranathunga K, Matthias M, Vinetz JM. Clinical spectrum of endemic leptospirosis in relation to cytokine response. PLOS ONE 2021, 16: e0261025. PMID: 34879100, PMCID: PMC8654203, DOI: 10.1371/journal.pone.0261025.Peer-Reviewed Original ResearchConceptsCytokine responsesLeptospirosis patientsClinical spectrumHigher IL-13 levelsHigher IL-5Acute kidney injuryHigher serum creatinineIL-13 levelsSerum cytokine levelsIL-6 levelsUniversity Teaching HospitalMultiplex cytokine kitKidney injuryLung involvementCytokine levelsSerum creatinineAcute phaseCytokine kitIL-1βAcute samplesConvalescence periodIL-8IL-5Prognostic informationEndemic settings766 Toward safe, systemic delivery of synthetic TLR7/8 agonists using Bottlebrush Prodrugs (BPDs)
Bhagchandani S, Milling L, Liu B, Fessenden T, Spranger S, Johnson J, Irvine D. 766 Toward safe, systemic delivery of synthetic TLR7/8 agonists using Bottlebrush Prodrugs (BPDs). Journal For ImmunoTherapy Of Cancer 2021, 9: a801-a801. DOI: 10.1136/jitc-2021-sitc2021.766.Peer-Reviewed Original ResearchTLR reporter cellsSystemic deliveryAnti-PD-1 antibody treatmentMC38 colon cancer modelImidazoquinoline derivativesToll-like receptor agonistsSerum cytokine levelsMaximum tolerable doseSystemic side effectsImproved survival ratesReporter cellsAnti-tumor efficacyColon cancer modelCytokine levelsMetastatic diseaseTLR agonistsTLR7/8 agonistAntibody treatmentTLR activationTreatment of cancerTolerable doseReceptor agonistIntravenous administrationTopical solutionSide effectsZinc Supplementation with or without Additional Micronutrients Does Not Affect Peripheral Blood Gene Expression or Serum Cytokine Level in Bangladeshi Children
Hayman T, Hickey P, Amann-Zalcenstein D, Bennett C, Ataide R, Sthity R, Khandaker A, Islam K, Stracke K, Yassi N, Watson R, Long J, Westcott J, Krebs N, King J, Black R, Islam M, McDonald C, Pasricha S. Zinc Supplementation with or without Additional Micronutrients Does Not Affect Peripheral Blood Gene Expression or Serum Cytokine Level in Bangladeshi Children. Nutrients 2021, 13: 3516. PMID: 34684517, PMCID: PMC8541127, DOI: 10.3390/nu13103516.Peer-Reviewed Original ResearchConceptsPeripheral blood gene expressionMultiple micronutrient powdersBlood gene expressionZinc supplementationZinc interventionCytokine levelsCommunity-based efficacy trialDispersible tabletsImpact of zinc supplementationEffect of zinc supplementationSerum cytokine levelsGene expressionPreventive zinc supplementationDetect cytokine profilesSensitive multiplex assayMonths of agePlacebo powderCytokine profileImmune profilePeripheral bloodCytokine signatureHome fortificationCytokine concentrationsMicronutrient powderZinc deficiency
2019
Acute alcohol consumption alters the peripheral cytokines IL-8 and TNF-α
Hillmer AT, Nadim H, Devine L, Jatlow P, O'Malley SS. Acute alcohol consumption alters the peripheral cytokines IL-8 and TNF-α. Alcohol 2019, 85: 95-99. PMID: 31759072, PMCID: PMC7739954, DOI: 10.1016/j.alcohol.2019.11.005.Peer-Reviewed Original ResearchConceptsCytokine levelsIL-8Cytokine responsesAlcohol challengePro-inflammatory cytokines TNFPro-inflammatory chemokine IL-8Acute alcohol challengePeripheral cytokine responseSerum cytokine levelsCytokine IL-8Moderate alcohol drinkersChemokine IL-8Peripheral cytokine levelsAlcohol consumption altersCytokines of interestAlcohol drinkersCytokines TNFBlood concentrationsImmune functionImmune communicationCytokinesTNFLinear mixed modelsTrigger releaseDrinking-related behaviorsTargeting neuroinflammation with minocycline in heavy drinkers
Petrakis IL, Ralevski E, Gueorguieva R, Sloan ME, Devine L, Yoon G, Arias AJ, Sofuoglu M. Targeting neuroinflammation with minocycline in heavy drinkers. Psychopharmacology 2019, 236: 3013-3021. PMID: 30919006, PMCID: PMC6764907, DOI: 10.1007/s00213-019-05205-3.Peer-Reviewed Original ResearchConceptsPro-inflammatory cytokine releaseEthanol-induced inflammationMicroglial activationCytokine levelsCytokine releaseHeavy drinkersSecond-generation tetracycline antibioticDose of minocyclinePlacebo-controlled trialSerum cytokine levelsSubjective responsesBaseline cytokine levelsEffects of minocyclineViable treatment strategyShort-term treatmentAlcohol use disorderNeuroimmune modulationMinocycline treatmentNeuroimmune signalingMinocycline effectsIntravenous ethanolEthanol intakeSedative responseTreatment strategiesPreclinical studies
2017
THU0062 Novel animal model of aromatase inhibitor-induced arthralgia suggests an estrogen-independent inflammatory mechanism
Young N, Thomas E, Snoad B, Sharma J, Mobeen M, DeVries A, Bratasz A, Lustberg M, Jarjour W, Reinbolt R. THU0062 Novel animal model of aromatase inhibitor-induced arthralgia suggests an estrogen-independent inflammatory mechanism. Annals Of The Rheumatic Diseases 2017, 76: 222. DOI: 10.1136/annrheumdis-2017-eular.5424.Peer-Reviewed Original ResearchBreast cancer patientsEarly-stage breast cancer patientsAromatase inhibitor-related arthralgiaStage breast cancer patientsBreast cancer researchSerum cytokine levelsBreast cancer survivorsAromatase inhibitorsNovel animal modelInflammatory mechanismsCancer patientsCytokine levelsCancer survivorsMusculoskeletal symptomsRisk factorsHistopathological analysisProspective characterizationAI treatmentHormone receptor-positive breast cancer patientsAnimal modelsReceptor-positive breast cancer patientsNFκB activationAromatase Inhibitor-Induced ArthralgiaBioluminescent imagingKnee jointDurability of the Rituximab Response in Acetylcholine Receptor Autoantibody–Positive Myasthenia Gravis
Robeson KR, Kumar A, Keung B, DiCapua DB, Grodinsky E, Patwa HS, Stathopoulos PA, Goldstein JM, O’Connor K, Nowak RJ. Durability of the Rituximab Response in Acetylcholine Receptor Autoantibody–Positive Myasthenia Gravis. JAMA Neurology 2017, 74: 60-66. PMID: 27893014, DOI: 10.1001/jamaneurol.2016.4190.Peer-Reviewed Original ResearchConceptsDurability of responseMyasthenia gravisRituximab treatmentAnti-AChR antibody levelsB cell-targeted therapiesLong-term clinical responseRetrospective case series studyTreatment of MGEvidence-based practice parametersLast rituximab treatmentRefractory myasthenia gravisSerum cytokine levelsComplete stable remissionSubset of patientsCase series studyMyasthenia Gravis FoundationMG clinicPharmacologic remissionRituximab cyclesSustained remissionAutoantibody levelsInflammatory markersRituximab therapyClinical improvementClinical response
2015
Superantigens produced by catheter-associated Staphylococcus aureus elicit systemic inflammatory disease in the absence of bacteremia
Chung J, Greenwood-Quaintance K, Karau MJ, Tilahun A, Khaleghi SR, Chowdhary VR, David CS, Patel R, Rajagopalan G. Superantigens produced by catheter-associated Staphylococcus aureus elicit systemic inflammatory disease in the absence of bacteremia. Journal Of Leukocyte Biology 2015, 98: 271-281. PMID: 25979434, PMCID: PMC4501677, DOI: 10.1189/jlb.4a1214-577rr.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCatheter-Related InfectionsCatheters, IndwellingCD4-Positive T-LymphocytesEnterotoxinsGene DeletionHistocompatibility AntigensHumansKidneyLiverLungLymphocyte ActivationMiceMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaSpleenStaphylococcal InfectionsStaphylococcus aureusSuperantigensConceptsS. aureusHLA-DR3 transgenic miceLong intravenous catheterSystemic immune activationSerum cytokine levelsSystemic inflammatory diseaseAbsence of bacteremiaMHC class II moleculesInvasive staphylococcal diseaseToxigenic S. aureusClinical S. aureus isolatesS. aureus isolatesClass II moleculesIsogenic S. aureusCytokine levelsHLA-DR3Immune activationInflammatory diseasesIntravenous cathetersStaphylococcal diseaseRole of SAgsDevice-associated infectionsT cellsClinical consequencesForeign bodySuppression of systemic autoimmunity by the innate immune adaptor STING
Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e710-e717. PMID: 25646421, PMCID: PMC4343138, DOI: 10.1073/pnas.1420217112.Peer-Reviewed Original ResearchConceptsAutoimmune-prone miceSystemic lupus erythematosusImmune activationSerum cytokine levelsSTING-deficient miceCytosolic DNA-sensing pathwayToll-like receptorsDNA-sensing pathwayCytokine levelsSystemic inflammationLupus erythematosusAutoantibody productionLymphoid hypertrophyTLR ligandsProinflammatory cytokinesAutoimmune pathologySystemic autoimmunityInflammatory macrophagesAdaptor STINGElevated numbersMiceInflammationInterferon genesMacrophagesNegative regulatory role
2014
Immune Markers Associated with Host Susceptibility to Infection with West Nile Virus
Qian F, Thakar J, Yuan X, Nolan M, Murray KO, Lee WT, Wong SJ, Meng H, Fikrig E, Kleinstein SH, Montgomery RR. Immune Markers Associated with Host Susceptibility to Infection with West Nile Virus. Viral Immunology 2014, 27: 39-47. PMID: 24605787, PMCID: PMC3949440, DOI: 10.1089/vim.2013.0074.Peer-Reviewed Original ResearchConceptsWest Nile virusSevere infectionsImmune markersIL-4IL-4 levelsSerum cytokine levelsSerum IL-4Nile virusSignificant risk factorsImmune system statusPeripheral blood cellsSevere neurological diseaseCytokine levelsAntibody levelsImmune statusRisk factorsHealthy subjectsStratified cohortWNV infectionNeurological diseasesInfectionAltered expression levelsBlood cellsAltered gene expression patternsHost susceptibility
2011
P1-01-15: Do Serum Cytokines Predict Breast Cancer Behavior?
Lush E, Dedert E, Daup M, Dhabhar F, Spiegel D, Tillie J, McMasters K, Sephton S, Chagpar A. P1-01-15: Do Serum Cytokines Predict Breast Cancer Behavior? Cancer Research 2011, 71: p1-01-15-p1-01-15. DOI: 10.1158/0008-5472.sabcs11-p1-01-15.Peer-Reviewed Original ResearchSerum cytokine levelsHormone receptor statusLymph node statusCytokine levelsReceptor statusTumor sizeBreast cancer behaviorSerum cytokinesNode statusCancer behaviorIFN-gamma serum levelsMedian patient ageMedian tumor sizeSerum IFN-gammaSerum inflammatory cytokinesProgesterone receptor statusRole of inflammationFinal pathologic resultsPresence of metastasesBreast cancer patientsBreast cancer developmentVariety of cytokinesCohort of interestLymphovascular invasionPatient age
2010
Cytokine levels in euthymic bipolar patients
Guloksuz S, Cetin E, Cetin T, Deniz G, Oral E, Nutt D. Cytokine levels in euthymic bipolar patients. Journal Of Affective Disorders 2010, 126: 458-462. PMID: 20537397, DOI: 10.1016/j.jad.2010.04.027.Peer-Reviewed Original ResearchConceptsEuthymic bipolar patientsBipolar patientsCytokine levelsHealthy controlsBipolar disorderDepressive episodeLithium monotherapyIL-10 levelsIL-4 levelsSerum cytokine levelsPro-inflammatory stateEffects of medicationNeuro-immune modulationTerms of agePatients 16Cytokine profileCytokine productionPresent studyIL-2IL-4IL-5Healthy volunteersPsychiatric disordersPatientsFlow cytometry
2008
Regulatory T cells and superantigen‐induced toxic shock. A study using HLA class II transgenic mice
Rajagopalan G, Epstein B, Lytle A, David C. Regulatory T cells and superantigen‐induced toxic shock. A study using HLA class II transgenic mice. The FASEB Journal 2008, 22: 848.11-848.11. DOI: 10.1096/fasebj.22.1_supplement.848.11.Peer-Reviewed Original ResearchToxic shock syndromeRegulatory T cellsHLA-DR3 transgenic miceT cellsTransgenic miceHLA class II transgenic miceDepletion of TregsII transgenic miceSerum cytokine levelsStaphylococcal enterotoxin BTreg cellsCytokine levelsIL-17Regulatory cellsSEB challengeIL-21IL-22Systemic exposureIL-6Shock syndromeIL-2IL-2RSplenic expressionTGF-b1Toxic shock
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