2024
Comprehensive Assessment of Inactivation Methods for Madariaga Virus
Boytz R, Keita K, Pawlak J, Laurent-Rolle M. Comprehensive Assessment of Inactivation Methods for Madariaga Virus. Viruses 2024, 16: 206. PMID: 38399982, PMCID: PMC10892135, DOI: 10.3390/v16020206.Peer-Reviewed Original ResearchConceptsEastern equine encephalitis virusMadariaga virusMethod of inactivationInactivation methodSelective agentNorth American strainsEEEV strainsEquine encephalitis virusTRIzol LSAmino acid levelsAmerican strainsEncephalitis virusAcid levelsTRIzolInfected cellsVirusFormalinInactivationPathogensPublic health threatInfected supernatantStrain
2023
Everglades virus: an underrecognized disease-causing subtype of Venezuelan equine encephalitis virus endemic to Florida, USA
Burkett-Cadena N, Fish D, Weaver S, Vittor A. Everglades virus: an underrecognized disease-causing subtype of Venezuelan equine encephalitis virus endemic to Florida, USA. Journal Of Medical Entomology 2023, 60: 1149-1164. PMID: 37862065, PMCID: PMC10645373, DOI: 10.1093/jme/tjad070.Peer-Reviewed Original ResearchConceptsEverglades virusEncephalitis virusCases of meningitisCotton rat Sigmodon hispidusHigh natural infection rateEpidemic strainsNatural infection rateInfection rateWidespread transmissionAbundance of AedesNatural infectionSubtype IISubtypesFrequent feedingFrequency of contactCertain mosquitoesVector competenceVirusHuman diseasesRodentsVertebrate hosts
2021
Emergence potential of mosquito-borne arboviruses from the Florida Everglades
Fish D, Tesh R, Guzman H, da Rosa A, Balta V, Underwood J, Sither C, Vasilakis N. Emergence potential of mosquito-borne arboviruses from the Florida Everglades. PLOS ONE 2021, 16: e0259419. PMID: 34807932, PMCID: PMC8608345, DOI: 10.1371/journal.pone.0259419.Peer-Reviewed Original ResearchConceptsHardwood hammocksEverglades regionWater levelEnvironmental changesTensaw virusBig Cypress National PreserveLargest natural wetlandWetland restoration projectsGreater Everglades regionEverglades National ParkMajor landscape featuresMajor environmental changesEmergence of arbovirusesInvasive speciesUndergoing restorationNatural wetlandsRestoration projectsSubtropical ecosystemsFlorida EvergladesLandscape featuresState ForestNational ParkNational PreservePathogenic mosquitoEverglades virus
2020
CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses
Lin T, Geng T, Harrison AG, Yang D, Vella AT, Fikrig E, Wang P. CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses. Viruses 2020, 12: 1252. PMID: 33147869, PMCID: PMC7692144, DOI: 10.3390/v12111252.Peer-Reviewed Original ResearchConceptsChikungunya virusAlphaviral arthritisArthritogenic alphavirusesLargest immune cell populationMacrophages/T cellsImmune cell populationsInflammatory immune responseLow viral loadWild-type miceO'nyong-nyong virusWild-type animalsRheumatic manifestationsImmune infiltratesViral loadT cellsImmune responseAlphaviral diseaseArthritic diseasesTherapeutic targetCXCL10PathogenesisViral RNACell populationsArthritisFootpad
2016
Genetics of War and Truce between Mosquitos and Emerging Viruses
Hwang J, Jurado KA, Fikrig E. Genetics of War and Truce between Mosquitos and Emerging Viruses. Cell Host & Microbe 2016, 19: 583-587. PMID: 27173926, PMCID: PMC7063512, DOI: 10.1016/j.chom.2016.04.009.Peer-Reviewed Original Research
2008
Nonmucosal Alphavirus Vaccination Stimulates a Mucosal Inductive Environment in the Peripheral Draining Lymph Node
Thompson JM, Nicholson MG, Whitmore AC, Zamora M, West A, Iwasaki A, Staats HF, Johnston RE. Nonmucosal Alphavirus Vaccination Stimulates a Mucosal Inductive Environment in the Peripheral Draining Lymph Node. The Journal Of Immunology 2008, 181: 574-585. PMID: 18566424, PMCID: PMC3603373, DOI: 10.4049/jimmunol.181.1.574.Peer-Reviewed Original ResearchConceptsDraining Lymph NodesVirus replicon particlesMucosal immune responsesMucosal lymphoid tissuesImmune inductionAg deliveryIgA AbsLymph nodesLymphoid tissueImmune responseMucosal surfacesMucosal addressin cell adhesion molecule-1Strong mucosal immune responsesEncephalitis virus replicon particlesCell adhesion molecule-1Multiple mucosal surfacesViral-based vaccinesAdhesion molecule-1Lymphoid structuresIL-6Immunological parametersImmunological componentsCC chemokinesIgA detectionReplicon particles
1998
Multiple Isolations of Eastern Equine Encephalitis and Highlands J Viruses from Mosquitoes (Diptera: Culicidae) During a 1996 Epizootic in Southeastern Connecticut
Andreadis T, Anderson J, Tirrell-Peck S. Multiple Isolations of Eastern Equine Encephalitis and Highlands J Viruses from Mosquitoes (Diptera: Culicidae) During a 1996 Epizootic in Southeastern Connecticut. Journal Of Medical Entomology 1998, 35: 296-302. PMID: 9615549, DOI: 10.1093/jmedent/35.3.296.Peer-Reviewed Original Research
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