2025
Cold snare endoscopic resection for large colon polyps: a randomised trial
Pohl H, Rex D, Barber J, Moyer M, Elmunzer B, Rastogi A, Gordon S, Zolotarevsky E, Levenick J, Aslanian H, Elatrache M, von Renteln D, Wallace M, Brahmbhatt B, Keswani R, Kumta N, Pleskow D, Smith Z, Abu Ghanimeh M, Simmer S, Sanaei O, Mackenzie T, Piraka C. Cold snare endoscopic resection for large colon polyps: a randomised trial. Gut 2025, gutjnl-2025-335075. PMID: 40393701, DOI: 10.1136/gutjnl-2025-335075.Peer-Reviewed Original ResearchCold endoscopic mucosal resectionEndoscopic mucosal resectionColorectal polypsSessile serrated polypsPrimary interventionEMR groupRandomised trialsSevere adverse eventsSerrated polypsMulticentre randomised trialPolyp sizePolyp recurrenceSecondary outcomesPrimary outcomeComplications of endoscopic mucosal resectionInterventionPolypsCold resectionRate of severe adverse eventsAntithrombotic medicationMucosal resectionColorectalPostprocedural bleedingComparative safetyEndoscopic resection
2022
Antithrombotic Therapy After Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation
Freeman JV, Higgins AY, Wang Y, Du C, Friedman DJ, Daimee UA, Minges KE, Pereira L, Goldsweig AM, Price MJ, Reddy VY, Gibson D, Doshi SK, Varosy PD, Masoudi FA, Curtis JP. Antithrombotic Therapy After Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation. Journal Of The American College Of Cardiology 2022, 79: 1785-1798. PMID: 35512858, PMCID: PMC9097170, DOI: 10.1016/j.jacc.2022.02.047.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionAdverse eventsPivotal trialsWatchman deviceTreatment protocolAntithrombotic strategiesAppendage occlusionLower riskFrailty regressionPercutaneous left atrial appendage occlusionNational Cardiovascular Data RegistryContemporary U.S. practiceDual antiplatelet therapyAtrial appendage occlusionConcomitant aspirinPostprocedure careAdjusted riskAntiplatelet therapyAntithrombotic medicationAntithrombotic therapyAtrial fibrillationAdverse outcomesTrial protocolAntithrombotic agentsMedication strategies
2019
Modelling care quality for patients after a transient ischaemic attack within the US Veterans Health Administration
Arling G, Sico JJ, Reeves MJ, Myers L, Baye F, Bravata DM. Modelling care quality for patients after a transient ischaemic attack within the US Veterans Health Administration. BMJ Open Quality 2019, 8: e000641. PMID: 31909209, PMCID: PMC6937041, DOI: 10.1136/bmjoq-2019-000641.Peer-Reviewed Original ResearchMeSH KeywordsAdministrative Claims, HealthcareAdultAgedAged, 80 and overEmergency Service, HospitalFemaleHumansIschemic Attack, TransientMaleMiddle AgedNeurologyPatient AdmissionQuality of Health CareReferral and ConsultationRetrospective StudiesStrokeTime FactorsUnited StatesUnited States Department of Veterans AffairsVeteransConceptsTransient ischemic attackCharlson Comorbidity IndexVeterans Health AdministrationHigher Charlson comorbidity indexUS Veterans Health AdministrationInpatient admissionsNeurological consultationNeurology consultationEmergency departmentIschemic attackPreventive careHealth AdministrationCare qualitySpeech deficitsHigher CCI scoresModerate potency statinRecurrent vascular eventsStroke center designationHistory of dementiaPreventive care qualityAntithrombotic medicationComorbidity indexCCI scoreED visitsRetrospective cohortIschaemic stroke
Campbell B, De Silva D, Macleod M, Coutts S, Schwamm L, Davis S, Donnan G. Ischaemic stroke. Nature Reviews Disease Primers 2019, 5: 70. PMID: 31601801, DOI: 10.1038/s41572-019-0118-8.Peer-Reviewed Original ResearchConceptsIschemic strokeIntravenous thrombolysisEndovascular thrombectomyStroke onsetSevere symptomatic carotid artery stenosisSymptomatic carotid artery stenosisSalvageable brain tissueBlood pressure controlCardiovascular risk managementLarge vessel occlusionMajority of strokesMechanism of strokeOnset of strokeCarotid artery stenosisCause of disabilitySecond highest causeSystems of careAntithrombotic medicationRapid reperfusionReperfusion therapySecondary preventionStroke symptomsArterial occlusionArtery stenosisCarotid endarterectomyRegional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-based Guidelines (Fourth Edition)
Horlocker T, Vandermeuelen E, Kopp S, Gogarten W, Leffert L, Benzon H. Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-based Guidelines (Fourth Edition). Obstetric Anesthesia Digest 2019, 39: 28-29. DOI: 10.1097/01.aoa.0000552901.03545.fb.Peer-Reviewed Original ResearchRegional anesthesiaFourth consensus conferenceVenous thromboembolism preventionEvidence-based guidelinesAmerican SocietyPatient safety issuesNeuraxial bleedingSpinal hematomaThromboembolism preventionAntithrombotic medicationSpinal anesthesiaCatastrophic complicationThrombolytic therapyObstetric anesthesiaPain medicineConsensus conferenceAnesthesiaConsensus documentEuropean SocietyHeightened riskRelevant literatureAnticoagulationSafety issuesBleedingHematoma
2015
Neuraxial and peripheral nerve blocks in patients taking anticoagulant or thromboprophylactic drugs: challenges and solutions
Li J, Halaszynski T. Neuraxial and peripheral nerve blocks in patients taking anticoagulant or thromboprophylactic drugs: challenges and solutions. Local And Regional Anesthesia 2015, 8: 21-32. PMID: 26347411, PMCID: PMC4531015, DOI: 10.2147/lra.s55306.Peer-Reviewed Original ResearchRegional anesthesiaConsensus statementPatient morbidity/mortalityDifficult needle placementMorbidity/mortalityPeripheral nerve blocksCertain patient populationsPatient-oriented outcomesEvidence-based reviewVertebral column abnormalitiesThromboprophylactic drugsThromboprophylactic therapyAntithrombotic medicationHemorrhagic complicationsPatient comorbiditiesSignificant bleedingTrauma patientsNerve blockClinical seriesPatient populationCase reportNeuraxial blockadeAdvanced ageSpinal cordEpidemiologic data
2013
A prospective study of growth and rupture risk of small-to-moderate size ascending aortic aneurysms
Geisbüsch S, Stefanovic A, Schray D, Oyfe I, Lin HM, Di Luozzo G, Griepp RB. A prospective study of growth and rupture risk of small-to-moderate size ascending aortic aneurysms. Journal Of Thoracic And Cardiovascular Surgery 2013, 147: 68-74. PMID: 23953716, DOI: 10.1016/j.jtcvs.2013.06.030.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsAortaAortic AneurysmAortic RuptureAortographyCase-Control StudiesChi-Square DistributionDisease ProgressionFemaleFibrinolytic AgentsHumansLeast-Squares AnalysisLinear ModelsMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsTime FactorsTomography, X-Ray ComputedVascular Surgical ProceduresConceptsTotal aortic volumeAscending Aortic AneurysmAortic aneurysmAortic volumeModerate size aneurysmsReference groupML/yearAntithrombotic medicationAortic pathologySurgical indicationsUnderwent operationAortic sizeProspective studyEmergency departmentAortic growthSurveillance groupLarge aneurysmsRisk factorsSinotubular junctionTomography scanTomography volume measurementsDissection riskPatientsCompelling indicationsAneurysms
2012
Wingspan experience in the treatment of symptomatic intracranial atherosclerotic disease after antithrombotic failure
Samaniego E, Tari-Capone F, Linfante I, Silva C, Spilberg G, Gounis M, Wakhloo A, Dabus G. Wingspan experience in the treatment of symptomatic intracranial atherosclerotic disease after antithrombotic failure. Journal Of NeuroInterventional Surgery 2012, 5: 302. PMID: 22544819, DOI: 10.1136/neurintsurg-2012-010321.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial atherosclerotic diseaseIntracranial atherosclerotic diseaseWingspan systemPeriprocedural complicationsHemorrhagic strokeAtherosclerotic diseaseAggressive medical therapyFatal hemorrhagic strokeTransient ischemic attackCohort of patientsIschemic attackVascular deathAntithrombotic medicationAntithrombotic therapyRevascularization strategySymptomatic patientsMedical therapyClinical outcomesDay incidenceStent stenosisIntracranial stentingPatientsDemographic dataStrokeStentingGet With The Guidelines Stroke Performance Indicators in a Brazilian Tertiary Hospital
de Carvalho F, Schwamm L, Kuster G, Alves M, Neto M, Silva G. Get With The Guidelines Stroke Performance Indicators in a Brazilian Tertiary Hospital. Cerebrovascular Diseases Extra 2012, 2: 26-35. PMID: 22811686, PMCID: PMC3398824, DOI: 10.1159/000339578.Peer-Reviewed Original ResearchDeep vein thrombosis prophylaxisGWTG-Stroke programEligible patientsBrazilian tertiary hospitalThrombosis prophylaxisAntithrombotic medicationStroke ProgramSymptom onsetTertiary hospitalAtrial fibrillationSmoking cessationDischarge useNational Cholesterol Education Program Adult Treatment Panel III guidelinesAmerican Heart Association/American Stroke AssociationAdult Treatment Panel III guidelinesAdult long-term disabilityTissue plasminogen activator useAntithrombotic medication useNCEP III guidelinesStroke quality improvementTransient ischemic attackAcute ischemic strokeAmerican Stroke AssociationClinical practice guidelinesLong-term disability
2010
Use of Antithrombotic Medications Among Elderly Ischemic Stroke Patients
Lichtman JH, Naert L, Allen NB, Watanabe E, Jones SB, Barry LC, Bravata DM, Goldstein LB. Use of Antithrombotic Medications Among Elderly Ischemic Stroke Patients. Circulation Cardiovascular Quality And Outcomes 2010, 4: 30-38. PMID: 21098780, PMCID: PMC3073519, DOI: 10.1161/circoutcomes.109.850883.Peer-Reviewed Original ResearchConceptsDeep vein thrombosis prophylaxisElderly ischemic stroke patientsIschemic stroke patientsThrombosis prophylaxisAntithrombotic medicationSkilled nursing facilitiesEligible patientsAntithrombotic therapyIschemic strokeAtrial fibrillationStroke patientsNursing facilitiesPatients ages 85 yearsSecondary stroke preventionAge 85 yearsRates of receiptLow treatment ratesRate of treatmentAntiplatelet medicationsStroke preventionEffect of agePatient agePatient characteristicsAntiplatelet drugsMedicare feeRapid Change in Prescribing Behavior in Hospitals Participating in Get With The Guidelines–Stroke After Release of the Management of Atherothrombosis With Clopidogrel in High-Risk Patients (MATCH) Clinical Trial Results
Menon B, Frankel M, Liang L, LaBresh K, Ellrodt G, Hernandez A, Fonarow G, Schwamm L, Smith E. Rapid Change in Prescribing Behavior in Hospitals Participating in Get With The Guidelines–Stroke After Release of the Management of Atherothrombosis With Clopidogrel in High-Risk Patients (MATCH) Clinical Trial Results. Stroke 2010, 41: 2094-2097. PMID: 20634476, DOI: 10.1161/strokeaha.110.584151.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIschemic attackIschemic strokeHigh-risk patients trialAmerican Heart Association Guidelines UpdateManagement of AtherothrombosisPatient clinical trialsGuidelines-StrokeGWTG-StrokeAntithrombotic medicationAntithrombotic therapyStroke ProgramDischarge prescriptionsGuideline updateRandomized trialsConsensus guidelinesHospital characteristicsClinical trialsPrescribing behaviorSustained decreasePatient trialsSustained reductionClinical informationPatientsMatch Study
2008
Gamma Knife surgery for the treatment of melanoma metastases: the effect of intratumoral hemorrhage on survival.
Redmond AJ, DiLuna ML, Hebert R, Moliterno JA, Desai R, Knisely JP, Chiang VL. Gamma Knife surgery for the treatment of melanoma metastases: the effect of intratumoral hemorrhage on survival. Journal Of Neurosurgery 2008, 109 Suppl: 99-105. PMID: 19123895, DOI: 10.3171/jns/2008/109/12/s16.Peer-Reviewed Original ResearchConceptsGamma Knife surgeryMelanoma metastasesIntratumoral bleedingTime of GKSWhole-brain radiation therapyPost-GKS hemorrhageMelanoma brain metastasesRate of hemorrhageConnecticut Tumor RegistryMalignant melanoma metastaticSurvival of patientsTotal tumor volumeTreatment-specific factorsMelanoma metastaticPosttreatment bleedingAntithrombotic medicationBrain metastasesMetastasis locationOverall survivalSolitary metastasisTumor RegistryTumor burdenWorse prognosisIntracranial metastasesPatient survivalHospital Treatment of Patients With Ischemic Stroke or Transient Ischemic Attack Using the “Get With The Guidelines” Program
LaBresh K, Reeves M, Frankel M, Albright D, Schwamm L. Hospital Treatment of Patients With Ischemic Stroke or Transient Ischemic Attack Using the “Get With The Guidelines” Program. JAMA Internal Medicine 2008, 168: 411-417. PMID: 18299497, DOI: 10.1001/archinternmed.2007.101.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIschemic strokeThrombolytic medicationIschemic attackAntithrombotic medicationLow-density lipoprotein levelsDeep venous thrombosisHours of onsetSecondary prevention measuresTreatment of patientsDiabetes mellitus treatmentMeasures of careEvidence-based interventionsQuality improvement measuresEligible patientsGuidelines-StrokeCessation counselingVenous thrombosisLipoprotein levelsStroke careAcute careAnticoagulation agentsAtrial fibrillationCerebrovascular diseaseHospital treatment
2004
Efficacy of Dextran Solutions in Vascular Surgery
Abir F, Barkhordarian S, Sumpio BE. Efficacy of Dextran Solutions in Vascular Surgery. Vascular And Endovascular Surgery 2004, 38: 483-491. PMID: 15592628, DOI: 10.1177/153857440403800601.Peer-Reviewed Original ResearchConceptsVascular surgeryMultiple randomized studiesProcedure-related strokeLower extremity bypassCarotid endarterectomy patientsEvidence-based dataEnglish-language articlesEfficacy of dextranInfragenicular bypassAntiplatelet therapyCEA patientsDistal bypassAntithrombotic medicationExtremity bypassRandomized studyEmbolic rateVenous conduitsEndarterectomy patientsVascular proceduresProphylactic agentAdjunctive proceduresMEDLINE searchOutflow vesselsComposite graftBetter outcomes
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