2025
Serial Lactate in Clinical Medicine - A Narrative Review.
Falter F, Tisherman S, Perrino A, Kumar A, Bush S, Nordström L, Pathan N, Liu R, Mebazaa A. Serial Lactate in Clinical Medicine - A Narrative Review. Journal Of Intensive Care Medicine 2025, 8850666241303460. PMID: 39925111, DOI: 10.1177/08850666241303460.Peer-Reviewed Original ResearchResponse to therapyWarning ScoreAcute clinical areasHospital IT systemsElectronic patient recordsPoint of careNursing workforceClinical medicineDeteriorating patientsClinical areasSerial lactateMultidisciplinary groupHospital areasPrognostic guidePatient recordsLactate clearanceTreatment decisionsClinical utilityIntensive careEmergency roomPatient statusLactate levelsDisciplines of clinical medicineTherapyOperating room
2024
SMART Medical Review: Acute Pancreatitis Assessment and Management in the First 24 Hours
Lee P, Bishu S, Breze C, Chak A, Gardner T, Guda N, Kaul V, Muniraj T, Papachristou G, Schrope B, Spagnolo D, Strand D, Tarnasky P, Taylor J, Wilcox C, Whitcomb D. SMART Medical Review: Acute Pancreatitis Assessment and Management in the First 24 Hours. SMART-MD Journal Of Precision Medicine 2024, 1: e19-e48. DOI: 10.69734/7dcnna53.Peer-Reviewed Original ResearchPoint of careManagement of APClinical decision support toolQuality of careQuality improvement recommendationsGroup of clinical expertsAcute pancreatitisInnate inflammatory responseCareClinical expertsExpert recommendationsLife-threatening consequencesDecision support toolEarly treatmentPhysical examinationInflammatory responseInflammatory reactionRecommendationsSeveral determinantsIndividualized treatmentImprovement recommendationsSupport toolDiagnosisLaboratory testsTreatment
2023
A fast-track to fungal diagnosis: the potential of molecular diagnostics for fungi at the point of care
Trubin P, Azar M. A fast-track to fungal diagnosis: the potential of molecular diagnostics for fungi at the point of care. Expert Review Of Molecular Diagnostics 2023, 24: 143-146. PMID: 37991006, DOI: 10.1080/14737159.2023.2287504.Peer-Reviewed Original ResearchDigital Tools for Decision-Making in Coronary Artery Disease
Grubman D, Grubman S, See C, Breen T, Hu J, Altin S. Digital Tools for Decision-Making in Coronary Artery Disease. Current Treatment Options In Cardiovascular Medicine 2023, 25: 737-752. DOI: 10.1007/s11936-023-01022-2.Peer-Reviewed Original ResearchCoronary artery diseaseAcute coronary syndromePercutaneous coronary interventionArtery diseaseRisk stratificationDiagnosis of patientsCoronary syndromeCoronary interventionPoint of carePrimary preventionElectrocardiographic patternCatheterization labClinical uptakeRisk estimation modelCliniciansDiseaseSummaryThe developmentPatientsSyndromeStratificationDiagnosisTriageBiomarkersDigital aidsCareSimplified rules-based tool to facilitate the application of up-to-date management recommendations in cardio-oncology
Brown S, Hamid A, Pederson E, BS A, Maddula R, Goodman R, Lamberg M, Caraballo P, Noseworthy P, Lukan O, Echefu G, Berman G, Choudhuri I. Simplified rules-based tool to facilitate the application of up-to-date management recommendations in cardio-oncology. Cardio-Oncology 2023, 9: 37. PMID: 37891699, PMCID: PMC10605976, DOI: 10.1186/s40959-023-00179-w.Peer-Reviewed Original ResearchCancer survivorsCare suggestionsCare of cancer survivorsScientific statementCardiovascular diseaseExpert consensusCardiovascular disease preventionRisk of cardiovascular diseaseRates of statin usePoint of carePrevent Cardiovascular DiseaseHealth systemCardiovascular carePrevention recommendationsInadequate utilizationDisease preventionCardiovascular medicationsCareMethodological studySociety recommendationsStatin useGuideline documentsPatient suitabilitySurvivorsConsensus recommendationsFocused cardiac ultrasound in pregnancy
Edwards P, Anyaogu C, Mezue K, Baugh D, Goha A, Egbuche O, Nunura F, Madu E. Focused cardiac ultrasound in pregnancy. Journal Of Investigative Medicine 2023, 71: 81-91. PMID: 36691704, DOI: 10.1177/10815589221142195.Peer-Reviewed Original ResearchConceptsFocused cardiac ultrasoundRheumatic heart diseaseCardiac diseaseMaternal morbidityMaternal outcomesMaternal mortality review committeesHeart diseaseAssociated with poor maternal outcomeCause of maternal mortalityCardiac ultrasoundMortality Review CommitteePoor maternal outcomeSymptoms of normal pregnancyMiddle-income countriesExcessive maternal morbidityHigh-income countriesPoint of careAcquired cardiac diseaseManagement of cardiac diseaseMaternal mortalityEmergency medicineDiagnosis of cardiac diseaseNormal pregnancyTreatment of heart diseasePrompt recognition
2022
A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation— part 1: a guide to decision-making
Detterbeck FC, Blasberg JD, Woodard GA, Decker RH, Kumbasar U, Park HS, Mase VJ, Bade BC, Li AX, Brandt WS, Madoff DC. A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation— part 1: a guide to decision-making. Journal Of Thoracic Disease 2022, 0: 0-0. PMID: 35813719, PMCID: PMC9264102, DOI: 10.21037/jtd-21-1823.Peer-Reviewed Original ResearchLong-term outcomesIndividual patientsHealthy patientsLung cancerFavorable tumorsStage I lung cancerBetter long-term outcomesI lung cancerStage I NSCLCOlder patientsPatient selectionPoint of careSurgical approachClinical careEffect modifiersTreatment selectionPatientsTreatment approachesPatient valuesClinical judgmentSystematic reviewRelevant outcomesLong-term differencesAvailable evidenceShort-term differencesA speculum free portable preterm imaging system
Boonya-Ananta T, Gonzalez M, Du Le V, DeHoog E, Paidas M, Jayakumar A, Ramella-Roman J. A speculum free portable preterm imaging system. Progress In Biomedical Optics And Imaging 2022, 11963: 119630a-119630a-8. DOI: 10.1117/12.2609915.Peer-Reviewed Original Research
2021
Traditional healer-delivered point-of-care HIV testing versus referral to clinical facilities for adults of unknown serostatus in rural Uganda: a mixed-methods, cluster-randomised trial
Sundararajan R, Ponticiello M, Lee M, Strathdee S, Muyindike W, Nansera D, King R, Fitzgerald D, Mwanga-Amumpaire J. Traditional healer-delivered point-of-care HIV testing versus referral to clinical facilities for adults of unknown serostatus in rural Uganda: a mixed-methods, cluster-randomised trial. The Lancet Global Health 2021, 9: e1579-e1588. PMID: 34678199, PMCID: PMC8562591, DOI: 10.1016/s2214-109x(21)00366-1.Peer-Reviewed Original ResearchConceptsPoint-of-care HIV testingUptake of HIV testingCluster randomised trialHIV testingTraditional healersTesting uptakeIncrease rates of HIV testingRural UgandaEffectiveness of traditional healersCommunity-based HIV testingLinkage to HIV careRates of HIV testingQualitative interviewsHIV testing uptakeRural southwestern UgandaSub-Saharan AfricaUS National Institute of Mental HealthNational Institute of Mental HealthInstitute of Mental HealthHealth-care resourcesClients per weekDays of study enrollmentMixed-methods studyPoint of careControl groupHIV Information Acquisition and Use Among Young Black Men Who Have Sex With Men Who Use the Internet: Mixed Methods Study
Threats M, Bond K. HIV Information Acquisition and Use Among Young Black Men Who Have Sex With Men Who Use the Internet: Mixed Methods Study. Journal Of Medical Internet Research 2021, 23: e22986. PMID: 33960953, PMCID: PMC8140385, DOI: 10.2196/22986.Peer-Reviewed Original ResearchConceptsHIV informationHIV preventionHealth care providersCare providersHealth information websitesYoung Black menPatient-provider communicationWeb-based self-administered surveyPatient-doctor communicationHealth care settingsBlack menHIV statusPoint of careTreatment optionsCare settingsHIV interventionsAverage ageHIVSelf-administered surveyCare servicesInformational support exchangesYBMSMConsumer health information websitesInformation websitesMost menTowards personalised management for non-variceal upper gastrointestinal bleeding
Sung JJY, Laine L, Kuipers EJ, Barkun AN. Towards personalised management for non-variceal upper gastrointestinal bleeding. Gut 2021, 70: 818-824. PMID: 33649044, DOI: 10.1136/gutjnl-2020-323846.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIndividual patientsNon-variceal upper gastrointestinal bleedingPre-endoscopic assessmentUpper gastrointestinal bleedingImportant clinical issuePostendoscopic managementGastrointestinal bleedingPatient characteristicsEndoscopic evaluationPoint of careOptimal treatmentInternational guidelinesClinical issuesInternational professional societiesClinical settingSpecific management strategiesStages of managementPatientsTreatmentProfessional societiesManagement strategiesGuidelinesBleedingHaemostasisLesions
2020
Statistical Considerations for Embedded Pragmatic Clinical Trials in People Living with Dementia
Allore HG, Goldfeld KS, Gutman R, Li F, Monin JK, Taljaard M, Travison TG. Statistical Considerations for Embedded Pragmatic Clinical Trials in People Living with Dementia. Journal Of The American Geriatrics Society 2020, 68: s68-s73. PMID: 32589276, PMCID: PMC7396162, DOI: 10.1111/jgs.16616.Peer-Reviewed Original ResearchConceptsEmbedded Pragmatic Clinical TrialsPragmatic clinical trialsClinical trialsAlzheimer's diseaseImbedded Pragmatic Alzheimer's DiseaseIMPACT CollaboratoryOutcome ascertainmentPoint of careNonpharmacological interventionsReal-world settingComplex interventionsTrialsIntervention effectivenessVulnerable populationsPragmatic designHealthcare systemNational InstituteClinical scientistsSuch interventionsInterventionDementiaPLWDDiseaseCaregiversResearch priorities
2019
Distributed Microbiology Testing Bringing Infectious Disease Diagnostics to Point of Care
Peaper DR, Durant T, Campbell S. Distributed Microbiology Testing Bringing Infectious Disease Diagnostics to Point of Care. Clinics In Laboratory Medicine 2019, 39: 419-431. PMID: 31383266, DOI: 10.1016/j.cll.2019.05.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2018
Enhancing the prediction of acute kidney injury risk after percutaneous coronary intervention using machine learning techniques: A retrospective cohort study
Huang C, Murugiah K, Mahajan S, Li SX, Dhruva SS, Haimovich JS, Wang Y, Schulz WL, Testani JM, Wilson FP, Mena CI, Masoudi FA, Rumsfeld JS, Spertus JA, Mortazavi BJ, Krumholz HM. Enhancing the prediction of acute kidney injury risk after percutaneous coronary intervention using machine learning techniques: A retrospective cohort study. PLOS Medicine 2018, 15: e1002703. PMID: 30481186, PMCID: PMC6258473, DOI: 10.1371/journal.pmed.1002703.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedClinical Decision-MakingData MiningDecision Support TechniquesFemaleHumansMachine LearningMaleMiddle AgedPercutaneous Coronary InterventionProtective FactorsRegistriesReproducibility of ResultsRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionNational Cardiovascular Data RegistryRisk prediction modelAKI eventsAKI riskCoronary interventionAKI modelMean ageCardiology-National Cardiovascular Data RegistryAcute kidney injury riskAKI risk predictionRetrospective cohort studyIdentification of patientsCandidate variablesAvailable candidate variablesCohort studyPCI proceduresPoint of careBrier scoreAmerican CollegeData registryPatientsCalibration slopeInjury riskSame cohort2000. Rapid, Point-of-care Diagnosis of Tuberculosis with Novel Truenat Assay: Cost-Effectiveness and Budgetary Impact Analysis for India’s Public Sector
Lee D, Kumarasamy N, Resch S, Sivaramakrishnan G, Mayer K, Tripathy S, Paltiel A, Freedberg K, Reddy K. 2000. Rapid, Point-of-care Diagnosis of Tuberculosis with Novel Truenat Assay: Cost-Effectiveness and Budgetary Impact Analysis for India’s Public Sector. Open Forum Infectious Diseases 2018, 5: s582-s582. PMCID: PMC6254532, DOI: 10.1093/ofid/ofy210.1656.Peer-Reviewed Original ResearchIncremental cost-effectiveness ratioPublic healthcare facilitiesLife expectancyXpert MTB/RIFHIV-negative patientsPeripheral healthcare settingsHealthcare facilitiesBudgetary impact analysisMTB/RIFDiagnostic test costsSputum smear microscopyCost-effectiveness ratioMulti-way sensitivity analysesTB outcomesTB diagnosisPoint of careTruenatSmear microscopyXpertBudget impactTuberculosis diagnosticsDiagnostic strategiesHealthcare expendituresHealthcare settingsRifampin resistanceShock Index Predicts Patient‐Related Clinical Outcomes in Stroke
Myint P, Sheng S, Xian Y, Matsouaka R, Reeves M, Saver J, Bhatt D, Fonarow G, Schwamm L, Smith E. Shock Index Predicts Patient‐Related Clinical Outcomes in Stroke. Journal Of The American Heart Association 2018, 7: e007581. PMID: 30371191, PMCID: PMC6222962, DOI: 10.1161/jaha.117.007581.Peer-Reviewed Original ResearchConceptsShock indexClinical outcomesWorse outcomesPatient-related clinical outcomesHealth Stroke ScaleBlood pressure componentsAcute stroke casesRankin Scale scoreSystolic blood pressureUseful prognostic indicatorMortality prediction modelIndividual stroke subtypesLinear spline modelsHospital mortalityHospital outcomesHospital stayStroke ScaleAcute strokeDischarge destinationBlood pressureStroke subtypesPoint of carePoor outcomePrognostic valueStroke casesDetection of Influenza A and B Viruses and Respiratory Syncytial Virus by Use of Clinical Laboratory Improvement Amendments of 1988 (CLIA)-Waived Point-of-Care Assays: a Paradigm Shift to Molecular Tests
Azar MM, Landry ML. Detection of Influenza A and B Viruses and Respiratory Syncytial Virus by Use of Clinical Laboratory Improvement Amendments of 1988 (CLIA)-Waived Point-of-Care Assays: a Paradigm Shift to Molecular Tests. Journal Of Clinical Microbiology 2018, 56: 10.1128/jcm.00367-18. PMID: 29695519, PMCID: PMC6018333, DOI: 10.1128/jcm.00367-18.BooksConceptsRapid influenza diagnostic testsRespiratory syncytial virusNucleic acid amplification testsSyncytial virusB virusInfluenza AClinical Laboratory Improvement AmendmentsAntiviral therapyPoint of careAvailable rapid influenza diagnostic testsSensitive nucleic acid amplification testsMolecular testsInfluenza diagnostic testsRespiratory virus infectionsInfection prevention strategiesRapid antigen detectionRapid laboratory testingViral diagnostic testingDetection of influenzaNew pandemic strainsAccurate laboratory diagnosisRapid antigenRespiratory virusesViral culturePatient managementImplementing Internet-Based Self-Care Programs in Primary Care: Qualitative Analysis of Determinants of Practice for Patients and Providers
Hermes E, Burrone L, Perez E, Martino S, Rowe M. Implementing Internet-Based Self-Care Programs in Primary Care: Qualitative Analysis of Determinants of Practice for Patients and Providers. JMIR Mental Health 2018, 5: e42. PMID: 29776898, PMCID: PMC5984276, DOI: 10.2196/mental.9600.Peer-Reviewed Original ResearchSelf-care programPrimary careDeterminants of practiceVeterans Health Administration (VHA) providersVeterans Health Administration primary careCommon mental health conditionsPatient-level determinantsProvider-level determinantsPrimary care providersPrimary care settingVeterans Health AdministrationMental health conditionsUS health care systemEvidence-based interventionsTraditional care deliveryProgram implementationHealth care systemPoint of careCare settingsCare providersProgram usePatient expectationsPatient experienceHealth AdministrationCare deliveryRisks Associated With Primary and Redo Carotid Endarterectomy in the Endovascular Era
Arhuidese I, Faateh M, Nejim B, Locham S, Abularrage C, Malas M. Risks Associated With Primary and Redo Carotid Endarterectomy in the Endovascular Era. JAMA Surgery 2018, 153: 252-259. PMID: 29117272, PMCID: PMC5885921, DOI: 10.1001/jamasurg.2017.4477.Peer-Reviewed Original ResearchConceptsPrimary carotid endarterectomyRedo carotid endarterectomyAsymptomatic patientsSymptomatic patientsCarotid endarterectomyMyocardial infarctionProspective cohort of patientsPoint of careCohort of patientsPerioperative myocardial infarctionRisk of deathAsymptomatic carotid stenosisVascular Quality InitiativeRisk of strokeExcess riskMain OutcomesSociety for Vascular SurgeryClinicians' expectationsCommunity hospitalProfessional guidelinesConsecutive patientsProspective cohortNo significant differenceEndovascular therapyQuality Initiative
2017
Preference phenotypes to facilitate shared decision-making in rheumatoid arthritis
Fraenkel L, Nowell WB, Michel G, Wiedmeyer C. Preference phenotypes to facilitate shared decision-making in rheumatoid arthritis. Annals Of The Rheumatic Diseases 2017, 77: 678-683. PMID: 29247126, PMCID: PMC5898982, DOI: 10.1136/annrheumdis-2017-212407.Peer-Reviewed Original ResearchConceptsBothersome side effectsRare side effectRheumatoid arthritisSide effectsSerious infectionsOnset of actionJanus kinase inhibitorPreferences of patientsMethotrexate monotherapyTriple therapyParenteral medicationsPoint of careTreatment preferencesGroup 2Patient valuesPatientsGroup 4Target strategyGroup 5Kinase inhibitorsConjoint analysis surveyLatent class analysisLarge groupArthritisMedications
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