2025
Mechanistic Insights into a Self-Management Intervention in Young Adults with Irritable Bowel Syndrome: A Pilot Multi-Omics Study
Wu W, Chen J, Li A, Chen M, Starkweather A, Cong X. Mechanistic Insights into a Self-Management Intervention in Young Adults with Irritable Bowel Syndrome: A Pilot Multi-Omics Study. Biomedicines 2025, 13: 2102. PMID: 41007665, PMCID: PMC12467349, DOI: 10.3390/biomedicines13092102.Peer-Reviewed Original ResearchSelf-management interventionsPost-interventionIrritable bowel syndromeSelf-reported pain severityResults:</b>Pre-post studyParent randomized controlled trialBrief Pain InventoryYoung adultsRandomized Controlled TrialsPain interferenceNon-HispanicSelf-ManagementLinear mixed-effects modelsLarger longitudinal studiesPain InventoryPain severityMethods:</b>Bowel syndromeLifestyle modificationMixed-effects modelsLongitudinal multi-omic profilingInterventionSleep disturbanceLongitudinal studySafety and Efficacy of Fecal Microbiota, Live-jslm to Prevent Recurrent Clostridioides difficile Infection in Participants With Irritable Bowel Syndrome
Aroniadis O, Guthmueller B, Dehlin K, Srivastava S, Feuerstadt P, Lembo A, Weber H. Safety and Efficacy of Fecal Microbiota, Live-jslm to Prevent Recurrent Clostridioides difficile Infection in Participants With Irritable Bowel Syndrome. Infectious Diseases And Therapy 2025, 14: 2157-2169. PMID: 40784972, PMCID: PMC12425869, DOI: 10.1007/s40121-025-01208-0.Peer-Reviewed Original ResearchTreatment-emergent adverse eventsConcurrent IBSStandard-of-careIrritable bowel syndromeSustained clinical responseExploratory subgroup analysisClinical responsePrimary endpointAntibiotic treatmentSerious treatment-emergent adverse eventsTreatment successBowel syndromeRecurrent ClostridioidesOpen-labelCDI recurrenceSingle-doseSecondary endpointsFecal microbiotaEfficacious optionAdverse eventsProspective studyIntroductionThe safetySubgroup analysisFDA approvalRCDIEnteric Elongation Induced by a Novel Sleeve Device in a Live Roux-en-Y Configuration
Colvin J, O’Quin C, Meyer H, Welch V, Solitro G, Alexander J, Sorrells D. Enteric Elongation Induced by a Novel Sleeve Device in a Live Roux-en-Y Configuration. Bioengineering 2025, 12: 771. PMID: 40722463, PMCID: PMC12292125, DOI: 10.3390/bioengineering12070771.Peer-Reviewed Original ResearchShort bowel syndromeRoux limb lengthRoux-en-YLong-term parenteral nutritionRoux-en-Y configurationDelayed gastric emptyingCurrent surgical optionsParenteral nutritionSurgical optionsIntestinal dilatationGastric emptyingBowel syndromeIntestinal lengtheningTissue remodelingRoux limbSleeve deviceWeeks post-deploymentBowelRatsLimb lengthWeeks
2024
Gut-brain axis and neuroplasticity in health and disease: a systematic review
Di Napoli A, Pasquini L, Visconti E, Vaccaro M, Rossi-Espagnet M, Napolitano A. Gut-brain axis and neuroplasticity in health and disease: a systematic review. La Radiologia Medica 2024, 130: 327-358. PMID: 39718685, DOI: 10.1007/s11547-024-01938-0.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imaging studyDiffusion tensor imagingHealthy subjectsArterial spin labelingGut-brain axisBrain connectivityStructural magnetic resonance imagingMagnetic resonance imaging studiesInflammatory bowel syndromeAssociated with connectivityMagnetic resonance imagingGut microbiotaBowel syndromeImaging studiesTranscranial magnetic stimulationTemporal cortexNon-human subjectsResonance imagingCurrent evidenceStructural MRISomatosensory cortexPatientsPsychiatric diseasesBrain functionTensor imagingInvestigating the overlapping presentation of irritable bowel syndrome and vulvodynia: a scoping review of the evidence and mechanisms
Perelmuter S, Soogoor A, Maliszewski K, Grimshaw A. Investigating the overlapping presentation of irritable bowel syndrome and vulvodynia: a scoping review of the evidence and mechanisms. Sexual Medicine Reviews 2024, 12: 559-568. PMID: 39084679, DOI: 10.1093/sxmrev/qeae053.Peer-Reviewed Original ResearchIrritable bowel syndromeDiagnostic delayPresentation of irritable bowel syndromeQuasi-experimental studyInception of databasesIncreased risk of sexual dysfunctionCross-sectional studyCase-control studyBowel syndromeRisk of sexual dysfunctionWeb of ScienceSignificant diagnostic delayImprove screeningMultifactorial medical conditionIBS diagnosisCohort studyMedical conditionsReduced qualityMast cell involvementCochrane LibraryComprehensive searchScience DirectIncreased likelihoodIncreased riskGoogle ScholarDistraction Enterogenesis in Rats: A Novel Approach for the Treatment of Short Bowel Syndrome
O’Quin C, Clayton S, Trosclair L, Meyer H, Dao N, Minagar A, White L, Welch V, Solitro G, Alexander J, Sorrells D. Distraction Enterogenesis in Rats: A Novel Approach for the Treatment of Short Bowel Syndrome. Pathophysiology 2024, 31: 388-397. PMID: 39189165, PMCID: PMC11348226, DOI: 10.3390/pathophysiology31030029.Peer-Reviewed Original ResearchTreatment of short bowel syndromeIn vivo rat studyRat intestinal modelShort bowel syndromeSprague Dawley ratsSmall intestineParenteral nutritionBowel histologyBowel lengthDawley ratsLength-tension relationshipMucosal erosionsRat small intestineRat studiesBowel syndromeEx vivoRatsBowel tissueFailure loadPost-deploymentPatientsBowelHistologyLoad test dataIntestinal modelMulti-Omics Analysis of Gut Microbiota and Host Transcriptomics Reveal Dysregulated Immune Response and Metabolism in Young Adults with Irritable Bowel Syndrome
Chen J, Zhao T, Li H, Xu W, Maas K, Singh V, Chen M, Dorsey S, Starkweather A, Cong X. Multi-Omics Analysis of Gut Microbiota and Host Transcriptomics Reveal Dysregulated Immune Response and Metabolism in Young Adults with Irritable Bowel Syndrome. International Journal Of Molecular Sciences 2024, 25: 3514. PMID: 38542485, PMCID: PMC10970623, DOI: 10.3390/ijms25063514.Peer-Reviewed Original ResearchConceptsGut microbiotaIrritable bowel syndrome subjectsHost transcriptomeIrritable bowel syndromeMetabolic pathways of gut microbiotaTranscriptome profilingAnalysis of gut microbiotaDysbiosis of gut microbiotaDysregulated immune responseRNA-seq dataHealthy controlsMulti-omics analysisImmune responseImmune system processRNA-seqGene OntologyBowel syndromeIBS participantsMulti-OmicsMicrobiotaMetabolic pathwaysPathways of antigen processingPeripheral blood samplesGutStool samples
2023
Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders
Koller D, Pathak G, Wendt F, Tylee D, Levey D, Overstreet C, Gelernter J, Taylor H, Polimanti R. Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders. JAMA Network Open 2023, 6: e2251214. PMID: 36652249, PMCID: PMC9856929, DOI: 10.1001/jamanetworkopen.2022.51214.Peer-Reviewed Original ResearchConceptsPsychiatric comorbidityMAIN OUTCOMEMental healthIrritable bowel syndromeBody mass indexAssociation of endometriosisOdds of depressionSevere physical symptomsPain-related phenotypesWomen's mental healthMultivariate regression analysisOdds of endometriosisBowel syndromeGenetic associationMass indexGynecologic pathologyMillion Veteran ProgramEndometriosisPsychiatric disordersWomen's healthFemale controlsPleiotropic mechanismsPhysical symptomsComorbiditiesFinnGen study
2022
Short Bowel Syndrome and Intestinal Lengthening Procedures
Salvi P, Cowles R. Short Bowel Syndrome and Intestinal Lengthening Procedures. 2022, 345-356. DOI: 10.1007/978-3-030-96542-6_31.ChaptersIntestinal lengthening proceduresParenteral nutritionLengthening proceduresIntestinal transplantSurgical interventionMultidisciplinary intestinal rehabilitation programParenteral nutrition failureIntestinal rehabilitation programShort bowel syndromeSmall bowel resectionSignificant physiologic consequencesCompensatory-adaptive changesBowel functionBowel resectionBowel syndromeIntestinal transitIntestinal adaptationIntestinal lossSpecialized epithelial cellsMucosal growthRehabilitation programPhysiologic consequencesDistal ileumPatientsFat absorptionGut instincts in neuroimmunity from the eighteenth to twenty-first centuries
Nguyen M, Palm NW. Gut instincts in neuroimmunity from the eighteenth to twenty-first centuries. Seminars In Immunopathology 2022, 44: 569-579. PMID: 35786740, PMCID: PMC9519704, DOI: 10.1007/s00281-022-00948-2.Peer-Reviewed Original ResearchConceptsNon-communicable chronic diseasesGut-brain interactionInflammatory bowel diseaseIrritable bowel syndromeDiverse diseasesMillions of adultsBowel diseaseBowel syndromeBrain axisChronic diseasesPutative etiologyGut microbiotaImmune systemAlzheimer's diseaseGut microbiomeDiseaseBrainAutism spectrum disorderDisordersSpectrum disorderMicrobiotaGutReciprocal interactionsHuman healthHealthSomatosensory Profiles Differentiate Pain and Psychophysiological Symptoms Among Young Adults With Irritable Bowel Syndrome
Chen J, Zhang Y, Barandouzi Z, Xu W, Feng B, Chon K, Santos M, Starkweather A, Cong X. Somatosensory Profiles Differentiate Pain and Psychophysiological Symptoms Among Young Adults With Irritable Bowel Syndrome. The Clinical Journal Of Pain 2022, 38: 492-501. PMID: 35686579, PMCID: PMC9205184, DOI: 10.1097/ajp.0000000000001046.Peer-Reviewed Original ResearchConceptsIrritable bowel syndromeIrritable bowel syndrome patientsHealthy controlsPain intensityPain thresholdBowel syndromeIBS-related painSomatic pain perceptionQuantitative sensory testingIncreased pain thresholdYoung adultsRandomized clinical trialsSelf-management interventionsSomatosensory profilesDifferentiate painPain perceptionPsychophysiological symptomsFollow-upClinical trialsPainNormal thresholdsIncreased thresholdSensory thresholdsSevere symptomsPatientsAssociations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome
Barandouzi Z, Lee J, del Carmen Rosas M, Chen J, Henderson W, Starkweather A, Cong X. Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome. Scientific Reports 2022, 12: 1648. PMID: 35102266, PMCID: PMC8803858, DOI: 10.1038/s41598-022-05756-0.Peer-Reviewed Original ResearchConceptsEmotional distressNeurotransmitter levelsHealthy controlsIrritable bowel syndrome groupIrritable bowel syndromeRegulation of neurotransmittersDepressive symptomsSerotonin levelsGut-brain axisEmotional symptomsHC groupPlasma neurotransmittersDistressGut microbiome profilesNeurotransmitterGut microbiomeNorepinephrine levelsBowel syndromeMicrobiome profilesPersonsNorepinephrineNested Case-Control StudySymptomsCase-control studySerotoninThe Associations of Single Nucleotide Polymorphisms with Risk and Symptoms of Irritable Bowel Syndrome
Zhao T, Zhang Y, Lee J, Starkweather A, Young E, Cong X. The Associations of Single Nucleotide Polymorphisms with Risk and Symptoms of Irritable Bowel Syndrome. Journal Of Personalized Medicine 2022, 12: 142. PMID: 35207633, PMCID: PMC8878682, DOI: 10.3390/jpm12020142.Peer-Reviewed Original ResearchAssociated with IBS riskPatient-Reported Outcomes Measurement Information SystemBrief Pain InventorySingle nucleotide polymorphismsPain severityIrritable bowel syndromeOutcomes Measurement Information SystemIrritable bowel syndrome symptomsAssociated with pain severityMeasurement Information SystemSleep disturbanceAssociated with fatigueRisk single nucleotide polymorphismsAssociation of single nucleotide polymorphismsAssociated with sleep disturbancesRandomized Controlled TrialsMultivariate linear regressionNucleotide polymorphismsPain InventoryBowel syndromeFisher's exact testHealthy controlsBaseline dataRisk allelesSymptoms of irritable bowel syndrome
2021
Functional Abdominal Pain
Drossman D, Deutsch J. Functional Abdominal Pain. 2021, 1191-1202. DOI: 10.1007/978-3-030-30192-7_99.Peer-Reviewed Original ResearchFunctional gastrointestinal disordersIrritable bowel syndromeCentral nervous systemAbdominal painCognitive behavioral therapyPain symptomsFunctional dyspepsiaOlder adultsAbdominal pain syndromeChronic abdominal painFunctional abdominal painGut-brain interactionGut motility disordersImprovement of symptomsChronic pain conditionsRed flagsQuality of lifePain syndromeBowel syndromeElderly patientsGastrointestinal painPain modulationPain conditionsMotility disordersGastrointestinal disordersComplementary and Alternative Medicine Therapies for Irritable Bowel Syndrome
Shapiro JM, Deutsch JK. Complementary and Alternative Medicine Therapies for Irritable Bowel Syndrome. Gastroenterology Clinics Of North America 2021, 50: 671-688. PMID: 34304794, DOI: 10.1016/j.gtc.2021.03.009.Peer-Reviewed Original ResearchAltered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components
Barandouzi Z, Lee J, Maas K, Starkweather A, Cong X. Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components. Journal Of Personalized Medicine 2021, 11: 35. PMID: 33429936, PMCID: PMC7827153, DOI: 10.3390/jpm11010035.Peer-Reviewed Original ResearchAlpha diversity indicesGut microbiotaIrritable bowel syndromeDiversity indexHealthy controlsHighest alpha-diversity indicesAlterations of gut microbiota compositionGut microbiota patternHigher alpha diversityGut microbiota compositionGut microbiota alterationsAltered gut microbiotaGut microbiome patternsCaffeine consumptionBowel syndromePathophysiology of irritable bowel syndromeIllumina sequencingFood frequency questionnaireAlpha diversityIrritable bowel syndrome groupIrritable bowel syndrome patientsMicrobial diversityMicrobiota compositionMicrobiota alterationsMicrobiota patterns
2020
Long-term Outcomes Following Multiply Recurrent Clostridioides difficile Infection and Fecal Microbiota Transplantation
Dawwas GK, Brensinger CM, Vajravelu RK, Wu Q, Kelly CR, Laine L, Wu GD, Lewis JD. Long-term Outcomes Following Multiply Recurrent Clostridioides difficile Infection and Fecal Microbiota Transplantation. Clinical Gastroenterology And Hepatology 2020, 20: 806-816.e6. PMID: 33307184, PMCID: PMC8184854, DOI: 10.1016/j.cgh.2020.12.004.Peer-Reviewed Original ResearchConceptsFecal microbiota transplantationIrritable bowel syndromeImmune-mediated diseasesBowel syndromeMyocardial infarctionMicrobiota transplantationRecurrent Clostridioides difficile infectionRecurrent Clostridioides difficileRetrospective cohort studyImmune-mediated conditionsInflammatory bowel diseaseInflammatory bowel syndromeCommercial claims databaseLong-term outcomesClostridioides difficile infectionCohort studyBowel diseaseMicrobiota disturbanceRheumatoid arthritisClaims databaseDifficile infectionHigh riskHigh incidenceGut microbiotaSignificant associationFecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry
Kelly CR, Yen EF, Grinspan AM, Kahn SA, Atreja A, Lewis JD, Moore TA, Rubin DT, Kim AM, Serra S, Nersesova Y, Fredell L, Hunsicker D, McDonald D, Knight R, Allegretti JR, Pekow J, Absah I, Hsu R, Vincent J, Khanna S, Tangen L, Crawford CV, Mattar MC, Chen LA, Fischer M, Arsenescu RI, Feuerstadt P, Goldstein J, Kerman D, Ehrlich AC, Wu GD, Laine L. Fecal Microbiota Transplantation Is Highly Effective in Real-World Practice: Initial Results From the FMT National Registry. Gastroenterology 2020, 160: 183-192.e3. PMID: 33011173, PMCID: PMC8034505, DOI: 10.1053/j.gastro.2020.09.038.Peer-Reviewed Original ResearchConceptsClostridioides difficile infectionMicrobiota transplantationSafety profileNational registryProspective real-world studyFull safety profileProspective safety dataBaseline patient characteristicsInflammatory bowel diseaseIrritable bowel syndromeFecal microbiota transplantationLong-term safety outcomesGood safety profileReal-world studyAbdominal painBowel syndromePatient characteristicsReal-world practiceBowel diseaseCDI recurrenceDifficile infectionSafety dataSafety outcomesEffectiveness outcomesSevere symptomsComplementary and Alternative Medicine for Functional Gastrointestinal Disorders.
Deutsch JK, Levitt J, Hass DJ. Complementary and Alternative Medicine for Functional Gastrointestinal Disorders. The American Journal Of Gastroenterology 2020, 115: 350-364. PMID: 32079860, DOI: 10.14309/ajg.0000000000000539.Peer-Reviewed Original ResearchConceptsFunctional GI disordersFunctional gastrointestinal disordersGI disordersGastrointestinal disordersAlternative therapiesIrritable bowel syndromeQuality of lifeFunctional dyspepsiaBowel syndromeTreatment algorithmTherapeutic resultsTreatment strategiesAlternative medicinePatientsDisordersComplex disorderGastroenterologistsTherapySignificant numberNauseaVomitingDyspepsiaSyndromeGastroenterologySymptoms
2019
Functional Abdominal Pain
Drossman D, Deutsch J. Functional Abdominal Pain. 2019, 1-12. DOI: 10.1007/978-3-319-90761-1_99-1.Peer-Reviewed Original ResearchFunctional gastrointestinal disordersIrritable bowel syndromeCentral nervous systemAbdominal painCognitive behavioral therapyPain symptomsFunctional dyspepsiaOlder adultsAbdominal pain syndromeChronic abdominal painFunctional abdominal painGut-brain interactionGut motility disordersImprovement of symptomsChronic pain conditionsRed flagsQuality of lifePain syndromeBowel syndromeElderly patientsGastrointestinal painPain modulationPain conditionsMotility disordersGastrointestinal disorders
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