2025
Low Anterior Resection Syndrome Evaluation and Management
Linhares S, Mongiu A. Low Anterior Resection Syndrome Evaluation and Management. Clinics In Colon And Rectal Surgery 2025 DOI: 10.1055/s-0045-1807741.Peer-Reviewed Original ResearchLow anterior resection syndromeTreatment optionsNerve stimulationTreatment of low anterior resection syndromePosterior tibial nerve stimulationSecond-line treatmentThird-line treatmentPelvic floor rehabilitationSphincter-sparing surgeryFirst-line treatmentSacral nerve stimulationPermanent stoma creationTibial nerve stimulationAnterior resection syndromeQuality of lifeMultiple measurement toolsConstellation of symptomsFlatus incontinenceAntegrade enemasFloor rehabilitationRectal cancerTreatment algorithmPreoperative educationStoma creationBowel habits
2024
Practice Advisory on the Implementation of Preoperative Anemia Management: The Society of Cardiovascular Anesthesiologists and the Society for the Advancement of Patient Blood Management.
Klompas A, Hensley N, Burt J, Grant M, Guinn N, Patel P, Popescu W, Raphael J, Salenger R, Shore-Lesserson L, Warner M. Practice Advisory on the Implementation of Preoperative Anemia Management: The Society of Cardiovascular Anesthesiologists and the Society for the Advancement of Patient Blood Management. Anesthesia & Analgesia 2024 PMID: 39671507, PMCID: PMC12095609, DOI: 10.1213/ane.0000000000007321.Peer-Reviewed Original ResearchPatient blood managementAdvancement of Patient Blood ManagementBlood managementPreoperative anemiaCardiac surgeryAnemia managementRed blood cell transfusionAssociated with worse outcomesPreoperative anemia clinicPatient blood management programBlood cell transfusionAcute kidney injuryBlood management programPreoperative anemia managementImproving clinical outcomesSociety of Cardiovascular Anesthesiologists (SCASociety of Cardiovascular AnesthesiologistsAnemia programCell transfusionAnemia clinicEducation of patientsAllogeneic transfusionCardiovascular complicationsKidney injuryTreatment algorithmUpdate on Practical Management of Early-Stage Non-Small Cell Lung Cancer (NSCLC): A Report from the Ontario Forum
Cheema P, Wheatley-Price P, Cecchini M, Ellis P, Louie A, Moore S, Sheffield B, Spicer J, Villeneuve P, Leighl N. Update on Practical Management of Early-Stage Non-Small Cell Lung Cancer (NSCLC): A Report from the Ontario Forum. Current Oncology 2024, 31: 6979-6999. PMID: 39590145, PMCID: PMC11592966, DOI: 10.3390/curroncol31110514.Peer-Reviewed Original ResearchNon-small cell lung cancerEarly-stage non-small cell lung cancerImmune checkpoint inhibitorsCell lung cancerLung cancerManagement of early-stage non-small cell lung cancerPre-meeting surveyTreatment approachesReview practice patternsAdjuvant settingCheckpoint inhibitorsRadiation therapyOntario cancer centersTargeted therapySurgical considerationsTreatment algorithmReview recent dataClinical dataBiomarker testingCancer CenterTherapeutic strategiesPractice patternsCancerTherapyPatientsCurrent state and potential applications of neonatal Fc receptor (FcRn) inhibitors in hematologic conditions
Jacobs J, Booth G, Raza S, Clark L, Fasano R, Gavriilaki E, Abels E, Binns T, Duque M, McQuilten Z, Mingot‐Castellano M, Savani B, Sharma D, Tran M, Tormey C, Moise K, Bloch E, Adkins B. Current state and potential applications of neonatal Fc receptor (FcRn) inhibitors in hematologic conditions. American Journal Of Hematology 2024, 99: 2351-2366. PMID: 39324647, PMCID: PMC11560617, DOI: 10.1002/ajh.27487.Peer-Reviewed Original ResearchHematological conditionsFcRn inhibitorsClinical trialsStandardized treatment algorithmClinical trial dataNeonatal Fc receptorIn vivo studiesImmune-mediatedHematological disordersTreatment algorithmTransports IgGAdverse eventsImmunomodulatory/immunosuppressive therapiesIgG levelsPatient populationProtective IgGFc receptorsTherapeutic strategiesMucosal surfacesRheumatologic conditionsIgG antibodiesImmunoglobulin isotypesTrial dataIgGFcRnClinical and Histologic Variants of CD8+ Cutaneous T-Cell Lymphomas
Swallow M, Micevic G, Zhou A, Carlson K, Foss F, Girardi M. Clinical and Histologic Variants of CD8+ Cutaneous T-Cell Lymphomas. Cancers 2024, 16: 3087. PMID: 39272944, PMCID: PMC11394026, DOI: 10.3390/cancers16173087.Peer-Reviewed Original ResearchT-cell lymphomaPrimary cutaneous gamma/delta T-cell lymphomaSubcutaneous panniculitis-like T-cell lymphomaLymphoproliferative disordersMycosis fungoidesCD8+ cutaneous T-cell lymphomasCutaneous gamma/delta T-cell lymphomaPanniculitis-like T-cell lymphomaGamma/delta T-cell lymphomaCytotoxic T-cell lymphomaT-cell lymphoproliferative disorderAbnormal T-cell populationCutaneous T-cell lymphomaCytotoxic molecule expressionT cell populationsIndicator of prognosisAppropriate treatment planCD8-positiveAggressive entityLymphomatoid papulosisHistological variantsHistopathological differentiationTreatment algorithmCD8Clinical manifestations6th and 7th International consensus guidelines for the management of advanced breast cancer (ABC guidelines 6 and 7)
Cardoso F, Paluch-Shimon S, Schumacher-Wulf E, Matos L, Gelmon K, Aapro M, Bajpai J, Barrios C, Bergh J, Bergsten-Nordström E, Biganzoli L, Cardoso M, Carey L, Mac Gregor M, Chidebe R, Cortés J, Curigliano G, Dent R, Saghir N, Eniu A, Fallowfield L, Francis P, Millan S, Gilchrist J, Gligorov J, Gradishar W, Haidinger R, Harbeck N, Hu X, Kaur R, Kiely B, Kim S, Koppikar S, Kuper-Hommel M, Lecouvet F, Mason G, Mertz S, Mueller V, Myerson C, Neciosup S, Offersen B, Ohno S, Pagani O, Partridge A, Penault-Llorca F, Prat A, Rugo H, Senkus E, Sledge G, Swain S, Thomssen C, Vorobiof D, Vuylsteke P, Wiseman T, Xu B, Costa A, Norton L, Winer E. 6th and 7th International consensus guidelines for the management of advanced breast cancer (ABC guidelines 6 and 7). The Breast 2024, 76: 103756. PMID: 38896983, PMCID: PMC11231614, DOI: 10.1016/j.breast.2024.103756.Peer-Reviewed Original ResearchAdvanced breast cancerLevel of evidenceInternational consensus guidelinesBreast cancerConsensus guidelinesGrading of RecommendationsConsensus conferenceHighest level of evidenceManagement of advanced breast cancerBreast cancer subtypesInternational Consensus ConferencePercentage of consensusTreatment algorithmCancer subtypesSupportive careGuidelinesExpert opinionGlobal AllianceCancerPatientsManagement optionsRecommendationsCareHigher levelsConsensusGeriatric Vertebral Compression Fracture: A Database Study Characterizing Use and Trends for Prescribed Thoracic/Lumbar Orthoses
Halperin S, Dhodapkar M, Moran J, Jeong S, Grauer J, Varthi A. Geriatric Vertebral Compression Fracture: A Database Study Characterizing Use and Trends for Prescribed Thoracic/Lumbar Orthoses. Global Spine Journal 2024, 15: 1318-1323. PMID: 38546972, PMCID: PMC11572230, DOI: 10.1177/21925682241238672.Peer-Reviewed Original ResearchCompression fracturesFractures associated with osteoporosisVertebral compression fracturesMultivariate logistic regressionIndicator of infectionPearlDiver databaseIndependent predictorsTreatment algorithmInclusion criteriaFemale sexLogistic regressionT5-L5Geographic regionsFracture managementFracture levelNational databasePatientsExclusion criteriaYounger ageBraceNon-clinicalCharacterized useOrthosesDatabaseFracture
2023
Chondromalacia patellae: Cartilaginous lesions of the patella in the setting of anterior knee pain
Levy B, Cossell C, Grimm N, Jimenez A, Bisson L. Chondromalacia patellae: Cartilaginous lesions of the patella in the setting of anterior knee pain. Journal Of Cartilage & Joint Preservation 2023, 3: 100096. DOI: 10.1016/j.jcjp.2022.100096.Peer-Reviewed Original ResearchAnterior knee painKnee painTreatment strategiesPresence of AKPLower extremity muscle weaknessCause of CPExtremity muscle weaknessSubsequent treatment strategiesBest treatment strategyNonoperative measuresCommon diagnosisInitial treatmentTreatment algorithmMuscle weaknessRecalcitrant casesExact etiologyFemale sexRisk factorsThorough literature searchPatellar maltrackingAdjunct modalityCartilaginous lesionsPainLiterature searchChondromalaciaDesign, implementation and preliminary results of a type-2 hybrid cluster-randomized trial of integrating screening and treatment for major depressive disorder into specialty clinics providing opioid agonist therapies in Ukraine
Machavariani E, Bromberg D, Dumchev K, Dvoriak S, Zeziulin O, Morozova O, Esserman D, Pykalo I, Saichuk N, Ivasiy R, Haddad M, Altice F. Design, implementation and preliminary results of a type-2 hybrid cluster-randomized trial of integrating screening and treatment for major depressive disorder into specialty clinics providing opioid agonist therapies in Ukraine. Contemporary Clinical Trials 2023, 131: 107248. PMID: 37263492, PMCID: PMC10527419, DOI: 10.1016/j.cct.2023.107248.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyMajor depressive disorderCo-occurring disordersAgonist therapyDepressive disorderSpecialty clinicPsychiatric disordersPatient-level outcomesPrevalent psychiatric disordersCluster-randomized trialPoor health outcomesProvider-level dataMDD treatmentTreatment algorithmExperimental armHigh prevalenceDelivery outcomesHealth outcomesSerial surveysClinicPatientsProject ECHOSubstance useMonthsDisordersA New Solution to an Age-old Problem: A Review of Ketamine and Esketamine for Treatment-resistant Depression in Late Life
Balaram K, van Dyck L, Wilkins K, Maruca-Sullivan P. A New Solution to an Age-old Problem: A Review of Ketamine and Esketamine for Treatment-resistant Depression in Late Life. Current Geriatrics Reports 2023, 12: 93-102. DOI: 10.1007/s13670-023-00389-1.Peer-Reviewed Original ResearchTreatment-resistant major depressive disorderUse of ketamineOlder adultsKetamine/esketamineTreatment-resistant depressionAnti-depressant effectsEfficacy of ketamineLate-onset depressionOnset of actionCurrent treatment strategiesLate-life depressionCase series dataMajor depressive disorderTypes of patientsDegree of disabilityPotential long termOpen labelAntidepressant effectsOnset depressionOverall mortalityHealthcare utilizationTreatment algorithmCase reportCaregiver burdenClinical trialsExtensor Mechanism Disruption Impacts Treatment of Dislocated and Multiligament Injured Knees
Medvecky M, Kahan J, Richter D, Islam W, McLaughlin W, Moran J, Alaia M, Miller M, Wascher D, Treme G, Campos T, Held M, Schenck R, Group T. Extensor Mechanism Disruption Impacts Treatment of Dislocated and Multiligament Injured Knees. Journal Of Bone And Joint Surgery 2023, 105: 1012-1019. PMID: 37186688, DOI: 10.2106/jbjs.23.00079.Peer-Reviewed Original ResearchConceptsMultiligament knee injuriesTreatment algorithmResponse rateExtensor mechanism disruptionLittle clinical evidenceLarge case seriesTreatment of patientsClinical outcome dataNumerous clinical factorsPositive consensusClassic Delphi techniqueInitial surgeryMechanism disruptionClinical factorsInjured kneesRare injuryCase seriesKnee injuriesProspective studyClinical evidenceOptimal treatmentLigamentous reconstructionTreatment decisionsOutcome dataClinical scenarios“Long Haulers”
Lutchmansingh D, Sevilla J, Possick J, Gulati M. “Long Haulers”. Seminars In Respiratory And Critical Care Medicine 2023, 44: 130-142. PMID: 36646091, DOI: 10.1055/s-0042-1759568.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPost-COVID conditionsAcute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionSARS-CoV-2 infectionChronic COVID-19Long-haul COVIDOngoing interventional trialsLong-term morbidityCoronavirus disease 2019Multiple organ systemsInterventional trialsLong COVIDTreatment algorithmNeuropsychiatric sequelaePostacute sequelaeRisk factorsObservational studyDisease 2019Long-term effectsSurvivors' qualityClinical protocolsLong haulersOrgan systems
2022
Randomized controlled trials of biomarker targets
Erlendsdottir M, Crawford F. Randomized controlled trials of biomarker targets. Clinical Trials 2022, 20: 47-58. PMID: 36373783, PMCID: PMC9974557, DOI: 10.1177/17407745221131820.Peer-Reviewed Original ResearchConceptsBlood pressure targetsManagement of hypertensionPressure targetsTreatment strategiesBiomarker targetsControlled TrialsRandomized trialsPatient populationLower blood pressure targetsIntensive blood pressure controlAcute respiratory distress syndromePhysicians attemptNew randomized trialsBlood pressure controlRespiratory distress syndromeLack of blindingTrial patient populationValidity of trialsAdaptive treatment strategiesAntihypertensive medicationsAvailable medicationsDistress syndromeTreat analysisTime-varying confoundingTreatment algorithmMyasthenia Gravis in the Setting of Immune Checkpoint Inhibitor Therapy: Practical Considerations and Opinion-Based Approach to Acute Management
Zubair A, Roy B, Baehring J, Nowak R. Myasthenia Gravis in the Setting of Immune Checkpoint Inhibitor Therapy: Practical Considerations and Opinion-Based Approach to Acute Management. Cureus 2022, 14: e30638. PMID: 36439604, PMCID: PMC9683636, DOI: 10.7759/cureus.30638.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsCheckpoint inhibitor therapyMyasthenia gravisCheckpoint inhibitorsInhibitor therapyICI therapyImmune checkpoint inhibitor therapyImmune checkpoint inhibitor useInflammatory adverse effectsBest treatment algorithmCell lung cancerCheckpoint inhibitor useRenal cell cancerSystem side effectsPotential treatment optionNeurologic complicationsInhibitor useAcute managementOncologic treatmentAnti-CTLA4Cell cancerClinical outcomesTreatment algorithmClinical manifestationsTreatment optionsSurgical Management of Tibialis Anterior Tendon Ruptures: A Systematic Review and Proposed Treatment Algorithm
Weiss M, Azam M, Ubillus H, Gianakos A, Kirschner N, Walls R, Kennedy J. Surgical Management of Tibialis Anterior Tendon Ruptures: A Systematic Review and Proposed Treatment Algorithm. Foot & Ankle Orthopaedics 2022, 7: 2473011421s01000. PMCID: PMC9703547, DOI: 10.1177/2473011421s01000.Peer-Reviewed Original ResearchTibialis anterior tendonAppropriate surgical treatmentSurgical treatmentSystematic reviewSurgical managementTreatment algorithmSurgical interventionDirect repairTibialis Anterior Tendon RuptureAnkle-hindfoot scoreLevel II evidenceFunctional outcome scoresBetter clinical outcomesDifferent surgical interventionsQuality of evidenceLevel of evidenceMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsPaucity of dataTwo-sample t-testAllograft cohortPostoperative AOFASSurgery criteriaTendon ruptureAnterior tendonSacituzumab govitecan: ascending the treatment algorithm in triple negative breast cancer
Rozenblit M, Lustberg MB. Sacituzumab govitecan: ascending the treatment algorithm in triple negative breast cancer. Annals Of Translational Medicine 2022, 0: 0-0. PMID: 35530962, PMCID: PMC9073796, DOI: 10.21037/atm-22-484.Peer-Reviewed Original ResearchAiming at a Tailored Cure for ERBB2-Positive Metastatic Breast Cancer
Tarantino P, Curigliano G, Parsons HA, Lin NU, Krop I, Mittendorf EA, Waks A, Winer EP, Tolaney SM. Aiming at a Tailored Cure for ERBB2-Positive Metastatic Breast Cancer. JAMA Oncology 2022, 8: 629-635. PMID: 35024766, DOI: 10.1001/jamaoncol.2021.6597.Peer-Reviewed Original ResearchConceptsErbB2-positive metastatic breast cancerMetastatic breast cancerPopulation of patientsBreast cancerDe novo metastaticErb-b2 receptor tyrosine kinase 2High ERBB2 expressionCurrent treatment algorithmsHigh-dose chemotherapyLong-term respondersFraction of patientsAntitumor immune activationReceptor tyrosine kinase 2Quality of lifeOverall survivalSystemic treatmentTrastuzumab deruxtecanPathologic featuresTreatment algorithmFrontline treatmentImmune activationBiologic treatmentPathologic termsDisease burdenLong-term benefits
2021
Pathogenesis and Treatment of Refractory Oedema in Nephrotic Syndrome
Jethwani P, Krishnan N. Pathogenesis and Treatment of Refractory Oedema in Nephrotic Syndrome. EMJ Urology 2021, 9: 107-117. DOI: 10.33590/emjurol/21-00041.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEffective arterial blood volumeNephrotic syndromeArterial blood volumeSodium retentionEdema formationLoop diureticsRefractory edemaClinical trialsBlood volumeSodium-potassium adenosine triphosphatase activityCombination diuretic therapySalt-poor albuminSecondary sodium retentionMainstay of therapySubset of patientsLarge clinical trialsSignificant patient morbidityVasopressin receptor antagonistsEpithelial sodium channel activationLimited available evidenceDiuretic resistanceDiuretic therapySodium channel activationTreatment algorithmInflammation contributesImaging of Neuromodulation and Surgical Interventions for Epilepsy
Adin ME, Spencer DD, Damisah E, Herlopian A, Gerrard JL, Bronen RA. Imaging of Neuromodulation and Surgical Interventions for Epilepsy. American Journal Of Neuroradiology 2021, 42: 1742-1750. PMID: 34353787, PMCID: PMC8562735, DOI: 10.3174/ajnr.a7222.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSurgical interventionPostoperative imaging findingsMultiple subpial transectionsComprehensive Epilepsy CenterGroup of patientsVagus nerve stimulationDeep brain stimulationInvasive treatment decisionsNew surgical interventionLobar resectionSubpial transectionMedical therapyEpilepsy centersImaging findingsNerve stimulationTreatment algorithmTherapeutic optionsTreatment modalitiesEpilepsy interventionsPotential complicationsEpilepsy casesTreatment decisionsBrain stimulationResponsive neurostimulationNeuromodulation techniquesPain Control in Dermatologic Conditions
Kodumudi V, Lam D, Rajput K. Pain Control in Dermatologic Conditions. Current Pain And Headache Reports 2021, 25: 38. PMID: 33821364, DOI: 10.1007/s11916-021-00955-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDermatologic conditionsPain controlPrimary disease burdenEpidural steroid injectionsSympathetic nerve blockPain management strategiesLower limb ulcersInterventional Pain PhysiciansQuality of lifeScope of practicePostherpetic neuralgiaSteroid injectionSystemic immunosuppressantsTopical steroidsModerate painSevere painPain physiciansNerve blockTreatment algorithmLimb ulcersNeuropathic agentsTopical agentsCounter analgesicsDisease burdenPatient expectations
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