2023
CD31 as a probable responding and gate-keeping protein of the blood-brain barrier and the risk of Alzheimer’s disease
Zhang Z, Gan Q, Han J, Tao Q, Qiu W, Madri J. CD31 as a probable responding and gate-keeping protein of the blood-brain barrier and the risk of Alzheimer’s disease. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 1027-1041. PMID: 37051650, PMCID: PMC10291450, DOI: 10.1177/0271678x231170041.Peer-Reviewed Original ResearchConceptsPlatelet endothelial cell adhesion moleculeImmune cellsDisease riskBlood-brain barrier permeabilityMajor genetic risk factorBlood-brain barrierNeuronal cell injuryEndothelial cell adhesion moleculesAlzheimer's disease riskGenetic risk factorsPeripheral inflammationBrain axisAPOE4 carriersAD pathogenesisRisk factorsBarrier permeabilityAD developmentCell adhesion moleculeCell injuryImmune systemAlzheimer's diseaseCD31Transendothelial migrationPotential drug targetsAdhesion molecules
2022
Gut instincts in neuroimmunity from the eighteenth to twenty-first centuries
Nguyen M, Palm NW. Gut instincts in neuroimmunity from the eighteenth to twenty-first centuries. Seminars In Immunopathology 2022, 44: 569-579. PMID: 35786740, PMCID: PMC9519704, DOI: 10.1007/s00281-022-00948-2.Peer-Reviewed Original ResearchConceptsNon-communicable chronic diseasesGut-brain interactionInflammatory bowel diseaseIrritable bowel syndromeDiverse diseasesMillions of adultsBowel diseaseBowel syndromeBrain axisChronic diseasesPutative etiologyGut microbiotaImmune systemAlzheimer's diseaseGut microbiomeDiseaseBrainAutism spectrum disorderDisordersSpectrum disorderMicrobiotaGutReciprocal interactionsHuman healthHealth
2018
Adipocyte OGT governs diet-induced hyperphagia and obesity
Li MD, Vera NB, Yang Y, Zhang B, Ni W, Ziso-Qejvanaj E, Ding S, Zhang K, Yin R, Wang S, Zhou X, Fang EX, Xu T, Erion DM, Yang X. Adipocyte OGT governs diet-induced hyperphagia and obesity. Nature Communications 2018, 9: 5103. PMID: 30504766, PMCID: PMC6269424, DOI: 10.1038/s41467-018-07461-x.Peer-Reviewed Original ResearchConceptsSerine/threonine residuesN-acetylglucosamine transferaseNutrient cuesThreonine residuesTranscriptional activationO-GlcNAcylationLipid desaturationIntracellular proteinsOGTHigh-fat diet-induced hyperphagiaDevelopment of obesityBaseline food intakeSignaling contributesLipid signalsCB1 signalingBrain axisChronic dysregulationFood intakeMetabolic diseasesPalatable foodPharmacological manipulationHyperphagiaObesityFat sensorSignalingA Neural Circuit for Gut-Induced Reward
Han W, Tellez LA, Perkins MH, Perez IO, Qu T, Ferreira J, Ferreira TL, Quinn D, Liu ZW, Gao XB, Kaelberer MM, Bohórquez DV, Shammah-Lagnado SJ, de Lartigue G, de Araujo IE. A Neural Circuit for Gut-Induced Reward. Cell 2018, 175: 665-678.e23. PMID: 30245012, PMCID: PMC6195474, DOI: 10.1016/j.cell.2018.08.049.Peer-Reviewed Original ResearchConceptsSubstantia nigraVagal sensory gangliaVagal sensory neuronsTransneuronal labelingTransneuronal tracingVagal originBrain axisGlutamatergic neuronsSelf-stimulation behaviorParabrachial regionSensory gangliaDopamine cellsObligatory relayDopamine releaseSensory neuronsRewarding effectsNeuronal circuitryPlace preferenceReward pathwayNeural circuitsNeuronsStimulation approachesReward neuronsMajor regulatorNigra
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