2025
The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour
Yoshida T, Nguyen M, Zhang L, Lu B, Zhu B, Murray K, Mineur Y, Zhang C, Xu D, Lin E, Luchsinger J, Bhatta S, Waizman D, Coden M, Ma Y, Israni-Winger K, Russo A, Wang H, Song W, Al Souz J, Zhao H, Craft J, Picciotto M, Grutzendler J, Distasio M, Palm N, Hafler D, Wang A. The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour. Nature 2025, 1-10. PMID: 40437096, DOI: 10.1038/s41586-025-09050-7.Peer-Reviewed Original ResearchMeningeal T cellsCentral nervous systemT cellsSubfornical organCD4 T cellsInnate immune compartmentGut-brain axisSteady-state brainGut microbiotaSpecialized immune cellsCentral nervous system homeostasisAdaptive immune systemBiological functionsImmune compartmentGut-derived T cellsImmune cellsWhite adiposeImmune systemNervous systemAdipose tissueComposition of adipose tissueGastrointestinal tissuesWell-characterizedHomeostasisBrainMicrobiome’s effect on white matter in autism
Canada K, Evans T, Pelphrey K. Microbiome’s effect on white matter in autism. Journal Of Neurophysiology 2025, 133: 1150-1158. PMID: 39998297, DOI: 10.1152/jn.00607.2024.Peer-Reviewed Original ResearchAutism spectrum disorderCore ASD symptomsAutism spectrum disorder managementRepetitive behavior patternsBrain imaging dataWhite matter developmentDiffusion tensor imagingNeuroimaging studiesSymptom severitySpectrum disorderGut-brain axisSocial skillsLanguage acquisitionSensory processingSocial communicationBidirectional relationshipOligodendrocyte functionTensor imagingShort-chain fatty acidsLongitudinal studyMotor performanceAutismDevelopmental patternsReduced myelinationNeuroinflammatory pathways
2024
Gut-brain axis and neuroplasticity in health and disease: a systematic review
Di Napoli A, Pasquini L, Visconti E, Vaccaro M, Rossi-Espagnet M, Napolitano A. Gut-brain axis and neuroplasticity in health and disease: a systematic review. La Radiologia Medica 2024, 130: 327-358. PMID: 39718685, DOI: 10.1007/s11547-024-01938-0.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imaging studyDiffusion tensor imagingHealthy subjectsArterial spin labelingGut-brain axisBrain connectivityStructural magnetic resonance imagingMagnetic resonance imaging studiesInflammatory bowel syndromeAssociated with connectivityMagnetic resonance imagingGut microbiotaBowel syndromeImaging studiesTranscranial magnetic stimulationTemporal cortexNon-human subjectsResonance imagingCurrent evidenceStructural MRISomatosensory cortexPatientsPsychiatric diseasesBrain functionTensor imagingComparative Analysis of Fecal Microbiota Between Adolescents with Early-Onset Psychosis and Adults with Schizophrenia
Nuncio-Mora L, Nicolini H, Lanzagorta N, García-Jaimes C, Sosa-Hernández F, González-Covarrubias V, Cabello-Rangel H, Sarmiento E, Glahn D, Genis-Mendoza A. Comparative Analysis of Fecal Microbiota Between Adolescents with Early-Onset Psychosis and Adults with Schizophrenia. Microorganisms 2024, 12: 2071. PMID: 39458380, PMCID: PMC11510430, DOI: 10.3390/microorganisms12102071.Peer-Reviewed Original ResearchEarly-onset psychosisPsychiatric disordersAtypical antipsychotic treatmentNon-psychotic individualsTreated with sertralineAntipsychotic treatmentSchizophrenia groupSchizophrenia patientsSchizophreniaGut-brain axisPsychosisGene orthology analysisPotential metabolic functionsAssociated with gut dysbiosisFunctional prediction analysisValproate treatmentPharmacological treatmentOscillospiraceae familiesOrthology analysisDecreased levelsFatty acid metabolismGut microbiomeExpressed genesMicrobial communitiesMicrobial compositionShared Genetic Architecture Among Gastrointestinal Diseases, Schizophrenia, and Brain Subcortical Volumes
Xie Y, Zhao Y, Zhou Y, Jiang Y, Zhang Y, Du J, Cai M, Fu J, Liu H. Shared Genetic Architecture Among Gastrointestinal Diseases, Schizophrenia, and Brain Subcortical Volumes. Schizophrenia Bulletin 2024, 50: 1243-1254. PMID: 38973257, PMCID: PMC11349026, DOI: 10.1093/schbul/sbae099.Peer-Reviewed Original ResearchConceptsLocal genetic correlationProtein-protein interactionsPolygenic overlapGenetic architectureBrain subcortical volumesGenome-wide association study dataSubcortical volumesProtein-protein interaction analysisCell-type enrichmentGenetic correlationsFunctional annotationGut-brain axisHub genesGenetic mechanismsGenetic variantsColocalization analysisBiological processesImmune systemData of schizophreniaGenesDevelopment of interventionsSchizophreniaGastrointestinal diseasesTherapy targetGI diseasesNutraceuticals Unveiled a Multifaceted Neuroprotective Mechanisms for Parkinson’s Disease: Elixir for the Brain
Soni D, Jamwal S, Chawla R, Singh S, Singh D, Singh T, Khurana N, Kanwal A, Dureja H, Patil U, Singh R, Kumar P. Nutraceuticals Unveiled a Multifaceted Neuroprotective Mechanisms for Parkinson’s Disease: Elixir for the Brain. Food Reviews International 2024, 40: 3079-3102. DOI: 10.1080/87559129.2024.2337766.Peer-Reviewed Original ResearchPre-clinicalGut-brain axisProtein ubiquitinationParkinson's diseaseMitochondrial dysfunctionSignaling pathwayMolecular mechanismsRelieve PD symptomsSymptoms of PDClinical trialsHealth benefits of nutraceuticalsBenefits of nutraceuticalsCustomized therapyClinical aspectsExpression of PDMediterranean dietNeurotransmitter imbalanceNeuroprotective mechanismsNeuroprotective potentialOxidative stressDiseasePD symptomsHealth benefitsSymptomsUbiquitin
2023
Eating disorders: are gut microbiota to blame?
Xu J, Carroll I, Huckins L. Eating disorders: are gut microbiota to blame? Trends In Molecular Medicine 2023, 30: 317-320. PMID: 38040602, PMCID: PMC11009075, DOI: 10.1016/j.molmed.2023.11.007.Peer-Reviewed Original Research
2022
Dietary adaptation for weight loss maintenance at Yale (DAWLY): Protocol and predictions for a randomized controlled trial
Fang X, Davis X, Flack KD, Duncan C, Li F, White M, Grilo C, Small DM. Dietary adaptation for weight loss maintenance at Yale (DAWLY): Protocol and predictions for a randomized controlled trial. Frontiers In Nutrition 2022, 9: 940064. PMID: 35967820, PMCID: PMC9369668, DOI: 10.3389/fnut.2022.940064.Peer-Reviewed Original ResearchWeight loss maintenanceHigh-fat dietWeight loss treatmentLoss maintenanceWeight lossLoss treatmentStandard behavioral weight loss treatmentShort-term weight lossBehavioral weight loss interventionBehavioral weight loss treatmentGut-brain pathwaysPlacebo-controlled trialGut-brain axisVagal afferent pathwaysGut-brain signalingDietary fat intakeOverweight/obesityWeight loss interventionPrecision medicine approachEnergy-dense foodsLoss interventionFat intakeAfferent pathwaysHabitual intakeMetabolic healthAssociations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome
Barandouzi Z, Lee J, del Carmen Rosas M, Chen J, Henderson W, Starkweather A, Cong X. Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome. Scientific Reports 2022, 12: 1648. PMID: 35102266, PMCID: PMC8803858, DOI: 10.1038/s41598-022-05756-0.Peer-Reviewed Original ResearchConceptsEmotional distressNeurotransmitter levelsHealthy controlsIrritable bowel syndrome groupIrritable bowel syndromeRegulation of neurotransmittersDepressive symptomsSerotonin levelsGut-brain axisEmotional symptomsHC groupPlasma neurotransmittersDistressGut microbiome profilesNeurotransmitterGut microbiomeNorepinephrine levelsBowel syndromeMicrobiome profilesPersonsNorepinephrineNested Case-Control StudySymptomsCase-control studySerotonin
2021
The immune system and autism spectrum disorder: association and therapeutic challenges
Heidari A, Rostam–Abadi Y, Rezaei N. The immune system and autism spectrum disorder: association and therapeutic challenges. Acta Neurobiologiae Experimentalis 2021, 81: 249-263. PMID: 34672295, DOI: 10.21307/ane-2021-023.Peer-Reviewed Original ResearchConceptsCentral nervous systemPlasma levels of pro-inflammatory cytokinesPrevalence of autoimmune disordersImmune systemLevels of pro-inflammatory cytokinesFirst-degree family membersAutism spectrum disorderPro-inflammatory cytokinesAnti-inflammatory drugsInnate immune systemDevelopment of autism spectrum disorderAutoimmune involvementDefinitive treatmentAutoimmune processAutoimmune disordersImmunological factorsPlasma levelsGut-brain axisTriggering inflammationASD patientsHighest prevalenceNervous systemPathogenesisASD pathogenesisGenetic factors
2020
The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms
Xiao C, Fedirko V, Beitler J, Bai J, Peng G, Zhou C, Gu J, Zhao H, Lin IH, Chico CE, Jeon S, Knobf TM, Conneely KN, Higgins K, Shin DM, Saba N, Miller A, Bruner D. The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms. Supportive Care In Cancer 2020, 29: 3173-3182. PMID: 33078326, PMCID: PMC8055716, DOI: 10.1007/s00520-020-05820-3.Peer-Reviewed Original ResearchConceptsCancer-related fatigueGut microbiomePilot studyHigh-fatigue groupLow-fatigue groupsGut-brain axisMultidimensional Fatigue InventoryGut microbiota patternBrain healthCancer patientsFatigue InventoryNeck cancerPurposeRecent evidenceStool samplesImmune responseMicrobiota patternsGut microbiotaInflammationOne monthBrain functionPatientsConclusionsOur resultsFatty acid synthesisEPIC BeadChipDNA methylation changes
2019
A Mechanistic Model of Gut–Brain Axis Perturbation and High-Fat Diet Pathways to Gut Microbiome Homeostatic Disruption, Systemic Inflammation, and Type 2 Diabetes
Lew K, Starkweather A, Cong X, Judge M. A Mechanistic Model of Gut–Brain Axis Perturbation and High-Fat Diet Pathways to Gut Microbiome Homeostatic Disruption, Systemic Inflammation, and Type 2 Diabetes. Biological Research For Nursing 2019, 21: 384-399. PMID: 31113222, DOI: 10.1177/1099800419849109.Peer-Reviewed Original ResearchConceptsGut-brain axisGut-brain axis pathwayHigh-fat dietDNA sequencing technologiesPro-inflammatory pathwaysMechanistic modelSequencing technologiesGut microbiomeHuman microbiomeHomeostatic disruptionProgression of T2DInsulin resistanceNonmodifiable risk factorsSystemic inflammationGutHigh-fatMicrobiomePathwayHomeostatic imbalanceMetabolic diseasesRisk factorsLow-grade systemic inflammationAmerican populationTranslocation of endotoxinWall permeability
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