2025
Mikrobiom, Ernährung und Rheuma
Heidt C, Kriegel M. Mikrobiom, Ernährung und Rheuma. Rheuma Plus 2025, 1-10. DOI: 10.1007/s12688-025-00861-0.Peer-Reviewed Original ResearchShort-chain fatty acidsSystemic lupus erythematosusIntestinal microbiotaImmune responseRheumatic diseasesGut barrierProduction of short-chain fatty acidsRheumatoid arthritisRegulatory T cellsProinflammatory immune responseProgressive tissue damagePersistent inflammatory processPotential therapeutic approachT cellsAnti-inflammatory propertiesCommensal bacteriaImmunological dysregulationLupus erythematosusGenetic predispositionNutritional interventionImmunomodulatory effectsTherapeutic conceptsFiber-rich dietTherapeutic approachesInflammatory process
2024
Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective
Fisher M, Weiler H, Kuiper J, Borghese M, Buckley J, Shutt R, Ashley-Martin J, Subramanian A, Arbuckle T, Potter B, Little J, Morisset A, Jukic A. Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective. Current Epidemiology Reports 2024, 11: 153-163. PMID: 39156920, PMCID: PMC11329583, DOI: 10.1007/s40471-024-00348-0.Peer-Reviewed Original ResearchVitamin DPregnant womenHigher vitamin D statusToxic metalsPrevention of adverse outcomesTrials of vitamin D supplementationVitamin D statusVitamin D supplementationOverall nutritional statusNutritional interventionPotential biological mechanismsPregnant populationEpidemiological studiesBlood metalsNutritional statusD statusD supplementationNorth American studiesProspective studyAdverse outcomesAbsorption of metalsPregnancyIntestinal absorptionMetal exposureEndocrine disruptionCaloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice
Rinne C, Soultoukis G, Oveisi M, Leer M, Schmidt-Bleek O, Burkhardt L, Bucher C, Moussa E, Makhlouf M, Duda G, Saraiva L, Schmidt-Bleek K, Schulz T. Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice. Frontiers In Endocrinology 2024, 15: 1394263. PMID: 38904042, PMCID: PMC11188307, DOI: 10.3389/fendo.2024.1394263.Peer-Reviewed Original ResearchConceptsBone marrow adipose tissueTrabecular bone lossAged miceCaloric restrictionBone lossEndocrine profileMale C57BL6J miceCardio-metabolic diseasesTime of CRAge-matched littermatesBiochemical lipid profilesAssess bone microstructureFree food accessC57BL6J miceBone healthYoung miceContext of agingMale miceDietary interventionNutritional interventionAnatomical localizationLipid profileAdipogenic gene expressionBone dysfunctionTrabecular bone structure
2023
“Zoom”ing to the Kitchen: A Novel Approach to Virtual Nutrition Education for Medical Trainees
Charles J, Wood N, Neary S, Moreno J, Scierka L, Brink B, Zhao X, Gielissen K. “Zoom”ing to the Kitchen: A Novel Approach to Virtual Nutrition Education for Medical Trainees. Nutrients 2023, 15: 4166. PMID: 37836450, PMCID: PMC10574391, DOI: 10.3390/nu15194166.Peer-Reviewed Original ResearchConceptsNutrition educationFirst-line therapyCoronary artery diseaseType 2 diabetesNutrition-related knowledgeMedical traineesPlant-based nutritionArtery diseaseNutrition counselingNutritional interventionChronic diseasesCulinary medicineDietary behaviorsKnowledge scoreNutritional issuesDietary changesPhysician assistant studentsTeaching kitchenNutrition curriculumAssistant studentsDiseaseWeeksCounselingPA studentsTraineesImpact of postnatal weight gain on brain white matter maturation in very preterm infants
Bobba P, Weber C, Higaki A, Mukherjee P, Scheinost D, Constable R, Ment L, Taylor S, Payabvash S. Impact of postnatal weight gain on brain white matter maturation in very preterm infants. Journal Of Neuroimaging 2023, 33: 991-1002. PMID: 37483073, PMCID: PMC10800683, DOI: 10.1111/jon.13145.Peer-Reviewed Original ResearchConceptsBirth weight z-scoreMagnetic resonance imagingVery preterm infantsPostnatal weight gainWeight z-scoreWhite matter maturationBirth weightDiffusion tensor imagingNeurological outcomePreterm infantsGestational ageWeight gainCorpus callosumHigher birth weight z-scoresBrain white matter maturationLong-term neurological deficitsZ-scoreBrain developmentWeight z-score changeWM tractsZ-score changeWM maturationWeeks of lifeNeurological deficitsNutritional intervention
2022
Non-Alcoholic Fatty Liver Disease Among Pregnant Women With Metabolic Syndrome: Should Nutritional Intervention Be a Priority? A Cross Sectional Study in Rural Sri Lanka
Koralegedara I, Warnasekara J, Jayasinghe I, Agampodi T, Agampodi S, Dayaratne K. Non-Alcoholic Fatty Liver Disease Among Pregnant Women With Metabolic Syndrome: Should Nutritional Intervention Be a Priority? A Cross Sectional Study in Rural Sri Lanka. Current Developments In Nutrition 2022, 6: 680. PMCID: PMC9194234, DOI: 10.1093/cdn/nzac061.064.Peer-Reviewed Original ResearchNon-alcoholic fatty liver diseaseProportion of NAFLDFatty liver diseaseMetS groupMetabolic syndromeNutritional interventionPregnant mothersAminotransferase levelsLiver diseaseAlcoholic fatty liver diseaseGamma-glutamyl transferase levelsCross-sectional comparative studyNon-MetS participantsAdverse pregnancy outcomesAlanine aminotransferase levelsInternational Diabetes FederationDetailed clinical examinationAspartate aminotransferase levelsAmerican Heart AssociationCross-sectional studyGlutamyl transferase levelsTime of recruitmentWorld Health OrganizationAnuradhapura districtMean dome
2021
Improving services for chronic non‐communicable diseases in Samoa: an implementation research study using the care cascade framework
Fraser‐Hurt N, Naseri LT, Thomsen R, Matalavea A, Ieremia‐Faasili V, Reupena MS, Hawley NL, Pomer A, Rivara AC, Obure DC, Zhang S. Improving services for chronic non‐communicable diseases in Samoa: an implementation research study using the care cascade framework. Australian And New Zealand Journal Of Public Health 2021, 46: 36-45. PMID: 34309937, DOI: 10.1111/1753-6405.13113.Peer-Reviewed Original ResearchConceptsChronic non-communicable diseasesNon-communicable diseasesChronic care servicesCare continuumNon-communicable disease burdenImplementation research studyEffective primary preventionContinuity of careMedical record dataHealth system redesignHealth service redesignBetter health communicationHypertension prevalenceBlood pressureHypertensive individualsHypertension patientsPrimary preventionNutritional interventionDisease burdenEffective patientTracer conditionsPrimary healthcarePatient needsTreatment supportCare services
2017
Impact of nutrition interventions on pediatric mortality and nutrition outcomes in humanitarian emergencies: A systematic review
Balhara KS, Silvestri DM, Winders W, Selvam A, Kivlehan SM, Becker TK, Levine AC, Group T. Impact of nutrition interventions on pediatric mortality and nutrition outcomes in humanitarian emergencies: A systematic review. Tropical Medicine And International Health 2017, 22: 1464-1492. PMID: 28992388, DOI: 10.1111/tmi.12986.Peer-Reviewed Original ResearchConceptsPediatric mortalityMicronutrient supplementationStudy qualitySystematic reviewModerate quality studiesSpecific nutritional interventionsOverall study qualityMedium-quality studiesUse therapeutic foodNutritional endpointsRecommendations AssessmentPediatric morbiditySerum markersCochrane LibraryNutritional interventionRobust trialsNutrition interventionsOvid MEDLINEInclusion criteriaOutcome dataRelevant grey literatureAnthropometric measuresTherapeutic foodHealth outcomesStudy characteristics
2016
Food as medicine: A randomized controlled trial (RCT) of home delivered, medically tailored meals (HDMTM) on quality of life (QoL) in metastatic lung and non-colorectal GI cancer patients.
Ishaq O, Mailhot Vega R, Zullig L, Wassung A, Walters D, Berland N, Du K, Ahn J, Leichman C, Jill Cohen D, Gu P, Chachoua A, Leichman L, Pearl K, Schiff P. Food as medicine: A randomized controlled trial (RCT) of home delivered, medically tailored meals (HDMTM) on quality of life (QoL) in metastatic lung and non-colorectal GI cancer patients. Journal Of Clinical Oncology 2016, 34: 155-155. DOI: 10.1200/jco.2016.34.26_suppl.155.Peer-Reviewed Original ResearchGI cancer patientsCancer patientsMetastatic lungHealthcare utilizationNutritional interventionFinancial toxicityFACT-G questionnaireTrial of homeAdvanced-stage cancerMetastatic cancer patientsLower healthcare costsQuality of lifeKnowledge of nutritionEligible patientsMalnutrition incidenceLonger hospitalMalnourished patientsPrimary endpointPS 0Oral alimentationPatient's symptomsQOL improvementShorter survivalFirst RCTGI cancersModerate Alcohol Consumption and Chronic Disease: The Case for a Long‐Term Trial
Mukamal KJ, Clowry CM, Murray MM, Hendriks HF, Rimm EB, Sink KM, Adebamowo CA, Dragsted LO, Lapinski PS, Lazo M, Krystal JH. Moderate Alcohol Consumption and Chronic Disease: The Case for a Long‐Term Trial. Alcohol Clinical And Experimental Research 2016, 40: 2283-2291. PMID: 27688006, PMCID: PMC5073014, DOI: 10.1111/acer.13231.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionChronic diseasesAlcohol consumptionRandomized trialsLong-term clinical trialsCoronary heart diseaseMajor chronic diseasesStrong epidemiological associationLong-term trialsGold standard evidenceNutritional interventionHeart diseaseClinical trialsBreast cancerEpidemiological associationModerate drinkingYears durationClinical investigatorsBiological mediatorsAvailable evidenceDiseaseObserved associationsTrialsStandard evidenceVariety of settings
2013
Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania
KAWAI K, MEYDANI SN, URASSA W, WU D, MUGUSI FM, SAATHOFF E, BOSCH RJ, VILLAMOR E, SPIEGELMAN D, FAWZI WW. Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania. Epidemiology And Infection 2013, 142: 1505-1509. PMID: 24093552, PMCID: PMC5639693, DOI: 10.1017/s0950268813002495.Peer-Reviewed Original ResearchConceptsCell-mediated immune responsesTB patientsMicronutrient supplementationMicronutrient supplementsImmune responseProliferative responseT cell-mediated immune responsesHIV-negative TB patientsHIV-positive TB patientsLymphocyte proliferative responsesLymphocyte proliferation responseHigher proliferative responsesT cell mitogensPlacebo groupPulmonary TBTB treatmentDaily doseEligible participantsNutritional interventionTuberculosis treatmentTime of initiationClinical relevanceMicronutrient groupProliferation responsePatients
2012
PREDICTORS OF INCIDENT TUBERCULOSIS IN HIV-EXPOSED CHILDREN IN TANZANIA.
Finkelstein J, Manji K, Duggan C, Hertzmark E, Mehta S, Msamanga G, Spiegelman D, Fawzi W. PREDICTORS OF INCIDENT TUBERCULOSIS IN HIV-EXPOSED CHILDREN IN TANZANIA. East African Medical Journal 2012, 89: 183-92. PMID: 26856040, PMCID: PMC10864092.Peer-Reviewed Original ResearchConceptsRisk of tuberculosisChild mid-upper arm circumferenceMid-upper arm circumferenceT-cell countsArm circumferenceReduced riskCD4 T-cell countCD8 T-cell countsLow vitamin E levelsAppropriate infant feedingDuration of breastfeedingLongitudinal cohort studyVitamin E levelsIncident tuberculosisAntenatal clinicCohort studyLymphocyte countHIV infectionTuberculosis infectionChild tuberculosisHIV statusNutritional interventionImmunological statusInfant feedingE levels
2008
Pathways leading to early growth faltering: an investigation into the importance of mucosal damage and immunostimulation in different socio-economic groups in Nepal
Panter-Brick C, Lunn PG, Langford RM, Maharjan M, Manandhar DS. Pathways leading to early growth faltering: an investigation into the importance of mucosal damage and immunostimulation in different socio-economic groups in Nepal. British Journal Of Nutrition 2008, 101: 558-567. PMID: 18662426, DOI: 10.1017/s000711450802744x.Peer-Reviewed Original ResearchConceptsMucosal damageSmall intestinal mucosal damageSquatter childrenMucosal damage indexSocio-economic groupsIntestinal mucosal damageEarly growth falteringAlpha-1-acid glycoproteinPublic health interventionsChronic immunostimulationNutritional interventionWeight deficitElevated morbidityBlood concentrationsGrowth falteringUbiquitous exposureHigher MDISignificant negative associationPoor growthHealth interventionsMorbidity reportsGrowth retardationImmunostimulationInfectionPathogen exposure
2007
Interdisciplinary Management of Pediatric Intestinal Failure: A 10-Year Review of Rehabilitation and Transplantation
Nucci A, Burns R, Armah T, Lowery K, Yaworski JA, Strohm S, Bond G, Mazariegos G, Squires R. Interdisciplinary Management of Pediatric Intestinal Failure: A 10-Year Review of Rehabilitation and Transplantation. Journal Of Gastrointestinal Surgery 2007, 12: 429-436. PMID: 18092190, DOI: 10.1007/s11605-007-0444-0.Peer-Reviewed Original ResearchConceptsMean total bilirubinIntestinal failureParenteral nutritionIntestinal transplantationTotal bilirubinBowel lengthening proceduresEnteral nutrition supportPediatric intestinal failureManagement of childrenEnteral autonomyEarly referralBowel lengthNutrition supportImproved survivalPediatric patientsMedical managementLengthening proceduresNutritional interventionInterdisciplinary managementPatientsTransplantationInterdisciplinary coordinationReferralBilirubinNutrition
2005
Pregnancy Increases BMI in Adolescents of a Population-Based Birth Cohort 1 2
Fawzi W, Msamanga G, Spiegelman D, Hunter DJ. Pregnancy Increases BMI in Adolescents of a Population-Based Birth Cohort 1 2. Journal Of Nutrition 2005, 135: 938-944. PMID: 15795466, DOI: 10.1093/jn/135.4.938.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyMultivitamin supplementsPregnant womenHIV-negative pregnant womenDaily multivitamin supplementEarly childhood infectionsAdverse pregnancy outcomesHIV disease progressionHIV-1 infectionAdequate dietary intakeEfficacy of vitaminAdverse health outcomesFurther studiesLow-cost interventionMo of ageUninfected childrenHIV diseasePregnancy outcomesPregnant HIVHIV infectionChildhood infectionsRandomized trialsNutritional interventionDietary intakeDisease progression
2004
Childhood stunting in Northeast Brazil: the role of Schistosoma mansoni infection and inadequate dietary intake
Assis A, Prado M, Barreto M, Reis M, Conceição Pinheiro S, Parraga I, Blanton R. Childhood stunting in Northeast Brazil: the role of Schistosoma mansoni infection and inadequate dietary intake. European Journal Of Clinical Nutrition 2004, 58: 1022-1029. PMID: 15220944, DOI: 10.1038/sj.ejcn.1601926.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnimalsBody HeightBrazilChildChild DevelopmentChild Nutritional Physiological PhenomenaCross-Sectional StudiesDietDietary CarbohydratesDietary FatsDietary ProteinsEnergy IntakeFecesFemaleGrowth DisordersHumansIntestinal Diseases, ParasiticLogistic ModelsMaleSchistosomiasis mansoniConceptsSchistosoma mansoni infectionS. mansoni infectionInadequate dietary intakeMansoni infectionDietary intakeS. mansoniHeavy S. mansoni infectionS. mansoni endemic areasDevelopment of stuntingRisk of stuntingCross-sectional studyUninfected childrenNutritional interventionDietary measuresInadequate intakeCarbohydrate intakeStool samplesHigh riskMedian proteinEndemic areasParasitic infectionsCaloric consumptionChildhood stuntingAge groupsAdequate diet
2000
Effects of Lead Counseling for Children with Lead Levels &ge20 μg/dL:Impact on Parental Knowledge, Attitudes, and Behavior
Serwint J, Dias M, White J. Effects of Lead Counseling for Children with Lead Levels &ge20 μg/dL:Impact on Parental Knowledge, Attitudes, and Behavior. Clinical Pediatrics 2000, 39: 643-650. PMID: 11110364, DOI: 10.1177/000992280003901103.Peer-Reviewed Original Research
1999
A retrospective study of percutaneous endoscopic gastrostomy in ALS patients during the BDNF and CNTF trials
Kasarskis E, Scarlata D, Hill R, Fuller C, Stambler N, Cedarbaum J, in the . B. A retrospective study of percutaneous endoscopic gastrostomy in ALS patients during the BDNF and CNTF trials. Journal Of The Neurological Sciences 1999, 169: 118-125. PMID: 10540019, DOI: 10.1016/s0022-510x(99)00230-0.Peer-Reviewed Original ResearchConceptsPercutaneous endoscopic gastrostomyALS patientsEndoscopic gastrostomyClinical statusRetrospective studyVital capacityNutritional interventionNutritional supplementationRetrospective analysisPEG insertionPatientsBDNF studiesRate of declineDisease statusEarly interventionMarked reductionWeight lossGastrostomyCNTFInterventionReduction of functionSequential measurementsDaysStatusDysphagia
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