2025
Switching From Active Vitamin d and Phosphate Supplementation to Burosumab Significantly Corrects Lower Limb Malalignment in Pediatric X-Linked Hypophosphatemia
Ward L, Imel E, Frumberg D, Dilworth L, Siener C, Chen Z, Krolczyk S, Carpenter T. Switching From Active Vitamin d and Phosphate Supplementation to Burosumab Significantly Corrects Lower Limb Malalignment in Pediatric X-Linked Hypophosphatemia. Journal Of Bone And Mineral Research 2025, zjaf079. PMID: 40511857, DOI: 10.1093/jbmr/zjaf079.Peer-Reviewed Original ResearchLower limb malalignmentLimb malalignmentLower-limb malalignmentBaseline height z scoreZ-scoreLower extremity deformitiesLimbs of patientsX-linked hypophosphatemiaAssociated with greater changesFactor analysisLower limb malformationsDisease monitoring programsHeight z-scoreChance of improvementExtremity deformitiesGauge improvementYounger ageVitamin DBurosumab treatmentMalalignmentTreating physicianPediatric populationPhosphate supplementationRenal phosphate wastingActive vitamin D
2024
Impact of burosumab on lower limb alignment in children with X-linked hypophosphatemia
Frumberg D, Merritt J, Chen A, Carpenter T. Impact of burosumab on lower limb alignment in children with X-linked hypophosphatemia. Journal Of The Pediatric Orthopaedic Society Of North America 2024, 6: 100012. PMID: 40433251, PMCID: PMC12088215, DOI: 10.1016/j.jposna.2024.100012.Peer-Reviewed Original ResearchMechanical femoral-tibial angleLower limbsNeutral alignmentLower limb malalignmentLower limb alignmentLevel of Evidence IIIX-linked hypophosphatemiaLower limb deformitiesFemoral-tibial angleLower limb radiographsValgus limbsLimb malalignmentImpact of burosumabLimb alignmentLimb radiographsCrossover armAngular deformityNormal limbsLimb deformitiesLimbVarusMalalignmentClinically normal limbsHemiepiphysiodesisBaseline
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