2022
Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study
Allen RJ, Oldham JM, Jenkins DA, Leavy OC, Guillen-Guio B, Melbourne CA, Ma SF, Jou J, Kim JS, Cooperative C, Fahy WA, Oballa E, Hubbard RB, Navaratnam V, Braybrooke R, Saini G, Roach KM, Tobin MD, Hirani N, Whyte MKB, Kaminski N, Zhang Y, Martinez FJ, Linderholm AL, Adegunsoye A, Strek ME, Maher TM, Molyneaux PL, Flores C, Noth I, Jenkins R, Wain LV. Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study. The Lancet Respiratory Medicine 2022, 11: 65-73. PMID: 35985358, PMCID: PMC10077113, DOI: 10.1016/s2213-2600(22)00251-x.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisLung capacityAmerican Thoracic Society/European Respiratory Society guidelinesDiagnosis of IPFEuropean Respiratory Society guidelinesPotential novel therapeutic approachHealth-National HeartLongitudinal lung functionRespiratory Society guidelinesGenetic variantsNovel therapeutic approachesIncurable lung diseaseMedical Research CouncilProgressive scarringFVC declineLung functionVital capacityBlood InstituteSociety guidelinesLung diseaseNational HeartDisease progressionTherapeutic approachesSignificant association
2020
Associations of marijuana with markers of chronic lung disease in people living with HIV
Wenger D, Triplette M, Shahrir S, Akgun K, Wongtrakool C, Brown, Kim J, Hoo G, Rodriguez‐Barradas M, Huang L, Feemster L, Zifodya J, Crothers K. Associations of marijuana with markers of chronic lung disease in people living with HIV. HIV Medicine 2020, 22: 92-101. PMID: 33022830, DOI: 10.1111/hiv.12966.Peer-Reviewed Original ResearchConceptsChronic lung diseaseLung diseaseMarijuana smokingRadiographic emphysemaMarijuana exposureHIV-Associated Lung Emphysema (EXHALE) studyLarger total lung capacityHIV-positive patientsTotal lung capacityHigh lung volumesCross-sectional analysisMarijuana useAssociation of marijuanaExpiratory volumeTobacco smokingVital capacityLung capacityLung healthLung volumeSmokingWeekly marijuana useHIVPLWHLogistic regressionEmphysema
2016
Validation of the prognostic value of MMP‐7 in idiopathic pulmonary fibrosis
Tzouvelekis A, Herazo‐Maya J, Slade M, Chu J, Deiuliis G, Ryu C, Li Q, Sakamoto K, Ibarra G, Pan H, Gulati M, Antin‐Ozerkis D, Herzog EL, Kaminski N. Validation of the prognostic value of MMP‐7 in idiopathic pulmonary fibrosis. Respirology 2016, 22: 486-493. PMID: 27761978, PMCID: PMC5352520, DOI: 10.1111/resp.12920.Peer-Reviewed Original ResearchConceptsTransplant-free survivalIdiopathic pulmonary fibrosisMMP-7 concentrationsMatrix metalloproteinase-7IPF patientsCause mortalityPulmonary fibrosisHealthy controlsMultivariate Cox proportional hazards modelCox proportional hazards modelPulmonary function parametersVariable clinical courseBaseline pulmonary function parametersProportional hazards modelIPF biomarkersProgressive diseaseClinical coursePoor prognosisPrognostic valueVital capacityIndependent biomarkerLung capacityPrognostic thresholdPlasma concentrationsMortality risk
1999
Assessment of Cardiac and Pulmonary Function in Adult Patients with Hodgkin's Disease Treated with ABVD or MOPP/ABVD Plus Adjuvant Low-Dose Mediastinal Irradiation
Salloum E, Tanoue L, Wackers F, Zelterman D, Hu G, Cooper D. Assessment of Cardiac and Pulmonary Function in Adult Patients with Hodgkin's Disease Treated with ABVD or MOPP/ABVD Plus Adjuvant Low-Dose Mediastinal Irradiation. Cancer Investigation 1999, 17: 171-180. PMID: 10099655, DOI: 10.3109/07357909909021418.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntineoplastic Combined Chemotherapy ProtocolsBleomycinCombined Modality TherapyDacarbazineDose-Response Relationship, RadiationDoxorubicinEvaluation Studies as TopicFemaleFollow-Up StudiesHeartHodgkin DiseaseHumansLungMaleMechlorethamineMiddle AgedPhysical ExertionPrednisoneProcarbazineRadiotherapy, AdjuvantRemission InductionRespiratory Function TestsVinblastineVincristineConceptsLeft ventricular ejection fractionMOPP/ABVDHodgkin's diseaseAdult patientsPulmonary functionInvolved-field radiation therapyFEV1/FVC ratioIU/m2Pulmonary function testsVentricular ejection fractionVital capacity valuesTotal lung capacityMediastinal irradiationPulmonary symptomsDiastolic functionModality therapyEjection fractionCardiopulmonary functionFunction testsFVC ratioStudy abnormalitiesCigarette smokersCardiac toxicityLung capacitySuch therapy
1984
Airway Effects of Low Concentrations of Sulfur Dioxide: Dose-Response Characteristics
Schachter E, Witek T, Beck G, Hosein H, Colice G, Leaderer B, Cain W. Airway Effects of Low Concentrations of Sulfur Dioxide: Dose-Response Characteristics. Archives Of Environmental & Occupational Health 1984, 39: 34-42. PMID: 6370145, DOI: 10.1080/00039896.1984.10545831.Peer-Reviewed Original ResearchConceptsAsthmatic subjectsVital capacityPartial flow-volume curvesAcute respiratory effectsTotal lung capacityMaximal expiratory flowAbsence of exerciseKpm/minEnd of exerciseFlow-volume curvesDose-response relationshipDose-response characteristicsAirway effectsExpiratory volumeAirway resistanceLung capacitySignificant changesExpiratory flowRespiratory effectsHealthy subjectsHealthy individualsSeparate daysMin subjectsVolume curvesVmax50
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