2021
Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity
Farina MG, Sandhu MRS, Parent M, Sanganahalli BG, Derbin M, Dhaher R, Wang H, Zaveri HP, Zhou Y, Danbolt NC, Hyder F, Eid T. Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity. Epilepsia 2021, 62: 2858-2870. PMID: 34536233, PMCID: PMC9006438, DOI: 10.1111/epi.17072.Peer-Reviewed Original ResearchConceptsPostnatal brainFunctional connectivityContinuous video-electroencephalographic recordingSpontaneous recurrent seizuresPathogenesis of epilepsyGlutamine synthetase deficiencyVideo-electroencephalographic recordingsSpecific animal modelsEx vivo studySeizure thresholdAdult patientsRecurrent seizuresFocal epilepsyAdeno-associated virusHippocampal formationAnimal modelsFocal mannerEpileptic seizuresGS deficiencySmall lociSynthetase deficiencyEpilepsyGradual returnVivo studiesBrain
2019
In vivo, ex vivo and in vitro evidence for atropine-mediated attenuation of glucagon-like peptide-1 secretion: findings from a systematic review
Rathish D, Agampodi S, Jayasumana C. In vivo, ex vivo and in vitro evidence for atropine-mediated attenuation of glucagon-like peptide-1 secretion: findings from a systematic review. Environmental Science And Pollution Research 2019, 26: 29597-29605. PMID: 31446595, DOI: 10.1007/s11356-019-06227-2.Peer-Reviewed Original ResearchConceptsGlucagon-like peptide-1GLP-1 secretionGlucagon-like peptide-1 secretionDipeptidyl peptidase-4 (DPP-4) enzymeRole of atropineVivo studiesPeptide-1 secretionRisk of biasPostprandial glucose homeostasisEx vivo studyPostprandial secretionCholinergic pathwaysAnticholinergic agentsCochrane LibraryHealthy menMuscarinic receptorsGlucose homeostasisPeptide-1Reference listsCompetitive antagonistHuman studiesAnimal studiesPRISMA statementSystematic reviewAtropineMechanics of the Thoracic Aortic Wall
Ziganshin B, Elefteriades J. Mechanics of the Thoracic Aortic Wall. 2019, 149-162. DOI: 10.1007/978-3-7091-4874-7_10.Peer-Reviewed Original Research
2016
Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18F-FP-DTBZ in baboons
Naganawa M, Lin SF, Lim K, Labaree D, Ropchan J, Harris P, Huang Y, Ichise M, Carson RE, Cline GW. Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18F-FP-DTBZ in baboons. Nuclear Medicine And Biology 2016, 43: 743-751. PMID: 27673755, PMCID: PMC5248981, DOI: 10.1016/j.nucmedbio.2016.08.018.Peer-Reviewed Original ResearchConceptsRenal cortexPositron emission tomographyInactive enantiomerRadiometabolite fractionΒ-cell massHuman β-cell massNon-displaceable bindingEx vivo studyF-FPLow inter-subject variabilityPET scansDTBZ bindingSpleen uptakeDistribution volumeEmission tomographySpleenPancreasDTBZCortexVivo studiesTissue samplesInter-subject variabilityHigh uptakePET signalRadiometabolitesEfficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue
Fischer S, Hirche C, Diehm Y, Nuutila K, Kiefer J, Gazyakan E, Bueno E, Kremer T, Kneser U, Pomahac B. Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue. PLOS ONE 2016, 11: e0156428. PMID: 27232716, PMCID: PMC4883774, DOI: 10.1371/journal.pone.0156428.Peer-Reviewed Original ResearchConceptsFull-thickness skin graftThickness skin graftBacterium Clostridium histolyticumCapsular contractureSkin graftsBreast sitesSilicone implantsReasonable treatment optionClostridium histolyticumFibrotic capsuleCollagen subtypesEx vivo studyCollagenase doseEx-vivo settingTreatment optionsContracture tissueAcellular tissue matrixOutcome measuresHistological assessmentSubtype 4Capsule tissueClinical utilizationDifferent dosesClinical realityType 4Role of the transcription factor Ikaros in development of autoimmune disease
Schjerven H, Frietze S, Hai S, Hermiston M, Kogan S, Muschen M. Role of the transcription factor Ikaros in development of autoimmune disease. The Journal Of Immunology 2016, 196: 47.14-47.14. DOI: 10.4049/jimmunol.196.supp.47.14.Peer-Reviewed Original ResearchAnti-nuclear antibodiesAutoimmune diseasesB cellsB cell developmentSerum anti-nuclear antibodiesAuto-reactive B cellsReactive B cellsEx vivo analysisSpleen B cellsEx vivo studySecond signalBCR stimulationEarly B cell developmentRecent genome-wide association studiesVivo analysisMouse modelGenetic predispositionIkaros mutant miceTranscription factor IkarosMouse strainsDiseaseVivo studiesTargeted deletionZinc finger 1Autoimmunity
2014
Ex vivo anti-malarial drugs sensitivity profile of Plasmodium falciparum field isolates from Burkina Faso five years after the national policy change
Tinto H, Bonkian L, Nana L, Yerbanga I, Lingani M, Kazienga A, Valéa I, Sorgho H, Kpoda H, Guiguemdé T, Ouédraogo J, Mens P, Schallig H, D’Alessandro U. Ex vivo anti-malarial drugs sensitivity profile of Plasmodium falciparum field isolates from Burkina Faso five years after the national policy change. Malaria Journal 2014, 13: 207. PMID: 24885950, PMCID: PMC4049403, DOI: 10.1186/1475-2875-13-207.Peer-Reviewed Original ResearchConceptsP. falciparum sensitivityVivo studiesFirst-line treatmentPlasmodium falciparum fieldAnti-malarial drugsEx vivo studyDrug sensitivity profilesDHA-PPQChloroquine resistanceIC50 valuesPartner drugsDrug efficacy testsDrug measurementsInhibitory concentration valuesMonodesethylamodiaquinePiperaquineEfficacy of ALHigher IC50 valuesPlasmodium falciparumDihydroartemisininFive yearsCellular proliferationDrugsRecent reportsLumefantrine
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