2025
Myeloperoxidase impacts vascular function by altering perivascular adipocytes’ secretome and phenotype in obesity
Hof A, Landerer M, Peitsmeyer P, Herzog R, Alber J, Ahdab M, Nettersheim F, Mehrkens D, Geißen S, Braumann S, Guthoff H, von Stein P, Nemade H, Picard F, Braun R, Hoyer F, Brüning J, Pfeifer A, Hildebrand S, Winkels H, Baldus S, Adam M, Schäkel J, Mollenhauer M. Myeloperoxidase impacts vascular function by altering perivascular adipocytes’ secretome and phenotype in obesity. Cell Reports Medicine 2025, 6: 102087. PMID: 40252642, PMCID: PMC12147848, DOI: 10.1016/j.xcrm.2025.102087.Peer-Reviewed Original ResearchConceptsPerivascular adipose tissueVascular functionEndothelial functionObesity-related cardiovascular diseaseImmune cell frequenciesAdipose tissuePerivascular adipose tissue inflammationReduced arterial stiffnessInflammatory cytokine releaseHuman white adipocytesInfluence vascular functionObese patientsAdipocyte marker expressionMyeloid cellsCardiovascular morbidityImmune cellsCytokine releaseEndothelial dysfunctionIncreased InflammationAdipocyte secretomeCell frequencyMarker expressionMPO levelsConsumption in vivoNitrotyrosine formation
2024
Vγ6/Vδ1+ γδ T cells protect from angiotensin II effects on blood pressure and endothelial function in mice
Mahmoud A, Caillon A, Shokoples B, Ferreira N, Comeau K, Hatano S, Yoshikai Y, Lewis J, Tigelaar R, Paradis P, Schiffrin E. Vγ6/Vδ1+ γδ T cells protect from angiotensin II effects on blood pressure and endothelial function in mice. Journal Of Hypertension 2024, 43: 109-119. PMID: 39248136, DOI: 10.1097/hjh.0000000000003871.Peer-Reviewed Original ResearchGd T cellsT cellsBlood pressureAngII infusionEndothelial dysfunctionBP elevationPerivascular tissueAngiotensin II (AngII)-induced hypertensionSpecific T cell receptorMesenteric arterial functionArtery endothelial dysfunctionAngiotensin II effectsDescending Thoracic AortaT cell receptorAngII-infused micePerivascular adipose tissuePressure myographyHypertensive effectEndothelial functionThoracic aortaII effectsMale miceVascular injuryArterial functionFlow cytometry
2021
Assessing Cardiovascular Risk by Using the Fat Attenuation Index in Coronary CT Angiography
Klüner LV, Oikonomou EK, Antoniades C. Assessing Cardiovascular Risk by Using the Fat Attenuation Index in Coronary CT Angiography. Radiology Cardiothoracic Imaging 2021, 3: e200563. PMID: 33778665, PMCID: PMC7977699, DOI: 10.1148/ryct.2021200563.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPerivascular adipose tissueFat attenuation indexCoronary CT angiographyCoronary inflammationPrognostic valueHigh-risk plaque featuresCoronary Artery Disease ReportingAnti-inflammatory interventionsTraditional risk factorsFirst-line diagnostic testSignificant prognostic valueChest painDisease activityCoronary atherosclerosisSecondary preventionPlaque featuresCCTA analysisCoronary arteryCoronary calciumRisk factorsObservational studyRisk discriminationCT angiographyAdipose tissueInflammation
2019
3258Perivascular fat attenuation index stratifies the cardiac risk associated with high-risk plaque features on coronary computed tomography angiography
Oikonomou E, Marwan M, Mancio J, Kotanidis C, Thomas K, Alashi A, Centeno E, Antonopoulos A, Shirodaria C, Neubauer S, Channon K, Achenbach S, Desai M, Antoniades C. 3258Perivascular fat attenuation index stratifies the cardiac risk associated with high-risk plaque features on coronary computed tomography angiography. European Heart Journal 2019, 40: ehz745.0049. DOI: 10.1093/eurheartj/ehz745.0049.Peer-Reviewed Original ResearchFat attenuation indexHigh-risk plaquesPerivascular fat attenuation indexAdverse cardiac eventsRisk of MACECoronary inflammationCardiac eventsCardiac riskTomography angiographyHRP featuresFuture major adverse cardiac eventsRoutine CCTAHigh-risk plaque featuresMajor adverse cardiac eventsPlaque morphologyLow-attenuation plaquePerivascular adipose tissueRight coronary arteryNapkin-ring signInflammation-induced changesBritish Heart FoundationAdipose tissue compositionBiomedical Research CentreHRP patientsMedian followA novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography
Oikonomou EK, Williams MC, Kotanidis CP, Desai MY, Marwan M, Antonopoulos AS, Thomas KE, Thomas S, Akoumianakis I, Fan LM, Kesavan S, Herdman L, Alashi A, Centeno EH, Lyasheva M, Griffin BP, Flamm SD, Shirodaria C, Sabharwal N, Kelion A, Dweck MR, Van Beek EJR, Deanfield J, Hopewell JC, Neubauer S, Channon KM, Achenbach S, Newby DE, Antoniades C. A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. European Heart Journal 2019, 40: 3529-3543. PMID: 31504423, PMCID: PMC6855141, DOI: 10.1093/eurheartj/ehz592.Peer-Reviewed Original ResearchConceptsPerivascular adipose tissueFat attenuation indexCoronary CT angiographyCardiac risk predictionCoronary perivascular adipose tissueMajor adverse cardiac eventsCT angiographyRisk predictionHigh-risk plaque featuresPerivascular fat attenuation indexRadiomic featuresAdverse cardiac eventsConsecutive eligible participantsSCOT-HEART trialTraditional risk stratificationCoronary artery diseaseCoronary calcium scoreStandard coronary CT angiographyAcute myocardial infarctionCoronary inflammationCardiac eventsArtery diseaseCalcium scoreCardiac surgeryMACE prediction
2018
Perivascular adipose tissue and coronary atherosclerosis
Mancio J, Oikonomou EK, Antoniades C. Perivascular adipose tissue and coronary atherosclerosis. Heart 2018, 104: 1654. PMID: 29853488, DOI: 10.1136/heartjnl-2017-312324.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiometabolic risk profilePerivascular ATPerivascular adipose tissueAdipose tissueCardiovascular diseaseVascular wallEpicardial adipose tissueClose anatomical proximityAnti-atherogenic rolePotential therapeutic targetNovel clinical diagnostic toolsPromising new modalityCoronary inflammationCoronary atherosclerosisInflammatory statusNon-invasive imagingCardiovascular healthBody of evidenceAnatomical proximityCurrent evidenceTherapeutic targetAdjacent vasculatureClinical diagnostic toolRisk profileTherapeutic opportunities
2017
Detecting human coronary inflammation by imaging perivascular fat
Antonopoulos AS, Sanna F, Sabharwal N, Thomas S, Oikonomou EK, Herdman L, Margaritis M, Shirodaria C, Kampoli AM, Akoumianakis I, Petrou M, Sayeed R, Krasopoulos G, Psarros C, Ciccone P, Brophy CM, Digby J, Kelion A, Uberoi R, Anthony S, Alexopoulos N, Tousoulis D, Achenbach S, Neubauer S, Channon KM, Antoniades C. Detecting human coronary inflammation by imaging perivascular fat. Science Translational Medicine 2017, 9 PMID: 28701474, DOI: 10.1126/scitranslmed.aal2658.Peer-Reviewed Original ResearchConceptsPerivascular adipose tissueFat attenuation indexVascular inflammationSubclinical coronary artery diseaseHuman adipose tissue explantsHuman vesselsLipid accumulationHuman coronary vasculatureAcute coronary syndromeCoronary artery diseaseVulnerable atherosclerotic plaquesIntracellular lipid accumulationHuman coronary arteriesAdipocyte lipid contentAdipose tissue explantsPositron emission tomographyCT scan informationCoronary inflammationCoronary syndromeArtery diseaseCardiac surgeryValidation cohortCoronary arteryMultiple disease statesTissue inflammation
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