2019
Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model
Mottola G, Werlin EC, Wu B, Chen M, Chatterjee A, Schaller MS, Conte MS. Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model. Prostaglandins And Other Lipid Mediators 2019, 146: 106401. PMID: 31841663, PMCID: PMC7265259, DOI: 10.1016/j.prostaglandins.2019.106401.Peer-Reviewed Original ResearchConceptsIntimal hyperplasiaResolvin D1Post-operative day 3Phagocytosis activityRat carotid angioplasty modelCAMP levelsLocal inflammatory responsePro-inflammatory genesArterial inflammationCarotid angioplastyOral gavageAcute inflammationVascular injuryThoracic aortaAngioplasty modelEarly inflammationInflammatory responseOral administrationPlasma concentrationsCarotid arteryRvD1Lipid mediatorsAnimal modelsDay 3Inflammation
2018
Trypanosoma cruzi Produces the Specialized Proresolving Mediators Resolvin D1, Resolvin D5, and Resolvin E2
Colas RA, Ashton AW, Mukherjee S, Dalli J, Akide-Ndunge OB, Huang H, Desruisseaux MS, Guan F, Jelicks LA, dos Santos F, Nagajyothi J, Zingman MA, Reyes J, Weiss LM, Serhan CN, Tanowitz HB. Trypanosoma cruzi Produces the Specialized Proresolving Mediators Resolvin D1, Resolvin D5, and Resolvin E2. Infection And Immunity 2018, 86: 10.1128/iai.00688-17. PMID: 29358332, PMCID: PMC5865043, DOI: 10.1128/iai.00688-17.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayResolvin D1Chagas diseaseMediators of inflammationCD-1 miceRvD1 levelsChronic cardiomyopathyAcute myocarditisMyocardial inflammationProinflammatory eicosanoidsProresolving mediatorsChronic phasePathological featuresPlasma levelsLifelong infectionLipid mediatorsResolvin D5Host responseHuman infectionsBacterial infectionsRvD1InflammationInfectionImmunosorbent assayElevated levels
2016
Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device
Lance KD, Chatterjee A, Wu B, Mottola G, Nuhn H, Lee PP, Sansbury BE, Spite M, Desai TA, Conte MS. Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device. Journal Of Biomedical Materials Research Part A 2016, 105: 31-41. PMID: 27508346, PMCID: PMC5124518, DOI: 10.1002/jbm.a.35861.Peer-Reviewed Original ResearchConceptsResolvin D1Rat carotid artery modelProresolving lipid mediatorsHuman vascular endothelialNF-κB activationSmooth muscle cellsCarotid artery modelTissue injuryEvidence of cytotoxicityRvD1Lipid mediatorsRabbit aortaVSMC migrationMuscle cellsFlow chamber systemBlood vesselsLocal deliveryVascular endothelialArtery modelRelevant levelsVivoTissueD1Vascular tissueDaysPerivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury
Wu B, Mottola G, Chatterjee A, Lance KD, Chen M, Siguenza IO, Desai TA, Conte MS. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury. Journal Of Vascular Surgery 2016, 65: 207-217.e3. PMID: 27034112, PMCID: PMC5040608, DOI: 10.1016/j.jvs.2016.01.030.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAnimalsAortaCardiovascular AgentsCarotid Artery DiseasesCell MovementCell ProliferationCells, CulturedCytoskeletonDisease Models, AnimalDocosahexaenoic AcidsDrug CarriersDrug CompoundingHyperplasiaInflammation MediatorsKi-67 AntigenLactic AcidMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaOxidative StressPoloxamerPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRats, Sprague-DawleyTime FactorsTranscription Factor RelAConceptsLocal perivascular deliveryPerivascular deliveryRat modelCarotid angioplastyNeointimal hyperplasiaResolvin D1Inflammatory pathwaysNeointimal formationArterial smooth muscle cell proliferationNuclear factor-κB activationEffects of RvD1Smooth muscle cell proliferationKi67 proliferation indexResolution of inflammationNegative vessel remodelingMuscle cell proliferationSmooth muscle cellsMuscle cell responseWrap groupArterial injuryRat aortaEvidence of cytotoxicityRvD1Lipid mediatorsProliferation index
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