2024
Psychometric Evaluation of the Modified E-cigarette Evaluation Questionnaire for Use With High School Adolescents and Young Adults
Morean M. Psychometric Evaluation of the Modified E-cigarette Evaluation Questionnaire for Use With High School Adolescents and Young Adults. Nicotine & Tobacco Research 2024, 26: 1420-1428. PMID: 38605432, DOI: 10.1093/ntr/ntae076.Peer-Reviewed Original ResearchModified Cigarette Evaluation QuestionnaireFour-factor structureBetween-group differencesMeasurement invarianceConcurrent relationshipsYoung adultsInternal consistencyEvidence of concurrent validitySubjective responsesFive-factor structureTest-criterion relationshipsPsychometrically-sound measureScalar measurement invarianceEffects of e-cigarette useNicotine e-cigarettesHigh school adolescentsCraving reductionFive-FactorEvaluation questionnaireSubjective effectsVaping frequencyE-cigarette useReduced aversionScalar invariancePsychometric properties
2022
Within‐ and between‐person effects of naltrexone on the subjective response to alcohol and craving: A daily diary investigation
Waddell JT, Corbin WR, MacKinnon DP, Leeman RF, DeMartini KS, Fucito LM, Kranzler HR, O’Malley S. Within‐ and between‐person effects of naltrexone on the subjective response to alcohol and craving: A daily diary investigation. Alcohol Clinical And Experimental Research 2022, 46: 477-491. PMID: 35076087, PMCID: PMC9679805, DOI: 10.1111/acer.14780.Peer-Reviewed Original ResearchConceptsMedication dosageYoung adultsLight drinkingSubjective responsesSubjective effectsHeavy drinkingPlacebo-controlled studyEffect sizePerson effectsEffective treatmentNaltrexoneDrinking daysNaltrexone efficacySmall effect sizesDrinking levelsCravingDrinkingAdultsLaboratory-based studiesPillsMomentary assessmentEfficacyTreatment conditionsDrinking environmentsDaily diary data
2019
Targeting neuroinflammation with minocycline in heavy drinkers
Petrakis IL, Ralevski E, Gueorguieva R, Sloan ME, Devine L, Yoon G, Arias AJ, Sofuoglu M. Targeting neuroinflammation with minocycline in heavy drinkers. Psychopharmacology 2019, 236: 3013-3021. PMID: 30919006, PMCID: PMC6764907, DOI: 10.1007/s00213-019-05205-3.Peer-Reviewed Original ResearchConceptsPro-inflammatory cytokine releaseEthanol-induced inflammationMicroglial activationCytokine levelsCytokine releaseHeavy drinkersSecond-generation tetracycline antibioticDose of minocyclinePlacebo-controlled trialSerum cytokine levelsSubjective responsesBaseline cytokine levelsEffects of minocyclineViable treatment strategyShort-term treatmentAlcohol use disorderNeuroimmune modulationMinocycline treatmentNeuroimmune signalingMinocycline effectsIntravenous ethanolEthanol intakeSedative responseTreatment strategiesPreclinical studiesPredictors of quickly progressing from initiating alcohol use to engaging in binge drinking among adolescents
Morean ME, Peterson J, L'Insalata A. Predictors of quickly progressing from initiating alcohol use to engaging in binge drinking among adolescents. Addictive Behaviors Reports 2019, 9: 100165. PMID: 31193836, PMCID: PMC6542839, DOI: 10.1016/j.abrep.2019.100165.Peer-Reviewed Original ResearchAlcohol-related risksAlcohol effectsAlcohol useAlcohol-related problemsBinge drinking statusAge of onsetFirst drinking experienceRisk factorsParental historyMore alcohol-related problemsDrinking statusBinge drinkingCurrent drinkingOlder ageHeavy drinkingUnderage alcohol useShort delayFirst intoxicationAlcohol problemsUnderage drinkersAgeLater ageNegative alcohol effectsSubjective responsesBingersDoes Self-Reported or Behavioral Impulsivity Predict Subjective Response to Low-Dose Alcohol?
Berey BL, Leeman RF, Pittman B, Franco N, Krishnan-Sarin S. Does Self-Reported or Behavioral Impulsivity Predict Subjective Response to Low-Dose Alcohol? Alcohol And Alcoholism 2019, 54: 180-187. PMID: 30649160, PMCID: PMC6476413, DOI: 10.1093/alcalc/agy092.Peer-Reviewed Original ResearchConceptsLow-dose alcoholBlood alcohol concentrationAlcohol use disorderHeavy drinkersSubjective responsesTrend-level predictorNMDA receptor antagonistBiphasic Alcohol Effects ScaleAlcohol administration studyIndependent predictorsReceptor antagonistRisk factorsUse disordersSubjective stimulationGo/No-Go taskMore impulsive individualsHigh dosesEffects ScaleSedationAlcohol useSubjective effectsAdministration studiesImpulsivity measuresBarratt Impulsiveness ScaleDrinking occasions
2018
Stress responding and stress‐related changes in cue reactivity in heavy smokers, problem gamblers, and healthy controls
Wemm SE, Cao Z, Han L, Wulfert E. Stress responding and stress‐related changes in cue reactivity in heavy smokers, problem gamblers, and healthy controls. Addiction Biology 2018, 25: e12687. PMID: 30421575, PMCID: PMC6513727, DOI: 10.1111/adb.12687.Peer-Reviewed Original ResearchConceptsHealthy controlsBlunted cortisol responseMaladaptive stress responsesHigher subjective stressCue-related cravingHeavy smokersStress-related changesControl group responsesSmokersCortisol responseCortisol levelsSubjective stress responsesPsychosocial stressorsSalivary cortisolAcute stressorCue reactivityBehavioral addictionsCravingSubjective cravingSmokingSubstance addictionSubjective responsesCortisolStress responseSubjective stressAcute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers
Valentine GW, DeVito EE, Jatlow PI, Gueorguieva R, Sofuoglu M. Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers. Journal Of Psychopharmacology 2018, 32: 986-994. PMID: 29788802, PMCID: PMC6329876, DOI: 10.1177/0269881118773972.Peer-Reviewed Original ResearchConceptsPositive subjective effectsPositive subjective responsesIntravenous nicotineNicotine metabolismSubjective effectsNicotine metabolite ratioYoung adult smokersSlower nicotine metabolismTest sessionsSubjective responsesSevere nicotine withdrawalMenthol inhalationNicotine withdrawalAcute effectsAdult smokersWithdrawal severityNicotine infusionRewarding effectsSmokersSmoking urgesChronic exposureMetabolite ratiosAversive effectsMenthol conditionsElectronic cigarettes
2017
A cis‐eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use
Otto J, Gizer I, Deak J, Fleming K, Bartholow B. A cis‐eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use. Alcohol Clinical And Experimental Research 2017, 41: 929-938. PMID: 28273335, PMCID: PMC5404990, DOI: 10.1111/acer.13369.Peer-Reviewed Original ResearchConceptsBiphasic Alcohol Effects ScaleAlcohol useAlcohol use phenotypesSubjective responsesΜ-opioid receptor geneConsistent significant associationsEffects of alcoholHeroin dependenceSignificant associationPast monthEffects ScaleFunctional polymorphismsAlcohol challengeObserved associationsLow levels
2016
An overview of alcohol and tobacco/nicotine interactions in the human laboratory
Verplaetse TL, McKee SA. An overview of alcohol and tobacco/nicotine interactions in the human laboratory. The American Journal Of Drug And Alcohol Abuse 2016, 43: 186-196. PMID: 27439453, PMCID: PMC5588903, DOI: 10.1080/00952990.2016.1189927.Peer-Reviewed Original ResearchConceptsAlcohol-tobacco interactionsNicotine interactionsHuman laboratorySubjective responsesBlood alcohol curveDrinking cuesAlcohol use disorderOverview of alcoholNicotine deprivationSelf-administration behaviorDrugs of abuseAlcohol cravingReciprocal influenceAlcohol curveAlcohol influenceSubjective effectsUse disordersTobacco/nicotineNicotine administrationTobacco useInteractive effectsCravingMajor public health concernPublic health concernDrinkers
2015
Evaluating the accuracy of alcohol expectancies relative to subjective response to alcohol
Morean M, Corbin W, Treat T. Evaluating the accuracy of alcohol expectancies relative to subjective response to alcohol. Addictive Behaviors 2015, 51: 197-203. PMID: 26291291, PMCID: PMC4772766, DOI: 10.1016/j.addbeh.2015.07.027.Peer-Reviewed Original ResearchConceptsNegative alcohol expectanciesEffects of Alcohol ScaleAlcohol expectanciesAlcohol-related problemsAlcohol ScaleSubjective Effects of Alcohol ScaleBinge drinkingArousal effectPositive effects of alcoholBlood alcohol levelsFrequent binge drinkingSimulated bar settingAssociated with frequent binge drinkingEffects of alcoholPositive alcohol expectanciesSubjective responsesPsychometrically sound assessmentAlcohol-related risksEvaluate measurement invarianceSubjective effectsAlcohol levelsSecondary data analysisEmpirical supportBar settingProtective function
2013
The Subjective Effects of Alcohol Scale: Development and Psychometric Evaluation of a Novel Assessment Tool for Measuring Subjective Response to Alcohol
Morean M, Corbin W, Treat T. The Subjective Effects of Alcohol Scale: Development and Psychometric Evaluation of a Novel Assessment Tool for Measuring Subjective Response to Alcohol. Psychological Assessment 2013, 25: 780-795. PMID: 23647036, PMCID: PMC3822039, DOI: 10.1037/a0032542.Peer-Reviewed Original ResearchConceptsSubjective Effects of Alcohol ScaleEffects of Alcohol ScaleAlcohol administration studyBlood alcohol curveAlcohol ScaleSubjective effectsSubjective responsesAcute alcohol effectsAlcohol-related outcomesAlcohol-related problemsConfirmatory factor analysisEffects of drinkingAdministration studiesAlcohol expectanciesMeasuring subjective responsesBeverage conditionAlcohol curveIntegration of findingsAlcohol effectsDrinking episodesHigh arousalLow arousalPsychometric evaluationHeavy drinkingAlcohol useEffects of Family History of Alcohol Dependence on the Subjective Response to Alcohol Using the Intravenous Alcohol Clamp
Kerfoot K, Pittman B, Ralevski E, Limoncelli D, Koretski J, Newcomb J, Arias AJ, Petrakis IL. Effects of Family History of Alcohol Dependence on the Subjective Response to Alcohol Using the Intravenous Alcohol Clamp. Alcohol Clinical And Experimental Research 2013, 37: 2011-2018. PMID: 23895557, PMCID: PMC3971638, DOI: 10.1111/acer.12199.Peer-Reviewed Original ResearchConceptsAlcohol use disorderSubjective responsesBiphasic Alcohol Effects ScaleSubjective effectsUse disordersEffects of FHSimilar dose-related effectsTest dayCognitive effectsCognitive functionHigh-dose alcoholMeasure of coordinationSeparate test daysFamily historySubjective measuresHigh-dose EtOHImpairment of coordinationAlcohol challengeAlcohol dependenceEffects ScaleDouble-blind conditionsLow-dose ethanolAlcohol administrationVisual analog scaleIndividualsA preliminary study on the effect of combined nicotine replacement therapy on alcohol responses and alcohol self‐administration
Udo T, Harrison EL, Shi J, Tetrault J, McKee SA. A preliminary study on the effect of combined nicotine replacement therapy on alcohol responses and alcohol self‐administration. American Journal On Addictions 2013, 22: 590-597. PMID: 24131167, PMCID: PMC3934424, DOI: 10.1111/j.1521-0391.2013.12014.x.Peer-Reviewed Original ResearchConceptsSelf-administration periodNicotine nasal sprayHeavy drinking smokersNasal sprayNicotine patchAlcohol responsesPriming drinkSerum nicotine levelsPlacebo-controlled studyNicotine replacement therapySubjective alcohol responsesPositive subjective responsesNumber of drinksPlacebo administrationReplacement therapyPriming doseSmoking relapseAlcohol consumptionPlacebo conditionPatch applicationNicotine levelsClinical settingPilot studySmokersSubjective responsesCocaine Cue-Induced Dopamine Release in Amygdala and Hippocampus: A High-Resolution PET [18F]Fallypride Study in Cocaine Dependent Participants
Fotros A, Casey K, Larcher K, Verhaeghe J, Cox S, Gravel P, Reader A, Dagher A, Benkelfat C, Leyton M. Cocaine Cue-Induced Dopamine Release in Amygdala and Hippocampus: A High-Resolution PET [18F]Fallypride Study in Cocaine Dependent Participants. Neuropsychopharmacology 2013, 38: 1780-1788. PMID: 23546387, PMCID: PMC3717549, DOI: 10.1038/npp.2013.77.Peer-Reviewed Original ResearchConceptsDA releaseDopamine releaseVisual analog scaleDrug cue exposureCocaine-dependent volunteersDrug-seeking behaviorCocaine-dependent participantsAnalog scaleDrug-related cuesLimbic networkAnimal studiesCocaine dependenceHippocampusCue exposureAmygdalaPreferential inductionBPND valuesPotent triggerStriatumDependent participantsCocaine cuesReward networkSubjective responsesNeutral cuesFirst evidenceEarly Subjective Response and Acquired Tolerance as Predictors of Alcohol Use and Related Problems in a Clinical Sample
Corbin WR, Scott C, Leeman RF, Fucito LM, Toll BA, O'Malley SS. Early Subjective Response and Acquired Tolerance as Predictors of Alcohol Use and Related Problems in a Clinical Sample. Alcohol Clinical And Experimental Research 2013, 37: 490-497. PMID: 23347236, PMCID: PMC3586307, DOI: 10.1111/j.1530-0277.2012.01956.x.Peer-Reviewed Original ResearchConceptsEarly subjective responseLow subjective responseAlcohol use disorderAlcohol-related problemsRisk factorsSubjective responsesAlcohol useYoung adultsBrief motivational counselingClinical samplesInitial subjective responseDrinking behaviorHeavy drinking young adultsSignificant alcohol problemsClinical trialsProtective effectModerate drinkersUse disordersMotivational counselingPrior studiesCurrent studyHeavy drinkersHazardous drinkingAlcohol effectsWeekly drinking
2012
The drug effects questionnaire: psychometric support across three drug types
Morean ME, de Wit H, King AC, Sofuoglu M, Rueger SY, O’Malley S. The drug effects questionnaire: psychometric support across three drug types. Psychopharmacology 2012, 227: 177-192. PMID: 23271193, PMCID: PMC3624068, DOI: 10.1007/s00213-012-2954-z.Peer-Reviewed Original ResearchConceptsDrug Effects QuestionnaireEffects QuestionnaireVariety of substancesPlacebo-controlled studySubjective responsesVisual analog scalePsychometric propertiesSubstance-related behaviorsAcute subjective responseAnalog scaleDrug typePreliminary psychometric supportPsychometric supportPromising psychometric propertiesMultiple substancesCurrent studyQuestionnaireStudy resultsSubjective Effects of Thiopental in Young Adults with and without a Family History of Alcoholism
Petrakis IL, Kerfoot K, Pittman B, Perrino A, Koretski J, Newcomb J, Limoncelli D, Acampora G, Ralevski E. Subjective Effects of Thiopental in Young Adults with and without a Family History of Alcoholism. Journal Of Addiction Research & Therapy 2012, 2013 PMID: 24273687, PMCID: PMC3835602, DOI: 10.4172/2155-6105.s7-002.Peer-Reviewed Original ResearchAlcohol use disorderSubjective effectsUse disordersSub-anesthetic dosesAlcohol-related measuresSignificant main effectCognitive effectsAlcohol-like effectsFHN individualsSeparate test daysStimulant effectsYoung adultsCognitionMain effectSubjective responsesAlcohol dependenceTest dayFamily historyImpaired coordinationIndividualsResponse differencesFamily history-negative subjectsDisordersHealthy individualsFHPReduced Subjective Response to Acute Ethanol Administration Among Young Men with a Broad Bipolar Phenotype
Yip SW, Doherty J, Wakeley J, Saunders K, Tzagarakis C, de Wit H, Goodwin GM, Rogers RD. Reduced Subjective Response to Acute Ethanol Administration Among Young Men with a Broad Bipolar Phenotype. Neuropsychopharmacology 2012, 37: 1808-1815. PMID: 22491350, PMCID: PMC3376329, DOI: 10.1038/npp.2012.45.Peer-Reviewed Original ResearchConceptsAlcohol use disorderWeekly alcohol intakeBipolar disorderAlcohol intakeSubjective responsesAcute ethanol administrationLifetime prevalence ratesDevelopment of AUDPlacebo administrationAcute alcoholEthanol administrationHealthy controlsSedative responsePharmacokinetic effectsEtiological factorsPrevalence ratesUse disordersAlcohol misusePharmacokinetic responseFamilial riskAlcohol responsesYoung malesIntoxication effectsBipolar phenotypeYoung menP.3.018 Reduced subjective response to acute ethanol administration among young men with the bipolar phenotype
Yip S, Doherty J, Wakeley J, Saunders K, Tzagarakis C, de Wit H, Goodwin G, Rogers R. P.3.018 Reduced subjective response to acute ethanol administration among young men with the bipolar phenotype. European Neuropsychopharmacology 2012, 22: s67-s68. DOI: 10.1016/s0924-977x(12)70071-8.Peer-Reviewed Original Research
2010
Alcohol expectancy increases positive responses to cigarettes in young, escalating smokers
McKee SA, Harrison EL, Shi J. Alcohol expectancy increases positive responses to cigarettes in young, escalating smokers. Psychopharmacology 2010, 210: 355-364. PMID: 20352411, PMCID: PMC2874601, DOI: 10.1007/s00213-010-1831-x.Peer-Reviewed Original ResearchConceptsSmoking behaviorAd lib smoking behaviorExpectation of alcoholHeavy-drinking young adultsDaily cigarette useExperience of smokingSmoking patternsNondaily smokersSubsequent smokingSmokingSingle cigaretteCigarette useAge groupsAlcohol altersSmokersSubjective effectsYoung adultsYoung adulthoodCigarettesPlaceboHigh rateSubjective reactivitySubjective responsesPrimary aimPositive response
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