2013
Effects of Family History of Alcohol Dependence on the Subjective Response to Alcohol Using the Intravenous Alcohol Clamp
Kerfoot K, Pittman B, Ralevski E, Limoncelli D, Koretski J, Newcomb J, Arias AJ, Petrakis IL. Effects of Family History of Alcohol Dependence on the Subjective Response to Alcohol Using the Intravenous Alcohol Clamp. Alcohol Clinical And Experimental Research 2013, 37: 2011-2018. PMID: 23895557, PMCID: PMC3971638, DOI: 10.1111/acer.12199.Peer-Reviewed Original ResearchConceptsAlcohol use disorderSubjective responsesBiphasic Alcohol Effects ScaleSubjective effectsUse disordersEffects of FHSimilar dose-related effectsTest dayCognitive effectsCognitive functionHigh-dose alcoholMeasure of coordinationSeparate test daysFamily historySubjective measuresHigh-dose EtOHImpairment of coordinationAlcohol challengeAlcohol dependenceEffects ScaleDouble-blind conditionsLow-dose ethanolAlcohol administrationVisual analog scaleIndividuals
2012
Subjective Effects of Thiopental in Young Adults with and without a Family History of Alcoholism
Petrakis IL, Kerfoot K, Pittman B, Perrino A, Koretski J, Newcomb J, Limoncelli D, Acampora G, Ralevski E. Subjective Effects of Thiopental in Young Adults with and without a Family History of Alcoholism. Journal Of Addiction Research & Therapy 2012, 2013 PMID: 24273687, PMCID: PMC3835602, DOI: 10.4172/2155-6105.s7-002.Peer-Reviewed Original ResearchAlcohol use disorderSubjective effectsUse disordersSub-anesthetic dosesAlcohol-related measuresSignificant main effectCognitive effectsAlcohol-like effectsFHN individualsSeparate test daysStimulant effectsYoung adultsCognitionMain effectSubjective responsesAlcohol dependenceTest dayFamily historyImpaired coordinationIndividualsResponse differencesFamily history-negative subjectsDisordersHealthy individualsFHP
2010
Analgesic Effects of Ethanol Are Influenced by Family History of Alcoholism and Neuroticism
Ralevski E, Perrino A, Acampora G, Koretski J, Limoncelli D, Petrakis I. Analgesic Effects of Ethanol Are Influenced by Family History of Alcoholism and Neuroticism. Alcohol Clinical And Experimental Research 2010, 34: 1433-1441. PMID: 20497133, PMCID: PMC9136640, DOI: 10.1111/j.1530-0277.2010.01228.x.Peer-Reviewed Original ResearchConceptsFamily historyAnalgesic responseHigh N scoresAnalgesic effectNoxious electrical stimulationPositive family historyStart of infusionDoses of ethanolSeparate test daysNegative family historyTest dayExperience of painN scoreMore analgesiaPlacebo dayPain assessmentPersonality traitsIntravenous administrationHealthy subjectsEthanol challengeLow doseElectrical stimulationAlcoholismThirty-oneLow N scores
2008
Ethanol-like effects of thiopental and ketamine in healthy humans
Dickerson D, Pittman B, Ralevski E, Perrino A, Limoncelli D, Edgecombe J, Acampora G, Krystal J, Petrakis I. Ethanol-like effects of thiopental and ketamine in healthy humans. Journal Of Psychopharmacology 2008, 24: 203-211. PMID: 19028835, PMCID: PMC4484757, DOI: 10.1177/0269881108098612.Peer-Reviewed Original ResearchConceptsEthanol-like effectsEthanol-related effectsNMDA receptor antagonistBlock NMDA receptorsNMDA receptor antagonismSeparate test daysGamma-aminobutyric acidReceptor antagonismSubanesthetic dosesReceptor antagonistNMDA receptorsFamily historyEthanol intoxicationHealthy humansPharmacological agentsEthanol effectsKetamineReceptor activityReceptor functionLarger studyBehavioral effectsThiopentalIntoxicationSubjective intoxicationTest day
1997
Noradrenergic and Serotonergic Function in Posttraumatic Stress Disorder
Southwick SM, Krystal JH, Bremner JD, Morgan CA, Nicolaou AL, Nagy LM, Johnson DR, Heninger GR, Charney DS. Noradrenergic and Serotonergic Function in Posttraumatic Stress Disorder. JAMA Psychiatry 1997, 54: 749-758. PMID: 9283511, DOI: 10.1001/archpsyc.1997.01830200083012.Peer-Reviewed Original ResearchConceptsYohimbine-induced panic attacksPosttraumatic stress disorderPanic attacksCardiovascular effectsCardiovascular measurementsStress disorderYohimbine hydrochloridePTSD symptomsDiastolic blood pressureDouble-blind fashionSeparate test daysGreater increaseBlood pressureIntravenous infusionSerotonergic functionNoradrenergic activitySerotonergic systemNoradrenergic systemHealthy subjectsSerotonergic activityPatientsDifferent patientsTest dayCombat veteransYohimbine
1995
m-Chlorophenylpiperazine in patients with obsessive-compulsive disorder: Absence of symptom exacerbation
Goodman W, McDougle C, Price L, Barr L, Hills O, Caplik J, Charney D, Heninger G. m-Chlorophenylpiperazine in patients with obsessive-compulsive disorder: Absence of symptom exacerbation. Biological Psychiatry 1995, 38: 138-149. PMID: 7578657, DOI: 10.1016/0006-3223(94)00235-u.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderDrug-free patientsPlasma prolactin responseSeparate test daysOCD symptomsRatings of anxietySymptom exacerbationIntravenous routeProlactin responseOral administrationSusceptible subgroupsBiochemical measuresObsessive-compulsive symptomsSymptomsRandom orderMCPPTest dayPatientsSignificant increaseDisordersBehavioral findingsFindingsPlaceboExacerbationChlorophenylpiperazine
1991
Behavioral, biochemical, and cardiovascular responses to the benzodiazepine receptor antagonist flumazenil in panic disorder
Woods S, Charney D, Silver J, Krystal J, Heninger G. Behavioral, biochemical, and cardiovascular responses to the benzodiazepine receptor antagonist flumazenil in panic disorder. Psychiatry Research 1991, 36: 115-127. PMID: 1850142, DOI: 10.1016/0165-1781(91)90124-8.Peer-Reviewed Original ResearchConceptsAntagonist flumazenilAnxiolytic effectsBenzodiazepine receptor antagonist flumazenilReceptor antagonist flumazenilDose of flumazenilVisual analog scaleBenzodiazepine receptor functionBZR inverse agonistsSignificant anxiolytic effectSeparate test daysPlacebo capsulesBlood pressureAnalog scaleCardiovascular responsesDisorder patientsHeart rateFlumazenilCrossover designPanic patientsPanic disorderPlasma cortisolBaseline levelsPanic attacksPlaceboReceptor function
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