2021
Effects of SSRI treatment on GABA and glutamate levels in an associative relearning paradigm
Spurny B, Vanicek T, Seiger R, Reed MB, Klöbl M, Ritter V, Unterholzner J, Godbersen GM, Silberbauer LR, Pacher D, Klug S, Konadu ME, Gryglewski G, Trattnig S, Bogner W, Lanzenberger R. Effects of SSRI treatment on GABA and glutamate levels in an associative relearning paradigm. NeuroImage 2021, 232: 117913. PMID: 33657450, PMCID: PMC7610796, DOI: 10.1016/j.neuroimage.2021.117913.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsGamma-aminobutyric acidMajor depressive disorderSerotonin reuptake inhibitorsSSRI treatmentPlacebo administrationReuptake inhibitorsGlutamatergic functionGlutamatergic neurotransmissionDepressive disorderNeuroplastic effectsSerotonergic systemNeurotransmitter systemsHealthy subjectsPsychiatric disordersImpaired cognitive flexibilityBrain regionsNeurotransmitter concentrationsCognitive functionWidespread symptomsMemory formationLast dayDisordersDownstream effectsTreatment
2013
Ketamine Effects on Memory Reconsolidation Favor a Learning Model of Delusions
Corlett PR, Cambridge V, Gardner JM, Piggot JS, Turner DC, Everitt JC, Arana FS, Morgan HL, Milton AL, Lee JL, Aitken MR, Dickinson A, Everitt BJ, Absalom AR, Adapa R, Subramanian N, Taylor JR, Krystal JH, Fletcher PC. Ketamine Effects on Memory Reconsolidation Favor a Learning Model of Delusions. PLOS ONE 2013, 8: e65088. PMID: 23776445, PMCID: PMC3680467, DOI: 10.1371/journal.pone.0065088.Peer-Reviewed Original ResearchConceptsMemory strengthMemory reconsolidationIndividual brain responsesError-dependent learningPsychotogenic effectsSubsequent memoryFear memoryBizarre beliefsBrain responsesDelusional beliefsPrediction errorImpact of ketamineIndividual vulnerabilityBrain signalsSubject studyReconsolidationIndependent samplesLearning procedureMemoryKetamine effectsDelusionsBeliefsPlacebo administrationPsychosisNMDA receptor antagonistA preliminary study on the effect of combined nicotine replacement therapy on alcohol responses and alcohol self‐administration
Udo T, Harrison EL, Shi J, Tetrault J, McKee SA. A preliminary study on the effect of combined nicotine replacement therapy on alcohol responses and alcohol self‐administration. American Journal On Addictions 2013, 22: 590-597. PMID: 24131167, PMCID: PMC3934424, DOI: 10.1111/j.1521-0391.2013.12014.x.Peer-Reviewed Original ResearchConceptsSelf-administration periodNicotine nasal sprayHeavy drinking smokersNasal sprayNicotine patchAlcohol responsesPriming drinkSerum nicotine levelsPlacebo-controlled studyNicotine replacement therapySubjective alcohol responsesPositive subjective responsesNumber of drinksPlacebo administrationReplacement therapyPriming doseSmoking relapseAlcohol consumptionPlacebo conditionPatch applicationNicotine levelsClinical settingPilot studySmokersSubjective responses
2012
Reduced Subjective Response to Acute Ethanol Administration Among Young Men with a Broad Bipolar Phenotype
Yip SW, Doherty J, Wakeley J, Saunders K, Tzagarakis C, de Wit H, Goodwin GM, Rogers RD. Reduced Subjective Response to Acute Ethanol Administration Among Young Men with a Broad Bipolar Phenotype. Neuropsychopharmacology 2012, 37: 1808-1815. PMID: 22491350, PMCID: PMC3376329, DOI: 10.1038/npp.2012.45.Peer-Reviewed Original ResearchConceptsAlcohol use disorderWeekly alcohol intakeBipolar disorderAlcohol intakeSubjective responsesAcute ethanol administrationLifetime prevalence ratesDevelopment of AUDPlacebo administrationAcute alcoholEthanol administrationHealthy controlsSedative responsePharmacokinetic effectsEtiological factorsPrevalence ratesUse disordersAlcohol misusePharmacokinetic responseFamilial riskAlcohol responsesYoung malesIntoxication effectsBipolar phenotypeYoung men
2008
Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans
D’Souza D, Pittman B, Perry E, Simen A. Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans. Psychopharmacology 2008, 202: 569. PMID: 18807247, PMCID: PMC2791800, DOI: 10.1007/s00213-008-1333-2.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorBDNF levelsBrain-derived neurotrophic factor levelsNeurotrophic factor levelsSerum BDNF levelsΔ9-THCEffects of cannabinoidsΔ9-THC administrationSpatial memory impairmentBasal BDNF levelsResultsΔ9-THCPlacebo administrationPrincipal active componentNeurotrophic factorControl subjectsPsychotomimetic effectsHealthy controlsCannabinoid effectsIntravenous administrationAltered neurodevelopmentPreclinical studiesHigh riskConsequence of exposureChronic exposureMemory impairment
2003
Regional Brain Metabolic Correlates of α-Methylparatyrosine–Induced Depressive Symptoms: Implications for the Neural Circuitry of Depression
Bremner JD, Vythilingam M, Ng CK, Vermetten E, Nazeer A, Oren DA, Berman RM, Charney DS. Regional Brain Metabolic Correlates of α-Methylparatyrosine–Induced Depressive Symptoms: Implications for the Neural Circuitry of Depression. JAMA 2003, 289: 3125-3134. PMID: 12813118, PMCID: PMC3233764, DOI: 10.1001/jama.289.23.3125.Peer-Reviewed Original ResearchConceptsNorepinephrine reuptake inhibitorsSelective serotonin reuptake inhibitorsBrain metabolic correlatesDepressive symptomsDorsolateral prefrontal cortexReuptake inhibitorsBrain metabolismMetabolic correlatesPrefrontal cortexPsychiatric research unitDouble-blind trialPositron emission tomography (PET) measurementsDepletion of norepinephrineSerotonin reuptake inhibitorsDifferent neurochemical systemsCommon brain circuitryAMPT administrationInitial medicationPlacebo administrationLimbic areasAcute decreaseDepressed patientsCortical areasPatientsDay 3
2000
Cerebrospinal Fluid Corticotropin-Releasing Hormone in Healthy Humans: Effects of Yohimbine and Naloxone1
Vythilingam M, Anderson G, Owens M, Halaszynski T, Bremner J, Carpenter L, Heninger G, Nemeroff C, Charney D. Cerebrospinal Fluid Corticotropin-Releasing Hormone in Healthy Humans: Effects of Yohimbine and Naloxone1. The Journal Of Clinical Endocrinology & Metabolism 2000, 85: 4138-4145. PMID: 11095445, DOI: 10.1210/jcem.85.11.6968.Peer-Reviewed Original ResearchConceptsCRH neuronsParaventricular nucleusCSF CRHCerebrospinal fluidPlasma cortisolHypothalamic pituitary adrenal axis activityCSF CRH concentrationsCSF CRH levelsCorticotropin-releasing hormoneCSF NE levelsEffects of yohimbineAdult normal volunteersPlasma cortisol concentrationsCRH concentrationsCentral norepinephrineOpioid regulationPlacebo administrationPVN neuronsCRH levelsNE levelsCSF norepinephrineHPA axisAxis activityHealthy humansMedian eminence
1999
Effect of catecholamine depletion on lithium-induced long-term remission of bipolar disorder
Anand A, Darnell A, Miller H, Berman R, Cappiello A, Oren D, Woods S, Charney D. Effect of catecholamine depletion on lithium-induced long-term remission of bipolar disorder. Biological Psychiatry 1999, 45: 972-978. PMID: 10386179, DOI: 10.1016/s0006-3223(98)00293-5.Peer-Reviewed Original ResearchConceptsLong-term remissionBipolar disorderCatecholamine depletionLithium therapyHypomanic symptomsLong-term lithium therapyRandomized double-blind mannerDSM-IV bipolar disorderDouble-blind mannerMechanism of preventionTransient relapseManic relapsePlacebo administrationSerum levelsCatecholamine systemsHomovanillic acidRemissionRelapseDisordersTherapyTest sessionsSymptomsSubjectsSignificant changesMood indices
1998
Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women
Stachenfeld N, Dipietro L, Palter S, Nadel E. Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women. American Journal Of Physiology 1998, 274: r187-r195. PMID: 9458917, DOI: 10.1152/ajpregu.1998.274.1.r187.Peer-Reviewed Original ResearchConceptsMin of drinkingPg/Body water balanceHypertonic salineFractional sodium excretionPlasma aldosterone concentrationRenal sodium reabsorptionFree water clearancePlasma estradiol concentrationsHypertonic saline infusionHigh E2 statesWater ad libitumMosmol/kgH2OAldosterone concentrationPostmenopausal womenSodium excretionPlacebo administrationUrine outputAVP secretionSodium reabsorptionFluid retentionE2 treatmentEstradiol concentrationsWater clearanceSaline infusion
1995
Octreotide blunts postprandial splanchnic hyperemia in cirrhotic patients: A double-blind randomized echo-doppler study
Buonamico P, Sabba C, Garcia-Tsao G, Berardi E, Antonica G, Ferraioli G, Jensen J, Lerner E, Taylor K, Albano O, Groszmann R. Octreotide blunts postprandial splanchnic hyperemia in cirrhotic patients: A double-blind randomized echo-doppler study. Hepatology 1995, 21: 134-139. DOI: 10.1016/0270-9139(95)90420-4.Peer-Reviewed Original ResearchPortal vein cross-sectional areaPostprandial splanchnic hyperemiaSuperior mesenteric arteryCirrhotic patientsSMA-VSplanchnic hyperemiaSplanchnic hemodynamicsPlacebo administrationMeal ingestionPV-VFasted stateVein cross-sectional areaEcho-Doppler studyEffect of octreotideCrossover studyMesenteric arteryPulsatility indexLiquid mealPatientsSeparate daysCross-sectional areaSignificant decreaseIngestionHyperemiaSignificant increaseOctreotide blunts postprandial splanchnic hyperemia in cirrhotic patients: A double‐blind randomized echo‐doppler study
Buonamico P, Sabbá C, Garcia‐Tsao G, Berardi E, Antonica G, Ferraioli G, Jensen J, Lerner E, Taylor K, Albano O, Groszmann R. Octreotide blunts postprandial splanchnic hyperemia in cirrhotic patients: A double‐blind randomized echo‐doppler study. Hepatology 1995, 21: 134-139. PMID: 7806146, DOI: 10.1002/hep.1840210123.Peer-Reviewed Original ResearchConceptsPortal vein cross-sectional areaPostprandial splanchnic hyperemiaSuperior mesenteric arterySMA-VCirrhotic patientsSplanchnic hyperemiaSplanchnic hemodynamicsPlacebo administrationMeal ingestionPV-VFasted stateVein cross-sectional areaEcho-Doppler studyEffect of octreotideCrossover studyMesenteric arteryPulsatility indexLiquid mealPatientsSeparate daysCross-sectional areaSignificant decreaseIngestionHyperemiaSignificant increase
1994
SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine
van Dyck C, Rosen M, Thomas H, McMahon T, Wallace E, O'Connor P, Sullivan M, Krystal J, Hoffer P, Woods S, Kosten T. SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine. Psychiatry Research 1994, 55: 181-191. PMID: 7701033, DOI: 10.1016/0925-4927(94)90013-2.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowRegional cerebral blood flow alterationsCerebral blood flow alterationsHexamethyl propylene amine oximeOpiate-induced analgesiaBlood flow alterationsSeverity of withdrawalCerebral blood flowOpiate-dependent patientsAnterior cingulate regionsAnterior cingulate cortexSingle photon emissionPlacebo administrationAmine oximeOpiate withdrawalRCBF ratiosWithdrawal severityBlood flowCingulate cortexCingulate regionsSignificant negative correlationBuprenorphineNaltrexonePlaceboPatients
1991
Effect of Silibinin on biliary lipid composition experimental and clinical study
Nassuato G, Iemmolo R, Strazzabosco M, Lirussi F, Deana R, Francesconi M, Muraca M, Passera D, Fragasso A, Orlando R, Csomós G, Okolicsányi L. Effect of Silibinin on biliary lipid composition experimental and clinical study. Journal Of Hepatology 1991, 12: 290-295. PMID: 1940257, DOI: 10.1016/0168-8278(91)90829-z.Peer-Reviewed Original ResearchConceptsBiliary lipid compositionBiliary cholesterol concentrationTotal bile salt concentrationBile salt concentrationBile flowBiliary cholesterolCholesterol concentrationsBody weightTotal liver cholesterol contentBile saturation indexSignificant dose-dependent inhibitionEffect of silymarinLiver cholesterol contentEffect of silibininDose-dependent inhibitionCoA reductase activitySilymarin treatmentLiver cholesterolPlacebo administrationCholecystectomized patientsControl ratsClinical studiesLipid compositionSilibinin doseSilibinin
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