2024
Reductions in World Health Organization Risk Drinking Level Are Associated With Reductions in Alcohol Use Disorder Diagnosis and Criteria: Evidence From an Alcohol Pharmacotherapy Trial
Richards D, Tuchman F, Hallgren K, Kranzler H, Aubin H, O'Malley S, Mann K, Aldridge A, Anton R, Witkiewitz K. Reductions in World Health Organization Risk Drinking Level Are Associated With Reductions in Alcohol Use Disorder Diagnosis and Criteria: Evidence From an Alcohol Pharmacotherapy Trial. Journal Of Addiction Medicine 2024, 18: 418-424. PMID: 38606854, PMCID: PMC11290995, DOI: 10.1097/adm.0000000000001303.Peer-Reviewed Original ResearchConceptsWorld Health Organization risk drinking levelsAlcohol use disorderAlcohol use disorder diagnosisAlcohol use disorder criteriaDrinking levelsMini International Neuropsychiatric InterviewSevere alcohol use disorderCurrent alcohol use disorderGabapentin enacarbilRisk drinking levelsMultisite Randomized Controlled TrialAlcohol intervention trialPharmacotherapy trialsAUD diagnosisAUD treatmentNeuropsychiatric InterviewBaseline to endDisorder diagnosisEnd of treatmentFollow-backUse disorderAssess DiagnosticWorld Health OrganizationAssociated with reductionsSecondary data analysisReductions in World Health Organization risk drinking level are associated with improvements in sleep problems among individuals with alcohol use disorder
Garcia C, Richards D, Tuchman F, Hallgren K, Kranzler H, Aubin H, O’Malley S, Mann K, Aldridge A, Hoffman M, Anton R, Witkiewitz K. Reductions in World Health Organization risk drinking level are associated with improvements in sleep problems among individuals with alcohol use disorder. Alcohol And Alcoholism 2024, 59: agae022. PMID: 38606931, PMCID: PMC11010310, DOI: 10.1093/alcalc/agae022.Peer-Reviewed Original ResearchConceptsAlcohol use disorderSleep problemsAssociated with improvementsUse disorderMaintenance of alcohol use disorderDrinking levelsWorld Health Organization risk drinking levelsRisk drinking levelsTimeline Follow-BackSleep problem scoreFewer sleep problemsMonths of treatmentDrinking reductionFollow-backPittsburgh Sleep Quality IndexActive medicationSleep Quality IndexProblem scoresExtended-releaseAlcohol usePlacebo groupSleep disturbanceHarm reduction approachesSleep qualityControlled TrialsReductions in WHO risk drinking levels correlate with alcohol craving among individuals with alcohol use disorder
Tuchman F, Hallgren K, Richards D, Aldridge A, Anton R, Aubin H, Kranzler H, Mann K, O'Malley S, Witkiewitz K. Reductions in WHO risk drinking levels correlate with alcohol craving among individuals with alcohol use disorder. Alcohol Clinical And Experimental Research 2024, 48: 420-429. PMID: 38149364, PMCID: PMC10922776, DOI: 10.1111/acer.15257.Peer-Reviewed Original ResearchWorld Health Organization risk drinking levelsAlcohol use disorderAlcohol use disorder severityDrinking reductionDrinking levelsAlcohol cravingUse disorderAlcohol use disorder treatmentAssociated with lower cravingRisk drinking levelsSelf-report measuresEnd-of-treatmentCraving reductionLower cravingCravingModeration analysisWorld Health OrganizationBehavioral interventionsSecondary analysis of dataAssociated with reductionsClinical trial endpointsDisordersSecondary analysisAlcoholDrinking
2022
Predictors of abstinence, no heavy drinking days, and a 2‐level reduction in World Health Organization drinking levels during treatment for alcohol use disorder in the COMBINE study
Wallach JD, Gueorguieva R, Phan H, Witkiewitz K, Wu R, O'Malley SS. Predictors of abstinence, no heavy drinking days, and a 2‐level reduction in World Health Organization drinking levels during treatment for alcohol use disorder in the COMBINE study. Alcohol Clinical And Experimental Research 2022, 46: 1331-1339. PMID: 35616436, PMCID: PMC9887652, DOI: 10.1111/acer.14877.Peer-Reviewed Original ResearchConceptsHeavy drinking daysWeeks of treatmentAlcohol use disorderDependence Scale scoresDrinking daysScale scoreDays abstinentPredictors of abstinenceConsecutive weeksUse disordersDrinking levelsCOMBINE StudyOlder subjectsRandomized placebo-controlled trialPlacebo-controlled trialEfficacy of naltrexoneMultiple patient characteristicsTrials of medicationsBehavioral intervention studyPatient characteristicsFuture trialsBaseline variablesCombined PharmacotherapiesYoung subjectsComplete abstinenceWithin‐ and between‐person effects of naltrexone on the subjective response to alcohol and craving: A daily diary investigation
Waddell JT, Corbin WR, MacKinnon DP, Leeman RF, DeMartini KS, Fucito LM, Kranzler HR, O’Malley S. Within‐ and between‐person effects of naltrexone on the subjective response to alcohol and craving: A daily diary investigation. Alcohol Clinical And Experimental Research 2022, 46: 477-491. PMID: 35076087, PMCID: PMC9679805, DOI: 10.1111/acer.14780.Peer-Reviewed Original ResearchConceptsMedication dosageYoung adultsLight drinkingSubjective responsesSubjective effectsHeavy drinkingPlacebo-controlled studyEffect sizePerson effectsEffective treatmentNaltrexoneDrinking daysNaltrexone efficacySmall effect sizesDrinking levelsCravingDrinkingAdultsLaboratory-based studiesPillsMomentary assessmentEfficacyTreatment conditionsDrinking environmentsDaily diary data
2021
Risk drinking levels and sex are associated with cancer and liver, respiratory, and other medical conditions
Verplaetse T, Roberts W, Peltier M, Zakiniaeiz Y, Burke C, Moore K, Pittman B, McKee S. Risk drinking levels and sex are associated with cancer and liver, respiratory, and other medical conditions. Drug And Alcohol Dependence Reports 2021, 1: 100007. PMID: 36843909, PMCID: PMC9948833, DOI: 10.1016/j.dadr.2021.100007.Peer-Reviewed Original ResearchRisk drinking levelsMedical conditionsDrinking levelsAlcohol useU.S. National Epidemiologic SurveySignificant medical conditionsHigh-risk drinking levelsAlcohol-related health consequencesNational Epidemiologic SurveyHeavy drinking femalesHeavy alcohol useHigh-risk drinkingRespiratory conditionsClinical careEpidemiologic SurveyAlcohol consumptionFemale abstainersMale abstainersOrgan systemsHealth consequencesRelated conditionsCancerSexHealth risksFemales
2019
Fluctuations in daily PTSD symptoms are related to proximal alcohol use: a micro-longitudinal study of women victims of intimate partner violence
Sullivan TP, Armeli S, Tennen H, Weiss NH, Hansen NB. Fluctuations in daily PTSD symptoms are related to proximal alcohol use: a micro-longitudinal study of women victims of intimate partner violence. The American Journal Of Drug And Alcohol Abuse 2019, 46: 98-108. PMID: 31311330, DOI: 10.1080/00952990.2019.1624765.Peer-Reviewed Original ResearchConceptsOverall PTSD severityPTSD symptomsAlcohol useIntimate partner violencePTSD severityCurrent intimate partner violenceHigh-risk populationDaily PTSD symptomsLevel of drinkingPTSD symptom cluster severityRace/ethnicitySymptom cluster severityAlcohol use problemsPTSD symptom severityPartner violenceOverall severitySymptomsSymptom severityCluster severityTreatment effortsSeverityInteractive voice responseDrinking levelsLower PTSD severityReverse causation
2014
Episode-specific drinking-to-cope motivation, daily mood, and fatigue-related symptoms among college students.
Armeli S, O'Hara RE, Ehrenberg E, Sullivan TP, Tennen H. Episode-specific drinking-to-cope motivation, daily mood, and fatigue-related symptoms among college students. Journal Of Studies On Alcohol And Drugs 2014, 75: 766-74. PMID: 25208194, PMCID: PMC4161697, DOI: 10.15288/jsad.2014.75.766.Peer-Reviewed Original ResearchConceptsDTC motivationFatigue-related symptomsNegative moodDaily moodCope motivationDaily diary studyDrinking eventsEpisode-specific drinkingDrinking levelsCollege student drinkersPhysical symptomsAlcohol-related problemsAttention allocationPositive moodDiary studyCurrent moodHierarchical linear modelsStudent drinkersCo-Occurring Chronic Depression and Alcohol Dependence
Penberthy J, Gioia C, Konig A, Martin A, Cockrell S, Meshberg-Cohen S. Co-Occurring Chronic Depression and Alcohol Dependence. Addictive Disorders & Their Treatment 2014, 13: 54-67. DOI: 10.1097/adt.0b013e31827de84e.Peer-Reviewed Original ResearchAlcohol-dependent individualsChronic depressionAlcohol dependenceAlcohol intakeCo-occurring alcohol dependenceSuccessful treatment optionCognitive Behavioral Analysis SystemBehavioral Analysis SystemTreatment optionsCBASPBehavioral treatmentIndividual disordersDepressionDrinking levelsAvoidance learningTherapyHigh rateEarly traumaTreatmentIntakeDisordersIndividualsPopulationSymptomsTrauma
2013
Drinking Less and Drinking Smarter: Direct and Indirect Protective Strategies in Young Adults
DeMartini KS, Palmer RS, Leeman RF, Corbin WR, Toll BA, Fucito LM, O’Malley S. Drinking Less and Drinking Smarter: Direct and Indirect Protective Strategies in Young Adults. Psychology Of Addictive Behaviors 2013, 27: 615-626. PMID: 23088406, PMCID: PMC3869566, DOI: 10.1037/a0030475.Peer-Reviewed Original ResearchConceptsAlcohol-related consequencesClinical samplesYoung adult drinkingLow alcohol consumptionAdult drinkingPatient goalsYoung adult drinkersAlcohol consumptionProtective behavioral strategiesAlcohol useYoung adultsConfirmatory factor analysisProtective strategiesDrinking levelsLow drinking levelsAdult drinkersDrinkingDrinkersInterventionStrategies QuestionnaireCFA modelFactors
1999
Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age.
Garland M, Hunter DJ, Colditz GA, Spiegelman DL, Manson JE, Stampfer MJ, Willett WC. Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 1017-21. PMID: 10566558.Peer-Reviewed Original ResearchConceptsBreast cancer riskMultivariate relative riskAlcohol consumptionCancer riskRelative riskBreast cancerDrinks/weekInvasive breast cancerModerate alcohol consumptionMore drinks/weekAverage lifetime alcohol consumptionLifetime alcohol consumptionWomen age 25Past alcohol consumptionYears of agePostmenopausal womenPremenopausal womenWomen 25Age 25Young womenHeavy drinkingAge 23Drinking levelsWomenFurther studies
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