2025
Acute Alcohol‐Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography
Raval N, Smart K, Angarita G, Miller R, Huang Y, Krystal J, Carson R, Cosgrove K, O'Malley S, Hillmer A. Acute Alcohol‐Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography. Addiction Biology 2025, 30: e70031. PMID: 40309934, PMCID: PMC12044519, DOI: 10.1111/adb.70031.Peer-Reviewed Original ResearchConceptsBlood alcohol levelsAlcohol challengeEffects of acute alcohol consumptionPeak blood alcohol levelsLaboratory alcohol challengeNon-displaceable binding potentialMetabotropic glutamate receptor 5Acute alcohol challengeGlutamate releaseAlcohol-induced changesGlutamate receptor 5Alcohol consumptionAcute alcohol consumptionMGluR5 availabilityPET scansSocial drinkersEthanol doseAlcohol effectsBrain regionsAcute alcoholBinding potentialCortical regionsClinically relevant dosesDrinking occasionsAlcohol levels
2023
Blunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment
Blaine S, Fogelman N, Lacadie C, Constable T, Sinha R. Blunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment. Alcohol Clinical And Experimental Research 2023, 47: 1067-1078. PMID: 37070596, PMCID: PMC10289130, DOI: 10.1111/acer.15082.Peer-Reviewed Original ResearchAlcohol taste testFunctional magnetic resonance imagingAlcohol motivationSupplementary motor areaOrbitofrontal cortexInferior frontal gyrus regionsPerfusion functional magnetic resonance imagingEnhanced neural responseNeural reward responsesMedial orbitofrontal cortexPlacebo sessionAlcohol use disorderBrain reward regionsPlacebo-controlled effectsNeural processesOFC responsesReward responsesNeural responsesPlacebo beerSocial drinkersCerebral blood flowReward regionsBD relativeVentral striatumAlcohol effects
2022
Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy Drinkers
Ralevski E, Horvath T, Shanabrough M, Newcomb J, Pisani E, Petrakis I. Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy Drinkers. Alcohol And Alcoholism 2022, 58: 100-106. PMID: 36382470, PMCID: PMC9830489, DOI: 10.1093/alcalc/agac058.Peer-Reviewed Original ResearchEffects of acute alcohol administration on working memory: a systematic review and meta-analysis
Spinola S, De Vita M, Gilmour C, Maisto S. Effects of acute alcohol administration on working memory: a systematic review and meta-analysis. Psychopharmacology 2022, 239: 695-708. PMID: 35075512, DOI: 10.1007/s00213-022-06060-5.Peer-Reviewed Original ResearchConceptsAcute alcohol administrationAlcohol administrationAlcohol dosesSystematic reviewMemory outcomeResultsThirty-two studiesAcute alcohol effectsAlcohol doseStudy qualityHealthy adultsMemory impairmentExecutive function deficitsFunction deficitsAlcohol effectsHealthy participantsAdministrationSystematic searchMixed-effects modelsComparative controlFunctioning componentHazardous behaviorDoseDosesControl conditionOutcomes
2019
Predictors of quickly progressing from initiating alcohol use to engaging in binge drinking among adolescents
Morean ME, Peterson J, L'Insalata A. Predictors of quickly progressing from initiating alcohol use to engaging in binge drinking among adolescents. Addictive Behaviors Reports 2019, 9: 100165. PMID: 31193836, PMCID: PMC6542839, DOI: 10.1016/j.abrep.2019.100165.Peer-Reviewed Original ResearchAlcohol-related risksAlcohol effectsAlcohol useAlcohol-related problemsBinge drinking statusAge of onsetFirst drinking experienceRisk factorsParental historyMore alcohol-related problemsDrinking statusBinge drinkingCurrent drinkingOlder ageHeavy drinkingUnderage alcohol useShort delayFirst intoxicationAlcohol problemsUnderage drinkersAgeLater ageNegative alcohol effectsSubjective responsesBingers
2018
Craving, cortisol and behavioral alcohol motivation responses to stress and alcohol cue contexts and discrete cues in binge and non‐binge drinkers
Blaine SK, Nautiyal N, Hart R, Guarnaccia JB, Sinha R. Craving, cortisol and behavioral alcohol motivation responses to stress and alcohol cue contexts and discrete cues in binge and non‐binge drinkers. Addiction Biology 2018, 24: 1096-1108. PMID: 30091823, PMCID: PMC6785022, DOI: 10.1111/adb.12665.Peer-Reviewed Original ResearchConceptsAlcohol taste testAlcohol cuesAlcohol motivationBehavioral motivationEffects of cravingCortisol responseSelf-reported alcohol useModerate social drinkersNon-binge drinkersGreater cortisol responseAlcohol use disorderCue conditionDiscrete cuesAlcohol contextContext cuesMotivation responsesSocial drinkersLower cortisol responseHigher cravingBinge/Group statusCuesAlcohol effectsCravingAlcohol use
2017
Alcohol Stimulation and Sedation: a Critical Review of the Biphasic Alcohol Effects Scale
Boyd S, Corbin W, Morean M, Martin C. Alcohol Stimulation and Sedation: a Critical Review of the Biphasic Alcohol Effects Scale. Current Addiction Reports 2017, 4: 209-220. DOI: 10.1007/s40429-017-0150-2.Peer-Reviewed Original ResearchBiphasic Alcohol Effects ScaleAlcohol effectsB-BAESPharmacotherapy effectsAlcohol problemsAlcohol stimulationDevelopmental influencesPsychometric propertiesFH effectPhysiological correlatesEffective scalePharmacological interventionsMeasure developmentComprehensive measureModel of SRRefined theoryAlcoholSedationScaleStimulationGhrelin is Supressed by Intravenous Alcohol and is Related to Stimulant and Sedative Effects of Alcohol
Ralevski E, Horvath TL, Shanabrough M, Hayden R, Newcomb J, Petrakis I. Ghrelin is Supressed by Intravenous Alcohol and is Related to Stimulant and Sedative Effects of Alcohol. Alcohol And Alcoholism 2017, 52: 431-438. PMID: 28481974, DOI: 10.1093/alcalc/agx022.Peer-Reviewed Original ResearchConceptsGhrelin levelsDoses of alcoholHealthy social drinkersSubjective effectsTG levelsAlcohol infusionSedative effectsLow doseHigh doseOral alcohol administrationIntravenous alcohol infusionFeeding-related peptidesSocial drinkersAlcohol administrationIntravenous alcoholOral alcoholGhrelinPercent changeInfusionRewarding propertiesBehavioral effectsAlcohol effectsDoseTime pointsSignificant predictors
2014
Acute effects of low and high dose alcohol on smoking lapse behavior in a laboratory analogue task
Kahler CW, Metrik J, Spillane NS, Day A, Leventhal AM, McKee SA, Tidey JW, McGeary JE, Knopik VS, Rohsenow DJ. Acute effects of low and high dose alcohol on smoking lapse behavior in a laboratory analogue task. Psychopharmacology 2014, 231: 4649-4657. PMID: 24858377, PMCID: PMC4232980, DOI: 10.1007/s00213-014-3613-3.Peer-Reviewed Original ResearchConceptsHigh-dose alcoholAlcohol consumptionAcute smoking abstinenceLaboratory analogue taskHeavy alcohol drinkersLow-dose alcoholDose-response effectDose-dependent fashionDose-dependent effectEffect of doseAlcohol drinkersSmoking abstinenceAcute effectsPlacebo beverageSmoking behaviorSmoking urgesSmokingEffect of LowSeparate daysGreater riskLapse behaviorAlcohol effectsPlaceboAbstinenceAlcohol lead
2013
The Subjective Effects of Alcohol Scale: Development and Psychometric Evaluation of a Novel Assessment Tool for Measuring Subjective Response to Alcohol
Morean M, Corbin W, Treat T. The Subjective Effects of Alcohol Scale: Development and Psychometric Evaluation of a Novel Assessment Tool for Measuring Subjective Response to Alcohol. Psychological Assessment 2013, 25: 780-795. PMID: 23647036, PMCID: PMC3822039, DOI: 10.1037/a0032542.Peer-Reviewed Original ResearchConceptsSubjective Effects of Alcohol ScaleEffects of Alcohol ScaleAlcohol administration studyBlood alcohol curveAlcohol ScaleSubjective effectsSubjective responsesAcute alcohol effectsAlcohol-related outcomesAlcohol-related problemsConfirmatory factor analysisEffects of drinkingAdministration studiesAlcohol expectanciesMeasuring subjective responsesBeverage conditionAlcohol curveIntegration of findingsAlcohol effectsDrinking episodesHigh arousalLow arousalPsychometric evaluationHeavy drinkingAlcohol useEarly Subjective Response and Acquired Tolerance as Predictors of Alcohol Use and Related Problems in a Clinical Sample
Corbin WR, Scott C, Leeman RF, Fucito LM, Toll BA, O'Malley SS. Early Subjective Response and Acquired Tolerance as Predictors of Alcohol Use and Related Problems in a Clinical Sample. Alcohol Clinical And Experimental Research 2013, 37: 490-497. PMID: 23347236, PMCID: PMC3586307, DOI: 10.1111/j.1530-0277.2012.01956.x.Peer-Reviewed Original ResearchConceptsEarly subjective responseLow subjective responseAlcohol use disorderAlcohol-related problemsRisk factorsSubjective responsesAlcohol useYoung adultsBrief motivational counselingClinical samplesInitial subjective responseDrinking behaviorHeavy drinking young adultsSignificant alcohol problemsClinical trialsProtective effectModerate drinkersUse disordersMotivational counselingPrior studiesCurrent studyHeavy drinkersHazardous drinkingAlcohol effectsWeekly drinking
2012
The Anticipated Effects of Alcohol Scale: Development and Psychometric Evaluation of a Novel Assessment Tool for Measuring Alcohol Expectancies
Morean M, Corbin W, Treat T. The Anticipated Effects of Alcohol Scale: Development and Psychometric Evaluation of a Novel Assessment Tool for Measuring Alcohol Expectancies. Psychological Assessment 2012, 24: 1008-1023. PMID: 22708572, PMCID: PMC3915927, DOI: 10.1037/a0028982.Peer-Reviewed Original ResearchConceptsBlood alcohol curveEffects of Alcohol ScaleAlcohol ScalePsychometric evaluationAlcohol effectsAlcohol-related problemsAlcohol-related outcomesTest-criterion relationshipsBinge drinking statusOutcomes of drinkingConfirmatory factor analysisNumber of drinksSample of effectsInternal consistency coefficientAnticipated effectsTest-retestAlcohol expectanciesHeavy drinkingDrinking statusAlcohol curveMeasure developmentDrinking individualsPilot dataSurvey studyEpisode lengthAlcohol Expectancies, Alcohol Use, and Hostility as Longitudinal Predictors of Alcohol-Related Aggression
Kachadourian LK, Homish GG, Quigley BM, Leonard KE. Alcohol Expectancies, Alcohol Use, and Hostility as Longitudinal Predictors of Alcohol-Related Aggression. Psychology Of Addictive Behaviors 2012, 26: 414-422. PMID: 22004128, PMCID: PMC4030542, DOI: 10.1037/a0025842.Peer-Reviewed Original ResearchConceptsAlcohol-related aggressionAlcohol-aggression expectanciesAggression expectanciesPhysical aggressionDispositional hostilityAlcohol expectanciesAlcohol effectsPrevious longitudinal researchLongitudinal predictorsYears of marriageAlcohol consumptionLongitudinal researchOwn behaviorAggressionAlcohol useMarried couplesHostilityPrevious researchInteractive effectsExpectancyHeavy alcohol consumptionHusbandsBehaviorFindingsResearchDrinking to Distraction: Does Alcohol Increase Attentional Bias in Adults With ADHD?
Roberts W, Fillmore MT, Milich R. Drinking to Distraction: Does Alcohol Increase Attentional Bias in Adults With ADHD? Experimental And Clinical Psychopharmacology 2012, 20: 107-117. PMID: 22121850, PMCID: PMC3338153, DOI: 10.1037/a0026379.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderAttentional biasSocial drinkersADHD groupHistory of ADHDVisual probe taskAlcohol-related stimuliAd libitum alcohol consumptionAcute alcohol effectsAcute alcohol doseDoses of alcoholAlcohol-related problemsNonclinical controlsHyperactivity disorderAlcohol effectsAlcohol dosesAlcohol dosePrevious researchSuch individualsDrinkersAdultsBiasAlcohol consumptionModerate doseAd libitum consumptionHuman Laboratory Paradigms in Alcohol Research
Plebani J, Ray L, Morean M, Corbin W, MacKillop J, Amlung M, King A. Human Laboratory Paradigms in Alcohol Research. Alcohol Clinical And Experimental Research 2012, 36: 972-983. PMID: 22309888, PMCID: PMC4167612, DOI: 10.1111/j.1530-0277.2011.01704.x.Peer-Reviewed Original ResearchConceptsHuman laboratory studiesAlcohol cravingAlcohol researchHuman laboratory paradigmsMechanisms of riskField of alcoholAlcohol phenotypesNeurobehavioral mechanismsAlcohol pharmacotherapyLaboratory paradigmAlcohol effectsExperimental laboratory approachAlcohol riskNeuropharmacological effectsMedication developmentPhenotype refinementTranslational phenotypesAlcohol usersCravingTreatment responsePhenotypically distinct subtypesFindings to studiesAlcoholAlcoholic etiologyBehavioral economics
2011
Preliminary Findings on the Interactive Effects of IV Ethanol and IV Nicotine on Human Behavior and Cognition: A Laboratory Study
Ralevski E, Perry EB, D’Souza D, Bufis V, Elander J, Limoncelli D, Vendetti M, Dean E, Cooper TB, McKee S, Petrakis I. Preliminary Findings on the Interactive Effects of IV Ethanol and IV Nicotine on Human Behavior and Cognition: A Laboratory Study. Nicotine & Tobacco Research 2011, 14: 596-606. PMID: 22180582, PMCID: PMC6281082, DOI: 10.1093/ntr/ntr258.Peer-Reviewed Original ResearchConceptsRey Auditory Verbal Learning TaskAuditory Verbal Learning TaskVerbal learning taskAcute intravenous alcoholSubjective alcohol effectsBiphasic Alcohol Effects ScaleAlcohol-induced deficitsAlcohol-induced impairmentDoses of alcoholActive nicotineInteractive effectsTest dayCognitive inhibitionVerbal learningCognitive performanceLearning taskSubjective intoxicationAlcohol effectsHuman behaviorNicotine effectsIntravenous alcoholAlcohol infusionManner oneSubjective effectsCognitionVariation in Genes Encoding the Neuroactive Steroid Synthetic Enzymes 5α‐Reductase Type 1 and 3α‐Reductase Type 2 Is Associated With Alcohol Dependence
Milivojevic V, Kranzler HR, Gelernter J, Burian L, Covault J. Variation in Genes Encoding the Neuroactive Steroid Synthetic Enzymes 5α‐Reductase Type 1 and 3α‐Reductase Type 2 Is Associated With Alcohol Dependence. Alcohol Clinical And Experimental Research 2011, 35: 946-952. PMID: 21323680, PMCID: PMC3083475, DOI: 10.1111/j.1530-0277.2010.01425.x.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxysteroid Dehydrogenases3-Oxo-5-alpha-Steroid 4-DehydrogenaseAdultAlcoholismAldo-Keto Reductase Family 1 Member C3Base SequenceCase-Control StudiesFemaleGenetic VariationHumansHydroxyprostaglandin DehydrogenasesMaleMembrane ProteinsMiddle AgedMolecular Sequence DataPolymorphism, Single NucleotideYoung AdultConceptsEndogenous neuroactive steroidsNeuroactive steroidsAlcohol dependenceAlcohol effectsType 2Minor alleleNon-Hispanic CaucasiansRatio of dihydrotestosteroneBladder cancerG alleleC alleleSteroid biosynthetic enzymesType 1Important mediatorKey mediatorSteroidsSingle nucleotide polymorphismsCase-control sampleHuman brainType IMarkersBiological phenotypesNucleotide polymorphismsIndirect evidenceMediatorsInvestigating the Pathobiology of Alcoholic Pancreatitis
Pandol SJ, Lugea A, Mareninova OA, Smoot D, Gorelick FS, Gukovskaya AS, Gukovsky I. Investigating the Pathobiology of Alcoholic Pancreatitis. Alcohol Clinical And Experimental Research 2011, 35: 830-837. PMID: 21284675, PMCID: PMC3083481, DOI: 10.1111/j.1530-0277.2010.01408.x.Peer-Reviewed Original ResearchConceptsAlcoholic pancreatitisAlcohol-induced pancreatitisPotential therapeutic strategyDuration of drinkingKey cellular organellesEffects of alcoholCigarette smokingClinical benefitDietary factorsCommon causeEpidemiologic studiesPancreatitisTherapeutic strategiesAlcohol abuseAnimal modelsHeavy drinkersDisease initiationPathobiologic processesAlcohol effectsCellular organellesMolecular mechanismsEndoplasmic reticulumRecent findingsCurrent studySmoking
2010
Functional Imaging of Cognitive Control During Acute Alcohol Intoxication
Anderson BM, Stevens MC, Meda SA, Jordan K, Calhoun VD, Pearlson GD. Functional Imaging of Cognitive Control During Acute Alcohol Intoxication. Alcohol Clinical And Experimental Research 2010, 35: 156-165. PMID: 20958334, PMCID: PMC3005103, DOI: 10.1111/j.1530-0277.2010.01332.x.Peer-Reviewed Original ResearchConceptsCognitive controlError processingBrain regionsAnterior cingulateFunctional magnetic resonance imaging (fMRI) taskFunctional MRILateral prefrontal cortexParietal brain regionsFalse alarm responsesBrain hemodynamic activityFalse alarm errorsParietal lobe regionsNeural basisBehavioral performancePrefrontal cortexFMRI analysisHemodynamic activityLobe regionsAcute alcohol intoxicationAlarm errorsAlcohol effectsReaction timeAlcohol intoxicationCingulateAlarm responseSubjective Response to Alcohol: A Critical Review of the Literature
Morean M, Corbin W. Subjective Response to Alcohol: A Critical Review of the Literature. Alcohol Clinical And Experimental Research 2010, 34: 385-395. PMID: 20028359, DOI: 10.1111/j.1530-0277.2009.01103.x.Peer-Reviewed Original ResearchConceptsAlcohol use disorderSubjective response to alcoholResponse to alcoholBlood alcohol curveSubjective responsesAlcohol effectsDevelopment of alcohol use disordersAlcohol’s positive effectsAlcohol challenge paradigmHigh-risk individualsAssessment of subjective responseChallenge paradigmNegative reinforcementAlcohol curveImpairing effectsUse disorderCognitive/behavioral impairmentDrinking behaviorAlcohol problemsGenetic influencesLaboratory-based researchPartial supportAlcohol usePlacebo-ControlledSensitive to negative effects
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