2024
FACTFINDERS for PATIENT SAFETY: Preventing procedure-related complications: Epidural lipomatosis and postpartum steroid exposure
D'Souza R, Zheng P, Christolias G, Holder E, Lee H, Miller D, Raghunandan A, Smith C, Patel J, Committee I. FACTFINDERS for PATIENT SAFETY: Preventing procedure-related complications: Epidural lipomatosis and postpartum steroid exposure. Interventional Pain Medicine 2024, 3: 100408. PMID: 39238584, PMCID: PMC11372935, DOI: 10.1016/j.inpm.2024.100408.Peer-Reviewed Original ResearchEpidural steroid injectionsSpinal epidural lipomatosisProcedure-related complicationsSpinal stenosisSteroid injectionHypothalamic-pituitary-adrenalEpidural lipomatosisSteroid exposureDuration of breastfeedingLow-level evidenceResponse to steroid administrationPatient safetySteroid administrationNeurological compromiseInsufficient evidencePostpartumBreast milkLipomatosisStenosisSpinalInfant exposureSteroidsComplicationsInjectionBreastfeeding
2023
Longitudinal Comparative Analysis of Complications and Subsequent Interventions Following Stand-Alone Interspinous Spacers, Open Decompression, or Fusion for Lumbar Stenosis
Whang P, Tran O, Rosner H. Longitudinal Comparative Analysis of Complications and Subsequent Interventions Following Stand-Alone Interspinous Spacers, Open Decompression, or Fusion for Lumbar Stenosis. Advances In Therapy 2023, 40: 3512-3524. PMID: 37289411, PMCID: PMC10329952, DOI: 10.1007/s12325-023-02562-6.Peer-Reviewed Original ResearchConceptsLong-term complicationsLumbar spinal stenosisLumbar spine surgeryFirst surgical interventionLife-threatening eventsSurgical interventionISD patientsSurgery cohortOpen decompressionOpen surgerySpine surgerySubsequent interventionsComplication-related costsOpen surgery cohortSubsequent surgical interventionInterspinous spacer devicesFusion cohortLSS patientsConservative therapyBaseline characteristicsPatient agePostoperative outcomesLumbar stenosisSpinal stenosisMedicare databaseQuantifying the Long-Term Impact of a Motion-Sparing Interspinous Spacer on Sagittal Alignment in Patients with Lumbar Spinal Stenosis
Whang P, Chen L, Jain R. Quantifying the Long-Term Impact of a Motion-Sparing Interspinous Spacer on Sagittal Alignment in Patients with Lumbar Spinal Stenosis. Interventional Pain Medicine 2023, 2: 100236. DOI: 10.1016/j.inpm.2023.100236.Peer-Reviewed Original Research
2022
Association between back and neck pain and workplace absenteeism in the USA: the role played by walking, standing, and sitting difficulties
Jacob L, López-Sánchez G, Oh H, Grabovac I, Stefanac S, Shin J, Tully M, López-Bueno R, Koyanagi A, Barnett Y, Haro J, Smith L. Association between back and neck pain and workplace absenteeism in the USA: the role played by walking, standing, and sitting difficulties. European Spine Journal 2022, 31: 926-934. PMID: 35034162, DOI: 10.1007/s00586-021-07084-9.Peer-Reviewed Original ResearchConceptsWorkplace absenteeismNeck painMethodsNationally representative dataHealth-related reasonsDays of absenceAnnual family incomeNegative binomial regression modelsLiterature identifying factorsBinomial regression modelsBack painMarital statusErgonomic interventionsUS populationSpinal stenosisPrevent absenteeismHealth insuranceFamily incomeRAND American Life PanelRepresentative dataAmerican Life PanelIdentified factorsAbsenteeismRegression modelsPainIntervention
2021
Musculoskeletal Features in Adults With X-linked Hypophosphatemia: An Analysis of Clinical Trial and Survey Data
Javaid MK, Ward L, Pinedo-Villanueva R, Rylands AJ, Williams A, Insogna K, Imel EA. Musculoskeletal Features in Adults With X-linked Hypophosphatemia: An Analysis of Clinical Trial and Survey Data. The Journal Of Clinical Endocrinology & Metabolism 2021, 107: e1249-e1262. PMID: 34636401, PMCID: PMC8852215, DOI: 10.1210/clinem/dgab739.Peer-Reviewed Original ResearchConceptsMusculoskeletal featuresClinical trialsHistory of fractureClinical Trials GroupAge 20 yearsClinical trial subjectsProportion of adultsMusculoskeletal manifestationsPain subgroupsSpinal stenosisGroup of adultsOverall prevalenceTrial groupLow prevalenceAge bandsTrial subjectsOnline survey participantsAdultsAgeSurgeryHigh ratePrevalenceXLHTrialsSurvey participantsExamining the Association Between Self-Reported Estimates of Function and Objective Measures of Gait and Physical Capacity in Lumbar Stenosis
Odonkor CA, Taraben S, Tomkins-Lane C, Zhang W, Muaremi A, Leutheuser H, Sun R, Smuck M. Examining the Association Between Self-Reported Estimates of Function and Objective Measures of Gait and Physical Capacity in Lumbar Stenosis. Archives Of Rehabilitation Research And Clinical Translation 2021, 3: 100147. PMID: 34589697, PMCID: PMC8463455, DOI: 10.1016/j.arrct.2021.100147.Peer-Reviewed Original ResearchSelf-reported physical functionLumbar spinal stenosisPhysical capacity measuresPhysical functionNeurogenic claudicationDisability ratingsNeurogenic Claudication Outcome ScoreSwiss Spinal Stenosis QuestionnaireCross-sectional pilot studyOswestry Disability IndexPhysical function scoresSymptom severity scoresLower disability ratingsSymptom severity ratingsObjective measuresDisability IndexLumbar stenosisOutcome scoresSpinal stenosisFunction scoresSeverity scoreMultispecialty clinicFurther evaluationPilot studyPhysical capacityAn 84-Year-Old Physician With Progressive Dyspnea and Bilateral Upper Lobe Opacities
Harris ZM, Antin-Ozerkis D. An 84-Year-Old Physician With Progressive Dyspnea and Bilateral Upper Lobe Opacities. CHEST Journal 2021, 159: e325-e329. PMID: 33965157, DOI: 10.1016/j.chest.2020.12.035.Peer-Reviewed Original ResearchConceptsProgressive exertional dyspneaNumbness/tinglingLong-term medicationProximal muscle weaknessParoxysmal atrial fibrillationLifelong nonsmokersNaproxen 250Progressive dyspneaDry coughExertional dyspneaNight sweatsPulmonary clinicLumbar radiculopathySinus congestionSpinal stenosisAtrial fibrillationMuscle weaknessHashimoto's thyroiditisRecent travelMedical historyOlder physiciansWeight lossDyspneaThyroiditisPhysiciansReal world adverse events of interspinous spacers using Manufacturer and User Facility Device Experience data
Aggarwal N, Chow R. Real world adverse events of interspinous spacers using Manufacturer and User Facility Device Experience data. Anesthesia And Pain Medicine 2021, 16: 177-183. PMID: 33866770, PMCID: PMC8107255, DOI: 10.17085/apm.20093.Peer-Reviewed Original ResearchAdverse eventsInterspinous spacerReal-world adverse eventsProgressive neurogenic claudicationLumbar decompression surgeryLumbar spinal stenosisUser Facility Device Experience (MAUDE) databaseInterspinous process spacerInterspinous spacer devicesInterspinous process deviceConservative therapyNeurogenic claudicationDecompression surgerySpinal stenosisPain/Spacer deviceUS FoodDrug AdministrationDisproportionality analysisFurther studiesExperience databaseClaudicationStenosisSurgeryTherapy
2020
Gait features for discriminating between mobility-limiting musculoskeletal disorders: Lumbar spinal stenosis and knee osteoarthritis
Odonkor C, Kuwabara A, Tomkins-Lane C, Zhang W, Muaremi A, Leutheuser H, Sun R, Smuck M. Gait features for discriminating between mobility-limiting musculoskeletal disorders: Lumbar spinal stenosis and knee osteoarthritis. Gait & Posture 2020, 80: 96-100. PMID: 32497982, DOI: 10.1016/j.gaitpost.2020.05.019.Peer-Reviewed Original ResearchConceptsLumbar spinal stenosisKnee osteoarthritisWalking testGait parametersGait characteristicsSpinal stenosisClinical walking testsSpatiotemporal gait characteristicsSpatiotemporal gait parametersGait speedPatient populationMusculoskeletal disordersOsteoarthritisSensor-based assessmentPatientsStride lengthClinical applicationStenosisAssessment protocolAppropriate test protocolsPhase timingCritical needControlTest protocol
2019
The Lifelong Impact of X-Linked Hypophosphatemia: Results From a Burden of Disease Survey
Skrinar A, Dvorak-Ewell M, Evins A, Macica C, Linglart A, Imel E, Theodore-Oklota C, San Martin J. The Lifelong Impact of X-Linked Hypophosphatemia: Results From a Burden of Disease Survey. Journal Of The Endocrine Society 2019, 3: 1321-1334. PMID: 31259293, PMCID: PMC6595532, DOI: 10.1210/js.2018-00365.Peer-Reviewed Original ResearchPatient-reported outcomesActive vitamin DParents/caregiversVitamin DMean ageExcess fibroblast growth factor 23Joint pain/stiffnessFibroblast growth factor 23Pain/stiffnessGrowth factor 23History of fractureSubstantial disease burdenBurden of diseaseHuman monoclonal antibodyTibia/fibulaAssistive device useSymptom onsetFactor 23Spinal stenosisPhysical functionDisease burdenDisease manifestationsPhysical functioningCurrent treatmentAbnormal gait
2018
Considering Spine Surgery
Moulton H, Tosteson TD, Zhao W, Pearson L, Mycek K, Scherer E, Weinstein JN, Pearson A, Abdu W, Schwarz S, Kelly M, McGuire K, Milam A, Lurie JD. Considering Spine Surgery. Spine 2018, 43: 1731-1738. PMID: 29877995, PMCID: PMC6279474, DOI: 10.1097/brs.0000000000002723.Peer-Reviewed Original ResearchConceptsTreatment optionsPatient participantsTreatment outcomesKnowledge scoreIntervertebral disc herniationComprehensive decision aidWeb-based calculatorNonsurgical treatmentDegenerative spondylolisthesisSpinal stenosisSpine centerBack surgeryClinical evidenceDisc herniationProspective evaluationProspective mannerSpine surgeryBACKGROUND DATAIndividualized riskInitial appointmentDecisional conflictTrial dataIndividualized toolSurgeryOutcomes
2017
Interspinous implants to treat spinal stenosis
Gala RJ, Russo GS, Whang PG. Interspinous implants to treat spinal stenosis. Current Reviews In Musculoskeletal Medicine 2017, 10: 182-188. PMID: 28324328, PMCID: PMC5435644, DOI: 10.1007/s12178-017-9413-8.Peer-Reviewed Original ResearchSpinal stenosisInterspinous spacerModerate spinal stenosisOpen decompressive surgeryLumbar spinal stenosisPedicle screw instrumentationFormal decompressionSuperion deviceDecompressive surgerySignificant morbidityPatient selectionInvasive optionInvasive strategyImproved outcomesInterspinous implantStenosisDecompressionInterspinous spaceSpinal anatomyCoflex deviceOutcomesImplantsMorbidityComplicationsPatients
2016
Laminectomy plus Fusion versus Laminectomy Alone for Lumbar Spondylolisthesis
Ghogawala Z, Dziura J, Butler WE, Dai F, Terrin N, Magge SN, Coumans JV, Harrington JF, Amin-Hanjani S, Schwartz JS, Sonntag VK, Barker FG, Benzel EC. Laminectomy plus Fusion versus Laminectomy Alone for Lumbar Spondylolisthesis. New England Journal Of Medicine 2016, 374: 1424-1434. PMID: 27074067, DOI: 10.1056/nejmoa1508788.Peer-Reviewed Original ResearchConceptsPhysical component summary scoreDecompression-alone groupSF-36 physical component summary scoreFusion groupSummary scoresDecompressive laminectomySpinal stenosisGrade IOutcome measuresSpinal fusionOswestry Disability Index scoresSymptomatic lumbar spinal stenosisPhysical health-related qualityDegenerative grade IStable degenerative spondylolisthesisLonger hospital stayMore blood lossOswestry Disability IndexDisability Index scoresSecondary outcome measuresHealth-related qualityMedical Outcomes StudyPosterolateral instrumented fusionPrimary outcome measureLumbar spinal stenosis
2015
Superion® InterSpinous Spacer for treatment of moderate degenerative lumbar spinal stenosis: durable three-year results of a randomized controlled trial
Patel VV, Nunley PD, Whang PG, Haley TR, Bradley WD, Davis RP, Block JE, Geisler FH. Superion® InterSpinous Spacer for treatment of moderate degenerative lumbar spinal stenosis: durable three-year results of a randomized controlled trial. Journal Of Pain Research 2015, 8: 657-662. PMID: 26491369, PMCID: PMC4599047, DOI: 10.2147/jpr.s92633.Peer-Reviewed Original ResearchDegenerative lumbar spinal stenosisLumbar spinal stenosisPrimary composite endpointSpinal stenosisComposite endpointClinical outcomesDrug Administration Investigational Device Exemption trialDisease-specific functional outcomesInvestigational device exemption trialDurable clinical improvementLeg pain severityRandomized study groupsZurich Claudication QuestionnaireProcedure-related complicationsIntermittent neurogenic claudicationTreatment of patientsProportion of subjectsThree-year resultsTreatment of subjectsIndividual patient successNeurogenic claudicationPrimary endpointClinical improvementCorresponding success ratesPain severityImaging of lumbar spinal surgery complications
Malhotra A, Kalra VB, Wu X, Grant R, Bronen RA, Abbed KM. Imaging of lumbar spinal surgery complications. Insights Into Imaging 2015, 6: 579-590. PMID: 26432098, PMCID: PMC4656239, DOI: 10.1007/s13244-015-0435-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEvaluation of patientsLumbar spine surgeryPostoperative complicationsPostoperative courseIncidental durotomySpine surgeryEarly detectionRecurrent disc herniationType of surgeryCross-sectional imaging techniquesEarly complicationsSpinal stenosisSurgery complicationsBrain findingsDisc herniationPostoperative collectionsIntracranial hypotensionThecal sacCT myelographySurgical invasivenessCSF leakLumbar spineMR findingsComplicationsEarly infectionSuperion Interspinous Process Spacer for Intermittent Neurogenic Claudication Secondary to Moderate Lumbar Spinal Stenosis
Patel VV, Whang PG, Haley TR, Bradley WD, Nunley PD, Davis RP, Miller LE, Block JE, Geisler FH. Superion Interspinous Process Spacer for Intermittent Neurogenic Claudication Secondary to Moderate Lumbar Spinal Stenosis. Spine 2015, 40: 275-282. PMID: 25494323, DOI: 10.1097/brs.0000000000000735.Peer-Reviewed Original ResearchConceptsLumbar spinal stenosisIntermittent neurogenic claudicationInterspinous process spacerNeurogenic claudicationClinical successSpinal stenosisModerate lumbar spinal stenosisPrimary composite endpointRate of complicationsMajority of patientsInvasive treatment alternativeConservative careLeg painSurgical decompressionControl patientsMost patientsComposite endpointNonsurgical managementHigh quality comparative dataPatient complaintsNoninferiority trialBACKGROUND DATAClaudicationInterspinous spacerPatients
2014
Two-year clinical outcomes of a multicenter randomized controlled trial comparing two interspinous spacers for treatment of moderate lumbar spinal stenosis
Patel VV, Whang PG, Haley TR, Bradley WD, Nunley PD, Miller LE, Block JE, Geisler FH. Two-year clinical outcomes of a multicenter randomized controlled trial comparing two interspinous spacers for treatment of moderate lumbar spinal stenosis. BMC Musculoskeletal Disorders 2014, 15: 221. PMID: 24996648, PMCID: PMC4109165, DOI: 10.1186/1471-2474-15-221.Peer-Reviewed Original ResearchMeSH KeywordsAgedBack PainDisability EvaluationEquipment DesignFemaleHumansLumbar VertebraeMaleOrthopedic ProceduresPain MeasurementPain, PostoperativePatient SatisfactionPredictive Value of TestsProspective StudiesRadiographyRecovery of FunctionSpinal StenosisSurveys and QuestionnairesTime FactorsTreatment OutcomeUnited StatesConceptsModerate lumbar spinal stenosisLumbar spinal stenosisConservative careInterspinous spacerClinical outcomesSpinal stenosisBack functionTwo-year clinical outcomesOswestry Disability IndexPhysical function scoresPatient-reported outcomesInvasive surgical alternativePatient satisfaction scoresExtremity painAxial painDisability IndexComplication dataFunction scoresSurgical alternativePatientsSatisfaction scoresSymptom severityPainIndex levelMulticenterPatient Characteristics Associated With Increased Postoperative Length of Stay and Readmission After Elective Laminectomy for Lumbar Spinal Stenosis
Basques BA, Varthi AG, Golinvaux NS, Bohl DD, Grauer JN. Patient Characteristics Associated With Increased Postoperative Length of Stay and Readmission After Elective Laminectomy for Lumbar Spinal Stenosis. Spine 2014, 39: 833-840. PMID: 24525996, PMCID: PMC4006290, DOI: 10.1097/brs.0000000000000276.Peer-Reviewed Original ResearchConceptsLumbar spinal stenosisAnesthesiologists class 3Independent risk factorBody mass indexSpinal stenosisRisk factorsElective laminectomyPostoperative lengthPatient characteristicsReadmission analysisMass indexAmerican CollegeNational Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical site-related infectionsQuality Improvement Program databaseSurgical Quality Improvement ProgramAverage postoperative LOSImprovement Program databaseAmerican SocietyQuality Improvement ProgramClass 3Preoperative hematocrit
2013
Spinal cord compression in pseudohypoparathyroidism
Roberts T, Khasnavis S, Papaliodis D, Citone I, Carl A. Spinal cord compression in pseudohypoparathyroidism. The Spine Journal 2013, 13: e15-e19. PMID: 24060230, DOI: 10.1016/j.spinee.2013.06.107.Peer-Reviewed Original ResearchConceptsSpinal cord compressionSpinal stenosisCord compressionCase reportSurgical decompressionNeurologic dysfunctionNeurologic functionBed-bound stateCongenital spinal stenosisFunctional upper extremityUnderlying metabolic syndromeLower extremity weaknessBilateral lower extremitiesReports of patientsLower extremity functionRelevant case reportsPatient's neurologic functionPHP type IaIatrogenic paraplegiaSymptomatic stenosisExtremity weaknessYounger patientsInstrumented fusionMetabolic syndromePediatric patientsMidterm Outcomes of a Prospective Multicenter Randomized Controlled Trial Comparing the Clinical Efficacy of Interspinous Spacers as a Treatment for Moderate Lumbar Spinal Stenosis
Whang P, Patel V, Bradley W, Block J. Midterm Outcomes of a Prospective Multicenter Randomized Controlled Trial Comparing the Clinical Efficacy of Interspinous Spacers as a Treatment for Moderate Lumbar Spinal Stenosis. The Spine Journal 2013, 13: s136-s137. DOI: 10.1016/j.spinee.2013.07.352.Peer-Reviewed Original Research
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