2025
Translational genomics of osteoarthritis in 1,962,069 individuals
Hatzikotoulas K, Southam L, Stefansdottir L, Boer C, McDonald M, Pett J, Park Y, Tuerlings M, Mulders R, Barysenka A, Arruda A, Tragante V, Rocco A, Bittner N, Chen S, Horn S, Srinivasasainagendra V, To K, Katsoula G, Kreitmaier P, Tenghe A, Gilly A, Arbeeva L, Chen L, de Pins A, Dochtermann D, Henkel C, Höijer J, Ito S, Lind P, Lukusa-Sawalena B, Minn A, Mola-Caminal M, Narita A, Nguyen C, Reimann E, Silberstein M, Skogholt A, Tiwari H, Yau M, Yue M, Zhao W, Zhou J, Alexiadis G, Banasik K, Brunak S, Campbell A, Cheung J, Dowsett J, Faquih T, Faul J, Fei L, Fenstad A, Funayama T, Gabrielsen M, Gocho C, Gromov K, Hansen T, Hudjashov G, Ingvarsson T, Johnson J, Jonsson H, Kakehi S, Karjalainen J, Kasbohm E, Lemmelä S, Lin K, Liu X, Loef M, Mangino M, McCartney D, Millwood I, Richman J, Roberts M, Ryan K, Samartzis D, Shivakumar M, Skou S, Sugimoto S, Suzuki K, Takuwa H, Teder-Laving M, Thomas L, Tomizuka K, Turman C, Weiss S, Wu T, Zengini E, Zhang Y, Ferreira M, Babis G, Baras A, Barker T, Carey D, Cheah K, Chen Z, Cheung J, Daly M, de Mutsert R, Eaton C, Erikstrup C, Furnes O, Golightly Y, Gudbjartsson D, Hailer N, Hayward C, Hochberg M, Homuth G, Huckins L, Hveem K, Ikegawa S, Ishijima M, Isomura M, Jones M, Kang J, Kardia S, Kloppenburg M, Kraft P, Kumahashi N, Kuwata S, Lee M, Lee P, Lerner R, Li L, Lietman S, Lotta L, Lupton M, Mägi R, Martin N, McAlindon T, Medland S, Michaëlsson K, Mitchell B, Mook-Kanamori D, Morris A, Nabika T, Nagami F, Nelson A, Ostrowski S, Palotie A, Pedersen O, Rosendaal F, Sakurai-Yageta M, Schmidt C, Sham P, Singh J, Smelser D, Smith J, Song Y, Sørensen E, Tamiya G, Tamura Y, Terao C, Thorleifsson G, Troelsen A, Tsezou A, Uchio Y, Uitterlinden A, Ullum H, Valdes A, van Heel D, Walters R, Weir D, Wilkinson J, Winsvold B, Yamamoto M, Zwart J, Stefansson K, Meulenbelt I, Teichmann S, van Meurs J, Styrkarsdottir U, Zeggini E. Translational genomics of osteoarthritis in 1,962,069 individuals. Nature 2025, 641: 1217-1224. PMID: 40205036, PMCID: PMC12119359, DOI: 10.1038/s41586-025-08771-z.Peer-Reviewed Original ResearchConceptsEffector genesGenome-wide association study meta-analysesTargets of approved drugsVariant associationsTranslational genomicsEpigenomic profilingStudy meta-analysesCircadian clockBiological processesLines of evidenceConditions associated with disabilityRepurposing opportunitiesSignal enrichmentGenesEffectorPathwayIndependent associationsMeta-analysesEffect sizeAccelerated translationEpigenomeTranscriptomeProteomicsDisease-modifying treatmentsOsteoarthritis
2024
Sodium channels in non-excitable cells: powerful actions and therapeutic targets beyond Hodgkin and Huxley
Vasylyev D, Liu C, Waxman S. Sodium channels in non-excitable cells: powerful actions and therapeutic targets beyond Hodgkin and Huxley. Trends In Cell Biology 2024, 35: 381-398. PMID: 39743470, DOI: 10.1016/j.tcb.2024.11.009.Peer-Reviewed Original ResearchVoltage-gated sodium channelsSodium channelsInvolvement of voltage-gated sodium channelsFunction of voltage-gated sodium channelsCellular functionsTherapeutic targetNon-excitable cellsRegulate diverse cellular functionsDiverse cellular functionsPropagation of action potentialsCardiac myocytesDynamic expression patternCytokine releaseInflammatory disordersAction potentialsMuscle cellsTherapeutic interventionsCell typesPathological conditionsPhysiological processesCellsCurrent knowledgeOsteoarthritisHodgkinRadiation Therapy for the Treatment of Osteoarthritis
Yu J, Grew D, Spraker M, Beckta J, Shah C, Brower J. Radiation Therapy for the Treatment of Osteoarthritis. Practical Radiation Oncology 2024, 15: 19-24. PMID: 39503700, DOI: 10.1016/j.prro.2024.09.003.Peer-Reviewed Original ResearchConceptsRadiation therapyAssessment of treatment responseTreatment of osteoarthritisMedically refractory diseaseNonsteroidal anti-inflammatory drugsNoninvasive treatment optionCause of painCyclooxygenase-2 inhibitorsIntra-articular corticosteroid therapyAnti-inflammatory drugsCorticosteroid therapyRefractory diseaseTreatment responseTreatment optionsClinical evidenceOlder patientsTherapyCyclooxygenase-2PatientsTraditional treatmentPhysical therapyPainTreatmentOsteoarthritisTechnical considerationsUltracongruent Versus Posterior-Stabilized Polyethylene: No Difference in Anterior Knee Pain but Decreased Noise Generation
Lizcano J, Molloy I, Kohli M, Yakkanti R, Tarabichi S, Austin M. Ultracongruent Versus Posterior-Stabilized Polyethylene: No Difference in Anterior Knee Pain but Decreased Noise Generation. Journal Of The American Academy Of Orthopaedic Surgeons 2024, 33: 135-144. PMID: 39018667, DOI: 10.5435/jaaos-d-24-00379.Peer-Reviewed Original ResearchAnterior knee painPatient-reported outcome measure scoresOutcome measure scoresKnee painPosterior stabilizationKnee injuriesMeasure scoresGenerator questionnairePatient satisfactionCohort of patientsIndependent risk factorPercentage of patientsNo differencePrimary outcomeSatisfaction ratePolyethylene designsPainNo notable differenceKneeScoresPS cohortTKAOsteoarthritisPS insertionPatientsNav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis
Fu W, Vasylyev D, Bi Y, Zhang M, Sun G, Khleborodova A, Huang G, Zhao L, Zhou R, Li Y, Liu S, Cai X, He W, Cui M, Zhao X, Hettinghouse A, Good J, Kim E, Strauss E, Leucht P, Schwarzkopf R, Guo E, Samuels J, Hu W, Attur M, Waxman S, Liu C. Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis. Nature 2024, 625: 557-565. PMID: 38172636, PMCID: PMC10794151, DOI: 10.1038/s41586-023-06888-7.Peer-Reviewed Original ResearchVoltage-gated sodium channelsOA progressionDorsal root ganglion neuronsStructural joint damagePain relief treatmentHuman OA chondrocytesCommon joint diseaseMultiple mouse modelsNav1.7 blockersPain behaviorGanglion neuronsPharmacological blockadeJoint damageJoint degenerationChannel blockersJoint diseaseOA chondrocytesMouse modelTherapeutic targetOsteoarthritisIntracellular Ca2Nav1.7Nav1.7 channelsGenetic ablationLimited evidence
2023
Targeting regulated chondrocyte death in osteoarthritis therapy
Zhu R, Wang Y, Ouyang Z, Hao W, Zhou F, Lin Y, Cheng Y, Zhou R, Hu W. Targeting regulated chondrocyte death in osteoarthritis therapy. Biochemical Pharmacology 2023, 215: 115707. PMID: 37506921, DOI: 10.1016/j.bcp.2023.115707.Peer-Reviewed Original ResearchConceptsChondrocyte deathCartilage degenerationArticular cartilage degenerationBone erosionExtracellular matrix degradationOA preventionOA pathogenesisChondrocyte senescenceCartilage lossOsteoarthritis therapyOA treatmentOsteoarthritisCell death modeDeathMatrix degradationEssential hallmarkTreatment methodsDegenerationForm of deathDeath modeTreatmentPathogenesisTherapyProgressionPreventionBiomechanical Impact of Phosphate Wasting on Articular Cartilage Using the Murine Hyp Model of X‐linked hypophosphatemia
Macica C, Tommasini S. Biomechanical Impact of Phosphate Wasting on Articular Cartilage Using the Murine Hyp Model of X‐linked hypophosphatemia. JBMR Plus 2023, 7: e10796. PMID: 37808393, PMCID: PMC10556269, DOI: 10.1002/jbm4.10796.Peer-Reviewed Original ResearchWT miceHyp miceMechanical propertiesArticular cartilageTrabecular bone volumeProgression of osteoarthritisEtiology of osteoarthritisRange of motionSubchondral bone plateOral phosphateDegenerative osteoarthritisTibial articular cartilageDaily livingAC stiffnessBone volumeTherapeutic restorationOsteoarthritisStructural stiffnessCompressive loadingMicePeak loadTherapyCellular changesMineral deficitStress relaxationCartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: From Pathogenesis to Therapeutics
Ouyang Z, Dong L, Yao F, Wang K, Chen Y, Li S, Zhou R, Zhao Y, Hu W. Cartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: From Pathogenesis to Therapeutics. International Journal Of Molecular Sciences 2023, 24: 9841. PMID: 37372989, PMCID: PMC10298547, DOI: 10.3390/ijms24129841.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisArticular cartilageCourse of osteoarthritisNew biochemical markersDisease progressionPathogenic factorsCartilage damageDegradation of collagenBiochemical markersProgressive destructionClinical diagnosisMechanical injuryConnective tissueDisease statesRole of collagenCollagen productionLow immunogenicityFacilitate drug developmentArthritisDrug developmentOsteoarthritisBiomechanical propertiesMechanical functionCartilageCollagen
2022
The Use of Race in Risk Assessment Tools Contributes to Systemic Racism
Dlott C, O’Connor M, Wiznia D. The Use of Race in Risk Assessment Tools Contributes to Systemic Racism. Journal Of Racial And Ethnic Health Disparities 2022, 10: 1-3. PMID: 36414930, DOI: 10.1007/s40615-022-01451-y.Peer-Reviewed Original ResearchConceptsTotal joint arthroplastyRisk of complicationsRisk of surgeryTotal joint replacementRisk assessment toolPerioperative riskRisk calculatorPatient raceJoint arthroplastyDecision-making discussionsJoint replacementInclusion of raceComplicationsPatientsSurgeryRiskAssessment toolReadmissionArthroplastyOsteoarthritisHipRaceSurgeonsComparison of the Independent and Combined Effects of Aerobic Training and Ozone Therapy on Selected Heart Variables in Rats with Osteoarthritis
Zandi A, Matinhomaee H, Moradi L. Comparison of the Independent and Combined Effects of Aerobic Training and Ozone Therapy on Selected Heart Variables in Rats with Osteoarthritis. Pharmaceutical Chemistry Journal 2022, 56: 1033-1040. DOI: 10.1007/s11094-022-02748-2.Peer-Reviewed Original ResearchCombined effects of aerobic trainingEffects of aerobic trainingAerobic trainingOsteoarthritis interventionsAerobic exerciseRegular exerciseOzone therapyResearch variablesExerciseMfn-2 geneRisk factorsCardiovascular diseaseHeart tissueInterventionPrevent such diseasesOsteoarthritisCollagen degradationTrainingKi67 protein expressionRat heart tissueMitochondrial fission 1 proteinTissues of ratsHeart tissue of ratsMitofusin 2Ki67 proteinAcid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation
Ding J, Chen Y, Zhao Y, Chen F, Dong L, Zhang H, Hu W, Li S, Zhou R, Hu W. Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation. Biochemical Pharmacology 2022, 202: 115107. PMID: 35643339, DOI: 10.1016/j.bcp.2022.115107.Peer-Reviewed Original ResearchConceptsAcid-sensitive ion channel 1aChondrocyte senescenceIon channel 1aChannel 1aBeclin-1Chronic joint diseaseBeclin-1 protein expressionRat OA modelProtein Beclin 1Senescence-related markersJoint diseaseOA modelAging of chondrocytesJoint cavityPsalmotoxin-1Chondrocyte autophagyOsteoarthritisB1 expressionProtein expressionCationic channelsHairpin RNALamin B1Autophagy pathwayArticular cartilageLamin B1 expressionRheumatic Disorders
Alexander S, Duddy C, Danve A, Sehra S. Rheumatic Disorders. 2022, 557-566. DOI: 10.1007/978-3-030-92042-5_55.ChaptersNoninflammatory causesJoint painMuscle painRheumatoid arthritisInflammatory bowel diseaseInflammatory causesInflammatory arthritidesPsoriatic arthritisReactive arthritisBowel diseaseCommon presentationRheumatic disordersLaboratory presentationCommon causeArthritisPainMultiple specialtiesCausePresentationArthritidesFibromyalgiaSpondylitisOsteoarthritisGoutDiseaseSurgical interventions for ankle osteoarthritis in the athletic population
MARANGON A, GIANAKOS A, PANTALONE A, Pietro R, KENNEDY J. Surgical interventions for ankle osteoarthritis in the athletic population. Minerva Orthopedics 2022, 72 DOI: 10.23736/s2784-8469.21.04104-7.Peer-Reviewed Original Research
2021
Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis
Wang K, Ding X, Jiang N, Zeng C, Wu J, Cai X, Hettinghouse A, Khleborodova A, Lei Z, Chen Z, Lei G, Liu C. Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis. Annals Of The Rheumatic Diseases 2021, 81: 544-555. PMID: 34853001, PMCID: PMC9082564, DOI: 10.1136/annrheumdis-2021-221380.Peer-Reviewed Original ResearchConceptsLow-density lipoprotein receptor-related protein 4Lipoprotein receptor-related protein 4Digoxin useCohort studyChondroprotective actionChondrocyte anabolismHealth Improvement NetworkProtein 4Risk of osteoarthritisPathogenesis of osteoarthritisBinding of digoxinAtrial fibrillationChondroprotective effectsJoint osteoarthritisTherapeutic effectSerial screeningOA modelImprovement NetworkOsteoarthritisDrug AdministrationChondrocyte catabolismDigoxinJoint replacementNovel targetPotential stimulatorTylenol or acetaminophen: a recurrent fixed drug eruption perpetuated through the use of inconsistent drug terminology
Federman D, Gruen JA, Merchant N. Tylenol or acetaminophen: a recurrent fixed drug eruption perpetuated through the use of inconsistent drug terminology. BMJ Case Reports 2021, 14: e241908. PMID: 34344644, PMCID: PMC8336122, DOI: 10.1136/bcr-2021-241908.Peer-Reviewed Case Reports and Technical Notes14-3-3 epsilon is an intracellular component of TNFbib2 receptor complex and its activation protects against osteoarthritis
Fu W, Hettinghouse A, Chen Y, Hu W, Ding X, Chen M, Ding Y, Mundra J, Song W, Liu R, Yi Y, Attur M, Samuels J, Strauss E, Leucht P, Schwarzkopf R, Liu C. 14-3-3 epsilon is an intracellular component of TNFbib2 receptor complex and its activation protects against osteoarthritis. Annals Of The Rheumatic Diseases 2021, 80: 1615-1627. PMID: 34226187, PMCID: PMC8595573, DOI: 10.1136/annrheumdis-2021-220000.Peer-Reviewed Original ResearchConceptsPathogenesis of osteoarthritisTNFR2 complexTherapeutic effectSingle-cell RNA-seqIntracellular componentsReceptor complexExtracellular signal-regulated kinaseNuclear factor kappa BSignal-regulated kinaseCommon joint diseaseFactor kappa BChondrocyte-specific deletionProteomic screenElk-1RNA-seqTranscription factorsCell-based assaysTNF signalingTNFR2 pathwayInducible componentJoint diseaseActivity screenTherapeutic targetKappa BOsteoarthritis
2020
Quality‐Adjusted Life‐Years Lost Due to Physical Inactivity in a US Population With Osteoarthritis
Losina E, Silva GS, Smith KC, Collins JE, Hunter DJ, Shrestha S, Messier SP, Yelin EH, Suter LG, Paltiel AD, Katz JN. Quality‐Adjusted Life‐Years Lost Due to Physical Inactivity in a US Population With Osteoarthritis. Arthritis Care & Research 2020, 72: 1349-1357. PMID: 31350803, PMCID: PMC6982563, DOI: 10.1002/acr.24035.Peer-Reviewed Original ResearchConceptsKnee osteoarthritisCases of cancerPhysical activityPhysical inactivityUS populationCardiovascular diseasePA levelsQuality-adjusted life year (QALY) lossBlack Hispanic womenHealth benefitsInsufficient physical activityQuality-adjusted life yearsLife-year lossHigher PA levelsRace/ethnicityDiabetes mellitusHispanic womenOsteoarthritisQALY lossLife yearsOsteoarthritis InitiativeLoss burdenDisease controlImproved healthActivity levelsGait features for discriminating between mobility-limiting musculoskeletal disorders: Lumbar spinal stenosis and knee osteoarthritis
Odonkor C, Kuwabara A, Tomkins-Lane C, Zhang W, Muaremi A, Leutheuser H, Sun R, Smuck M. Gait features for discriminating between mobility-limiting musculoskeletal disorders: Lumbar spinal stenosis and knee osteoarthritis. Gait & Posture 2020, 80: 96-100. PMID: 32497982, DOI: 10.1016/j.gaitpost.2020.05.019.Peer-Reviewed Original ResearchConceptsLumbar spinal stenosisKnee osteoarthritisWalking testGait parametersGait characteristicsSpinal stenosisClinical walking testsSpatiotemporal gait characteristicsSpatiotemporal gait parametersGait speedPatient populationMusculoskeletal disordersOsteoarthritisSensor-based assessmentPatientsStride lengthClinical applicationStenosisAssessment protocolAppropriate test protocolsPhase timingCritical needControlTest protocol
2019
Budget Impact of Funding an Intensive Diet and Exercise Program for Overweight and Obese Patients With Knee Osteoarthritis
Smith KC, Losina E, Messier SP, Hunter DJ, Chen AT, Katz JN, Paltiel AD. Budget Impact of Funding an Intensive Diet and Exercise Program for Overweight and Obese Patients With Knee Osteoarthritis. ACR Open Rheumatology 2019, 2: 26-36. PMID: 31943972, PMCID: PMC6957917, DOI: 10.1002/acr2.11090.Peer-Reviewed Original ResearchKnee osteoarthritisMedicare plansIntensive dietKnee OA treatmentIncidence of comorbiditiesCommercial insurance plansHealth promotion interventionsMedicare-eligible individualsOsteoarthritis Policy ModelTotal knee replacementCommercial plansObese patientsOpioid useMore patientsExercise programArthritis trialsKnee replacementMedicare Advantage plansOsteoarthritisOA treatmentBudget impactMedical expendituresInsurance plansPatientsDietRole of Alpha-2-Microglobulin in the Treatment of Osteoarthritic Knee Pain: a Brief Review of the Literature
Orhurhu V, Schwartz R, Potts J, Peck J, Urits I, Orhurhu MS, Odonkor C, Viswanath O, Kaye A, Gill J. Role of Alpha-2-Microglobulin in the Treatment of Osteoarthritic Knee Pain: a Brief Review of the Literature. Current Pain And Headache Reports 2019, 23: 82. PMID: 31502073, DOI: 10.1007/s11916-019-0822-9.Peer-Reviewed Original ResearchConceptsAnti-inflammatory propertiesAlpha-2 microglobulinOsteoarthritic knee painKnee painPlatelet-rich plasmaCartilage preservationQuality of lifePRP injectionKnee osteoarthritisBody of evidenceActive protease inhibitorsJoint degenerationAnimal modelsPainProtease inhibitorsActive inhibitorTreatmentInhibitorsCurrent understandingPatientsOsteoarthritisReviewActive componentsDegeneration
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