2025
Sex-specific gonadal status determines prefrontal cortex proteome response to tibolone
McGovern A, Arevalo M, Ciordia S, Garcia-Segura L, Barreto G. Sex-specific gonadal status determines prefrontal cortex proteome response to tibolone. Biomedicine & Pharmacotherapy 2025, 190: 118419. PMID: 40779885, DOI: 10.1016/j.biopha.2025.118419.Peer-Reviewed Original ResearchPrefrontal cortexHormone therapyCellular stress response pathwaysStress response pathwaysFemale miceFunctional enrichment analysisSex-SpecificEmotion regulationClinical trialsCytoskeletal functionBrain functionMitochondrial metabolismSex differencesMenopausal hormone therapyResponse pathwaysGonadal hormonesProteomic analysisSynaptic plasticityEnrichment analysisNeurotransmitter signalingMolecular mechanismsFunctional convergenceGonadectomized animalsHormone therapy efficacyNeurodegenerative diseases
2024
IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy
Tanner G, Barrow R, Ajaib S, Al-Jabri M, Ahmed N, Pollock S, Finetti M, Rippaus N, Bruns A, Syed K, Poulter J, Matthews L, Hughes T, Wilson E, Johnson C, Varn F, Brüning-Richardson A, Hogg C, Droop A, Gusnanto A, Care M, Cutillo L, Westhead D, Short S, Jenkinson M, Brodbelt A, Chakrabarty A, Ismail A, Verhaak R, Stead L. IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy. Genome Biology 2024, 25: 45. PMID: 38326875, PMCID: PMC10848526, DOI: 10.1186/s13059-024-03172-3.Peer-Reviewed Original ResearchConceptsGBM tumorsTumor microenvironmentNeoplastic cellsResponse to standard treatmentTreatment resistance mechanismsDifferentiated neoplastic cellsSurrounding normal brainResponder subtypesGBM stem cellsAssociated with distinct changesRecurrent tumorsIDHwt glioblastomasTargeted therapyIDH1 mutationStandard treatmentBrain neoplasmsTumorCancer-cellBrain tumorsEffective treatmentNeurotransmitter signalingStem cellsMesenchymal transitionPairs of pre-Subtypes
2017
Glucagon-like Peptide-1 (GLP-1) and neurotransmitters signaling in epilepsy: An insight review
Koshal P, Jamwal S, Kumar P. Glucagon-like Peptide-1 (GLP-1) and neurotransmitters signaling in epilepsy: An insight review. Neuropharmacology 2017, 136: 271-279. PMID: 29129776, DOI: 10.1016/j.neuropharm.2017.11.015.Peer-Reviewed Original ResearchConceptsGlucagon-like peptide-1Neurotransmitter systemsAltered neurotransmittersProtective roleNeurological disordersNeurotransmitter signalingProgression of seizuresGABAergic neurotransmitter systemAnti-epileptic drugsManagement of epilepsyGLP-1 analoguesGLP-1 receptorTreatment of epilepsyFuture drug therapiesOnly symptomatic reliefBasic pathogenic mechanismsPrevalent neurological disordersPreproglucagon neuronsSymptomatic reliefGlutamatergic systemPathophysiological mechanismsDrug therapyRisk factorsMetabolic impairmentPeptide-1
2010
Neurotransmitter signaling in postnatal neurogenesis: The first leg
Platel JC, Stamboulian S, Nguyen I, Bordey A. Neurotransmitter signaling in postnatal neurogenesis: The first leg. Brain Research Reviews 2010, 63: 60-71. PMID: 20188124, PMCID: PMC2862802, DOI: 10.1016/j.brainresrev.2010.02.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFate determinationSonic hedgehogNeurotransmitter signalingDifferent cell typesSubventricular zoneMultitude of receptorsMaster regulatorGenetic signaturesMosaic natureGamma-aminobutyric acidMicroenvironmental signalsCell typesIntracellular pathwaysAstrocyte-like cellsFunction of neurotransmittersHedgehogSignalingNeurogenesisNeurogenic zonesAdult brainPostnatal neurogenesisPeripheral organsNeurotransmitter functionSynaptic integrationGenes
1996
EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins
Koelle M, Horvitz H. EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins. Cell 1996, 84: 115-125. PMID: 8548815, DOI: 10.1016/s0092-8674(00)80998-8.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAmino Acid SequenceAnimalsBase SequenceCaenorhabditis elegansCaenorhabditis elegans ProteinsConserved SequenceFungal ProteinsGene DosageGenes, HelminthGTP-Binding ProteinsMammalsMolecular Sequence DataMusclesMutationNervous SystemNervous System Physiological PhenomenaOvumProteinsRatsRGS ProteinsSerotoninSignal TransductionYeastsConceptsEGL-10G proteinsNematode C. elegansG protein signalingMammalian genesGOA-1Mammalian proteinsC. elegansConserved domainProtein signalingNegative regulatorNeurotransmitter signalingProteinSignalingDose-dependent mannerPathwaySst2pElegansYeastGenesNervous systemDose-dependent fashionRegulatorCertain periodic behaviorsActivity
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