2025
O-149 No effect of maternal age on embryo implantation and live birth rates after preimplantation genetic testing for aneuploidies: retrospective analysis of 11,855 single blastocyst transfers
Gayete-Mor B, Miguel-Escalada I, Kalafat E, Zamora M, Pujol A, Lledó B, Stoop D, Lorenzon A, Rodriguez-Aranda A, Sakkas D, Popovic M. O-149 No effect of maternal age on embryo implantation and live birth rates after preimplantation genetic testing for aneuploidies: retrospective analysis of 11,855 single blastocyst transfers. Human Reproduction 2025, 40: deaf097.149. DOI: 10.1093/humrep/deaf097.149.Peer-Reviewed Original ResearchEuploid embryo transferAge-related fertility declineAdvanced maternal ageLive birth ratePreimplantation genetic testingEmbryo qualityMaternal ageLive birthsEuploid embryosFertility declineEmbryo transferClinical outcomesClinical pregnancyEffect of maternal agePGT-AAssociated with poor embryo qualityBirth rateOlder patientsGenetic testingReproductive outcomesEuploid blastocyst transferGood-quality blastocystsReduced oocyte yieldPoor embryo qualityPoor-quality embryos
2024
Does Recurrent Implantation Failure Exist? Prevalence and Outcomes of Five Consecutive Euploid Blastocyst Transfers in 123 987 Patients
Gill P, Ata B, Arnanz A, Cimadomo D, Vaiarelli A, Fatemi H, Ubaldi F, Garcia-Velasco J, Seli E. Does Recurrent Implantation Failure Exist? Prevalence and Outcomes of Five Consecutive Euploid Blastocyst Transfers in 123 987 Patients. Obstetrical & Gynecological Survey 2024, 79: 473-474. DOI: 10.1097/ogx.0000000000001310.Peer-Reviewed Original ResearchReply: Consecutive euploid blastocyst transfers currently represent the best available model for investigating the true prevalence of recurrent implantation failure (RIF), a rare pathology at best
Ata B, Gill P, Cimadomo D, Ubaldi F, Garcia-Velasco J, Seli E. Reply: Consecutive euploid blastocyst transfers currently represent the best available model for investigating the true prevalence of recurrent implantation failure (RIF), a rare pathology at best. Human Reproduction 2024, 39: 1575-1576. PMID: 38741229, DOI: 10.1093/humrep/deae096.Peer-Reviewed Original ResearchDoes recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients
Gill P, Ata B, Arnanz A, Cimadomo D, Vaiarelli A, Fatemi H, Ubaldi F, Garcia-Velasco J, Seli E. Does recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients. Human Reproduction 2024, 39: 974-980. PMID: 38452358, DOI: 10.1093/humrep/deae040.Peer-Reviewed Original ResearchEuploid blastocyst transferLive birth rateCumulative live birth rateBlastocyst transferEmbryo transferEuploid blastocystsImplant failureBirth ratePreimplantation genetic testing cyclesMulti-center retrospective studyDay of embryo transferCongenital uterine anomaliesEuploid embryo transferComprehensive chromosome screeningEndometrial preparation protocolsNon-obstructive azoospermiaModified natural cyclePositive pregnancy testOvarian stimulation protocolsRecurrent implantation failureParental karyotype abnormalitiesChromosome copy numberEuploid transfersTrophectoderm biopsyUterine anomalies
2021
Individual culture leads to decreased blastocyst formation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer
Glatthorn HN, Hanson BM, Kim JG, Herlihy NS, Klimczak AM, Hong KH, Seli E, Scott RT. Individual culture leads to decreased blastocyst formation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer. Journal Of Assisted Reproduction And Genetics 2021, 38: 2157-2164. PMID: 34086147, PMCID: PMC8417170, DOI: 10.1007/s10815-021-02252-8.Peer-Reviewed Original ResearchConceptsEuploid blastocyst transferIntracytoplasmic sperm injectionPregnancy outcomesBlastocyst transferSignificant differencesBlastocyst formationSingle embryo transferMann-Whitney U testPreimplantation genetic testingLogistic regression modelsOvarian stimulationClinical miscarriageEuploid blastocystsSperm injectionEuploid embryosEmbryo transferTrophectoderm biopsyGenetic testingGroup embryo cultureU testSame time frameDecreased rateOutcomesMiscarriageFertilization rate
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