2023
Implications of Toll-like receptors (TLRs) and their signaling mechanisms in human cancers
Chandrasekar S, Palaniyandi T, Parthasarathy U, Surendran H, Viswanathan S, Wahab M, Baskar G, Natarajan S, Ranjan K. Implications of Toll-like receptors (TLRs) and their signaling mechanisms in human cancers. Pathology - Research And Practice 2023, 248: 154673. PMID: 37453359, DOI: 10.1016/j.prp.2023.154673.Peer-Reviewed Original ResearchToll-like receptorsActivation of TLRsHuman cancersEssential pattern recognition receptorsInnate immune functionNew therapeutic targetsPattern recognition receptorsControl of cancerTLRs 2Inflammatory responseInflammatory microenvironmentEffector functionsImmune functionTherapeutic targetHepatic cancerEpithelial markersCancerHuman lungMost cancersTLR genesReceptorsCancer biomarkersMajor mechanismGene expressionSuch deregulation
2022
Cytomorphologic features of SMARCA4‐deficient non–small cell lung carcinoma and correlation with immunohistochemical and molecular features
Sun T, Gilani SM, Podany P, Harigopal M, Zhong M, Wang H. Cytomorphologic features of SMARCA4‐deficient non–small cell lung carcinoma and correlation with immunohistochemical and molecular features. Cancer Cytopathology 2022, 130: 620-629. PMID: 35468657, DOI: 10.1002/cncy.22581.Peer-Reviewed Original ResearchConceptsNon-small cell lung carcinomaCell lung carcinomaCytomorphologic featuresLung carcinomaExtensive antibody panelHigh-grade featuresCommon cytologic featuresDifferent anatomic sitesVariable expressionMajority of casesSquamoid featuresCo-mutated genesUndifferentiated carcinomaImmunohistochemical profileGlandular featuresPapillary architectureAnatomic sitesCytologic featuresAggressive carcinomasClinical informationAntibody panelEpithelial markersScant cytoplasmCarcinomaNuclear enlargement
2019
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas arising from an intraductal papillary mucinous neoplasm
Charifa A, Walther Z, Salem R, Jain D. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas arising from an intraductal papillary mucinous neoplasm. Human Pathology Reports 2019, 15: 95-98. DOI: 10.1016/j.ehpc.2018.12.007.Peer-Reviewed Case Reports and Technical NotesOsteoclast-like giant cellsUndifferentiated carcinomaInvasive carcinomaGiant cellsMucinous neoplasmsEndoscopic ultrasoundIntraductal papillary mucinous neoplasmIntraductal mucinous neoplasmPapillary mucinous neoplasmRare pancreatic tumorPancreatic ductal carcinomaDuctal lesionsDuctal carcinomaPancreatic tumorsPancreatic adenocarcinomaCarcinoma subtypesHistological examinationPancreatic massCarcinomaEpithelial markersAmpullary massEpithelial originIPMNNeoplastic progressionNeoplasms
2018
Characterization of cell fusion in an experimental mouse model of endometriosis†
Tal A, Tal R, Shaikh S, Gidicsin S, Mamillapalli R, Taylor H. Characterization of cell fusion in an experimental mouse model of endometriosis†. Biology Of Reproduction 2018, 100: 390-397. PMID: 30304517, PMCID: PMC7302516, DOI: 10.1093/biolre/ioy221.Peer-Reviewed Original ResearchConceptsMouse modelLimited proliferative activityFunctional endometrial tissueBone marrow transplantation modelExperimental mouse modelEndometrial stem cellsPrincipal cell sourceRepair/regeneration processBone marrow cellsEndometriosis shareCell fusionEndometrial tissueEndometriosis lesionsEndometriotic lesionsUterine cavityTransplantation modelCell fusion eventsCre-lox systemEndometriosisEpithelial markersStromal compartmentLesionsMarrow cellsProliferative activitySca-1
2017
Bioengineered lungs generated from human iPSCs‐derived epithelial cells on native extracellular matrix
Ghaedi M, Le AV, Hatachi G, Beloiartsev A, Rocco K, Sivarapatna A, Mendez JJ, Baevova P, Dyal RN, Leiby KL, White ES, Niklason LE. Bioengineered lungs generated from human iPSCs‐derived epithelial cells on native extracellular matrix. Journal Of Tissue Engineering And Regenerative Medicine 2017, 12: e1623-e1635. PMID: 29024475, PMCID: PMC5991621, DOI: 10.1002/term.2589.Peer-Reviewed Original ResearchConceptsEpithelial progenitor cellsProgenitor cellsStem cellsEpithelial cellsLung progenitor cellsLung epithelial cellsHuman lungHuman-derived cellsReliable cell sourceNative extracellular matrixEarly stepsExtracellular matrixRat lungImportant early stepHuman iPSCLung regenerationLung tissue regenerationHuman lung tissueIPSCsLung scaffoldsCell sourceCellsEpithelial markersLung transplantationTissue regenerationAberrant expression of epithelial leucine-rich repeat containing G protein–coupled receptor 5–positive cells in the eutopic endometrium in endometriosis and implications in deep-infiltrating endometriosis
Vallvé-Juanico J, Suárez-Salvador E, Castellví J, Ballesteros A, Taylor HS, Gil-Moreno A, Santamaria X. Aberrant expression of epithelial leucine-rich repeat containing G protein–coupled receptor 5–positive cells in the eutopic endometrium in endometriosis and implications in deep-infiltrating endometriosis. Fertility And Sterility 2017, 108: 858-867.e2. PMID: 28923287, DOI: 10.1016/j.fertnstert.2017.08.018.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsProtein-coupled receptorsEutopic endometriumEpithelial markersHealthy egg donorsHuman eutopic endometriumType of endometriosisEndometrium of womenMenstrual cycle phaseProspective experimental studyParaffin-embedded tissuesEndometriotic patientsInflammatory markersEndometrial samplesUterine aspiratesHuman endometriumLeucine-rich repeatsFluorescence-activated cell sortingPathologic endometriumMAIN OUTCOMEEndometriosisReproductive outcomesEndometriumFertility clinicsStromal compartment
2012
Multiparameter Analysis, including EMT Markers, on Negatively Enriched Blood Samples from Patients with Squamous Cell Carcinoma of the Head and Neck
Balasubramanian P, Lang J, Jatana K, Miller B, Ozer E, Old M, Schuller D, Agrawal A, Teknos T, Summers T, Lustberg M, Zborowski M, Chalmers J. Multiparameter Analysis, including EMT Markers, on Negatively Enriched Blood Samples from Patients with Squamous Cell Carcinoma of the Head and Neck. PLOS ONE 2012, 7: e42048. PMID: 22844540, PMCID: PMC3406036, DOI: 10.1371/journal.pone.0042048.Peer-Reviewed Original ResearchConceptsEpithelial surface markersN-cadherinEpidermal growth factor receptorGrowth factor receptorSurface markersPositive selection approachEpithelial markersAforementioned proteinsMesenchymal transitionFactor receptorConfocal microscopyCancer metastasisEMT processCancer cellsPhenotypic patternsMesenchymal markersTumor metastasisEnrichment methodologyEMT markersEnrichment technologyCellsEMTExpressionTumor cellsMarkers
2010
Detection of bone marrow–derived lung epithelial cells
Kassmer SH, Krause DS. Detection of bone marrow–derived lung epithelial cells. Experimental Hematology 2010, 38: 564-573. PMID: 20447442, PMCID: PMC2909593, DOI: 10.1016/j.exphem.2010.04.011.Peer-Reviewed Original ResearchConceptsMarrow-derived epithelial cellsBone marrow-derived cellsMarrow-derived cellsLung epithelial cellsEpithelial cellsBone marrow-derived epithelial cellsDonor bone marrow originBone marrow originBone marrow cellsBlood cell markersNormal tissue repairSpecific cell subsetsCell subsetsGastrointestinal tractTherapeutic benefitMarrow originMultiple organsEpithelial markersDefinitive dataCell markersMarrow cellsProtein expression patternsTissue repairEngraftmentLung
2007
Lack of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Signaling Shows a New Type of Melanoma
Shields JM, Thomas NE, Cregger M, Berger AJ, Leslie M, Torrice C, Hao H, Penland S, Arbiser J, Scott G, Zhou T, Bar-Eli M, Bear JE, Der CJ, Kaufmann WK, Rimm DL, Sharpless NE. Lack of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Signaling Shows a New Type of Melanoma. Cancer Research 2007, 67: 1502-1512. PMID: 17308088, DOI: 10.1158/0008-5472.can-06-3311.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseERK activationB-RafERK activityMitogen-Activated Protein Kinase SignalingSignal-regulated kinase kinaseN-rasERK MAPK cascadeProtein Kinase SignalingPrimary human melanocytesRNA expression profilesCell linesEpithelial-mesenchymal transformationDistinct melanoma subtypeMAPK cascadeKinase kinaseExtracellular signalsTranscriptional targetsKinase signalingProtein kinaseExpression profilesEpithelial markersMelanoma cell linesRAS/RAFPrimary human tumors
2001
Expression of thyroid transcription factor-1 and other markers in sclerosing hemangioma of the lung.
Illei P, Rosai J, Klimstra D. Expression of thyroid transcription factor-1 and other markers in sclerosing hemangioma of the lung. Archives Of Pathology & Laboratory Medicine 2001, 125: 1335-9. PMID: 11570910, DOI: 10.5858/2001-125-1335-eottfa.Peer-Reviewed Original ResearchConceptsThyroid transcription factor-1Sclerosing hemangiomaTranscription factor 1Tumor cellsPulmonary epitheliumThyroid transcription factor-1 positivityFactor 1Expression of thyroid transcription factor-1Pale cellsLining cellsSolid areasPulmonary sclerosing hemangiomaCell typesPan-epithelialEpithelial tumorsFocal stainingEMA stainingVascular neoplasmPapillary structuresEpithelial markersAlveolar epitheliumHemangiomaNeoplastic cellsStaining intensityTumor
1998
K-ras Oncogene Mutations in Osteoclast-like Giant Cell Tumors of the Pancreas and Liver
Westra W, Sturm P, Drillenburg P, Choti M, Klimstra D, Albores-Saavedra J, Montag A, Offerhaus G, Hruban R. K-ras Oncogene Mutations in Osteoclast-like Giant Cell Tumors of the Pancreas and Liver. The American Journal Of Surgical Pathology 1998, 22: 1247-1254. PMID: 9777987, DOI: 10.1097/00000478-199810000-00010.Peer-Reviewed Original ResearchConceptsOsteoclast-like giant cell tumorOsteoclast-like giant cellsK-ras mutationsGiant cell tumorK-ras oncogeneK-rasGiant cellsCell tumorsEpithelial proliferationMononuclear cellsEpithelial markersAtypical intraductal epithelial proliferationEpithelial precursorsK-ras oncogene mutationsIntraductal epithelial proliferationMucinous cystic neoplasmsFinding of K-ras mutationsInfiltrating mononuclear cellsPhagocytize tumor cellsEnigmatic tumorsUndifferentiated carcinomaMesenchymal tumorsAbsent stainingEpithelial lesionsCystic neoplasms
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