2024
Outcomes of patients with alcohol‐associated hepatitis and acute kidney injury – Results from the HRS Harmony Consortium
T. A, Allegretti A, Cullaro G, Ouyang T, Asrani S, Chung R, Przybyszewski E, Wilechansky R, Robinson J, Sharma P, Simonetto D, Jalal P, Orman E, Wadei H, St. Hillien S, Saly D, Ufere N, Dageforde L, Regner K, Belcher J, Patidar K, Consortium F. Outcomes of patients with alcohol‐associated hepatitis and acute kidney injury – Results from the HRS Harmony Consortium. Alimentary Pharmacology & Therapeutics 2024, 60: 778-786. PMID: 39010302, PMCID: PMC11349455, DOI: 10.1111/apt.18159.Peer-Reviewed Original ResearchAlcohol-associated hepatitisAcute kidney injuryAcute kidney injury phenotypesHepatorenal syndromeMELD-NaDevelopment of acute kidney injuryCumulative incidence of deathConsecutive adult patientsOutcomes of patientsAlcohol Abuse and Alcoholism (NIAAANon-AH groupRenal replacement therapyPresence of AHAcute tubular necrosisRetrospective cohort studyPredictors of mortalityIncidence of deathAKI stageClinical courseReplacement therapyAdult patientsKidney injuryCumulative incidencePoor prognosisTubular necrosis
2023
Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US
Patidar K, Belcher J, Regner K, St. Hillien S, Simonetto D, Asrani S, Neyra J, Sharma P, Velez J, Wadei H, Nadim M, Chung R, Seethapathy R, Parada X, Ouyang T, Ufere N, Robinson J, Diaz P, Wilechansky R, Przybyszewski E, Smith T, Ali A, Orman E, Schulz P, Siddiqui S, Shabbir R, Liu L, Cama-Olivares A, Flannery A, Baker M, Gunasekaran D, Aswine A, Issa R, Li J, Verma S, Chalmers D, Varghese V, Lam W, Mohamed M, Kovacic R, Gaddy A, Attieh R, Cortes P, Semnani S, Wang L, Khemichian S, Allegretti A, consortium F. Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US. Journal Of Hepatology 2023, 79: 1408-1417. PMID: 37517455, PMCID: PMC10807505, DOI: 10.1016/j.jhep.2023.07.010.Peer-Reviewed Original ResearchConceptsEtiology of AKIHRS-AKISubdistribution hazard ratiosHepatorenal syndromePrerenal AKIKidney injuryHigh morbidityIncidence ratePractice patternsSimilar outcomesHigher AKI stageAcute kidney injuryRetrospective cohort studyAcute tubular necrosisConsecutive adult patientsEtiology of injuryAKI stageAKI definitionLiver transplantAdult patientsCohort studyHazard ratioSevere complicationsTubular necrosisComplete response
2020
Association of Deceased Donor Acute Kidney Injury With Recipient Graft Survival
Liu C, Hall IE, Mansour S, Philbrook H, Jia Y, Parikh CR. Association of Deceased Donor Acute Kidney Injury With Recipient Graft Survival. JAMA Network Open 2020, 3: e1918634. PMID: 31913491, PMCID: PMC6991314, DOI: 10.1001/jamanetworkopen.2019.18634.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryRecipient graft survivalDeath-censored graft failureCause graft failureAKI kidneysDeceased donorsGraft failureGraft survivalOrgan procurement organizationsAKI statusGraft functionKidney injuryPrimary nonfunctionMean agePropensity score-matched cohort studyTerminal serum creatinine levelPropensity score-matched analysisFollowing secondary outcomesDelayed graft functionSerum creatinine levelsProcurement organizationsDeceased donor kidneysDates of analysisAKI stage
2018
Deceased-donor acute kidney injury is not associated with kidney allograft failure
Hall IE, Akalin E, Bromberg JS, Doshi MD, Greene T, Harhay MN, Jia Y, Mansour SG, Mohan S, Muthukumar T, Reese PP, Schröppel B, Singh P, Thiessen-Philbrook HR, Weng FL, Parikh CR. Deceased-donor acute kidney injury is not associated with kidney allograft failure. Kidney International 2018, 95: 199-209. PMID: 30470437, PMCID: PMC6331055, DOI: 10.1016/j.kint.2018.08.047.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryCause graft failureGraft survivalGraft failureGraft functionKidney injuryComposite outcomeDeceased donorsDonor-recipient gender combinationsLong-term allograft survivalKidney Donor Profile IndexDonor AKI stageExpanded-criteria donationKidney allograft failureUtilization of kidneysGlomerular filtration rateCold ischemia timePre-specified variablesKidney machine perfusionAKI stageAllograft failureAllograft survivalCardiac deathIschemia timeBiomarkers of AKI Progression after Pediatric Cardiac Surgery
Greenberg JH, Zappitelli M, Jia Y, Thiessen-Philbrook HR, de Fontnouvelle CA, Wilson FP, Coca S, Devarajan P, Parikh CR. Biomarkers of AKI Progression after Pediatric Cardiac Surgery. Journal Of The American Society Of Nephrology 2018, 29: 1549-1556. PMID: 29472416, PMCID: PMC5967766, DOI: 10.1681/asn.2017090989.Peer-Reviewed Original ResearchConceptsAKI progressionOptimism-corrected areaIL-8First dayStage 3 AKIUrine L-FABPProspective cohort studyBiomarkers of inflammationPediatric cardiac surgeryConfidence intervalsAKI stagePostoperative AKIKidney injuryCohort studySerum creatinineCardiac surgeryCardiopulmonary bypassTherapeutic trialsUrine biomarkersAdverse outcomesHospitalized childrenPlasma biomarkersClinical careAdditional cohortAKI
2012
Association of AKI With mortality and complications in hospitalized patients with cirrhosis
Belcher JM, Garcia‐Tsao G, Sanyal AJ, Bhogal H, Lim JK, Ansari N, Coca SG, Parikh CR, Consortium F. Association of AKI With mortality and complications in hospitalized patients with cirrhosis. Hepatology 2012, 57: 753-762. PMID: 22454364, PMCID: PMC3390443, DOI: 10.1002/hep.25735.Peer-Reviewed Original ResearchConceptsAcute kidney injuryAcute Kidney Injury Network definitionAssociation of AKIDefinition of AKISeverity of AKIProgression of AKIProspective observational cohort studyAKIN stage 1Baseline renal functionObservational cohort studyIncidence of mortalityAKI criteriaAKI severityAKI stageAKIN criteriaAKIN stageHospital mortalityKidney injuryCohort studyDevastating complicationRenal functionHospitalized patientsImproved outcomesEarly diagnosisTimely treatment
2011
Risk of Poor Outcomes with Novel and Traditional Biomarkers at Clinical AKI Diagnosis
Hall IE, Coca SG, Perazella MA, Eko UU, Luciano RL, Peter PR, Han WK, Parikh CR. Risk of Poor Outcomes with Novel and Traditional Biomarkers at Clinical AKI Diagnosis. Clinical Journal Of The American Society Of Nephrology 2011, 6: 2740-2749. PMID: 22034509, PMCID: PMC3255362, DOI: 10.2215/cjn.04960511.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Neutrophil Gelatinase-Associated LipocalinAcute kidney injuryAcute tubular necrosisMicroscopy scorePrimary outcomeIL-18Prognostic utilityClinical assessmentInjury molecule-1Peak serum creatinineProspective cohort studyGelatinase-Associated LipocalinFirst dayUrine protein biomarkersProtein biomarker concentrationsAKI criteriaAKI diagnosisAKI stageBaseline GFRHospital deathKidney injuryCohort studySerum creatinineTubular necrosis
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