2024
Initiation of noninvasive ventilation in patients with amyotrophic lateral sclerosis
Jimenez J, Tang M, Wilson M, Morrison A, Ackrivo J, Choi P. Initiation of noninvasive ventilation in patients with amyotrophic lateral sclerosis. Muscle & Nerve 2024, 70: 1099-1103. PMID: 39243146, DOI: 10.1002/mus.28250.Peer-Reviewed Original ResearchConceptsNoninvasive ventilation initiationMaximal inspiratory pressureChronic respiratory failureNoninvasive ventilationNIV initiationAmyotrophic lateral sclerosisRespiratory failureMm HgSingle-center retrospective cohort studyInitiation of noninvasive ventilationTranscutaneous CO<sub>2</sub> (TRetrospective cohort studyCohort of ALS patientsBulbar onset amyotrophic lateral sclerosisDaytime hypercapniaInspiratory forceImproved survivalLateral sclerosisClinical characteristicsInspiratory pressureConcomitant indicationCohort studyPatientsALS patientsEligibility criteriaImpact of Multiarterial Revascularization on Long-term Major Adverse Cardiovascular Events After Coronary Bypass in 23,798 Patients
Jameie M, Valinejad K, Pashang M, Jameie M, Bagheri J, Soleimani H, Jalali A, Mehrabanian M, Nayebirad S, Abbasi K, Masoudkabir F, Tajdini M, Mehrani M, Movahedi N, Hameed I, Hosseini K, Gaudino M. Impact of Multiarterial Revascularization on Long-term Major Adverse Cardiovascular Events After Coronary Bypass in 23,798 Patients. The Annals Of Thoracic Surgery 2024, 118: 863-872. PMID: 39009058, DOI: 10.1016/j.athoracsur.2024.06.034.Peer-Reviewed Original ResearchInverse probability weightingRisks of study outcomesAssociated with reduced riskRisk factorsCovariate-adjusted modelsPatient subgroupsAll-Cause MortalitySingle-center retrospective cohort studyCardiovascular risk factorsLong-term major adverse cardiovascular eventsAdverse cardiocerebrovascular eventsMajor adverse cardiovascular eventsRetrospective cohort studyRisk of adverse eventsAdverse cardiovascular eventsArtery Bypass GraftingCohort studyPost-surgery outcomesSaphenous vein graftsStudy outcomesStudy populationCrude mortalityCardiocerebrovascular eventsProbability weightingUnivariate levelPrimary Tumor Characteristics as Biomarkers of Immunotherapy Response in Advanced Melanoma: A Retrospective Cohort Study
Goodman R, Jung S, Fletcher K, Burnette H, Mohyuddin I, Irlmeier R, Ye F, Johnson D. Primary Tumor Characteristics as Biomarkers of Immunotherapy Response in Advanced Melanoma: A Retrospective Cohort Study. Cancers 2024, 16: 2355. PMID: 39001417, PMCID: PMC11240575, DOI: 10.3390/cancers16132355.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsRetrospective cohort studyCutaneous melanomaAssociated with responseMelanoma patientsImmunotherapy responseTreated with immune checkpoint inhibitorsCohort studySingle-center retrospective cohort studyAssociated with shorter PFSAnti-PD-1 monotherapyAssociated with inferior outcomesBiomarkers of immunotherapy responsePrimary tumor characteristicsPrimary tumor featuresAdvanced melanoma patientsResponse to immunotherapySingle-center designCheckpoint inhibitorsShorter PFSAdvanced melanomaTumor characteristicsPrimary melanomaMutation statusMetastatic stage
2023
Kidney Function in Patients With Adrenal Adenomas: A Single-Center Retrospective Cohort Study
Rahimi L, Kittithaworn A, Garcia R, Saini J, Dogra P, Atkinson E, Achenbach S, Kattah A, Bancos I. Kidney Function in Patients With Adrenal Adenomas: A Single-Center Retrospective Cohort Study. The Journal Of Clinical Endocrinology & Metabolism 2023, 109: e1750-e1758. PMID: 38157409, PMCID: PMC11318994, DOI: 10.1210/clinem/dgad765.Peer-Reviewed Original ResearchMild autonomous cortisol secretionNonfunctioning adrenal adenomasFactors associated with chronic kidney diseaseChronic kidney diseaseTime of diagnosisAdrenal adenomaKidney functionSingle-center retrospective cohort studyMultivariate analysisSingle-center cohort study of patientsSingle-center cohort studyIncreased risk of chronic kidney diseaseCohort study of patientsRisk of chronic kidney diseaseAngiotensin II receptor blockersAutonomous cortisol secretionAngiotensin-converting enzyme inhibitorsTreated with adrenalectomyImpact of adrenalectomyIndependent risk factorRetrospective cohort studyII receptor blockersFollow-up periodStudy of patientsConverting Enzyme InhibitorsPredictive Value of CT Biomarkers in Lung Transplantation Survival: Preliminary Investigation in a Diverse, Underserved, Urban Population
Friedman R, Tarasova A, Jain V, Ye K, Mansour A, Haramati L. Predictive Value of CT Biomarkers in Lung Transplantation Survival: Preliminary Investigation in a Diverse, Underserved, Urban Population. Lung 2023, 201: 581-590. PMID: 37917190, DOI: 10.1007/s00408-023-00650-6.Peer-Reviewed Original ResearchConceptsCT biomarkersPredictive valueHounsfield unitsFat areaErector spinaeSingle-center retrospective cohort studyHigh visceral fat areaDonor lung availabilityLung transplant programsLung transplant survivalLung transplantation survivalResultsThe study cohortRetrospective cohort studyPost-transplant survivalVertebral body Hounsfield unitsVisceral fat areaKaplan-Meier curvesSubcutaneous fat areaAbsence of sarcopeniaMuscle areaCox proportional hazardsPectoralis muscle areaLung transplantCohort studyStudy cohortCombination Therapy of Low-dose Steroids, Tacrolimus and Mycophenolate Mofetil in Primary Membranous Nephropathy: A Single-center Retrospective Cohort Study
Zhao S, Jia L, Cui C, Chen Z, Duan Z, Gao J, Wei L, Xue X, Lei F, Yang Y, Liu J, Xu P, Wang R, Wei Y, Tian X, Fu R. Combination Therapy of Low-dose Steroids, Tacrolimus and Mycophenolate Mofetil in Primary Membranous Nephropathy: A Single-center Retrospective Cohort Study. Integrative Medicine In Nephrology And Andrology 2023, 10: e00012. DOI: 10.1097/imna-d-22-00012.Peer-Reviewed Original ResearchPrimary membranous nephropathyIntravenous cyclophosphamideRegimen groupMycophenolate mofetilMembranous nephropathyNephrotic syndromeCombination therapyBiopsy-proven primary membranous nephropathySingle-center retrospective cohort studyPC groupCumulative complete remission ratesLow-dose glucocorticoidsLow-dose steroidsNon-inferior efficacyRetrospective cohort studySerum creatinine levelsComplete remission rateCommon pathological typeUrinary protein levelsFavorable safety profileBest combination therapyAlternative treatment choiceRemission rateAdverse eventsCohort study
2022
Immune checkpoints inhibitors and its link to acute kidney injury and renal prognosis
Kanbay M, Yildiz AB, Siriopol D, Vehbi S, Hasbal NB, Kesgin YE, Celayir M, Selcukbiricik F, Covic A, Perazella MA. Immune checkpoints inhibitors and its link to acute kidney injury and renal prognosis. International Urology And Nephrology 2022, 55: 1025-1032. PMID: 36282399, DOI: 10.1007/s11255-022-03395-y.Peer-Reviewed Original ResearchConceptsAcute kidney injuryImmune checkpoint inhibitorsSolid organ malignanciesCheckpoint inhibitorsKidney injuryOrgan malignanciesNephrotoxic agentsSingle-center retrospective cohort studyType of ICIBaseline serum creatinine levelAcute interstitial nephritisLocation of malignancyRetrospective cohort studySerum creatinine levelsKidney function recoveryRenal replacement therapyUrinary tract obstructionRisk of mortalityICPI treatmentRenal prognosisTract obstructionCohort studyCreatinine levelsFive patientsInterstitial nephritisADVERSE CARDIOVASCULAR EVENTS ASSOCIATED WITH KINASE INHIBITORS IN THE TREATMENT OF CANCER REVEAL SPECIFIC RISK BASED ON THE KINASE INHIBITOR - A SINGLE-CENTER RETROSPECTIVE COHORT STUDY
Kwan J, Shen M, Mankbadi M, Wang P, Zaman S, Lee S, Jiang M, Tao W, Wei W, Akhlaghi N. ADVERSE CARDIOVASCULAR EVENTS ASSOCIATED WITH KINASE INHIBITORS IN THE TREATMENT OF CANCER REVEAL SPECIFIC RISK BASED ON THE KINASE INHIBITOR - A SINGLE-CENTER RETROSPECTIVE COHORT STUDY. Journal Of The American College Of Cardiology 2022, 79: 1924. DOI: 10.1016/s0735-1097(22)02915-1.Peer-Reviewed Original ResearchSingle-center retrospective cohort studyKinase inhibitorsRetrospective cohort studyCohort studyAdverse CardiovascularCancer revealsInhibitorsCardiovascularADVERSE CARDIOVASCULAR EVENTS ASSOCIATED WITH IMMUNE CHECKPOINT INHIBITORS - A SINGLE CENTER RETROSPECTIVE COHORT STUDY
Kwan J, Akhlaghi N, Jiang M, Shen M, Im Y, Mankbadi M, Wang P, Zaman S, Lee S, Tao W, Wei W, Ma S. ADVERSE CARDIOVASCULAR EVENTS ASSOCIATED WITH IMMUNE CHECKPOINT INHIBITORS - A SINGLE CENTER RETROSPECTIVE COHORT STUDY. Journal Of The American College Of Cardiology 2022, 79: 1909. DOI: 10.1016/s0735-1097(22)02900-x.Peer-Reviewed Original ResearchSingle-center retrospective cohort studyCenter retrospective cohort studyImmune checkpoint inhibitorsRetrospective cohort studyCheckpoint inhibitorsCohort studyAdverse CardiovascularCardiovascular
2020
1164. Epidemiology of Cryptococcal Infections in Non-HIV Patients: A 20-year Single Center Experience
Kumar R, Nam H, Roberts S, Penugonda S, Angarone M, Stosor V. 1164. Epidemiology of Cryptococcal Infections in Non-HIV Patients: A 20-year Single Center Experience. Open Forum Infectious Diseases 2020, 7: s608-s608. PMCID: PMC7776216, DOI: 10.1093/ofid/ofaa439.1350.Peer-Reviewed Original ResearchCryptococcal antigenRisk factorsCerebrospinal fluidSingle-center retrospective cohort studyCenter retrospective cohort studySolid organ transplant recipientsCommon predisposing conditionsNon-HIV patientsPositive cryptococcal antigenPositive culture dataRetrospective cohort studyChronic kidney diseaseOrgan transplant recipientsSingle-center experienceSolid organ transplantsTime of diagnosisUse of immunosuppressionNorthwestern Memorial HospitalCentral nervous systemSite of infectionHospital mortalityCryptococcal infectionTransplant recipientsCohort studyPredisposing condition
2018
The use of acute normovolemic hemodilution in paediatric cardiac surgery
Crescini WM, Muralidaran A, Shen I, LeBlanc A, You J, Giacomuzzi C, Treggiari MM. The use of acute normovolemic hemodilution in paediatric cardiac surgery. Acta Anaesthesiologica Scandinavica 2018, 62: 756-764. PMID: 29504128, DOI: 10.1111/aas.13095.Peer-Reviewed Original ResearchConceptsAcute normovolemic hemodilutionPediatric cardiac surgery patientsCardiac surgery patientsBlood productsHospital stayBaseline characteristicsSurgery patientsBlood lossNormovolemic hemodilutionSingle-center retrospective cohort studyUse of ANHHigh blood loss surgeryLower postoperative blood lossCongenital Heart Surgery scoreAllogenic blood productsAllogeneic blood productsDuration of ICUPostoperative blood lossRetrospective cohort studyLower blood lossPediatric cardiac surgeryMonths of ageAnaesthesiologists classificationANH groupPerioperative transfusion
2017
Derivation of a Clinical Model to Predict Unchanged Inpatient Echocardiograms
Gunderson CG, Gromisch ES, Chang JJ, Malm BJ. Derivation of a Clinical Model to Predict Unchanged Inpatient Echocardiograms. Journal Of Hospital Medicine 2017, 13: 164-169. PMID: 29073315, DOI: 10.12788/jhm.2866.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseAcute myocardial infarctionCAVE scoreClinical prediction modelKidney diseaseMyocardial infarctionSingle-center retrospective cohort studyRetrospective cohort studyGood discriminationInpatient echocardiogramSubset of studiesCohort studyIndependent predictorsValvular diseaseECG changesElectrocardiogram changesC-statisticCardiothoracic surgeryRepeat studyFull cohortClinical modelDiseaseTTEΒ coefficientsInfarctionElectronic Health Data Predict Outcomes After Aneurysmal Subarachnoid Hemorrhage
Zafar SF, Postma EN, Biswal S, Fleuren L, Boyle EJ, Bechek S, O’Connor K, Shenoy A, Jonnalagadda D, Kim J, Shafi MS, Patel AB, Rosenthal ES, Westover MB. Electronic Health Data Predict Outcomes After Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care 2017, 28: 184-193. PMID: 28983801, PMCID: PMC5886829, DOI: 10.1007/s12028-017-0466-8.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageGlasgow Outcome ScaleWhite blood cellsIntracranial pressureAPACHE IIElectronic health dataSubarachnoid hemorrhageBetter outcomesSingle-center retrospective cohort studyDischarge Glasgow Outcome ScaleEarly goal-directed therapyAPACHE II scoreGoal-directed therapyRetrospective cohort studyMean arterial pressureRisk stratification scoresAdmission APACHE IIPredictors of outcomeMultivariate analysis predictorsLogistic regression modelsHealth dataAdmission dayII scoreNeurologic outcomeArterial pressure
2015
Safety and efficacy of pharmacological thromboprophylaxis for hospitalized patients with cirrhosis: a single‐center retrospective cohort study
Shatzel J, Dulai P, Harbin D, Cheung H, Reid T, Kim J, James S, Khine H, Batman S, Whyman J, Dickson R, Ornstein D. Safety and efficacy of pharmacological thromboprophylaxis for hospitalized patients with cirrhosis: a single‐center retrospective cohort study. Journal Of Thrombosis And Haemostasis 2015, 13: 1245-1253. PMID: 25955079, PMCID: PMC6658183, DOI: 10.1111/jth.13000.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAgedAnticoagulantsDrug Administration ScheduleFemaleGastrointestinal HemorrhageHeparin, Low-Molecular-WeightHospitalizationHumansLength of StayLiver CirrhosisMaleMiddle AgedNew HampshireOdds RatioRetrospective StudiesRisk FactorsTertiary Care CentersTime FactorsTreatment OutcomeVenous ThromboembolismConceptsLow molecular weight heparinHospital bleeding eventsRetrospective cohort studyMolecular weight heparinVTE prophylaxisVenous thromboembolismBleeding eventsPharmacological thromboprophylaxisCirrhotic patientsCohort studyUnfractionated heparinWeight heparinSingle-center retrospective cohort studyEnd-stage liver disease (MELD) scoreAcademic tertiary care referral centerRate of VTETertiary care referral centerRisk of VTEGastrointestinal bleeding eventsHospitalized cirrhotic patientsNew VTE eventsPharmacological VTE prophylaxisLiver Disease scoreHospital bleedingVTE events
2011
Pretransplant Risk Score for New-Onset Diabetes After Kidney Transplantation
Chakkera HA, Weil EJ, Swanson CM, Dueck AC, Heilman RL, Reddy KS, Hamawi K, Khamash H, Moss AA, Mulligan DC, Katariya N, Knowler WC. Pretransplant Risk Score for New-Onset Diabetes After Kidney Transplantation. Diabetes Care 2011, 34: 2141-2145. PMID: 21949218, PMCID: PMC3177751, DOI: 10.2337/dc11-0752.Peer-Reviewed Original ResearchConceptsRisk of NODATNew-onset diabetesRisk scoreKidney transplantationPretransplant variablesSingle-center retrospective cohort studyUnivariate logistic regression analysisMultivariate logistic regression modelRetrospective cohort studySimple risk scoreLogistic regression analysisLogistic regression modelsRelevant cut pointsYear posttransplantCohort studySerum glucoseNODATSummary scoresIntervention studiesDiabetesMultivariate modelCut pointsSum of pointsScoresRegression analysis
2008
Risk of Infection and Death due to Methicillin- Resistant Staphylococcus aureus in Long-Term Carriers
Datta R, Huang SS. Risk of Infection and Death due to Methicillin- Resistant Staphylococcus aureus in Long-Term Carriers. Clinical Infectious Diseases 2008, 47: 176-181. PMID: 18532892, PMCID: PMC2649874, DOI: 10.1086/589241.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBacteremiaBostonCarrier StateCatheterization, Central VenousCohort StudiesFemaleHospitalizationHumansLogistic ModelsMaleMethicillin ResistanceMiddle AgedPneumoniaRetrospective StudiesRisk FactorsSex FactorsSoft Tissue InfectionsStaphylococcal InfectionsStaphylococcus aureusTime FactorsConceptsMethicillin-resistant Staphylococcus aureusLong-term carriersRisk of infectionMRSA infectionSingle-center retrospective cohort studyCentral venous catheter infectionSubsequent MRSA infectionVenous catheter infectionRetrospective cohort studyShort-term morbiditySoft tissue infectionsDuration of carriageStaphylococcus aureusMRSA colonizationCohort studyCatheter infectionCommon infectionsNew hospitalizationHigh riskSubsequent infectionTime of detectionPersistent riskInfectionSignificant riskDeath
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